ライフサイエンスコーパス: beta-TrCP

1 beta-TrCP and SKP2 are two well-studied F-box proteins,

2 beta-TrCP binds to IkappaBalpha only when the latter is

3 beta-TrCP F-box protein mediates ubiquitination of phosp

4 beta-TrCP function is essential for the induction of nuc

5 beta-TrCP thus plays a critical role in both canonical a

6 beta-TrCP ubiquitinates EZH2 and Jak2-mediated phosphory

7 beta-TrCP ubiquitinates LPCAT1 at an acceptor site (Lys(

8 beta-TrCP, the substrate recognition subunit of SCF-type

9 SCF complex, a heterotetramer (Skp1, Cul-1, beta-TrCP [F-box protein], and ROC1) involved with ubiqu

10 e presence of HPV-16 E7, including cullin 1, beta-TrCP, Aurora A, and Polo-like kinase-1 (PLK1).

11 A beta-TrCP mutant lacking the F-box inhibits the signal-i

12 augmentation was also inhibited by Vpu in a beta-TrCP-dependent manner.

13 entified PHLPP1 as a proteolytic target of a beta-TrCP-containing Skp-Cullin 1-F-box protein (SCF) co

14 We focused on SNAT1, a beta-TrCP-dependent Vpu substrate.

15 f beta-TrCP reduced the expression of Sp1, a beta-TrCP substrate, which, in turn, reduced Skp2 gene e

16 CG12 to mimic glucose starvation to activate beta-TrCP-mediated Sp1 degradation has translational pot

17 ay is Siah2 and APC dependent, but GSK-3 and beta-TrCP independent.

18 howed increased cytosolic levels of Axin and beta-TrCP and decreased phosphorylation of glycogen synt

19 wn to act as a scaffold for beta-catenin and beta-TrCP and thereby to potentiate beta-TrCP-mediated b

20 Endogenous beta-catenin and beta-TrCP could be coimmunoprecipitated from mammalian c

21 odulating the expression of beta-catenin and beta-TrCP, suggesting the translation potential of using

22 confirm the interaction between circPVT1 and beta-TrCP in NPC cells.

23 correlated during cell cycle with FBXW2 and beta-TrCP/SKP2 being high or low, respectively, in arres

24 components, including Ck1alpha, GSK3beta and beta-TrCP, suppress beta-catenin levels in the larval ep

25 ated PD-L1 forms a complex with GSK3beta and beta-TrCP.

26 SP1 proteins to target IRF3, IRF5, IRF7, and beta-TrCP for degradation.

27 nately regulated by Pak1 phosphorylation and beta-TrCP-dependent ubiquitin-proteasome pathways.

28 IkappaB kinase-dependent phosphorylation and beta-TrCP-dependent ubiquitylation of the N-terminal sig

29 first time that interaction between PRLr and beta-TrCP is less efficient in human breast cancer cells

30 Moreover, we determined that Skp2 and beta-TrCP are mutually regulated, providing a feedback m

31 hysical association of Cdc25A with Smad3 and beta-TrCP.

32 n between expression levels of beta-TrCP and beta-TrCP activity, indicating post-transcriptional regu

33 n of Mcl-1 with the E3 ligase beta-TrCP, and beta-TrCP then facilitates the ubiquitination and degrad

34 d to be required for maximal binding between beta-TrCP and phosphorylated I kappaB alpha.

35 -TrCP activity by inhibiting binding between beta-TrCP and the core SCF complex.

36 performed to confirm the interaction between beta-TrCP and c-Myc in NPC cells.

37 but viruses expressing A49 that cannot bind beta-TrCP or bind beta-TrCP constitutively had intermedi

38 ncogenic REST-FS mutant, which does not bind beta-TrCP.

39 ssing A49 that cannot bind beta-TrCP or bind beta-TrCP constitutively had intermediate virulence.

40 stable REST mutant, which is unable to bind beta-TrCP, inhibited Mad2 expression and resulted in a p

41 -TrCP degron sequence that was found to bind beta-TrCP.

42 in lymphoma pathogenesis are unable to bind beta-TrCP.

43 this is necessary and sufficient for binding beta-TrCP and antagonism of NF-kappaB.

44 nsistent with their proposed role in binding beta-TrCP.

