ライフサイエンスコーパス: bent conformation

1 inhibition, and in solution adopts a stable bent conformation.

2 ts to restrain the I domain in the inactive, bent conformation.

3 intact alpha(IIb)beta(3) adopted a compact, bent conformation.

4 bbeta3 results from alphaIIbbeta3 adopting a bent conformation.

5 ences with A:T-rich spacers that adopt a pre-bent conformation.

6 r between the labeled ends of the DNA in the bent conformation.

7 monovalent ligands and basally retained the bent conformation.

8 on one H chain by adopting an asymmetrically bent conformation.

9 ence of the presence of alpha(L)beta(2) in a bent conformation.

10 accommodate a protein moiety in its severely bent conformation.

11 and extended-open conformations as well as a bent conformation.

12 It has an overall bent conformation.

13 ion, demonstrating that these sites are in a bent conformation.

14 e in such a way that stabilizes the DNA in a bent conformation.

15 opulations in all states called straight and bent conformations.

16 (dsDNA) in low-probability, cyclic or highly bent conformations.

17 s the tropomyosin molecule to adopt multiple bent conformations.

18 complexes showed that FAD adopted an unusual bent conformation, allowing its ribityl side chain and A

19 e accommodates chromosomal DNA in a severely bent conformation, allowing widely spaced IN active site

20 Bent conformation and chain prenylation, were molecular

21 The structure reveals a bent conformation and defines the alpha-beta interface b

22 eptor distance, which is consistent with the bent conformation and does not change in the activated i

23 es suggest that all CNTN ectodomains adopt a bent conformation and might lie parallel to the cell sur

24 cated E2 with the membrane binding loop in a bent conformation and the aromatic side chains sequester

25 d high affinity for ligand, whereas both the bent conformation and the extended-closed headpiece conf

26 d that it depends both on its characteristic bent conformation and two conserved RNA motifs, an apica

27 They transitioned between a bent conformation and two extended conformations in whic

28 peptide, containing three prolines, adopts a bent conformation, and the C-terminal segment of the pep

29 Coenzyme A binds in a bent conformation, and the details of its interactions a

30 ll to an alphaIIbbeta3 construct locked in a bent conformation, and unlocking the conformation restor

31 ences at their stem junctions imply the same bent conformation as in the mouse mammary tumor viral RN

32 The loop region of the complex enables its bent conformation, as deletion of the loop promotes stra

33 ke domain that adopts either a straight or a bent conformation at various positions along the length.

34 The opened duplex manifests a bent conformation (bending angle approximately 60 degree

35 icated a cognate cis interaction between the bent conformation beta5/beta3 integrins and an arginine-

36 ely reacts with AT-rich DNA sequences with a bent conformation; bizelesin also reacts with the minor

37 form a contiguous patch in the more severely bent conformation but become separated upon straightenin

38 Stabilization of the bent conformation by integrin transmembrane and cytoplas

39 ontaining a p53 binding site was locked in a bent conformation by ligating its ends to form a microci

40 after synthesis, and then beta3 assumes its bent conformation by virtue of its interaction with the

41 Resting a(5)B(1) adopts an incompletely bent conformation, challenging the model of integrin sha

42 Bound acetylcholine adopts a bent conformation characterized with a quaternary ammoni

43 ression of alphavbeta3 locked in an inactive bent conformation conferred hantavirus infectivity of CH

44 that the domain is not straight but adopts a bent conformation (D-shaped) in the docked state of the

45 g the possibility that pro-alphaIIb adopts a bent conformation early in biogenesis.

46 approximately 175 degrees) and two distinct bent conformations (Fe-C-N angles <140 degrees).

47 140/CD4/GSK3732394 complex clearly shows the bent conformation for CD4 while bound to gp140.

48 TAP complexes were generated, which indicate bent conformation for peptides.

49 The S22W peptide adopts a bent conformation forming a hydrophobic pocket by hydrop

50 recycling factor and binds tRNA in a highly bent conformation in a hybrid peptidyl/exit site.

51 ) and the ligand-binding betaA domain of the bent conformation in regulating interaction of integrin

52 revealed not only that the IgEFc exists in a bent conformation in solution but also that the bend is

53 tent with alphaIIbbeta3 existing in variably bent conformations in equilibrium with each other on una

54 ganese ions (Mn(2+)) while adopting the half-bent conformation, indicating that ligand-binding affini

55 et in which substrates are bound in distinct bent conformations involving the Zn-binding site.

