ライフサイエンスコーパス: best-characterized

1 of which CCCTC-binding factor (CTCF) is the best characterized.

2 ylation has been one of the most studied and best characterized.

3 ing debate about how this capacity should be best characterized.

4 ozyme derived from Bacillus anthracis is the best characterized.

5 stem (Nrg1-3) and of these Nrg1 has been the best characterized.

6 ng the Rho GTPases, RhoA, Rac1 and Cdc42 are best characterized.

7 ers of the class 5 fimbrial family being the best characterized.

8 The best characterized, 4E10 and 2F5, are polyreactive, bind

9 Thus far, the best characterized AA-responsive genes are all transcrip

10 The best-characterized acetylation of newly synthesized hist

11 in many aspects of the viral life cycle, its best-characterized activity is self-assembly into 240-mo

12 s mRNA is a central component of SGs and the best-characterized activity of vhs is as an endoribonucl

13 ed mutagenesis and are, therefore, among the best characterized AFPs.

14 e hippocampus and cerebellum is probably the best characterized, although there are also other brain

15 hole bacterium transmission (WBT), which was best characterized among poultry in the Netherlands.

16 s in two genes, KCNA1 and CACNA1A, cause the best characterized and account for the majority of ident

17 icrobial oxylipins, the fungal oxylipins are best characterized and function as hormone-like signals

18 s on pediatric migraine as this has been the best characterized and studied.

19 , which binds CD20 on B cells, is one of the best-characterized antibodies used in the treatment of B

20 agnosis and name has since become one of the best-characterized arboviral diseases.

21 Two of the best characterized are CwlO and LytE: cells lacking both

22 The best characterized are the copper deficiency and toxicit

23 nt and theory show that the rearrangement is best characterized as a [1,2] carbon shift toward an ele

24 sting that motor challenges in autism may be best characterized as a developmental motor delay rather

25 The S2 state, best characterized as a pi --> (pi*, aryl) transition, h

26 een the metal fragment and the alkane can be best characterized as a three-center, two-electron inter

27 protein conserved from plants to humans and best characterized as a transcriptional coactivator, is

28 E-cadherin is best characterized as adherens junction protein, which t

29 ological insulators have been proposed to be best characterized as bulk magnetoelectric materials tha

30 also observed activity in Ecl mice that was best characterized as bursty--a pattern of activity simi

31 disease that accompanies CKD and is perhaps best characterized as diastolic dysfunction seen in conj

32 Wnt glycolipoproteins are best characterized as regulators of embryonic developmen

33 The network of cancer clinical trialists is best characterized as strategic or mixed-motive, with co

34 Clozapine represents the best-characterized atypical antipsychotic, although it d

35 The S2056 cluster is the best-characterized autophosphorylation site in human DNA

36 The oral microbial community is the best-characterized bacterial ecosystem in the human host

37 n-endocytic trafficking roles are known, the best characterized being the transport of hydrolases fro

38 lanking region of the hetP gene provides the best-characterized binding site for the HetR protein so

39 Hematopoiesis is one of the best characterized biological systems but the connection

40 C-reactive protein (CRP), the best characterized biomarker of inflammation, is also an

41 The best characterized biosynthetic enzyme is GmhA, which ca

42 The best-characterized BMC is the carboxysome, a central par

43 wledge on the microbial composition of the 5 best-characterized body sites (gut, skin, oral, airways,

44 These findings support a system model best characterized by a cascading network failure--analo

45 carriers had more disrupted sleep, which was best characterized by a fragmented sleep profile.