45 Microtubule inhibition blocked beta-TrCP-mediated proteasomal processing of Gli2 in ost

46 E1A in virus-transformed cells reduced both beta-TrCP and ubiquitination of nuclear REST.

47 sults indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induce

48 Binding of IkappaBalpha and beta-catenin by beta-TrCP causes their ubiquitylation and thereafter pro

49 the ubiquitylation of mutant beta-Catenin by beta-TrCP in vitro and induce the degradation of an engi

50 s ubiquitination dependent and controlled by beta-TrCP.

51 dependent proteasome degradation of PD-L1 by beta-TrCP.

52 t of the phosphorylation sites recognized by beta-TrCP.

53 G motif whose phosphorylation is targeted by beta-TrCP E3 ligase during interphase.

54 yses indicate that cyclin D1 was targeted by beta-TrCP through an unconventional recognition site, (2

55 first evidence that cyclin D1 is targeted by beta-TrCP.

56 eventing proteasomal degradation of Twist by beta-TrCP.

57 SK-3beta and then cannot be ubiquitinated by beta-TrCP, is much more stable than wild-type Mcl-1 and

58 ppaB to the nucleus by sequestering cellular beta-TrCP, a protein required for the degradation of the

59 required Vpu's ability to bind the cellular beta-TrCP-E3-ubiquitin ligase complex.

60 DMRT1 contains a consensus beta-TrCP degron sequence that was found to bind beta-Tr

61 We found two conserved beta-TrCP recognition motif (DSGVVYS and DSGSIVVS) in th

62 t the ubiquitination of beta-catenin by CRL1(beta-TrCP) and Nedd8-CRL1(beta-TrCP) almost equally.

63 to target the latter for degradation by CRL1(beta-TrCP) and so inhibit origin firing.

64 ta-catenin by CRL1(beta-TrCP) and Nedd8-CRL1(beta-TrCP) almost equally.

65 Thus, neddylation of CRL1(beta-TrCP) does not negatively impact the sensitivity to

66 degron and leading to ubiquitination by CUL1(beta-TrCP) and degradation.

67 Two ubiquitin ligases, the Skp1-cullin-beta-TrCP (SCFbeta-TrCP) complex and the anaphase-promot

68 Stabilized ATF4 mutants exhibit decreased beta-TrCP degron phosphorylation, beta-TrCP interaction,

69 ion of either binding site in Nrf2 decreased beta-TrCP-mediated ubiquitylation of the transcription f

70 ak2-mediated phosphorylation on Y641 directs beta-TrCP-mediated EZH2 degradation.

71 8-facilitated beta-catenin ablation, ectopic beta-TrCP expression enhanced the degradation.

72 e Sp1 degradation, suppression of endogenous beta-TrCP function by a dominant-negative mutant or smal

73 n of PHLPP1, whereas knockdown of endogenous beta-TrCP has the opposite effect.

74 ull-down analysis with bacterially expressed beta-TrCP.

75 ition of either mTORC1 or p70S6K facilitated beta-TrCP degradation accompanied with enhanced PD-L1 pr

76 This facilitates beta-TrCP binding and ubiquitin-mediated proteolysis of

77 We find beta-TrCP remains constitutively active throughout the c

78 ylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.

79 her, our findings demonstrate a key role for beta-TrCP in controlling the level of PHLPP1, and activa

80 LPCAT1 is the first lipogenic substrate for beta-TrCP, and the results suggest that modulation of th

81 tion of Gsk3beta ubiquitination and Gsk3beta-beta-TrCP binding.

82 monoubiquitination of Gsk3beta and Gsk3beta-beta-TrCP interaction.

83 ased monoubiquitination of Gsk3beta/Gsk3beta-beta-TrCP association suppressed beta-catenin recruitmen

84 n accumulation requires Wnt-induced GSK3beta/beta-TrCP interaction; the current study revealed that p

85 ng axis composed of p38 MAP kinase-MK2-Hsp27-beta-TrCP may promote AUF1 degradation by proteasomes an

86 In this study, we have identified beta-TrCP as the ubiquitin ligase for lysosomal degradat

87 a specific recognition site for E3RS(IkappaB/beta-TrCP), an SCF-type E3 ubiquitin ligase, thereby exp

88 Moreover, immunopurified beta-TrCP ubiquitinates phosphorylated IkappaBalpha at s

89 novel SCF(beta-TrCP) substrate and implicate beta-TrCP as an important negative regulator of PRL sign

90 ation of cells, and deletion of the F-box in beta-TrCP abolishes its ability to ubiquitinate IkappaBb

91 Heterozygous deletion of Dmrt1 in beta-TrCP-deficient spermatogonia increased meiotic cell

92 s showed intracellular accumulation of FN in beta-TrCP siRNA-treated cells without showing much alter

93 tion dysfunction and alleviates mucositis in beta-TrCP-deficient mice.

