ライフサイエンスコーパス: bell-shaped

1 rrent-voltage (I-V) relationship for ICa was bell shaped.

2 se curve of GRP-stimulated DNA synthesis was bell shaped.

3 3-O-[(R)-3-hydroxymyristoyl]-GlcNAc are both bell-shaped.

4 The V/K(ne) pH profile is bell-shaped.

5 d probability of having African ancestry was bell-shaped.

6 permine, the k(cat)/K(amine)-pH profiles are bell-shaped.

7 second-order rate constants of inhibition is bell-shaped.

8 tes it at low concentrations, resulting in a bell-shaped activation profile.

9 HIV RNase H with Mn2+ or Co2+ ions generated bell-shaped activity dose-response curves.

10 c-Jun exhibits a bell-shaped activity on androgen receptor-mediated trans

11 H253A, K227A, H253A/K227A, and D234N remain bell-shaped, although their significantly lower activiti

12 ociation constant (k(lim)/K(d)) versus pH is bell-shaped and characterized by two macroscopic pK(a) v

13 tion of free enzyme with free cytochrome) is bell-shaped and closely resembles that of kox/Kd(cyt c),

14 he matrix metalloproteinase (MMP) family are bell-shaped and exhibit neutral pH optima.

15 (cat)/K(m) for URI from Escherichia coli are bell-shaped and indicate that one group must be unproton

16 ting with the l(o) phase, the OTP profile is bell-shaped and lies above that in the pure ESM membrane

17 ce of the fast central release component was bell-shaped and similar to that of I(Ca) in both cell gr

18 The pH profile of H224Q sHS is bell-shaped and similar to those reported for other MMPs

19 voltage dependence of the Ca2+ transient was bell-shaped and the maximum was centered at approximatel

20 nd the two components of central release was bell shaped, and the magnitude of each release component

21 citive component as a function of voltage is bell-shaped, and decreases with frequency.

22 Plots of activity versus log [metal ion] are bell-shaped, and the inhibitory phases of the profiles h

23 al evolution of Ca(2+) spark frequencies was bell-shaped, and the maximal spark frequency was reached

24 the data show that the size distribution is bell-shaped, and there is an approximately 40-A differen

25 en to separate the approximately symmetrical bell-shaped areas (negatives) from the skewed tails (pos

26 oM) concentration-response curve for LTP was bell shaped as no enhancement was seen with 30 microM se

27 s for the Y82F enzyme-catalysed reaction was bell-shaped as for the wild-type protein.

28 these inverted relationships, explaining the bell-shaped behavior.

29 3 to dissociate from the DNA, resulting in a bell-shaped binding curve.

30 r PAD in response to 0.1-100 microM 5-HT was bell-shaped but in the capsaicin pre-treated group, a no

31 mutations shifted the peak of the InsP(3)R1 bell-shaped Ca(2+) dependence from 0.2 micro M to 1.5 mi

32 In [3H]ryanodine binding measurements, bell-shaped Ca2+ activation/inactivation curves were obt

33 all three mammalian InsP3R isoforms display bell-shaped Ca2+ dependence in physiological range of Ca

34 y InsP3 without shifting the peak of InsP3R1 bell-shaped Ca2+ dependence.

35 The bell-shaped Ca2+-dependence curve of type I InsP3R is id

36 Ca2+ for all three InsP3R1 isoforms; 3) the bell-shaped Ca2+-dependence is wider for the InsP3R1-SII

37 pS) than the InsP3R1-SII(+) (81 pS); 2) the bell-shaped Ca2+-dependence peaks at 200-300 nM Ca2+ for

38 Bell-shaped cell spreading curves encompassing all subst

39 do not respond to RANTES with the classical bell-shaped chemotactic response curve, suggesting that

40 about the monopole creating a reverberating bell-shaped cloak in between which vibrates the ear bone

41 lution structure reveals an asymmetric, dumb-bell-shaped complex with 4-fold symmetry, a length of 14

42 With these constructs, the bell-shaped concentration dependence of leukocyte migrat

43 tokines like IL-8, and also has the familiar bell-shaped concentration dependence seen for CXC cytoki

44 st-noncompetitive antagonist hybrids produce bell-shaped concentration-response curves, whereas the a

45 response at higher concentrations, producing bell-shaped concentration-response curves.

