ライフサイエンスコーパス: bed rest

1 participated in a 5-day bed rest challenge (BED REST).

2 Treatment is supportive with bed rest.

3 cardiovascular deconditioning resulting from bed rest.

4 male volunteers before and after 60 days of bed rest.

5 0.044) and were still elevated on day 6 post-bed rest.

6 orientation in the same way before and after bed rest.

7 e tolerance test (OGTT) at baseline and post-bed rest.

8 ulators of mitochondrial dynamics induced by bed rest.

9 nd postprandial MyoPS (aMyoPS) at the end of bed rest.

10 uld mitigate the adverse metabolic effect of bed rest.

11 impaired balance commonly observed following bed rest.

12 nondiabetic older adults following 7 days of bed rest.

13 . m(-2)) were subjected to 1 week of strict bed rest.

14 th LEU: -1.5 +/- 0.3 and -1.0 +/- 0.3 kg) of bed rest.

15 ), can protect skeletal muscle health during bed rest.

16 oung persons to muscle loss after short-term bed rest.

17 d muscle anabolic and catabolic responses to bed rest.

18 with no music, white noise, and undisturbed bed rest.

19 abnormal GS site 2+2a phosphorylation after bed rest.

20 uring the clamp were lower after than before bed rest.

21 scles, may also reduce some complications of bed rest.

22 in centroparietal regions, after 30 days of bed rest.

23 (HU) is an animal model of microgravity and bed rest.

24 nd heart rate were measured after a 5-minute bed rest.

25 e similar to those observed after 17 days of bed rest.

26 xed, less anxious, and less tired than after Bed-REST.

27 ance exercise performed the evening prior to bed-rest.

28 RE the evening prior to 5 days of in-patient bed-rest.

29 X) and non-exercised control (CTL) legs with bed-rest.

30 (CSA) was determined prior to and following bed-rest.

31 aturation levels persisted after 57 d of HDT bed rest (+13.5%, P = 0.026), suggesting that long-term

32 yofibrillar protein synthesis (MyoPS) during bed rest accelerate skeletal muscle loss in older adults

33 Empirical treatment includes bed rest, administration of caffeine, corticosteroids or

34 nt position, indication for lumbar puncture, bed rest after puncture, or clinician specialty.

35 ed to 60 min of Floatation-REST or 60 min of Bed-REST (an active control condition that entailed lyin

36 tion on three occasions: before (PRE), after bed rest and after rehabilitation.

37 x activities involving the back, and days of bed rest and days of limited activity due to back pain w

38 t normal comparison subjects after overnight bed rest and following orthostatic challenge.

39 lved with conservative therapy consisting of bed rest and hydration with hypotonic intravenous fluids

40 During prolonged bed rest and immobilization, circulating sclerostin incr

41 line rapidly in situations of disuse such as bed rest and limb immobilisation.

42 Extended periods of bed rest and limb immobilization are required for healin

43 Conditions of extended bed rest and limb immobilization can initiate rapid and

44 onally, preoperative posturing consisting of bed rest and positioning is prescribed to patients with

45 Preoperative bed rest and positioning were prescribed.

46 y changes in physical activity, ranging from bed rest and spaceflight to endurance exercise training,

47 itochondrial function adapt to long duration bed rest and whether changes can be prevented by nutriti

48 bilitating fatigue that is not improved with bed rest and worsens after physical activity or mental e

49 BR did not exercise during bed-rest and had a 17 and 40% decrease in whole muscle s

50 ion of the MHC I fibres was more affected by bed-rest and less influenced by the resistance exercise

51 Bed rest, and its associated mechanisms, may play an imp

52 ariability significantly increased following bed rest, and this was correlated with the increases in

53 f drains, irrigation of the hematoma cavity, bed rest, and treatment of recurrences following CSDH ma

54 ependent and clinically important in ageing, bed-rest, and cachexia, where muscle weakening leads to

55 of ambulation and deconditioning effects of bed rest are one of the most predictable causes of loss

56 = 0.009) increased in males after 6 d of HDT bed rest, as well as serum hepcidin concentrations (+36.

57 Chronic bed rest (BR) serves as a model for studying the effects

58 females) before, on days 1, 9, 15 and 30 of bed rest (BR), and 6 and 13 days after HDTBR.

59 reased and muscle strength reduced following bed rest, but, in keeping with previous research, these

60 Bed rest can cause several complications that may delay

61 e results support the idea that ground-based bed rest can serve as a model of human spaceflight.

62 Bed rest caused up to 63% increases in spontaneous stand

63 ourteen young adults participated in a 5-day bed rest challenge (BED REST).