46 n, transmembrane outer membrane proteins are best characterized by assessing membrane integration and

47 This group was best characterized by chromothripsis and the presence of

48 ti-organ autosomal dominant disorder that is best characterized by neurodevelopmental deficits and th

49 escription of p-MOF crystallization which is best characterized by particle aggregation and colloidal

50 of the glutamate carboxypeptidase II family, best characterized by prostate-specific membrane antigen

51 Dose to healthy tissues is best characterized by scanning patients in the first 2 d

52 Dose to healthy tissues is best characterized by scanning patients in the first two

53 te that B cell-mediated immune regulation is best characterized by the cytokine polarization profile,

54 BK inhibition by PAX is best characterized by the idea that PAX gains access to

55 Whether dominant humans are best characterized by the lay stereotype or the animal v

56 These properties are best characterized by the self-diffusion coefficients D

57 t follow a single-step binding model but was best characterized by two distinct types of interactions

58 roteins regulate internalization events, the best characterized C-terminal EHD, EHD1, regulates endoc

59 HSPA1 is among the best characterized cancer-related chaperones, while the

60 lin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme implicated in proteo

61 However, IV.3, perhaps the best characterized CD32a-blocking mAb, was recently show

62 This review focuses on the three best-characterized cell surface mucins expressed in the

63 em, spinal motor neurons serve as one of the best-characterized cell types for addressing these two q

64 Currently, the best-characterized chaperone-histone interaction is that

65 To date, the best characterized choline-oxidizing enzyme is the flavi

66 by nuclear factor of activated T cells, the best characterized CnB substrate.

67 In bacteria, the best characterized co-chaperone is the Escherichia coli

68 The best characterized component of lipofuscin is A2E, a bis

69 215A/E217A (WE thrombin) has been one of the best characterized constructs with selective activity to

70 take a systematic mutational analysis of the best characterized context of the ARS motif, namely the

71 review, I will discuss the functions of the best-characterized copper-responsive proteins in M. tube

72 sequence similarity to SARS-CoV-2 and is the best-characterized coronavirus in terms of epitope respo

73 One of the best-characterized costimulatory pathways includes the I

74 URB597 is one of the best characterized covalent inhibitors of the endocannab

75 contributions of an additional VMPFC pathway best characterized deletion carriers.

76 with the classic HLA genetic loci being the best-characterized determinants.

77 ngers (ZFs) are one of the most abundant and best characterized DNA-binding domains.

78 S6 kinase is the best-characterized downstream effector of mTORC1.

79 dala modulated the lateral occipital complex best characterized EEV-related activity in noncarriers,

80 he regulation of shoot branching, one of the best-characterized endogenous roles for SLs.

81 Lysozymes are among the best-characterized enzymes, acting upon the cell wall su

82 ersible acetylation of lysines is one of the best characterized epigenetic modifications.

83 Focusing on the best-characterized example of meiotic silencing, meiotic

84 Currently, the best-characterized example of sizer behavior is in fissi

85 eferred to as trans-tail regulation, and the best-characterized example of this is the dependence of

86 One of the best-characterized families of E3 ubiquitin ligases faci

87 ere mutated in the dehydratase domain of the best characterized family member, lacticin 481 synthetas

88 The Toll-like receptors (TLRs) are the best-characterized family of PRRs and control the activa

89 Like hepatitis C virus, the best characterized Flaviviridae species known to cause h

90 The tethering mechanism has been best characterized for bovine papillomavirus type 1 (BPV

91 Exhaustion has been best characterized for CD8 T cell responses, and occurs

92 e that the Mex67-Mtr2 (TAP-p15) heterodimer, best characterized for its essential role in mRNA nuclea

93 mmatory cells, including eosinophils, and is best characterized for its role during the initiation of

94 Although best characterized for its role in regulating transcript

95 t the necessity for blocking H2R, a receptor best characterized for its role in stomach acid producti

96 and break (DSB) repair pathway that has been best characterized for mycobacteria.

97 Although best characterized for sustaining T cell exhaustion duri

98 stromal cells, a relationship that has been best characterized for the interaction between thymocyte

99 Human DNA polymerases eta and iota are best characterized for their ability to facilitate trans

100 Although best characterized for their ability to traverse a varie

101 ats contaminated with various toxins and are best characterized for their bioremediation potential.