46 ar Ca2+ and [3H]noradrenaline release with a bell-shaped concentration-response profile; maximum enha

47 o and in cells, generating a characteristic 'bell-shaped' concentration-response curve, reminiscent o

48 The k(cat)/K(m) value for the peptide is bell-shaped, consistent with a requirement that the nitr

49 Principal component analysis revealed two bell-shaped covariance channels, peaking at different nu

50 e-channel Ca2+ current (iCa) rather than the bell-shaped current-voltage (I-V) relation of macroscopi

51 onditions, Hg(II) bioavailability followed a bell shaped curve as DOM concentrations increased, both

52 a coli and Aquifex aeolicus LpxC displayed a bell-shaped curve (EcLpxC yields apparent pKa values of

53 We calculate the bell-shaped curve and show that, if materials can be eng

54 te constant versus pH profiles were fit to a bell-shaped curve for all adducts.

55 PtNHase was found to exhibit a bell-shaped curve for plots of relative activity versus

56 CtNHase was found to exhibit a bell-shaped curve for plots of relative activity vs pH o

57 The acidic pK(a) in the bell-shaped curve is due to the phenolic hydroxyl of Tyr

58 We show that a bell-shaped curve of cleavage activation is obtained as

59 Analysis at different pH values produced a bell-shaped curve of the WT enzyme, but D387G exhibited

60 esulted in mitotic arrest with a symmetrical bell-shaped curve over time.

61 -direction the dependence of kcat of pH is a bell-shaped curve that is described by pKaS of 6.4 and 1

62 distinguishable from the second phase of the bell-shaped curve that was obtained in the absence of ha

63 nectin concentrations tested and shifted the bell-shaped curve upwards.

64 In general, a bell-shaped curve was obtained for each of the MT-MMPs i

65 ergent concentration dependent, exhibiting a bell-shaped curve with its maximum activity near the cri

66 all treatments, offspring weight followed a bell-shaped curve with maternal age.

67 nase (MMP) catalysis is described by a broad bell-shaped curve, indicating the involvement of two uns

68 ct of heparin with all FXa derivatives was a bell-shaped curve, which disappeared if the ionic streng

69 The ANG pH-rate profile is a classic bell-shaped curve, with pK(1) = 5.0 and pK(2) = 7.0.

70 of log k(cat)/K(m) versus pH is a distorted bell-shaped curve, with slopes of +1 on the acid side an

71 at n = 3, and then declines: the result is a bell-shaped curve.

72 ing channels as a function of log10(Ca) is a bell-shaped curve.

73 was dosage dependent on the inducer, with a bell-shaped curve.

74 cose with a response profile that followed a bell-shaped curve.

75 The 'bell-shaped' curve relating cytosolic Ca(2+) concentrati

76 the trough concentrations obtained from the bell-shaped curves are comparable to normal plasma level

77 Apparently corresponding bell-shaped curves displaying the pro-oxidant effect of

78 th log k cat/ K m and log k cat conformed to bell-shaped curves for which an inverse solvent kinetic

79 he mutants as a function of pH display broad bell-shaped curves that are similar to the wild-type enz

80 the pH-dependence of V(max) and V/K describe bell-shaped curves, consistent with the hypothesis that

81 trations (10(-1) to 10(5) units/ml) produced bell-shaped curves, demonstrating that inhibition occurs

82 cant dose-response associations emerged with bell-shaped curves: (1) in schizophrenia, high-frequency

83 Instead of the expected narrow bell-shaped cytoplasmic free Ca2+ concentration ([Ca2+]i

84 we show that in contrast to IL-8, where the bell-shaped dependence arises from the effects of CXCR1/

85 The bell-shaped dependence for electron-hole pair recombinat

86 rmediate at 505 nm is affected by pH, with a bell-shaped dependence for the forward rate constant, k(

87 Unlike interfering with the bell-shaped dependence of InsP(3)Rs to [Ca(2+)](i), CT9

88 wever, these synthetic lipids give rise to a bell-shaped dependence of membrane permeability on [Chol

89 two p K a values previously observed by the bell-shaped dependence of the LpxC-catalyzed reaction.

