ライフサイエンスコーパス: beta structure

1 iented orthogonal to the fibril axis ("cross beta" structure).

2 ide or protein aggregates containing a cross-beta structure.

3 ambda Cro sequence strongly favors the alpha+beta structure.

4 y protected by systematically H-bonded cross-beta structure.

5 must be modular, compact, and adopt a cross-beta structure.

6 prions immediately C-terminal to their cross-beta structure.

7 pha-helix and that the 1-123 region may have beta structure.

8 the misfolding of Abeta42 into pathological beta structure.

9 s thermally stable and has a high content of beta structure.

10 diffraction patterns consistent with a cross-beta structure.

11 pecially applicable to the de novo design of beta structure.

12 Second, Hsp104 unfolds cross-beta structure.

13 m of polypeptide configuration, termed cross-beta structure.

14 of 4.7 A, oriented appropriately for a cross-beta structure.

15 ed helical bridge joining a two-domain alpha/beta structure.

16 er transform-infrared spectrum indicative of beta structure.

17 pact, highly soluble, monomeric form rich in beta structure.

18 th high fidelity into a double-layered cross-beta structure.

19 rientations in the beta subunit of the alpha beta structure.

20 acked the single-stranded DNA, and assumed a beta structure.

21 ation-prone regions (APRs) that favour cross-beta structure.

22 version of the native protein into the cross-beta structure.

23 find detailed evidence for an extended cross-beta structure.

24 nd extended conformation that can form cross-beta structure.

25 L9 (NTL9), a model protein with mixed alpha/beta structure.

26 harged surface of the fibrillar amylin cross-beta structure.

27 II helix that is closely packed to the core beta-structure.

28 n the region found to undergo a refolding to beta-structure.

29 , and propensities to form alpha-helices and beta-structure.

30 ent of residues within this region in stable beta-structure.

31 glycine), in equilibrium predominantly with beta-structure.

32 iates, the earliest of which appears to lack beta-structure.

33 alpha-helical PrP(C) into aggregates rich in beta-structure.

34 d PrPSc containing additional intermolecular beta-structure.

35 pha-helical secondary structure with a minor beta-structure.

36 de features, indicating a "loosening" of the beta-structure.

37 These intermediates were high in beta-structure.

38 es in alpha-helical conformation and <10% in beta-structure.

39 omain, domain C, which forms an antiparallel beta-structure.

40 hroism spectral properties characteristic of beta-structure.

41 ain with three helices and a small amount of beta-structure.

42 protofibril, consistent with a superpleated beta-structure.

43 There is no evidence for any increase in beta-structure.

44 embrane-inserted peptide from alpha-helix to beta-structure.

45 C to PrPSc by template-assisted formation of beta-structure.

46 trinsic property of these peptides to form a beta-structure.

47 exhibits a reversible temperature-dependent beta-structure.

48 fibrils probably have a parallel in-register beta-structure.

49 ichroism measurements, this peptide adopts a beta-structure.

50 e aggregates, doing so by a slow increase in beta-structure.

51 t, and CD spectra that are characteristic of beta-structure.

52 are inconsistent with the formation of cross-beta-structure.

53 reflect two different architectures of cross-beta-structure.

54 gument for the dynamic nature of their cross-beta-structure.

55 form a globular domain containingalpha- and beta-structure.

56 tional equilibrium in Abeta42 shifts towards beta-structure.

57 ing pattern and strand twist, when designing beta structures.

58 the formation of the highly stable extended beta structures.

59 nd P-loop NTP hydrolase) are all mixed alpha-beta structures.

60 siently self-associate through labile, cross-beta structures.

61 isting of both random coil and heterogeneous beta structures.

62 0 oligomers are rich in beta-sheet and cross-beta structures.

63 tially improve remote homology detection for beta structures.

64 duli were 378 MPa for alpha- and 460 MPa for beta-structures.

65 nvolving transient populations of non-native beta-structures.

66 PSIIFILAYSLKKKS) retained a tendency to form beta-structures.

67 Circular dichroism shows primarily beta-structures.

68 2 promotes formation of more benign parallel beta-structures.

69 ls consist of conformationally uniform cross-beta-structures.

70 isease, where it forms interdigitating cross-beta-structures.

71 P-2 had 3-fold less alpha-helix, 7-fold more beta-structure, 6-fold more reactive C terminus to carbo

72 ngements of the peptide satisfied the "cross-beta-structure", a hallmark of amyloid fibrils.