102 Vps proteins are best characterized for their role in endosome and vacuol

103 Toll-like receptors (TLRs) are best characterized for their roles in mediating dorsoven

104 However, these have been best characterized for their roles in mRNA export, leavi

105 rin-Eph signaling system is conserved and is best characterized for their roles in neuroblast migrati

106 The best characterized form of an Fe(V) equivalent described

107 Structural domains, the best characterized form of reuse in proteins, are just o

108 endent long-term depression (eCB-LTD) is the best characterized form of striatal plasticity, but the

109 Necroptosis is one the best-characterized forms of regulated necrosis.

110 Engrailed (En), the best-characterized Ftz/Ftz-F1 downstream target, is not

111 rmation from various synaptic inputs and its best characterized function is the regulation of transla

112 o be independent of protein lipoylation, the best characterized function of mtFAS, as mutants lacking

113 genes are important tumor suppressors whose best-characterized function is repair of damaged nuclear

114 The best-characterized function of SMN is as an assembler of

115 Curli fibrils, the best-characterized functional bacterial amyloids, are an

116 Considering that one of the best characterized functions of piRNAs in humans is post

117 in Arabidopsis thaliana comprise one of the best characterized genetic networks in plants.

118 Among the best-characterized genetic alterations in gliomas is the

119 The two best-characterized gp41-specific cross-reactive neutrali

120 rous cell signaling processes, are among the best characterized groups of client proteins for the 90-

121 The 5-HT3AB receptor is the best-characterized heteropentameric 5-HT3 receptor.

122 Acetylation is one of the most studied and best characterized histone posttranslational modificatio

123 The erythrocyte is one of the best characterized human cells.

124 osomal ClC-5 and the lysosomal ClC-7 are the best characterized human CLC transporters.

125 Currently, even for the best characterized human septin heterocomplex (SEPT2/SEP

126 MLL1 is the best characterized human SET1 family member, which inclu

127 and occasional pandemics, and is one of the best-characterized human RNA viral pathogens(1).

128 disease-specific manner - a problem that is best characterized in Alzheimer disease, where it begins

129 iochemical basis of circadian timekeeping is best characterized in cyanobacteria.

130 Their function has been best characterized in DCs and macrophages, where they ac

131 This has been best characterized in Drosophila, where genes encoding r

132 This phenomenon has been best characterized in laminated structures like the reti

133 ) is a recently described DNA repair pathway best characterized in mycobacteria.

134 Although slamf4 function is best characterized in NK cells, the enhanced humoral aut

135 The impact of LAP to immune regulation is best characterized in professional phagocytes, in partic

136 although immunity to transfused platelets is best characterized in relation to HLA-specific antibodie

137 While modifications are best characterized in short, noncoding RNAs such as tRNA

138 ycoprotein complex, the function of which is best characterized in skeletal muscle in relation to mus

139 PY neurons, NPY expressing neurons have been best characterized in the Arcuate Nucleus of the Hypotha

140 erlying molecular mechanisms are complex and best characterized in the flowering plant Arabidopsis th

141 Stress erythropoiesis is best characterized in the mouse, where it is extramedull

142 nctions in many Gram-positive species and is best characterized in the pathogen Staphylococcus aureus

143 Since somatotopy is best characterized in the primary somatosensory (S1) and

144 This process is best characterized in yeast, where V-ATPases are reversi

145 The best characterized inhibitors of Hsp90 target its ATP bi

146 Ole1p was chosen because it is one of the best characterized integral membrane desaturase and beca

147 can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene ex

148 also via noncanonical pathways of which the best characterized is the planar polarity pathway.

149 thelin 1 (ET-1) is the most abundant and the best-characterized isoform.

150 Herein, we submit the best-characterized LasR modulators to standardized cell-

151 on-classical MHC molecule T22 represents the best characterized ligand for murine gammadelta T cells,

152 stinct mature cell types, and represents the best characterized mammalian adult stem cell system.