90 arcus theory of electron transfer predicts a bell-shaped dependence of the reaction rate on the react

91 ude of the caged ADP tension transient had a bell-shaped dependence on Ca(2+), reaching a maximum at

92 open probabilities for PC-2 and S812A show a bell-shaped dependence on cytoplasmic Ca(2+) but there i

93 centration, whereas the type I isoform has a bell-shaped dependence on cytoplasmic Ca2+.

94 e constants did not exhibit a characteristic bell-shaped dependence on heparin concentration.

95 currents, the membrane capacitance showed a bell-shaped dependence on membrane potential with a peak

96 ve previously shown that MshB activity has a bell-shaped dependence on pH with pK(a) values of approx

97 d to Zn(2+)-LpxC; both metalloenzymes have a bell-shaped dependence on pH with similar pK(a) values,

98 rated chromium(0) complex exhibit an unusual bell-shaped dependence on solvent polarity, indicative o

99 In particular, movement amplitude showed a bell-shaped dependence on stimulus frequency, with a pea

100 tion kinetics, and the noise has a predicted bell-shaped dependence on the activation states of the e

101 er, the rate of charge recombination shows a bell-shaped dependence on the inverse temperature, first

102 2+)](i) transient amplitudes and I(Ca) had a bell-shaped dependence on V(m), but [Ca(2+)](i) reached

103 reasonably well the experimentally observed bell-shaped dependencies of bovine serum albumin or gela

104 These traits also showed a bell-shaped dependency on exogenous ABA, and their regul

105 y blocked by cobalt, and exhibited a similar bell-shaped dependency on voltage with a peak response a

106 elongation and whole-root hydraulics, had a bell-shaped dependency on WD, displaying stimulation und

107 The pH dependence of the activity was bell-shaped, depending on the ionization state of two gr

108 The pH-activity profile was bell-shaped, depending on the ionization state of two gr

109 The pH profile was bell-shaped, depending on the ionization state of two io

110 ially after lavage and were sigmoidal with a bell-shaped derivative function.

111 eric species built from the association of a bell-shaped dimer, a process we characterized by electro

112 Slopes of eGFR had a bell-shaped distribution (mean [SD], -1.5 [-2] ml/min pe

113 ind the Dorsal gradient maintains a constant bell-shaped distribution during embryogenesis.

114 ns exhibit a 60% incidence of diabetes and a bell-shaped distribution of insulin levels as related to

115 ted earlier at initial flower opening with a bell-shaped distribution pattern.

116 hanges from an asymmetric "double peak" to a bell-shaped distribution, and the deviatoric stress of r

117 f subjects to clopidogrel followed a normal, bell-shaped distribution, with a mean and standard devia

118 verall occupancies of ~8 P(i) (+/- 5) with a bell-shaped distribution; the highly phosphorylated frac

119 doses of 0.1, 0.3 and 1.0 mg/kg, produced a bell-shaped dose response effect on DA efflux in the mPF

120 fic IgE and challenged with Pen a 1 showed a bell-shaped dose response for secretion, with optimal Pe

121 The ORL-1 antagonist also eliminated the bell-shaped dose-response curve for buprenorphine-induce

122 Thus, Cas exhibits an unusual bell-shaped dose-response curve in response to EGF stimu

123 and high concentrations, reminiscent of the bell-shaped dose-response curve obtained for TBS-induced

124 ) versus 5-HT(7) receptors, may underlie the bell-shaped dose-response curve via a mechanism of 'cros

125 he presence of tetrodotoxin, NMDA produced a bell-shaped dose-response curve with stimulation of phos

126 ed the GTPase activity following an inverted bell-shaped dose-response curve, whereas when EF-2 and r

127 uced pMF was dose dependent, but exhibited a bell-shaped dose-response curve.

128 ions in both pMHC affinity and dose produced bell-shaped dose-response curves and different optimal p

129 In addition, two narrow bell-shaped dose-response curves were identified with ma

130 e sinks for the free inhibitor, resulting in bell-shaped dose-response curves.