73 e inhibitors bind to and stabilize the early beta-structured Abeta oligomers and thus delay aggregati

74 tures of this complex reveal an unusual, all-beta structure adopted by the TCP domain and explain how

75 amorphous aggregates (protofibrils) rich in beta-structure after the lag phase but prior to the deve

76 due to nearly random allocation of alpha and beta structure along wild-type sequences.

77 In the former, an infinite, open beta-structure along one crystal axis results, while in

78 promoting increases in both alpha-helix and beta-structure, although they differ in binding affinity

79 Protein misfolding and formation of cross-beta structured amyloid fibrils are linked to many neuro

80 ns is essential for effective attenuation of beta-structured amyloid oligomeric species often associa

81 l N-terminal domain and a central open alpha/beta structure, an active site consisting of a SAM bindi

82 ling constants indicate the presence of some beta structure and a short helix, but the intervening lo

83 II' turn facilitates transformation to cross-beta structure and assembly of a dry steric zipper.

84 ry amino acid sequence, share a common cross-beta structure and bind the histochemical dye Congo Red

85 provide a new route for accessing the cross-beta structure and expanding the scope of protein design

86 NTL9 has a mixed alpha-beta structure and folds via a two-state mechanism.

87 a LC secreted by both cell lines contained a beta structure and formed amyloid fibrils.

88 Comparisons, made to pol beta structure and motions in the presence of a correct

89 s for molecular assembly of an amyloid cross-beta structure and provide insights into mechanistic asp

90 ined models of proteins with mixed alpha and beta structure and the analysis of the structural databa

91 the transcriptome is enriched in mixed alpha-beta structures and depleted in membrane proteins relati

92 of enzymatic degradation of Abeta with cross-beta structures and show the series of steps involved in

93 at VP5* forms the body and base primarily in beta-structure and alpha-helical conformations, respecti

94 500-A-long secreted protein that is rich in beta-structure and contains two regions, R1 and R2, of t

95 Smaller quantities of beta-structure and poly(l-proline) II (PPII) helix were

96 e indicated the presence of small amounts of beta-structure and substantial amounts (>50%) of alpha-h

97 r alanine, leads to increased propensity for beta-structure and the formation of amyloid-like fibrils

98 tions of the NHA hydroxyl with active center beta-structure and the heme ring polarize and distort th

99 fibrils to amorphous aggregates with reduced beta-structures and increased random coil content.

100 xistence of fibril-like parallel in-register beta-structures and strongly suggest an antiparallel bet

101 lding progressed to thermodynamically stable beta-structures and then to kinetically trapped alpha-st

102 ared data suggest that unique alpha-helical, beta structures, and side chain rearrangements are assoc

103 in a coiled coil motif, with no evidence of beta structures, and this was confirmed by circular dich

104 otein is monomeric in solution, has residual beta-structure, and is in a premolten globule state that

105 bule-like states cluster in the alpha-helix, beta-structure, and PPII-helix regions of the Ramachandr

106 udies of synthetic sPLA2 showed alpha-helix, beta-structure, and random coil contents consistent with

107 associated with turns, bends, alpha-helices, beta-structures, and random coils for inactivated viruse

108 al residues that are disordered in the alpha beta structure are fully resolved in our structure.

109 exists in a region where short stretches of beta-structure are found at analogous positions in GM-CS

110 ese changes concerned mainly glutenins since beta-structures are characteristic for them.

111 al structure, and the transverse axes of any beta structure, are preferentially oriented parallel to

112 wo subunits with in-register, parallel cross-beta structures, arranged with quasi-2(1) symmetry.

113 show evidence of changes in alpha-helix and beta-structures as well as signals consistent with Arg,

114 ection at (0.47 nm)(-1), indicative of cross-beta structure, as predicted.

115 Globular heads folded in an unusual Beta-structure associate to form molecular dimers, and e

116 s work contributes to our understanding of A beta structure associated with aggregation and toxicity

117 mine at near residue level, the changes in A beta structure associated with aggregation to a fibril f

118 te that elastin has more turns and distorted beta-structure at higher temperatures.

119 bilayer and an increased propensity to form beta-structures at the membrane surface.

120 ble with higher distribution in the extended beta structure basin, but not a coil.

121 vent reveal that the CTFs adopt a metastable beta-structure: beta-hairpin for Abeta(x-42) (x=29-31) a

122 ys2 and Cys99 stabilizes a long and parallel beta-structure between strand A (residues 3-12) and stra

123 Arg(28) to Lys(181) and consists of an alpha/beta structure built from a six-stranded parallel beta-s

124 circular dichroism, it possesses no alpha or beta structure but has some organized structure associat

125 circular dichroism, they possess no alpha or beta structure but have some organized structure associa

126 Recombinant Hwp1 lacks alpha and beta structures by circular dichroism and likely exists

127 d of globules and short rods, show primarily beta-structure by circular dichroism (CD), enhance the f

128 d thioflavin T fluorescence and were rich in beta-structure by circular dichroism.