94 cumulation of DMRT1 at the Stra8 promoter in beta-TrCP-deficient testes.

95 idative modification of cysteine residues in beta-TrCP.

96 dependent upon the WD40 repeat sequences in beta-TrCP and on phosphorylation of the GSK3beta sites i

97 It is noteworthy that this drug-induced beta-TrCP up-regulation was accompanied by the concomita

98 Smad3 siRNA inhibits beta-TrCP-Cdc25A interaction and Cdc25A degradation in r

99 and the concurrent down-regulation of known beta-TrCP substrates examined, including Wee1, Ikappabet

100 appears to inhibit binding of the E3 ligase beta-TrCP and prevents beta-catenin ubiquitination and d

101 the association of Mcl-1 with the E3 ligase beta-TrCP, and beta-TrCP then facilitates the ubiquitina

102 and substrate of the SCF E3 ubiquitin ligase beta-TrCP (FBXW1).

103 o the WD40 domain of the E3 ubiquitin ligase beta-TrCP and blocks its interaction with phosphorylated

104 owing for binding of the E3-ubiquitin ligase beta-TrCP and consequently ubiquitylation.

105 ctive recruitment of the E3-ubiquitin ligase beta-TrCP to phospho-IkappaBalpha proteosomal degradatio

106 a Delta F-box mutant of the ubiquitin ligase beta-TrCP, which serves as a specific substrate trap for

107 ables recognition by the E3 ubiquitin ligase beta-TrCP.

108 oded region by competing with the E3 ligases beta-TrCP and CUL3.

109 orescent biosensor to quantitatively measure beta-TrCP activity in live, single cells in real-time.

110 that although small interfering RNA-mediated beta-TrCP knockdown protected cells against STG28-facili

111 ruction box ((727)DSGAGS(732)) that mediates beta-TrCP recognition and encompasses a glycogen synthas

112 Our study introduces a method to monitor beta-TrCP activity in live cells and identifies a key si

113 Moreover, beta-TrCP expression was up-regulated in response to STG

114 ssion of wild-type but not DeltaF-box mutant beta-TrCP leads to decreased expression and increased ub

115 CP to a specific site, and dominant negative beta-TrCP blocks phosphorylation-dependent degradation o

116 by forced expression of a dominant-negative beta-TrCP mutant suppresses growth and survival of human

117 However, the action of Ras/NORE1A/beta-TrCP is substrate-specific because IkappaB, another

118 Specifically, cellular accumulation of beta-TrCP reduced the expression of Sp1, a beta-TrCP sub

119 K1 or IKKbeta) also leads to accumulation of beta-TrCP.

120 e C terminus of REST critical for binding of beta-TrCP and targeting of REST for proteasomal degradat

121 We found that the binding of beta-TrCP to beta-catenin was direct and dependent upon

122 quitin ligase activity as well as binding of beta-TrCP to phosphorylated I kappaB alpha was decreased

123 ggested that the NSP1-induced degradation of beta-TrCP is an uncommon mechanism of subverting IFN-bet

124 Depletion of beta-TrCP reduced FAF1-mediated beta-catenin polyubiquit

125 Depletion of beta-TrCP stabilized AUF1.

126 small interfering RNA-mediated knock-down of beta-TrCP enhanced and protected against STG28-facilitat

127 Although ectopic expression of beta-TrCP enhanced the ability of OSU-CG12 to facilitate

128 itutive processing of p100 is independent of beta-TrCP but rather is regulated by the nuclear shuttli

129 rocessing of p100 mutants was independent of beta-TrCP.

130 s not required for JNK-mediated induction of beta-TrCP.

131 In addition, inhibition of beta-TrCP augments the antiproliferative effects of anti

132 Here we show that inhibition of beta-TrCP either by RNAi approach or by forced expressio

133 The involvement of beta-TrCP in beta-catenin degradation was also corrobora

134 Knockdown of beta-TrCP expression inhibits the ubiquitination and deg

135 no correlation between expression levels of beta-TrCP and beta-TrCP activity, indicating post-transc

136 ce an increase in the steady state levels of beta-TrCP mRNA and protein levels in human cells.

