ライフサイエンスコーパス: beta-Ala

1 aacetic acid (DOTA)-X-BBN[7-14]NH(2) (X = 0, beta-Ala, 5-Ava, 8-Aoc, or 11-Aun) conjugates and their

2 ocks to the GRPR-selective ligand [d-Phe(6), beta-Ala(11), Ala(13), Nle(14)]Bn(6-14) (sBB2L) generati

3 We have recently discovered that [d-Tyr(6),beta-Ala(11),Phe(13),Nle(14)]Bn-(6-14) has high affinity

4 no acids into the prototype ligand [d-Tyr(6),beta-Ala(11),Phe(13),Nle(14)]Bn-(6-14) or its d-Phe(6) a

5 for nuclear access include the presence of a beta-Ala-tail residue and the lack of a cationic alkyl a

6 dministration of hybrid 13a (H-Dmt-d-Arg-Aba-beta-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) to mice resulted i

7 -opioid agonist tetrapeptide H-Dmt-d-Arg-Aba-beta-Ala-NH(2) (KGOP01) was fused to NT(8-13) analogues.

8 in, the opioid pharmacophore H-Dmt-d-Arg-Aba-beta-Ala-NH2 (7) was linked to peptide ligands for the n

9 beta-Alanine (beta-Ala) betaine is an osmoprotective compound accumula

10 at the position of Asn15, N-butylglycine and beta-Ala at Met16, naphthylalanine (Nal) at Trp19, 4-pyr

11 -(Arg(11))CCMSH (1) {c[Arg-Ser-Asp-dTyr-Asp]-beta-Ala-Cys-Cys-Glu-His-dPhe-Arg-Trp-Cys-Arg-Pro-Val-NH

12 One ligand, GXH-32B-c[beta-Ala-His-d-Nal(2')-Arg-Trp-Glu]-Val-Val-Gly-NH(2), t

13 In particular, the mu-agonist c[beta-Ala-d-Pro-Phe-Trp] 9 was shown to elicit potent ant

14 eta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala as methyl acceptors.

15 eta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala, respectively.

16 eta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala.

17 a-Ala via N-methyl beta-Ala and N,N-dimethyl beta-Ala.

18 4), NAD-beta-Ala-(Arg(11))CCMSH (5), and EAD-beta-Ala-(Arg(11))CCMSH (6) peptides were synthesized an

19 expressing phosphoacceptor mutants rat C/EBP beta Ala-105 or mouse C/EBP beta Ala-217.

20 utants rat C/EBP beta Ala-105 or mouse C/EBP beta Ala-217.

21 tor substrates were 5.3, 5.7, and 5.9 mM for beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala,

22 e genus that lacks the synthetic pathway for beta-Ala betaine.

23 mino-3-phenylpropionic acid substitution for beta-Ala(11) in the prototype ligand had the highest sel

24 convert the substrate preference of hGS from beta-Ala to Gly.

25 -Val and the three achiral amino acids Gly, beta-Ala, and GABA).

26 -Glu]-Val-Val-Gly-NH(2) [XXX = nothing, Gly, beta-Ala, gamma-Abu, 6-Ahx; YYY = His, His(3-Bom), (S)-c

27 of the torsional flexibility of the main His-beta-Ala chain, while retaining the rigidity conferred b

28 using PET with (68)Ga-NOTA-GZP (where GZP is beta-Ala-Gly-Gly-Ile-Glu-Phe-Asp-CHO) to detect early in

29 rovide extra space to accommodate the longer beta-Ala moiety of hGSH in comparison to the glycinyl gr

30 unctional S-adenosyl L-methionine (Ado-Met): beta-Ala N-methyltransferase (NMTase).

31 ndent N-methylation of beta-Ala via N-methyl beta-Ala and N,N-dimethyl beta-Ala.

32 t were highly specific to beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala as methyl acceptors.

33 5.3, 5.7, and 5.9 mM for beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala, respectively.

34 rifunctional, methylating beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala.

35 rified NMTase was trifunctional, methylating beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala.

36 SH (3), RAD-beta-Ala-(Arg(11))CCMSH (4), NAD-beta-Ala-(Arg(11))CCMSH (5), and EAD-beta-Ala-(Arg(11))C

37 aceae), it is synthesized via methylation of beta-Ala by the action of a trifunctional S-adenosyl L-m

38 osyl-L-methionine-dependent N-methylation of beta-Ala via N-methyl beta-Ala and N,N-dimethyl beta-Ala

39 ) participate in the three N-methylations of beta-Ala.

40 betaine (93-101 micromol g(-1) dry weight of beta-Ala betaine and Gly betaine) than untransformed cel

41 nosinase activity and the ability to grow on beta-Ala and/or L-His were similar in the mutant and the

42 steine followed by a C-terminal Gly, Ser, or beta-Ala residue [poly-(gamma-Glu-Cys)n-Xaa].

43 ine, tri(ethylene glycol), and Tyr-D-Arg-Phe-beta-Ala (YRFA) peptide were synthesized.

44 In the Plumbaginaceae, beta-Ala betaine is synthesized by S-adenosyl-L-methioni

45 Peptide sequences from purified beta-Ala NMTase were used to design primers for reverse

46 SH (2), RVD-beta-Ala-(Arg(11))CCMSH (3), RAD-beta-Ala-(Arg(11))CCMSH (4), NAD-beta-Ala-(Arg(11))CCMSH

47 RSD-beta-Ala-(Arg(11))CCMSH (1) {c[Arg-Ser-Asp-dTyr-Asp]-bet

48 -His-dPhe-Arg-Trp-Cys-Arg-Pro-Val-NH 2}, RTD-beta-Ala-(Arg(11))CCMSH (2), RVD-beta-Ala-(Arg(11))CCMSH

49 -NH 2}, RTD-beta-Ala-(Arg(11))CCMSH (2), RVD-beta-Ala-(Arg(11))CCMSH (3), RAD-beta-Ala-(Arg(11))CCMSH

50 Phylogenetic analyses suggested that beta-Ala NMTase represents a novel family of N-methyltra

51 the substitution of the Lys linker with the beta-Ala could reduce the renal uptake of (99m)Tc-labele

52 Tase activities that were highly specific to beta-Ala, N-methyl beta-Ala, and N,N-dimethyl beta-Ala a

53 bitory concentration of 50% for analogs with beta-Ala, 5-Ava, and 8-Aoc spacers.

54 The substitution of the Lys linker with beta-Ala linker dramatically reduced the renal uptake of