153 The best characterized mammalian PITPs are the Class I PITPs

154 The best characterized mammalian sleep/wake regulator is hyp

155 The 4 best-characterized MAP kinase pathways, ERK1/2, JNK, p38

156 The best characterized marker of sleep homeostasis is slow w

157 pid eye movement (NREM) sleep, is one of the best characterized markers of sleep need, because it inc

158 The best characterized means of intercellular communication

159 Symmetrical division is the best characterized mechanism of stem cell replacement, b

160 Haploinsufficiency (HI) is the best characterized mechanism through which dominant muta

161 The best-characterized mechanism for endocytosis involves cl

162 degradation of homologous transcripts is the best-characterized mechanism.

163 m acute osmotic downshock and is to date the best characterized mechanosensitive channel.

164 VEGF is the best characterized mediator of tumor angiogenesis.

165 Although Stat5 is the best-characterized mediator of PRL signals, PRL also act

166 s and function were independent of MITF, the best-characterized melanocyte lineage-specific transcrip

167 Bcl-2 is the best characterized member of a large family of proteins

168 Polo-like kinase 1 (Plk1), the best characterized member of the mammalian polo-like kin

169 P450cam from Pseudomonas putida is the best characterized member of the vast family of cytochro

170 The best characterized member of this family is ExoU, an eff

171 soforms, Pak1 is the most ubiquitous and the best characterized member.

172 Bacteriophage T7 RNA polymerase is the best-characterized member of a widespread family of sing

173 ic elongation factor 2 kinase (eEF2K) is the best-characterized member of the alpha-kinase family.

174 The best-characterized member of the family is RASSF1A, whic

175 HIPK2, thus far the best-characterized member of this largely understudied f

176 metallo KDO8PS from Aquifex aeolicus are the best characterized members of each class.

177 NOD2 is one of the best characterized members of the cytosolic NOD-like rec

178 chia coli MalE-MalFGK2 complex is one of the best characterized members of the large and ubiquitous f

179 ial structure-function relationships for the best characterized members of the zinc finger (ZF) famil

180 in with a high frequency of leucine) are the best-characterized members of a group of cytoplasmic reg

181 Here, we studied the secretion of the three best-characterized members of the IL-1 superfamily, IL-1

182 ATPases are the most frequently observed and best-characterized members of this group of transporters

183 The mir-17-92 miRNA is among the best characterized miRNA oncogenes, whose genomic amplif

184 ) infection of rhesus macaques (RhMs) is the best-characterized model for AIDS research.

185 The virus in the best-characterized model species, Schmidtea mediterranea

186 are a requirement for seizures in two of the best characterized models of absence epilepsy, and the s

187 dicate that PROG is beneficial in one of the best-characterized models of stroke, and may warrant fur

188 ned capabilities of three of the largest and best characterized module archives by enabling users to

189 Given that the best characterized MPS-I murine model is an immunocompet

190 ly of translational repressors, arguably the best characterized mTORC1 substrates, is sufficient to r

191 One of the best characterized mutations found in several forms of h

192 REMs are the best-characterized nanodomain markers via an uncharacter

193 One of the best-characterized natural RIG-I agonists is the defecti

194 oligodendrocyte progenitor cells-one of the best-characterized neural progenitor cells in the mammal

195 ctory projection neurons (PNs) are among the best-characterized neuronal types: different PN classes

196 The best characterized noncanonical Wnt, Wnt5a, has been sug

197 e results identify the SPICE interval as the best characterized ocean anoxic event in the pre-Mesozoi

198 esis of acute myeloid leukemia are among the best characterized of all human malignancies.

199 uper elongation complex (SEC), is by far the best characterized of CDK9, CDK12, and CDK13.

