ライフサイエンスコーパス: benefit

1 of efficacy and safety events (net clinical benefit).

2 arkers are required, as most patients do not benefit.

3 d damaged soma can hinder achievement of ACM benefit.

4 -L1 monotherapy failed to show a significant benefit.

5 imately, to help select those most likely to benefit.

6 tention to provide help and the value of the benefit.

7 hemolysis and confer a significant survival benefit.

8 tion is likely to have the population health benefit.

9 viruses co-opt these pathways for their own benefit.

10 root systems to determine which had the most benefit.

11 s across lesions that can provide functional benefit.

12 h pathologies resulting from it for clinical benefit.

13 re critical factors for obtaining a survival benefit.

14 pe and therefore could provide unanticipated benefit.

15 ce, which does not have a clear clinical net benefit.

16 FA, but we are unable to exclude more modest benefits.

17 therapies have shown only marginal clinical benefits.

18 patient stratification and maximize clinical benefits.

19 is lower than estimated from their separate benefits.

20 targeting resulted in significant RFS and OS benefits.

21 or the allocation of environmental harms and benefits.

22 ics, and eligibility rules for privileges or benefits.

23 d the addition of TRP yielded no therapeutic benefits.

24 has long been known for its health-promoting benefits.

25 ients to develop foods with promising health benefits.

26 ncome countries that offset its hypothesized benefits.

27 ly be based on future-and not past-costs and benefits.

28 s provide patients with significant clinical benefits.

29 egimen optimisation for patient and societal benefits.

30 illness, due to biomolecules with recognised benefits.

31 phenotype metrics offer the following three benefits.

32 tes mellitus, both subgroups derived similar benefit (2.3% versus 1.4% for the primary efficacy end p

33 r resection margins do not confer a survival benefit [57 months (95% confidence interval 38.5-75.5) v

34 nalysis of health benefits of RGGI, the only benefits accruing to children were limited to prevented

35 gies and trade-offs between the biodiversity benefits achieved in the different plans and the deliver

36 ry function, hippocampal volume and training benefit across the human lifespan.

37 ted for precision, we found balanced fitness benefits across the entire dataset, but a consistently h

38 sed how cannibalism-derived female fecundity benefits affected extinction risk.

39 chloroquine are unlikely to provide clinical benefit against COVID-19.

40 ing for eye complaints that can help balance benefits against financial costs and health risk are war

41 of malaria elimination, while weighing these benefits against potential risks of chemoprevention.

42 d-species group formation, and that dilution benefits alone are not enough to explain patterns in int

43 t in a way that allows patients to make cost-benefit analyses for themselves.

44 chanistic, physiological results inform risk-benefit analysis for clinicians administering low dose k

45 nhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic respons

46 certainty about whether MNPs give net health benefits and are cost-effective.

47 ulture and Food (TEEBAgriFood) to assess key benefits and costs on the production side of genetically

48 rviewed identified a wide array of potential benefits and disadvantages of overlapping surgery, some

49 Such observations show the benefits and feasibility of pairing a potentially ideal

50 anism of generalism, we measured host growth benefits and functional traits.

51 This work sheds light on the benefits and restrictions of employing the air cathode i

52 th the need and COU, assessment of biomarker benefits and risks relevant to the COU, and the evidenti

53 rank categories by their trade-off of social benefits and transmission risk via dominance across 13 d

54 ithin RCTs to define risk-based variation in benefit, and an "effect-modeling" approach, wherein a mo

55 The high recovery rate suggested benefit, and those with lower inflammatory markers had b

56 c information use by predators might further benefit aposematic prey, but this remains untested.