137 The mechanisms of beta-TrCP induction via stress and its role in NF-kappaB

138 In contrast, overexpression of beta-TrCP enhanced ubiquitination and degradation of AUF

139 Overexpression of beta-TrCP induced the ubiquitylation and degradation of

140 ation suppressed beta-catenin recruitment of beta-TrCP, leading to long-term inhibition of beta-caten

141 cular determinant of GSK3beta recruitment of beta-TrCP.

142 motif of TRIM9 and the WD40 repeat region of beta-TrCP prevented beta-TrCP from binding its substrate

143 itor or by siRNA-mediated down-regulation of beta-TrCP.

144 We have examined the role of beta-TrCP (beta-transducin repeat-containing protein) in

145 To appreciate tissue-specific roles of beta-TrCP, we studied the consequences of inducible abla

146 RNA interference-mediated silencing of beta-TrCP or inhibition of Jak2 results in EZH2 stabiliz

147 ubstrates, Vpu leads to the stabilization of beta-TrCP substrates such as beta-catenin, IkappaBalpha,

148 (NF-kappa-B inhibitor), a known substrate of beta-TrCP, was rescued by Src, suggesting a wider effect

149 6K signaling is likely due to suppression of beta-TrCP-mediated proteasomal degradation of PD-L1, bec

150 AUF1 is a target of beta-TrCP, the substrate recognition subunit of the E3 u

151 by Src, suggesting a wider effect of Src on beta-TrCP substrates.

152 -catenin is destabilized and is GSK-3beta or beta-TrCP independent.

153 decreased beta-TrCP degron phosphorylation, beta-TrCP interaction, and ubiquitination, as well as el

154 enin and beta-TrCP and thereby to potentiate beta-TrCP-mediated beta-catenin ubiquitination and degra

155 he WD40 repeat region of beta-TrCP prevented beta-TrCP from binding its substrates, stabilizing Ikapp

156 ecruits the ubiquitin ligase adapter protein beta-TrCP to a specific site, and dominant negative beta

157 nd by interacting with F-box-binding protein beta-TrCP, undergoes ubiquitin-dependent proteolysis.

158 nd Ser33 are recognized by the F-box protein beta-TrCP, a component of a ubiquitin ligase complex tha

159 t REST is an interactor of the F-box protein beta-TrCP.

160 lation and did not require the F box protein beta-TrCP.

161 ependent interactions with the F box protein beta-TrCP.

162 n beta-transducin repeat containing protein (beta-TrCP) acts as a substrate adapter for the SCF E3 ub

163 s beta-transducin repeat-containing protein (beta-TrCP) and mediates proteasomal degradation of CD4.

164 t beta-transducin repeat-containing protein (beta-TrCP) E3 ubiquitin ligase is required for Gli2 degr

165 f beta-transducin repeat-containing protein (beta-TrCP) expression represents a cellular response in

166 e beta-transducin repeat-containing protein (beta-TrCP) is required for FAF1 to suppress Wnt signalin

167 t beta-transducin repeat-containing protein (beta-TrCP) targets Sp1 for proteasomal degradation in re

168 beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase.

169 f beta-transducin repeat-containing protein (beta-TrCP), a component of the SCF ubiquitin ligase comp

170 e beta-transducin repeat-containing protein (beta-TrCP), a component of the Skp-Cullin-F-box-containi

171 f beta-transducin repeat-containing protein (beta-TrCP), an F-box component of the Skp1-Cul1-F-box pr

172 , beta-transducin repeat-containing protein (beta-TrCP), and occurs only in the cytoplasm, the consti

173 , beta-transducin repeat-containing protein (beta-TrCP), that polyubiquitinates LPCAT1, thereby targe

174 r beta-transducin repeat-containing protein (beta-TrCP), which acts as a substrate receptor for the S

175 (beta-transducin repeat-containing protein [beta-TrCP]).

176 iates with the SCF (Skp1-Cul1-F-box protein)-beta-TrCP complex.

177 via a mechanism involving the F-box protein, beta-TrCP (SLIMB in Drosophila).

178 ex containing the F-box/WD40-repeat protein, beta-TrCP, a vertebrate homolog of Drosophila Slimb.