129 als how both parallel and antiparallel cross-beta structures can be constructed from similar peptide

130 Whereas beta structures can now be predicted with the new proced

131 idin distinguishes it from alpha-helical and beta-structured cationic peptides, because five of indol

132 l structure; the beta-solenoid has the cross-beta structure characteristic of all amyloids, but is in

133 The protein has a typical two-domain alpha/beta structure, characteristic of periplasmic extracytop

134 We show that the fractions of beta structure computed in our simulations and measured

135 The beta-structure condenses about beta(3-4), while alpha1 a

136 nding to DNA the disordered peptides adopt a beta-structure conformation.

137 oes an immediate conversion to a predominant beta-structured conformation in 2 mM SDS which does not

138 observed in the gluten structure concerning beta-structures, conformation of disulphide bridges, and

139 the Ig fold architecture-the non-local cross-beta structure connecting the two beta-sheets-and use th

140 The catalytic domain is an alpha/beta structure contained within the first 92 amino acids

141 a folding topology in which three primarily beta-structure-containing domains meet to form a shallow

142 as accompanied by a dramatic increase in the beta-structure content and a characteristic increase in

143 e change involved an increase in predominant beta-structure content and in fluorescence with thioflav

144 in secondary structure from random coils to beta-structures, creating infrared spectra in the phosph

145 ut no substantial population of alpha(L)- or beta-structures, despite sampling alpha(L)- and beta-str

146 better alignment in the turn region and the beta-structure domain.

147 The minimal beta-structure element is the beta-hairpin, which is als

148 l regions were consistently found to contain beta-structure elements and hairpins.

149 was completely inhibited due to formation of beta-structure-enriched oligomers with high concentratio

150 results suggest that a parallel in-register beta structure exists at these spin-labeled positions.

151 family members, giving rise to a novel alpha/beta structure for the serotonin binding slot.

152 thods may be applicable to recognizing other beta structures for which strand topology and profiles o

153 and Arg66 accessible on the same face of the beta-structure for interaction with RNA.

154 he critical part of the parallel in-register beta-structure for the studied [PSI(+)] prion variant li

155 minal strand hint to the initiation of cross-beta structure formation.

156 ulations also successfully predict increased beta-structure formation in the condensate, consistent w

157 nilino-1-napthalenesulfonic acid binding and beta-structure formation inhibits FN multimerization and

158 f a simplified amino acid alphabet to design beta-structure forming L2 peptides with improved RecA-li

159 rgetically unfavorable in the extended cross-beta structure found in amyloid.

160 ADP-ribosylating toxins that have a similar beta-structure framework.

161 In contrast, the mechanism of formation of beta structures has not been studied experimentally.

162 of the structure, whereas the addition of a beta-structure has less effect.

163 s of wild-type proteins with mixed alpha and beta structure have symmetric distribution of alpha and

164 ing by Hsp104 then resolves N-terminal cross-beta structure in a stepwise manner.

165 sistent with an important role for a compact beta structure in mutant huntingtin-induced cell toxicit

166 u, are consistent with an important role for beta structure in PHF formation, and may also help expla

167 rm infrared (FTIR) spectra characteristic of beta structure in solution, binds to lipid bilayer vesic

168 his segment of the peptide are involved in a beta structure in the fibril.

169 o N- and C-terminal regions within the rigid beta structure in the repeat region of Tau(3RD).

170 y, this change involves the formation of new beta structure in which interstrand hydrogen bonds orien

171 ulated the formation of ordered amyloid-like beta structures in a system formed by 18 polyvaline chai

172 Electron diffraction confirmed cross-beta structures in both fibrils.

173 gnetic resonance techniques to contain cross-beta structures in which the beta-sheets have an in-regi

174 s showed that when the FLIVI sequence adopts beta-structure in aqueous solution, it associates into a

175 ocess, with the association process inducing beta-structure in otherwise non-beta-monomers.

176 d Arg38 is caused by a disruption of regular beta-structure in strand C opposite the beta-bulge in st

177 This leads to an increased population of beta-structure in the CHC.

178 ibril, the hinge loop that forms an extended beta-structure in the dimer remains protected, consisten

179 The beta-structure in the DNA pairing peptides can be induce

180 loid nucleation without measurably enhancing beta-structure in the monomer ensemble.

181 n monomers and oligomers is the formation of beta-structure in the oligomers occurring together with

182 epeat domain, which partially adopts a cross-beta-structure in the resulting amyloid-like fibrils.