57 Moreover, these benefits are conserved despite appreciable corticospinal

58 Its key benefits are that extraction of mycotoxins can be carrie

59 ery of pro-angiogenic factors has shown some benefit, but it is difficult to recapitulate the complex

60 broadly expressed, many ASD individuals may benefit by being treated as having a broader medical dis

61 9:10734-10745, 2019), because one parent can benefit by mating with a new partner and reproducing sho

62 ough trade-offs where migrants gain survival benefits by avoiding unfavourable conditions, while resi

63 This benefit can extend to a large region because two thirds

64 can also be in alignment with policies that benefit community and transportation infrastructure, sus

65 l cases, there are climate change mitigation benefits compared to fossil fuel alternatives.

66 imited regions, as irrigation water not only benefits crops through fulfilling crops' water demand bu

67 termine which trials have the best chance of benefiting current and future patients and (2) how to es

68 different confident levels, this method can benefit decision-makers to determine the risks associate

69 including patients perceived to be deriving benefit despite radiographic progression, were randomly

70 troversial because progression-free survival benefit did not translate into an overall survival (OS)

71 useful to assist physicians in informed risk-benefit discussions to explain COVID-19 risk and enable

72 slated into clinical utilization and patient benefits due to issues associated with reticuloendotheli

73 ely following release, retained survivorship benefits during 1 and 6 months of continued exposure, an

74 if the credit provided the greatest economic benefit early on and decreasing over time as deployment

75 therapy (ART), incarcerated people have not benefited equally from test-and-treat recommendations fo

76 hospitalization for heart failure, with this benefit extending to patients without diabetes who have

77 means that, without subsidies, few consumers benefit financially from electric technology vehicles (1

78 Despite accruing evidence supporting its benefit following pancreatoduodenectomy, early drain rem

79 ur data reveal that QR-313 also shows direct benefit for DDEB caused by exon 73 mutations.

80 RF T(1) prior to DCE imaging to maintain its benefit for improving detection of both peripheral and t

81 in this evolving landscape to derive maximum benefit for the patients.

82 by data, there is not yet strong evidence of benefit for the post-traumatic variant.

83 ing and vocal behaviour of beaked whales has benefits for abatement of predation risk and thus could

84 tation does not provide clinically important benefits for BMD in lactating women.

85 rly fermented dairy foods, demonstrates some benefits for cardiometabolic diseases.

86 aloric restriction and fasting have putative benefits for disease prevention and longevity.

87 roportion to need and to mediate therapeutic benefits for months or years following a single applicat

88 itizen-science projects can provide numerous benefits for participants while educating and connecting

89 (NOACs) have been shown to confer equivalent benefits for stroke prevention with less bleeding risk a

90 e pooled treatment effects showed consistent benefits for subgroups based on age, sex, diabetes, trea

91 decreases in Pb exposure can result in large benefits for the adult population.

92 Anticipated laser benefits for ThuVARP of reduced hospital stay and compli

93 medication claims datasets, and Ontario Drug Benefit Formulary medication consumption costs.

94 ly diverse sparsely-distributed features may benefit from 3D-reconstruction.

95 gations of plant cell division would greatly benefit from a fast, inducible system.

96 t liver candidates awaiting transplant would benefit from a model employing continuous distribution a

97 Tackling these problems will benefit from a more explicit and concerted effort to wor

98 est that the traditional cognitive model may benefit from a reformulation that takes current Bayesian

99 es of identifying patients that derive an OS benefit from bevacizumab.

100 inhibitor is one of many peptides that could benefit from bioactive cyclization, a strategy that is a

101 Plant breeding would benefit from borrowing approaches found useful in other

102 Regardless of admission time, patients had a benefit from culprit-lesion-only as compared to immediat

103 rkers to stratify patients who are likely to benefit from DPS, but instead used in conjunction with t

104 tial number of lesions appear to continue to benefit from enzalutamide beyond progression.