56 We show here that this same bent conformation is retained in the active site regardl

57 The bent conformation is sterically incompatable with the oc

58 The computed relative stability of bent conformations is sensitive to the ionic strength of

59 gh flexible arm control between extended and bent conformations, it is possible to selectively induce

60 blasticus RC-LH1 dimer has a less bent conformation, lacks the PufY subunit near the LH1 o

61 ta-tubulin dimers need to convert between a 'bent' conformation observed for free dimers in solution

62 Binding of DNA to hFEN1 in a bent conformation occurred independently of 5'-flap acco

63 ETD3 with Lys73-containing peptide reveals a bent conformation of Lys73, with its side chain aliphati

64 cules, for example, by understanding how the bent conformation of SIgA enables robust cross-linking b

65 ared with the crystal structure, including a bent conformation of the alpha4 relay helix and ordering

66 olchicine-like inhibitors that stabilize the bent conformation of tubulin allosterically inhibit Eg5

67 tes of myosin, corresponding to straight and bent conformations of the relay helix.

68 -binding protein, either stabilizes DNA in a bent conformation or induces a bend upon binding to give

69 c contraction at extremes where straight and bent conformations predominate, respectively.

70 The PBS domain adopts a bent conformation resembling the shape of a tRNA in apo

71 ic DNA reflect a propensity to adopt unwound/bent conformations resembling Rad4-bound DNA structures.

72 he MD simulations starting from an initially bent conformation resulted in the formation of a straigh

73 minus-strand DNA and the tRNA because of its bent conformation resulting in error-prone plus-strand D

74 e default state, likely corresponding to the bent conformation seen in the crystal structure of alpha

75 working model in which pro-alphaIIb adopts a bent conformation soon after synthesis, and then beta3 a

76 nced by solution x-ray scattering displaying bent conformations spanning 150 and 180 A for the mouse

77 conformation stabilized by origin DNA and a bent conformation stabilized by ssDNA.

78 egrin alpha and beta subunits stabilized the bent conformation strongly for alpha(X)beta(2) and less

79 at the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a ph

80 eg separation causes the integrin to adopt a bent conformation that is unable to respond to agonists

81 binds to both the wild-type and mutant in a bent conformation that orients the NO O atom toward the

82 nt models portray the inactive receptor in a bent conformation that upon activation converts to a ful

83 We conclude that HS displays bent conformations that are significantly distinct from

84 In an overall bent conformation, the intermediate affinity state of al

85 alysis shows that kinesin-1 forms a compact, bent conformation through a break in coiled-coil 3.

86 We show that KIF5A forms a compact, bent conformation, through a bend between coiled-coils 2

87 ves conformational changes from an inactive, bent conformation to an extended conformation (E+) with

88 cognition mode by KIT, in which KIT adopts a bent conformation to facilitate each of its first three

89 We also observe cyanide binding in a bent conformation to Ni of the C-cluster, adjacent the s

90 dduct is six-coordinate with NO ligated in a bent conformation trans to the cysteinyl S, as evidenced

91 s and how alphaIIbbeta3 initially adopts the bent conformation, we mapped the conformational states o

92 the bound state, whereas THp-(1-43) adopts a bent conformation when free in solution, with higher con

93 hat 6,13-(CAAC)(2)-DBP is only stable in its bent conformation, whereas 1,4-(CAAC)(2)-(Et2)DBN exists

94 l rigidification, locking the molecules in a bent conformation, while also modulating the electronic

95 itchblade-like" opening, from a low affinity bent conformation with a closed headpiece to an extended

96 nd that mutations that lock integrins in the bent conformation with disulfide bonds resist inside-out

97 neck, which folds into an almost 90 degrees bent conformation with respect to the stalk.

98 -1 at different conformations, including the bent conformation with the lowest affinity.

99 showed the substrate alone frequently adopts bent conformations with 1-2 nt fraying around the gap, s

100 ameshifting pseudoknots adopt characteristic bent conformations with stem 1 bending towards the major

101 with the IM-MS cross sections, indicate two "bent" conformations with the planes of the porphyrin and