183 f such side-chain interactions but it lacked beta-structure in two of the three denatured ensembles:

184 ost entirely helical, the Abeta analogs were beta-structured in the resulting vesicle dispersions.

185 s, the domain is partially converted to form beta-structures in lipid bilayers.

186 a-structures, despite sampling alpha(L)- and beta-structures in our MC simulations.

187 vent models predict that PHF6 forms extended beta-structures in solution, a finding consistent with t

188 suggesting conformational non-equivalence of beta-structures in the disease-associated Y145Stop varia

189 that M2-10, M2-14, M2-18, and M2-30 assumed beta-structures in this environment.

190 shares with mature amyloid fibrils the cross-beta structure, in which adjacent beta-sheets adhere by

191 s have shown that RRMs adopt a compact alpha/beta structure, in which four antiparallel beta-strands

192 ernative packing arrangements of native-like beta-structure, in which proline isomerism is important

193 self-associate in a specific manner to form beta-structured inclusions.

194 helix (helix A, or helix C) and the central beta structure involving the residues in the sixth, seve

195 The fucose alpha(1-->2) galactose beta structure is expressed by uterine epithelial cells

196 s predominantly alpha-helical, although some beta structure is likely to be present.

197 A CD spectrum indicative of beta structure is observed within 1 min of the solvent s

198 The alpha/beta structure is strikingly similar to the globular dom

199 detected with FTIR, indicating that a final beta-structure is attained.

200 al change of the peptide from random coil to beta-structure is important in binding ss- and dsDNA.

201 The resulting beta-structure is relatively planar and loose in the maj

202 ive folding in beta-hairpins and other small beta-structures is driven by cooperative strand-strand a

203 By analogy with the rat pol beta structure, it is suggested that each of these HhH m

204 more exposed and has a higher propensity to beta structure may accelerate the rate of fibril formati

205 stinction can be explained by a superpleated beta-structure model for PolyQKd-33 and a model with two

206 A beta-structure model for the loop L2 of RecA protein whe

207 s process leads to co-aggregates featuring a beta-structure motif that is characteristic for mature a

208 Both CCP and LmP have an extended section of beta structure near Trp(191) and Trp(208), respectively,

209 he 4.7 A spacing characteristic of the cross-beta structure of amyloids.

210 The alpha+beta structure of the protein reveals an SH3-like topolo

211 Through comparative analysis of the cross-beta structures of fibril-forming peptides, we identifie

212 novo approach for predicting both alpha and beta structures of proteins are described.

213 onserved loop that links predicted alpha and beta structures of this RNA binding motif lack who funct

214 As a result, the beta-structure of Abeta42 is more stable than that of Ab

215 no acids crucial to G(34) recognition by the beta-structure of the anticodon-binding domain of Thermu

216 linked macrocyclic beta-sheets 6 bind to the beta-structured oligomers more strongly, because N-termi

217 can bind to the N-terminal-based core of the beta-structured oligomers, while the C-terminal-derived

218 , we report an analysis of the effect of TGF-beta structure on its binding to TbetaRII by using TGF-b

219 This motif, with beta-structure on the outside and alpha-helix on the ins

220 nstructured polypeptide that adopts an alpha-beta structure only in the presence of the protease.

221 erminus of NEDD8 locking it into an extended beta-structure optimal for catalysis.

222 agments Sup35 prions without unfolding cross-beta structure or releasing soluble Sup35.

223 ed conformational change to either primarily beta-structure or helical structure, depending, among ot

224 of the C-terminal helix followed by loss of beta-structure or the opposite.

225 regates progressed to soluble fibers rich in beta-structure over a roughly 2 day period.

226 minal region, on the other hand, retains its beta-structure over the pH range 1-11, whereas more alka

227 erstanding of how arsenic binding influences beta-structure, pairs of cysteines were introduced into

228 variation in the amino-acid sequences of the beta-structures presents a challenge to developing a mod

229 When interacting with beta-structure promoting substances, such as surfactants

230 OPLS-AA reveals moderate beta-structure propensity coupled with extensive, but we

231 domains in the tau protein; all contain high beta-structure propensity in their R2, R3, and R4 repeat

232 echanism to form energetically-favored cross-beta structures, regardless of their precise sequences.

233 2.2-A resolution, revealing a compact alpha/beta structure related to the START domain present in th

234 lution, it can form aggregates rich in cross-beta structure, relatively long helical segments when bo

235 bow (with the active site nucleophile)-alpha-beta structure, residues 131-175 of the synthase.

236 ficiency, highlighting the importance of the beta-structure-rich regions for tau aggregation.