64 The change in iMyoPS over bed-rest correlated with the change in quadriceps CSA in

65 ross-links were measured before bed rest; on bed rest days 5-6, 12-13, 19-20, and 26-27; and daily du

66 Bed rest decreased postabsorptive MPS by 30% +/- 9% (CON

67 eading to choroid engorgement over 3 days of bed rest (Delta area: +0.09 mm2 [95% CI, 0.04-0.13]; P =

68 Micronutrient supplementation throughout bed rest did not preserve whole body metabolic changes.

69 In females, 6 and 57 d of HDT bed rest did not significantly change serum iron, transf

70 Earth-based analogs, including bed rest, dry immersion, and parabolic flights, reproduc

71 aceflight and spaceflight analogues, such as bed rest, dry immersion, parabolic flights, and isolated

72 2.6 [CI, 1.9 to 3.7]) and at least 1 day of bed rest due to back pain (OR, 6.7 [CI, 4.4 to 10.2]) an

73 ence-based methods to reduce the duration of bed rest during critical illness may be important for im

74 The duration of bed rest during critical illness was consistently associ

75 Prolonged bed rest ensues changes in key regulators of mitochondri

76 Treatments include bed rest, epidural blood patching, percutaneous placemen

77 g and changes in cardiac function induced by bed rest, exercise training and spaceflight, as well as

78 In a bed rest experiment, use of high-precision isotope ratio

79 ale participants who were all exposed to HDT bed rest for 60 d.

80 vastus lateralis before and after 84 days of bed-rest from six control (BR) and six resistance-exerci

81 cingulate gyrus, insula and precuneus in the bed rest group in both ERP time frames for emotional, bu

82 Bed rest has a profoundly negative effect on muscle meta

83 Bed rest has been prescribed in the past for several oth

84 ver, in more recent times, deep sedation and bed rest have been part of routine medical care for many

85 from two ground analog 60-day head-down tilt bed rest (HDBR) experiments (ESA/DLR "Cocktail" and "RSL

86 Head down-tilt bed rest (HDBR) serves as a microgravity analog because

87 I, in contrast to 2 months of head-down tilt bed rest (HDBR), another spaceflight analog.

88 e 30 days of strict 6 degrees head-down tilt bed rest (HDTBR) in a mild hypercapnic environment ( PCO

89 ic adaptation of the heart to head-down tilt bed rest (HDTBR) or acute hypovolemia alone.

90 ibres showed no change in size or V(o) after bed-rest; however, P(o) was 19% lower (P < 0.05), result

91 udies employing several experimental models: bed rest, immobilization, reduced step count, and reduci

92 Prolonged bed rest impairs standing balance but the underlying mec

93 During bed-rest, iMyoPS rates decreased from habitual values in

94 Patients were admitted to the ward for bed rest in anticipation of surgery and were positioned

95 lling and protein synthesis increased before bed rest in both age groups (P < 0.05).

96 lowing weightlessness simulated by head-down bed rest in humans, and is proposed as a mechanism respo

97 failed to demonstrate beneficial effects of bed rest in most of these conditions.

98 orrelated with pyridinium cross-links before bed rest in the EX group (r = 0.83), in the EX group dur

99 ake and work performance and requirement for bed rest in the year after injury.

100 synthesis and muscle atrophy over 5 days of bed-rest in older men was attenuated by a single bout of

101 rates and quadriceps atrophy with 5 days of bed-rest in older men.

102 (peak torque/kg leg lean mass) after 14 d of bed-rest inactivity (CON compared with LEU: -9% +/- 2% a

103 Bed rest increased 2-h OGTT blood glucose and insulin in

104 d, with an increase in pDrp1(s616) following bed rest indicative of an increase in mitochondrial fiss

105 flight or resumption of normal posture after bed rest, individuals often exhibit cardiovascular decon

106 Bed rest induced a 29 +/- 5% decrease in whole-body insu

107 Finally, rehabilitation restored bed rest-induced deficits in lean mass and strength in o

108 This bed rest-induced insulin resistance occurred together wi

109 Bed rest-induced muscle loss and impaired muscle recover

110 Bed rest is a well-established spaceflight analogue that

111 Orthostatic intolerance after bed rest is characterized by hypovolemia and an excessiv

112 Bed rest is frequently prescribed for critically ill pat

113 Bed rest is not more helpful than activity as tolerated

114 ntensive care unit-acquired weakness include bed rest itself, sepsis, and corticosteroid exposure.

115 Two weeks of head-down-tilt bed rest leads to a smaller, less distensible left ventr

116 The cardiovascular adaptation to bed rest leads to orthostatic intolerance, characterized

117 l of loading via microgravity, paralysis, or bed rest leads to rapid loss of muscle mass and function

118 Sixty days of -6 degrees head down tilt bed rest leads to significant changes in body compositio

119 Prior to and after bed rest, lean body mass (dual-energy X-ray absorptiomet

120 Bed rest led to a reduction in plasma volume (17%), base

121 nsory overload, sleep deprivation, prolonged bed rest, malnourishment, and sleep is usually inherentl

122 e in choroid area and volume after 3 days of bed rest measured by optical coherence tomography.