200 n regulatory system of Escherichia coli, the best characterized of the biotin-sensing systems, the bi

201 ]) is economically very important and is the best characterized of the herpesviruses that occur prima

202 ead ribozyme from Schistosoma mansoni is the best characterized of the natural hammerhead ribozymes.

203 The best characterized of these fibrils are SEVI (semen-deri

204 The best characterized of these have been mutations in the c

205 The best characterized of these is c-myc/IgH translocation,

206 The best characterized of these is IPEX, resulting from muta

207 The best characterized of these pathways, the ER-associated

208 he radical S-adenosyl-l-methionine HydG, the best characterized of these proteins, is responsible for

209 They are now the best characterized of these rather mysterious enzymes th

210 The best characterized of these responses involves activatio

211 The best characterized of these RNA-binding proteins is the

212 The best characterized of these signals is the leucine-induc

213 ular genomic integrity in multiple ways, the best characterized of which are as a host defense agains

214 re-forming proteins known as gasdermins, the best characterized of which is gasdermin D (GSDMD).

215 HL gene has multiple reported functions, the best characterized of which is its role as the recogniti

216 ave been found to inhibit Treg activity, the best characterized of which is the glucocorticoid-induce

217 coli Na(+)/H(+) antiporter (Ec-NhaA) is the best-characterized of all pH-regulated Na(+)/H(+) exchan

218 phila melanogaster has emerged as one of the best characterized olfactory systems, which in addition

219 Ontogenetically, the kidney is one of the best-characterized organs, but concepts of the regulated

220 One of the best characterized oxidative DNA lesions is 7,8-dihydro-

221 hrocyte-binding antigen 175 (EBA-175) is the best-characterized P. falciparum invasion ligand, report

222 The best-characterized p53 activity in vitro is as a transcr

223 The best-characterized par system contains a centromere-bind

224 The best-characterized Parkinsonian DJ-1 missense mutation,

225 The best characterized pathway for subsequent oxalate degrad

226 The best characterized pathway for the initiation of mRNA de

227 The best-characterized pathway for intrinsic forgetting incl

228 The chaperone/usher system is one of the best characterized pathways for protein secretion and as

229 data demonstrate overlap between two of the best-characterized pathways for recognition of pathogen

230 One of the best-characterized pause sequences is a binding site for

231 In animals, the two best-characterized PcG complexes are PRC1 and PRC2.

232 -ATPase (NKA) residue Ser(936), which is the best characterized phosphorylation site in NKA, targeted

233 The best-characterized piRNAs mediate a conserved pathway th

234 The best-characterized plant gene exhibiting a complex antis

235 The genes encoding some of the best-characterized plant secondary metabolite biosynthet

236 in seedling establishment, and are among the best-characterized plant signaling components.

237 Protein phosphorylation is the best characterized post-translational modification that

238 ense-mediated mRNA decay (NMD), which is the best-characterized posttranscriptional quality control m

239 One of the best-characterized PP2A substrates is MYC proto-oncogene

240 ed myometrium from humans and Eker rats, the best characterized preclinical model of leiomyomata.

241 One of the best-characterized prions, [PSI(+)], is governed by a co

242 advances in our understanding of some of the best-characterized proteins required for the membrane fi

243 The best characterized putative cleavage event is at amino a

244 absorption to dose relationships that can be best characterized quantitatively by using power equatio

245 d subsequent calcium (Ca(2+)) fluxes are the best characterized receptor-regulated signaling events.

246 cal applications, focusing mainly on the two best-characterized receptors CTLA4 and PD-1.