131 rease in its inhibitory effect, resulting in bell-shaped dose-response curves.

132 tly increased cell proliferation albeit with bell-shaped dose-response kinetics.

133 mber of these analogues were found to have a bell-shaped dose-response profile in the alpha1 beta2 ga

134 a distinct pharmacological profile without a bell-shaped dose-response relationship or tachyphylaxis

135 tment increased the PKCalpha activity with a bell-shaped dose-response relationship peaking at 10 nM,

136 d each affected the rotational behavior in a bell-shaped dose-response relationship producing increas

137 s 3-5 each affected rotational behavior in a bell-shaped dose-response relationship producing maximal

138 ents but to a lesser extent, indicative of a bell-shaped dose-response relationship.

139 PKCalpha-PLC-phospholipase D (PLD)-mTOR in a bell-shaped, dose-dependent manner requiring the Ca2+ se

140 with the 5' flanking region of Tac1 showed a bell-shaped effect of SDF-1alpha on luciferase activity

141 The bell-shaped effect of the field frequency with maximum a

142 nct binding sites for halides comes from the bell-shaped effects observed when the second-order rate

143 Extreme values of Psi0 lead to asymmetric, bell-shaped extension-rotation profiles with sharp maxim

144 L5 (alpha5beta1) showed bell-shaped FAK activation at both concentrations, block

145 ed by circular dichroism exhibit reversible, bell-shaped folding and unfolding transitions, implying

146 rofiles for both k(cat) and k(cat)/K(m) were bell-shaped for all of the HDAC isozymes, with pH optima

147 (M)-pH profiles with N(1)-acetylspermine are bell-shaped for all the mutants; the similarity to the p

148 t)/K(m)(L-OSHS) versus pH profile of eCGS is bell-shaped for both reactions.

149 The resistive component is bell-shaped for both voltage and frequency.

150 erating effects on heparin concentration was bell-shaped for ZPI reactions with both factors Xa and X

151 f STIM1, CRAC current was a highly nonlinear bell-shaped function of Orai1 expression and the minimum

152 ies or nonrecombining chromosome region is a bell-shaped function of the mutation rate: at some point

153 ma distribution, which is in contrast to the bell-shaped Gamma distribution when the gene effects wer

154 speed tuning curves of MT neurons should be bell-shaped (Gaussian) as a function of the logarithm of

155 Saturating HCII dependences and bell-shaped heparin dependences of the fluorescence chan

156 In computational models, such a bell-shaped "hill of activity" is commonly assumed to be

157 (R2N)PPn(+*) further show that the symmetric bell-shaped hole distribution distorts and shifts toward

158 merizes via the FAD-binding domain to form a bell-shaped homodimer in solution with a maximal dimensi

159 endence of phasic contraction which was more bell-shaped (i.e. more similar to that of ICa,L) than th

160 Cyclosporine treatment caused bell-shaped improvements in cardiac output, stroke volum

161 The voltage-contraction relationship was bell-shaped in Na+-free solutions (to eliminate the Na+

162 tate concentration-response curves that were bell-shaped in response to either glutamate or AMPA.

163 tionship between contraction and voltage was bell-shaped in the absence of Na-Ca exchange.

164 The time course of D was bell-shaped, indicating it was an intermediate.

165 me modest effects, the shapes of neither the bell-shaped k(cat)/S(0.5)-pH (and related functions) plo

166 The bell-shaped logarithmic GAG dependences fit an obligator

167 rge of the membrane motor is manifested as a bell-shaped membrane potential dependence of the membran

168 The crystal structure of PfPA28 reveals a bell-shaped molecule with an inner pore that has a stron

169 trong plasmonic coupling effect, and (iii) a bell-shaped nanostructure that can effectively amplify t

170 ctural units (dialkyammonium groups) in dumb-bell-shaped organic molecules template the assembly of e

171 otation and cross-stream translation along a bell-shaped path.

172 ore fatty acid synthesis enzymes displayed a bell-shaped pattern of expression between 5 and 13 days

173 males), and, respectively, showed a U- and a bell-shaped pattern with age.