105 onstruction of deep-learning algorithms that benefit from expert knowledge and allow a biological und

106 tients with type 2 diabetes who would derive benefit from fenofibrate treatment, in addition to those

107 T/T homozygotes experienced a cardiovascular benefit from fibrate even in the absence of atherogenic

108 tion is modifiable; public health policy may benefit from focusing on reductions in environmental met

109 fore, native mass spectrometry would greatly benefit from higher resolution approaches for intact pro

110 Future research might benefit from improved imaging technology, and attention

111 d patients, even after remission, might also benefit from less commonly used treatments such as cogni

112 o progress on gemcitabine-based regimens may benefit from multidrug immunotherapy.See related comment

113 A C-terminal frameshift mutations may derive benefit from p110alpha-selective inhibitors, including t

114 Goal-directed behavior can benefit from proactive adjustments of cognitive control

115 the neural basis of adaptive behavior could benefit from renewed experimental and theoretical invest

116 we detail scenarios in disease ecology that benefit from spatial-social analysis.

117 According to our findings, Brazil would benefit from strategies to more accurately identify wome

118 Patients who are HLA-A*01:01pos could benefit from such products, since no T cells recognizing

119 substantial long-term relapse-free survival benefit from targeted therapy (HR [versus placebo] 0.49,

120 ent study we tested whether older adults can benefit from task repetition in order to improve their p

121 LGG regardless of codeletion status receive benefit from the addition of PCV.

122 Females conceivably benefit from the mimetic pheromone during mate search bu

123 cardio-inflammatory phenotype and will thus benefit from therapies targeting inflammation.

124 Patients with CKD are uniquely poised to benefit from these integrative, multi-omics approaches s

125 factors to identify subjects most likely to benefit from these therapies.

126 h swipes across many application areas could benefit from this convenient approach, including the use

127 ign of efficient sugar-baited traps will all benefit from understanding the molecular basis of nectar

128 ly, we propose that RNA ligand discovery can benefit from using progress made within these three fram

129 tors of reading abilities and the ability to benefit from visual speech to represent the syllabic con

130 Systemic mastocytosis (SM) has greatly benefited from the broad application of precision medici

131 Peptide stapling has benefited from the development of several chemical react

132 Benefiting from the unique host-guest interaction (e.g.,

133 Benefiting from their superior chemical and physical sta

134 This review describes platforms benefiting from these cytosensors to identify cancerous

135 known about the host's actual role and if it benefits from biodegradation of this synthetic polymer.

136 le conditions, while residents gain breeding benefits from early access to resources.

137 We reveal benefits from information transfer about predators as a

138 Benefitting from the above, the overall electrochemical

139 posed to multiple DMARDs without necessarily benefitting from them; a group of patients variously des

140 insight into the Ag species dispersion will benefit future design of more efficient supported Ag cat

141 This benefit generalized to improvements in real-world functi

142 hey place on four key affordance dimensions: benefit-generation ability, benefit-generation willingne

143 ance dimensions: benefit-generation ability, benefit-generation willingness, cost-infliction ability,

144 The study of animal behaviour could benefit greatly from generally expanding to incorporate

145 that pulmonary vasodilators are unlikely to benefit group 2/3 pulmonary hypertension patients and ma

146 Among all teeth, molars showed the highest benefit (>40%) for flossing behavior (P = 0.0005).

147 ow exercise is able to promote such systemic benefits has remained somewhat of a mystery but has been

148 d molecular signals induced by exercise that benefits health and prevents disease.

149 rength of social connectedness, which itself benefits human health and wellbeing and indirectly raise

150 to significant improvements in air quality, benefiting hundreds of millions of people.

151 Public health will benefit if proper policies and regulatory frameworks are

152 as past research shows that offspring would benefit-improve postfledging survival-by staying in the

153 Sorafenib leads to clinical benefit in a subgroup of patients, whereas all are expos

154 -cell-activating factors may therefore be of benefit in a subset of patients.

155 st, and challenges communicating evidence of benefit in a way that allows patients to make cost-benef

156 rapid tests to exclude bacteraemia may be of benefit in antimicrobial stewardship.