247 The best characterized regulator of thiols in proteins is Tr

248 PUF family proteins are among the best-characterized regulatory RNA-binding proteins in no

249 This review is a survey of the best-characterized restriction factors capable of inhibi

250 cross-modal impact of a sound for one of the best-characterized rhythms arising from the visual syste

251 The best characterized ribosomopathies, with the exception o

252 Here we focused on examining the role of the best characterized RNA demethylase, FTO (fat mass and ob

253 d that this activation is independent of the best-characterized RNA- and protein-sensing PRRs includi

254 The best-characterized role for ARF is in stabilizing p53 in

255 Its best-characterized role is as part of the destruction co

256 live-attenuated MP-12 vaccine is one of the best-characterized RVF vaccines for safety and efficacy

257 The best-characterized Saccharomyces cerevisiae gene regulat

258 RNA-dependent RNA-polymerase (RdRp) are the best characterized SARS-CoV-2 targets and show the highe

259 The Rhg1 locus is the most used and best characterized SCN resistance locus, and contains th

260 We apply our theory to what is arguably the best-characterized sensing system in biology, the chemot

261 Polo-like kinase 1 (Plk1), the best characterized Ser/Thr kinase, is involved in mitoti

262 tural differences between AAV8 and AAV2 (the best-characterized serotype) are located on the capsid s

263 The best-characterized signaling pathways use STAT1, however

264 We describe a model in which the two best-characterized skin-resident DCs, langerhans cells (

265 The best-characterized SM protein is the synaptic factor Mun

266 The best-characterized SOCE channels are the Ca(2+) release-

267 In Arabidopsis, the best characterized START domain proteins are the 14 PYR/

268 One of the best characterized stress response pathways is the unfol

269 gradients of chemoattractants, is among the best-characterized subjects in molecular biology(1-10),

270 s in CuZn superoxide dismutase (SOD1) is the best characterized subset of familial amyotrophic latera

271 PK autophosphorylates DNA-PKcs, which is its best characterized substrate.

272 lity to assemble and secrete antibodies, the best-characterized substrate of BiP, has not been invest

273 DNA-PKcs itself is the best-characterized substrate of DNA-PK.

274 Esx-1, the best-characterized system, is required for virulence of

275 sophila antimicrobial response is one of the best characterized systems of pattern recognition recept

276 Fast-folding WW domains are among the best-characterized systems for comparing experiments and

277 respect, peptidic foldamers are perhaps the best-characterized systems, as they populate a number of

278 The best characterized T4SS are the type IVA systems, which

279 The best-characterized tandem BRCT domains to date are from

280 TORC2 does not regulate cell growth via its best-characterized target, AKT.

281 itis C virus (HCV) has emerged as one of the best characterized targets for next-generation HCV thera

282 The best-characterized targets of Nef are major histocompati

283 us laevis egg extract, where the gradient is best characterized, that spindles can assemble in the ab

284 ought to determine which biological features best characterized those viruses that have achieved sust

285 Hematopoietic stem cells (HSCs) are the best-characterized tissue-specific stem cells, yet exper

286 factors, and human equivalents of the three best-characterized tissue-Treg populations-those operati

287 CSLF proteins are the best characterized to date but relatively little informa

288 NF-kappaB is one of the best-characterized transcription factors, providing the

289 or thyroid-hormone receptors (SMRT) are the best characterized transcriptional co-repressors from a

290 Arguably, the best-characterized transsynaptic interactions are formed

291 culture conversion using solid medium is the best-characterized tuberculosis biomarker, having been e

292 133 epitope of CD133 currently is one of the best-characterized tumor stem cell markers for many intr

293 , an inhibitor of Hedgehog signaling, is the best-characterized tumor suppressor in medulloblastoma.

294 The best-characterized type 1 interferon (IFN) signaling pat

295 Clathrin-mediated endocytosis (CME) is the best-characterized type of endocytosis in eukaryotic cel

296 The two best-characterized types of CD4(+) regulatory T cells (T

297 se inositol-requiring enzyme 1 (IRE1) is the best characterized UPR signal transduction molecule.

298 IVs) are considered multigenic, although the best characterized virulence factor is the hemagglutinin

299 munomodulatory properties of AhR ligands are best characterized with extensive studies of changes in

300 One of the best-characterized WNK1 targets is the protein kinase OS