174 rmal eyes and optic nerve crush alone showed bell-shaped patterns of change: approximately 50% below

175 is qualitatively different from the largely bell-shaped patterns typical of EMG activity associated

176 the chemical shift analysis, nonuniform and bell-shaped peak intensity profiles, and limited proteol

177 The concept of bell-shaped persistent neural activity represents a corn

178 ssociated with a rate constant that showed a bell-shaped pH dependence indicative of participation of

179 Furthermore, we conclude that the simple bell-shaped pH dependence of k(cat) and k(cat)/K(m) for

180 The bell-shaped pH dependence of permeability suggests that,

181 Furthermore, the wild-type hydratase shows a bell-shaped pH dependence of the kcat/Km with pKa values

182 o-step mechanism is also consistent with the bell-shaped pH dependence of the reaction rate.

183 In addition, normal bell-shaped pH dependence on the reaction catalyzed by M

184 The bell-shaped pH dependence upon pK(app)'s of 7.1 and 9.1

185 -)(CoA), and V/K(homoserine) all exhibited a bell-shaped pH dependence with apparent pK's of 6.6 and

186 (kcat/Km)app and kred/Kd exhibit comparable bell-shaped pH dependence with pKa values of 6.4 +/- 0.2

187 lated cytochrome c(3+) reduction displayed a bell-shaped pH dependence with the protonation of a grou

188 ecovery to the colored ground state showed a bell-shaped pH dependence, controlled by two pKa values

189 Formation of this complex exhibits bell-shaped pH dependence, with pKa values of 6.5 and 7.

190 ameter klim/Kd for the fast phase exhibits a bell-shaped pH dependence, with two pKa values of 9.3 +/

191 A bell-shaped pH profile and salt concentration dependence

192 s ranging from minutes to hours, exhibited a bell-shaped pH profile for k(bkdn), typical of the pH-ra

193 The simulation data reveal a bell-shaped pH profile for the total helix content, in a

194 c parameters of SARS-CoV-2 3CLpro revealed a bell-shaped pH profile with 2 pK(a) values (6.9 +/- 0.1

195 he k(cat)/K(M) value for spermine exhibits a bell-shaped pH profile, with an average pK(a) value of 8

196 The k(cat)/K(m) value for BESPM exhibits a bell-shaped pH profile, with pK(a) values of 9.8 and 10.

197 Both bell-shaped pH profiles are quantitatively accounted for

198 pKa values range from 7.0 to 8.7) exhibited bell-shaped pH profiles whose maxima were distinct for e

199 strated that the mutant proteases maintained bell-shaped pH profiles, as well as suicide-inhibitor su

200 finity of MKP3 for oxyanion, and restore the bell-shaped pH rate profile for the MKP3-catalyzed react

201 ysis of bulky polycyclic substrates exhibits bell-shaped pH rate profiles in the absence of ERK2.

202 from RNase A and serve to generate a similar bell-shaped pH versus k(cat)/K(M) profile for RNA cleava

203 Bell-shaped pH versus rate profiles were observed for V(

204 These measurements show bell-shaped pH-rate curves for each enzyme in the presen

205 A bell-shaped pH-rate profile for k(cat) and k(cat)/K(m) i

206 yl phosphate (4NPP), the reaction exhibits a bell-shaped pH-rate profile for kcat/KM indicative of ca

207 bstrate Cdk2-pTpY/CycA, however, did yield a bell-shaped pH-rate profile with a pK(a) of 6.1 for the

208 stingly, Cdc25B does not exhibit the typical bell-shaped pH-rate profile with small molecule substrat

209 gnificant shift in pK(1) to higher pH in the bell-shaped pH-rate profiles (k(cat)/K(m)) for several p

210 Both YopH and Cdc25A exhibit bell-shaped pH-rate profiles for the hydrolysis of mNBP,

211 The existence of bell-shaped pH-rate profiles for the K73A variant sugges

212 ypoxanthine and 1,N(6)-ethenoadenine follows bell-shaped pH-rate profiles, indicating that AAG-cataly

213 erified by experiment, are consistent with a bell-shaped pH/rate profile but are at odds with hydroly

214 a 1 gamma 2S delta constructs resulted in a 'bell-shaped' pH titration relationship.