123 ambient PCO2 with the strict head-down tilt bed rest model of spaceflight and this led to the develo

124 fects of 30 days of 6 degrees head-down tilt bed rest on affective picture processing using event-rel

125 aimed (1) to assess the effect of prolonged bed rest on skeletal muscle mitochondrial function and d

126 pyridinium cross-links were measured before bed rest; on bed rest days 5-6, 12-13, 19-20, and 26-27;

127 No bed rest or activity restriction was recommended.

128 ocolysis drugs, 1276 (27%) were treated with bed rest or hydration and 2248 (48%) received no treatme

129 ity loading and muscle activity, for example bed rest or microgravity.

130 paceflight and for patients during prolonged bed rest or paralysis.

131 Severe inactivity during bed rest or spaceflight leads to cardiac atrophy and ven

132 cardiac changes during prolonged periods of bed rest or spaceflight.

133 2.2 [CI, 1.5 to 3.1]) and at least 1 day of bed rest (OR, 7.9 [CI, 4.9 to 12.9]) and 7 days of limit

134 ne loss that plagues long-term space flight, bed rest, or immobilization caused by paralysis.

135 chanical loading due to physical inactivity, bed rest, or immobilization.

136 r (V(o)), and 54 and 24% less powerful after bed-rest (P < 0.05).

137 Compared to a control group, bed rest participants showed significantly decreased P30

138 nal limited-activity days and 1 to 2 days of bed rest per year.

139 a 7 day habitual 'free-living' phase and the bed-rest phase, and rates of acute postabsorptive and po

140 navoidable for many of reasons (i.e. injury, bed rest, post-surgery), and can have significant advers

141 s a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inact

142 Compared across vascular beds, resting renal blood flow was correlated with maxim

143 to determine if rehabilitation could reverse bed rest responses.

144 Bed rest resulted in 1.4 +/- 0.2 kg lean tissue loss and

145 Bed rest results in a decrease in skeletal muscle mitoch

146 ntical twins were assigned to 1 of 2 groups: bed rest (sedentary, or SED, group) or bed rest with sup

147 ure a period of immobility such as prolonged bed rest should resume their daily activities in additio

148 e rate observed by densitometry in long-term bed rest studies.

149 tained in participants of the head down tilt bed rest study.

150 ium intake may affect bone in ambulatory and bed-rest subjects.

151 In conclusion, 1 week of bed rest substantially reduces skeletal muscle mass and

152 crease in SV during orthostatic stress after bed rest than hypovolemia alone, potentially contributin

153 n mitochondrial content following 60 days of bed rest, the maintenance of regulators of mitophagy in

154 participants exposed to head-down tilt (HDT) bed rest, the reference ground-based model of microgravi

155 ay: 0.5 ng/kg) combined with a 36-h fast and bed rest to mimic catabolic inflammatory disease (CAT) o

156 ke sway responses before, 1 and 6 days after bed rest under different head yaw orientations.

157 ntrol of balance before and after 60 days of bed rest using electrical vestibular stimulation (EVS) t

158 EX group (r = 0.83), in the EX group during bed rest week 1 (r = 0.84), and in the SED group during

159 ek 1 (r = 0.84), and in the SED group during bed rest week 2 (r = 0.72) but not during either chamber

160 d with N-telopeptide in the SED group during bed rest weeks 3 and 4 (r = 0.77 and 0.80) and during th

161 Cervical lymphadenopathy and initial bed rest were associated with, or predicted, a fatigue s

162 ly means of studying this in human beings is bed rest, which is resource intensive and inconvenient f

163 leg glucose extraction both before and after bed rest, which was accompanied by higher GS activity in

164 owed no change in size, P(o) and power after bed-rest, while V(o) was elevated 13% (P < 0.05).

165 saline infusion before and after 2 weeks of bed rest with -6 degrees head-down tilt (n=12 subjects a

166 ease completed 3 days of supine (0 degrees ) bed rest with and 3 days without 8 hours of nightly LBNP

167 ined in energy balance throughout 60 days of bed rest with micronutrient supplementation (INT) (body

168 oups: bed rest (sedentary, or SED, group) or bed rest with supine treadmill exercise in a lower-body

169 g, healthy male subjects completed 7 days of bed rest with vastus lateralis muscle biopsies obtained

170 1 and Drp1 protein expression decreased with bed rest, with an increase pDrp1(s616).

171 ULLS at rates comparable to those seen with bed rest, without alteration in limb fluid volumes thus