237 hese aggregates contain intermolecular cross-beta structure similar to that found in amyloid diseases

238 e, we observe the formation of two different beta-structured states with similar but distinct spectro

239 ty packing tends to occur toward the ends of beta-structure strands where hydrogen bonds are more lik

240 he aromatic side chains does not occur until beta-structure sufficient to bind thioflavin T has devel

241 nd C453 is populated by both random coil and beta-structure, suggesting that the cooperative structur

242 ectroscopy of StAR in PC membranes show more beta-structure than in aqueous buffers, and the presence

243 fined secondary structure that contains more beta-structure than the native state.

244 including a conserved beta alpha beta alpha beta structure that comprises the phosphoesterase motif.

245 GAR-syn adopts an alpha/beta structure that consists of four domains labeled N,

246 nstrate that curli fibrils possess the cross-beta structure that distinguishes protein amyloid.

247 Therefore, the extended D2 beta-structure that connects D1 to membrane-bound D4 app

248 s) fold at cell surfaces, adopting alpha- or beta-structure that enable their intracellular transport

249 prion protein-like conformation enriched in beta-structure that is in good agreement with available

250 can form soluble aggregates with predominant beta-structures that differ in stability and morphology.

251 Due to universality of the amyloid beta structure, the anisotropic mechanical dissociation

252 For the beta portions of alpha/beta structures, the C(alpha) rmsd's are less than 6.0 A

253 In the L(beta) structure, the acyl chains of the phospholipids oc

254 i, which isomerizes to form the active alpha beta structure; the structure of the enzyme has been det

255 her with selected beta-O-4, beta-5, and beta-beta structures, these compounds provide a detailed unde

256 use of the higher flexibility and entropy of beta structures, they could be preferred under the influ

257 nverted the all-alpha structure to the alpha+beta structure through sequences that could adopt both f

258 mbles: beta(3-4) was the only portion of the beta-structure to contain significant residual structure

259 om coil at low surfactant concentration, via beta-structure to the fully formed alpha-helical state a

260 n conformation, by causing an alpha-helix to beta-structures transition in both proteins.

261 As minimalist versions of beta-structure, two-stranded beta-hairpins are commonly

262 ore, the P protein folds to its native alpha/beta structure upon addition of various small molecule a

263 that mutant huntingtin polyglutamine adopts beta structure upon conversion to a toxic form.

264 an aqueous buffer and adopts a more ordered beta-structure upon binding to negatively charged membra

265 he structurally disordered N-terminus adopts beta-structure upon conversion to PrP(Sc) at low pH.

266 ajor refolding to a parallel and in-register beta-structure upon conversion.

267 lly soluble but that fragments or designs of beta structure usually aggregate suggests that natural b

268 sidual native helical structure, whereas the beta-structure was completely disrupted.

269 The beta-structure was oriented along the bilayer normal.

270 Consistent with their defining cross-beta structure, we find that in this series the amyloid

271 pair homologous DNAs by forming filamentous beta-structures, we propose how the information from the

272 beta-strand propagation and the promotion of beta-structure when an Arg is introduced adjacent to the

273 omprising an alpha-helix, a 3(10) helix, and beta-structure when bound to cyclin A-Cdk2.

274 e data suggest that the pro-peptide adopts a beta-structure when in contact with the protein, but it

275 dSP-C is fully recoverable from the amyloid beta-structure when the pH is once again lowered.

276 bles of proteins with significant amounts of beta-structure, where the specific entropy costs of cont

277 hat the N-terminal half was likely to form a beta-structure whereas the C-terminal half was likely to

278 hroism of the complex revealed a mixed alpha/beta structure, whereas Aga2p alone had no periodic seco

279 structure that is followed by conversion to beta-structure, whereas EtOH only unfolds the protein.

280 MeOH result in the formation of a non-native beta-structure, whereas subsequent additions of TFE indu

281 o an (alpha/beta)8 barrel with an associated beta-structure, whereas the attached CBM35 displays a je

282 e-2,6-bisphosphatase domain has a core alpha/beta structure which consists of six stacked beta-strand

283 The enzyme has an open (alpha, beta) structure which differs from the classical dinucle

284 ists of three domains: domain 1 has an alpha/beta structure; while domain 2 and domain 3 are beta-bar

285 nter-chain disulfides, and their presence in beta-structures with dense backbone hydrogen bonds creat

286 delicately balanced between alpha and alpha/beta structures, with different functions encoded with o

287 lical domains accompanied by the increase of beta structures within the PrP molecule.

288 s no evidence for significant enhancement of beta-structure within the monomer ensemble.