215 MAD2 complex is cell cycle regulated with a "Bell" shaped profile and peaks at prometaphase.

216 A bell-shaped profile of the observed rate constant for an

217 diates was measured and exhibited an unusual bell-shaped profile over the pH range of 5.0-9.5 with a

218 ate of assembly depends on the pH level in a bell-shaped profile, and two pK(a) values that are in go

219 for isoleucyl 4-cyanothiazolidide yielded a bell-shaped profile, with pK(a)=5.0 and pK(b)=7.6.

220 he pH dependence of the IMPDH reaction shows bell-shaped profiles for kcat and the kcat/Km values for

221 The broad and bell-shaped profiles representing the diversity of the V

222 Bell-shaped profiles were observed for k(cat) and k(cat)

223 Bell-shaped profiles were observed for kcat and kcat/Km

224 en expression for the urease reaction with a bell-shaped rate-pH dependence.

225 ents of the mixed-linker MOFs, four distinct bell-shaped redox conductivity profiles are observed at

226 Among all nelfinavir-treated patients, a bell-shaped relationship between adherence and the risk

227 The standard view postulates a bell-shaped relationship between adherence to therapy an

228 atients with detectable viremia, there was a bell-shaped relationship between Gag-specific CD4+ T cel

229 A distinct bell-shaped relationship between lung volume and carbon

230 These characteristics produce a bell-shaped relationship between the apparent dissociati

231 c substrate-based lipase assays, there was a bell-shaped relationship for the effect of ApoC-II on GP

232 ch case, superoxide production had a similar bell-shaped relationship to the reduction state of cytoc

233 A bell-shaped relationship was also observed for the proba

234 A bell-shaped relationship was found between NC targeting

235 tatic conditions, cell migration speed had a bell-shaped relationship with fibronectin concentration.

236 unctional conductance (G(j)), which showed a bell-shaped relationship with junctional potential (V(j)

237 nt of shortening blocked by nifedipine had a bell-shaped relationship with voltage, whereas the "nife

238 We observe an asymmetric, approximately bell-shaped, relationship between the average intracellu

239 Bell-shaped relationships between adherence and resistan

240 te but produced an increase (potassium) or a bell-shaped response (rubidium) with a supercoiled templ

241 nocytes, neutrophils, and macrophages with a bell-shaped response curve in a pertussis toxin-sensitiv

242 e.g. dihydrorhodamine) previously revealed a bell-shaped response to co-generated (*)NO and O(2) flux

243 The activity of the enzyme exhibited a bell-shaped response to divalent cations and pH.

244 Similar bell-shaped results were found when the GRT analysis was

245 at which superoxide oxidation ensued yielded bell-shaped ring currents.

246 ly speckled intensity pattern into a single, bell-shaped spot, sitting on a low energy background.

247 The proposed bell-shaped structure consists of 11 alternating prohibi

248 The dose-response curve was bell-shaped, suggesting that doses greater than 400 mg o

249 elationship in 200 microM cadmium (Cd2+) was bell-shaped, supporting a role of ICa,L rather than VDCR

250 xhibit distinct pH dependence (the former is bell-shaped, the latter sigmoidal), again consistent wit

251 These data generate classic bell-shaped time-constant-potential curves.

252 nd C(20):C(20:3Delta11,14,17)PE, an inverted bell-shaped Tm profile was detected in the plot of Tm ag

253 have shown that the information conveyed by bell-shaped tuning curves increases as their width decre

254 Numerosity-selective neurons showed bell-shaped tuning curves with one of the presented nume

255 ivities of large populations of neurons with bell-shaped tuning curves.

256 of episodes, each consisting of a distinct, bell-shaped velocity profile (submovement) that rarely o

257 pear to be consistent with the arm-referent, bell-shaped, visual target tuning curves and target sele

258 A bell-shaped voltage dependence and modest sensitivities

259 hannel current (I(Ca)), and it shifted their bell-shaped voltage dependence leftward by approximately

260 -cAMP, membrane-permeable form of cAMP), the bell-shaped voltage dependence of cytosolic Ca2+ transie

261 ISO dramatically broadened the bell-shaped voltage dependence of intracellular Ca(2+) t

262 Confocal imaging revealed that the bell-shaped voltage dependence of SR Ca(2+) release is a

263 ials and the I-V relationship maintained its bell-shaped voltage dependence.