157 s of clinical stage, which would be of great benefit in clinical practice and a large cost-saving in

158 integrin mAb induces a substantial survival benefit in highly metastatic murine TNBC models poorly r

159 aracetamol toxicity with limited evidence of benefit in liver injury due to other causes.

160 us plus nintedanib might provide therapeutic benefit in patients with HHT.

161 not translate into an overall survival (OS) benefit in randomized phase III trials.

162 iopulmonary resuscitation has shown survival benefit in select patients with refractory cardiac arres

163 mised studies for the evaluation of clinical benefit in the post-marketing period should be limited t

164 )S to the mitochondria may be of therapeutic benefit in the prevention of endothelial dysfunction ass

165 g the autophagy pathway may have therapeutic benefit in the treatment of kidney disorders.

166 condary resistance to immunotherapy prevents benefits in a significant proportion of patients.

167 II adjuvant trials have reported significant benefits in both relapse-free survival (RFS) and overall

168 and efficacy that parallel associated health benefits in humans, we propose C15:0 as a potential esse

169 ewer generation AEDs does not bring tangible benefits in the management of patients with epilepsy.

170 er this translates into meaningful metabolic benefits in vivo, wherein the dynamics of insulin signal

171 as part of a randomized control trial, WASH Benefits) in rural Bangladeshi household compounds by as

172 w that in most of the hotspots examined this benefit is driven by protected areas preventing both for

173 -effective if only a fraction of anticipated benefit is realized.

174 hat precision weighting of prediction errors benefits learning in health and is impaired in psychosis

175 chizophrenia), acute rather than chronic, or benefitting little from self-care (e.g. dementia) were e

176 m the stability of the relapse-free survival benefit, longer-term data were needed.

177 Pharmacy benefit managers negotiate with drug companies for lower

178 step towards precision medicine, which will benefit men's and women's health.

179 Nanotechnology benefits modern vaccine design since nanomaterials are i

180 Further, the diatom C. meneghiniana benefits more from mineral dust particles in direct cont

181 rovides the basis by which sustained running benefits motor skill learning, presenting a target for c

182 d the modulation of caspase 3 activation may benefit neurons from spine loss in diseases, at least, i

183 tric cancer can provide a substantial health benefit not only for the patient but especially for affe

184 SPRINT was terminated early due to benefit observed in the primary outcome (composite of ca

185 e reported median showed a greater monetized benefit of $10,658 (Adjunctive Corticosteroid Treatment

186 To characterize the survival benefit of accepting DCD50 kidneys, we used 2010-2018 Sc

187 the cleaning bundle returned a net monetary benefit of AUD$1.02 million and an incremental cost-effe

188 The functional benefit of cardiac cell therapy is thus due to an acute

189 bined CXCR4 and PD-1 blockade may expand the benefit of chemotherapy in PDAC and warrants confirmatio

190 We discuss the potential benefit of concurrent administration of OT and naloxone

191 g S. aureus IMI and highlights the potential benefit of diagnostics tools to identify S. aureus CC du

192 However, the size of the benefit of earlier initiation of treatment and the overa

193 We observed no survival benefit of ECD transplants vs remaining on the waitlist

194 for ER is recommended to determine potential benefit of endocrine therapies to reduce risk of future

195 onsistent across most subgroups, but greater benefit of ertugliflozin was observed in 3 populations:

196 enetic profiles that are able to predict the benefit of GO on outcome.

197 r of dual-ended readout, with the additional benefit of improved crystal identification.

198 ble from medium mass resolution offering the benefit of increased sensitivity and versatility of this

199 The clinical benefit of LDL cholesterol lowering treatment in older p

200 h larger genomes and we demonstrate that the benefit of LGT declines rapidly with genome size.

201 While the therapeutic benefit of monoclonal antibodies against infectious dise

202 The results also highlight the potential benefit of neurofeedback training in facilitating volunt

203 r any conclusion to be reached regarding the benefit of one formula over another formula intended for

204 s alter host metabolism and immunity for the benefit of pathogens.

205 on investment: scientific knowledge for the benefit of patients and society.

206 and result in a health-related net monetary benefit of pound 7.4 billion (95% UI pound 2.0 billion-p

207 Angioplasty) aimed to evaluate the survival benefit of prophylactic implantable cardioverter defibri

208 creatic centers, demonstrating the potential benefit of quality assurance programs.

209 sorbent for fluoride removal, with the added benefit of re-use of a waste product.

210 Reducing size could have the benefit of reducing potential immunogenicity problems.

211 its is highly recommended to obtain the full benefit of the nutrients, bioactives, and antioxidants t

212 s (1) more accurate in capturing the overall benefit of the regenerative procedure and (2) to better

213 fective behavior, highlighting the potential benefits of 5-HT2C receptor antagonists for both reducti

214 p with an economic analysis of the costs and benefits of an illustrative double-duty intervention tha

215 all, there were no statistically significant benefits of any intervention individually or in combinat

216 ent in understanding the potential risks and benefits of autonomous AI, and understand its design, sa

217 ls are currently registered to inform on the benefits of BCG vaccinations upon exposure to CoV-2.

218 ith polypharmacy and multimorbidity when the benefits of continued treatment may not outweigh the har

219 Still, other important benefits of exercise training appeared in women with PCO

220 The benefits of indirect defences to natural enemies should

221 e supplementation or degradation, eroded the benefits of informed nomadic movements, particularly for

222 is highlighted the practicality and economic benefits of large-scale extraction for industrial applic

223 /Ang1-7/Mas axis and previously demonstrated benefits of lung function improvement in SARS-CoV infect

224 We discuss benefits of mapping a mouse brain at the level of synaps

225 There were no significant benefits of medication on likelihood of smoking cessatio

226 s the green wave and influences the foraging benefits of migration.

227 We further illustrate the benefits of our methods in applications to summary-level

228 both the versatility of the reactor and the benefits of performing kinetic analysis as a routine par

229 The benefits of play fighting were therefore limited to spec

230 e data and prior experience suggest that the benefits of population-based screening for CKD are uncer

231 d-controlled trial was to evaluate the risks/benefits of prophylactic central neck dissection (pCND)

232 nely reporting the costs, effectiveness, and benefits of psychological interventions from client, pra

233 o altruism by reminding the public about the benefits of quarantine to wider society can be favourabl

234 In a previous analysis of health benefits of RGGI, the only benefits accruing to children

235 Growing interest in the health benefits of soy isoflavones has led to research in the i

236 The potential benefits of statin use in PWH with normal lipid levels r

237 ns for fisheries managers weighing the costs/benefits of stocking-or removing established non-native

238 hanges at scales that capture the grid-scale benefits of technologies and policies that enhance renew

239 The benefits of tethering the two functions of the catalyst

240 Based on the anti-inflammatory benefits of the upregulation of the ACE2/Ang1-7/Mas axis

241 Therefore, this work highlights the health benefits of these honey samples.

242 eveloped to increase and expand the clinical benefits of these treatments in patients with diverse ca

243 ith symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.

244 ute a judgment about the relative danger and benefits of those locations.

245 nfections, it has been hypothesized that the benefits of treatment with renin-angiotensin system inhi

246 The health benefits of vaccination of 12-year-old girls were estima

247 and human health are often discussed as "co-benefits" of mitigating climate change, yet they are rar

248 ous ocrelizumab treatment provided sustained benefits on measures of disease progression over the 6.5

249 iation is that individuals face differential benefits or costs depending on the group's order, but em

250 possible to reasonably infer the comparative benefits or risks in settings, in which doing a randomis

251 Of important scientific and therapeutic benefit, our results reveal a diverse activation and sig

252 red to address whether MAR confers long-term benefit over SAR in patients with renal dysfunction who

253 w suspicion for COVID-19, PPCI had mortality benefit over the pharmaco-invasive strategy, and the ris

254 and lower hospitalization risk are needed to benefit patients and reduce CKD's economic burden.