264 nd total amount of released Ca2+ exhibited a bell-shaped voltage dependence.

265 mplitude of the Ca2+ transient also showed a bell-shaped voltage dependence.

266 plitude of the Ca2+ transient again showed a bell-shaped voltage dependence.

267 id kinetics of activation/deactivation and a bell-shaped voltage dependency, reminiscent of the rapid

268 ntraction in physiological [Na+] and a broad bell-shaped voltage-contraction relationship was observe

269 K(+)-based, Na(+)-free solution exhibited a 'bell-shaped' voltage dependence of the L-type Ca2+ chann

270 in's voltage sensor imparts a characteristic bell-shaped, voltage-dependent nonlinear capacitance (NL

271 tinociception display ceiling effects or are bell shaped, which have been attributed to the partial a

272 The V profile is bell shaped with slopes of 1 and -1, giving pKa values o

273 voltage dependence of phasic contraction was bell-shaped with 0 Na+, became much loss bell-shaped wit

274 was bell-shaped with 0 Na+, became much loss bell-shaped with 10 mM Na+ and with 20 mM Na+ the phasic

275 We found that the distribution is nearly bell-shaped with a peak at 50 base pairs (bp) upstream o

276 The (catR)/ versus pH profile of ytCBS is bell-shaped with a pH optimum of 8.3, and the pK(a) valu

277 The pH-k(cat) profile is bell-shaped with a pK(a) of 6.4 +/- 0.1 for the ascendin

278 he pH dependence of k(cat)/K(m,phosphite) is bell-shaped with a pK(a) of 6.8 for the acidic limb and

279 ip (assessed 45 min after DPAT injection) is bell-shaped with an ED50 approximately 1 mg/kg on the as

280 The pH dependence of V/K was bell-shaped with apparent pKs of 6.5 and 8.3.

281 By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX pho

282 The activity dependence on pH was bell-shaped with highest activity between pH 6.8 and pH

283 ate 2b, which lacks a 6-carboxyl group, were bell-shaped with limiting slopes of unity on both sides

284 dase activity and beta-lactam acylation were bell-shaped with maximal activity at pH 8.0-8.5.

285 tionship predicted by the CICR hypothesis is bell-shaped with no contraction at ECa.

286 profile of V/K for L-ribulose 5-phosphate is bell-shaped with pK values of 5.94 and 8.24.

287 the substrate Abz-LPETG-Dap(Dnp)-NH(2) were bell-shaped with pK(a) values of 6.3 +/- 0.2 and 9.4 +/-

288 versus pH profiles with and without CaM were bell-shaped with the ionization of a group at pK(a) of 7

289 ons in LiCl with and without MgCl2 were both bell-shaped with the pH optima in the neutral range.

290 or the observed first-order rate constant is bell-shaped with two ionizable groups of pK(a) 4.9 and 5

291 aF/F versus voltage curve, from sigmoidal to bell-shaped, with a maximum at approximately +30 mV.

292 taining a pro-alpha factor cleavage site was bell-shaped, with a maximum near pH 4.0.

293 (III) as a function of SCN- concentration is bell-shaped, with a trough comparable with normal SCN- p

294 pH dependence of kcat/Km for L-kynurenine is bell-shaped, with apparent pKa's of 6.25 +/- 0.05 on the

295 e of kcat/Km for 3-hydroxykynurenine is also bell-shaped, with apparent pKa's of 6.49 +/- 0.07 and 8.

296 rves for these T-cell activation markers are bell-shaped, with different maxima and midpoints, depend

297 The plot of log k(cat)/K(m) versus pH is bell-shaped, with fitted pK(a) values of 6.76 +/- 0.09 a

298 NLC is bell-shaped, with its peak occurring at a voltage, V(h),

299 The k(cat)/K(sarc) pH profile is bell-shaped, with pK(a) values of 8.8 and about 10; the

300 against Ac2-l-Lys-D-Ala-d-Ala (kcat/Km) was bell-shaped, with pKa values at 6.9 and 10.1.