255 ols are needed to assess whether these drugs benefit patients on outcomes that matter most to them.

256 death signaling pathway identified here may benefit patients with COVID-19 or other infectious and a

257 g the propensity score matching sample, this benefit persisted for node-negative women (HR 0.80 [95%

258 d the flexion/extension of joints, which may benefit personalized orthopedic recuperation.

259 Here, we explore a biophysical cost-benefit principle, namely that the cell should keep its

260 M to assess their efficacy, safety, and risk-benefit profile.

261 We suggest that such substantial fitness benefits provide the opportunity for the evolution of co

262 essional >= restored prairie; direct climate benefits ranged from ~80% (stover) to 290% (restored pra

263 Objective response was 4% and clinical benefit rate (CR + PR + SD > 6 m) was 19%.

264 4 of 45 patients; 95% CI 18-47) and clinical benefit rate of 49% (22 of 45; 34-64) in the all-treated

265 (ORR), duration of response (DOR), clinical-benefit rate, biomarkers, and safety.

266 lving technology that might enhance the risk-benefit ratio.

267 Blood transfusion might benefit some patients with malaria but could potentially

268 pplementation of spermine does not appear to benefit SRS patients or mouse models.

269 ral conditions under which the interventions benefit students.

270 Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts derived from mesenchyma

271 on actions can have substantial human health benefits that accrue quickly and locally.

272 Rescuable genes - genes with small fitness benefits that are lost from the population without HGT -

273 s is being placed on the additional survival benefits that could potentially be achieved with local c

274 es yield previously unrecognized stabilizing benefits that ensure a consistent larval supply to reple

275 al neurodegeneration and cognitive recovery, benefits that persisted for months after treatment cessa

276 Improving chronic recording will benefit the brain-computer interface technologies and ne

277 ion and metabolism pathways present that may benefit the host, as well as genomic signatures of host

278 r with the lack of progression-free survival benefit, these findings do not support routine use of we

279 Economic and environmental benefits through preventative monitoring programs at ear

280 e novel medicines not only bring significant benefit to patients but also represent precision tools t

281 ic shock, PPCI offered substantial mortality benefit to patients relative to the pharmaco-invasive st

282 w mass cell suicide can evolve, as any small benefit to surviving clonemates can lead to this retalia

283 operly, thereby imparting a relative fitness benefit to symbiont-transmitting mothers.

284 ent of evidence-based guidelines would be of benefit to the periodontal practicing community.

285 inued exposure, and further displayed growth benefits to at least 1 month post release.

286 d women, or whether there are any additional benefits to physical function, remains uncertain.

287 ative to chemical fungicides, provides broad benefits to the environment, farmers and consumers.

288 lutionary considerations regarding potential benefits to the host, the virus, or the TEs.

289 ridement provides clinical and immunological benefits to the treatment of periodontitis in patients w

290 hold dose (or concentration) for significant benefit versus threshold for adversity.

291 ownstream target that can provide additional benefits via transcriptional activation of mitochondrial

292 ysis revealed that judgments about risks and benefits were the strongest predictors of acceptance of

293 combinations demonstrate clinically relevant benefits, which remain concentrated in patients with lun

294 targeted to high-risk children may preserve benefit while minimizing antibiotic exposure.

295 However, true analysis of risk and benefit will require a randomized control trial.

296 nts with nonbasal phenotype seemed to obtain benefit with capecitabine, although this will require ad

297 amide was also associated with a significant benefit with respect to all other secondary end points,

298 tional burden seem to have a less pronounced benefit with targeted therapy (HR [versus placebo] 0.75,

299 o pursue and understanding their relative co-benefits with and trade-offs against different social an

300 ion incur a variety of pleiotropic costs and benefits with different probabilities.