179 beta-Transducin repeat-containing proteins (beta-TrCP) serve as substrate recognition component of E

180 Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits f

181 beta-transducin repeats-containing proteins (beta-TrCP)-mediated degradation due to phosphorylation b

182 ta (GSK-3beta) phosphorylation that recruits beta-TrCP docking within the enzyme.

183 liver triglyceride content, through reduced beta-TrCP-mediated degradation of the Akt phosphatase, P

184 ifies a key signaling network that regulates beta-TrCP activity throughout the cell cycle.

185 inase signaling as a key axis for regulating beta-TrCP activity by inhibiting binding between beta-Tr

186 n this regulatory pathway is to create a SCF(beta-TrCP) E3 ubiquitin ligase binding site for beta-cat

187 etween phosphorylated I kappaB alpha and SCF(beta-TrCP) but no change in the composition of the SCF(b

188 new gene (RING) E3 enzymes SCF(Cdc4) and SCF(beta-TrCP) work with the E2 Cdc34 to build polyubiquitin

189 e association between I kappaB alpha and SCF(beta-TrCP).

190 vidence that the distinct Cullin-1 based SCF(beta-TrCP)complex regulates beta-catenin stability, our

191 rylated PRLR undergoes ubiquitination by SCF(beta-TrCP) in vitro.

192 Repression by SCF(beta-TrCP) requires phosphorylation of Nrf2 by GSK3, the

193 kp-Cullin 1-F-box protein (SCF) complex (SCF(beta-TrCP)) E3 ubiquitin ligase in a phosphorylation-dep

194 igase Skp1-cullin-F-box protein complex, SCF(beta-TrCP).

195 itin ligases (CRL3(Keap1), CRL4(DCAF11), SCF(beta-TrCP), and Hrd1).

196 tination of I kappaB alpha and decreased SCF(beta-TrCP) ubiquitin ligase activity.

197 n and degradation of a target of the E3- SCF(beta-TrCP) ubiquitin ligase, the NF-kappaB inhibitor Ika

198 itination, a process catalyzed by the E3-SCF(beta-TrCP) ubiquitin ligase.

199 Lipopolysaccharide-induced SCF(beta-TrCP) ubiquitin ligase activity as well as binding

200 egraded by means of the ubiquitin ligase SCF(beta-TrCP) during the G2 phase of the cell cycle to allo

201 t are recognized by the ubiquitin ligase SCF(beta-TrCP), since deletion or mutation of either degron

202 cyclin D1 by up-regulating the E3 ligase SCF(beta-TrCP), we hypothesized that beta-transducin repeat-

203 pha is triggered by the ubiquitin ligase SCF(beta-TrCP), which requires the modification of the culli

204 ng their ubiquitination by the E3 ligase SCF(beta-TrCP).

205 beta-Catenin, and its cognate E3 ligase, SCF(beta-TrCP).

206 These data indicate that PRLR is a novel SCF(beta-TrCP) substrate and implicate beta-TrCP as an impor

207 at allows for the specific regulation of SCF(beta-TrCP) targets.

208 imulate the ubiquitin ligase activity of SCF(beta-TrCP) toward its target beta-catenin, resulting in

209 ic because IkappaB, another substrate of SCF(beta-TrCP), is not sensitive to NORE1A-promoted degradat

210 hosphorylated IkappaB via recruitment of SCF(beta-TrCP)-Roc1 E3 ubiquitin ligase complex.

211 ed motifs present in other substrates of SCF(beta-TrCP).

212 he Src tyrosine kinase as a regulator of SCF(beta-TrCP).

213 ion of a degron for either Keap1-Cul3 or SCF(beta-TrCP)-mediated degradation decreased the fluorescen

214 r beta (TGF-beta)-Smad3 pathway promotes SCF(beta-TrCP)-mediated Cdc25A ubiquitination.

215 Here we show that the SCF(beta-TrCP) binding site created by phosphorylation of be

216 ild-type APC protein is recruited to the SCF(beta-TrCP) complex, ubiquitin conjugated, and degraded.

217 but no change in the composition of the SCF(beta-TrCP) complex.

218 s a substrate recognition subunit of the SCF(beta-TrCP) E3 ubiquitin ligase.

219 nstead, we found that Src attenuates the SCF(beta-TrCP) E3-ligase activity in blunting Taz proteasoma

220 at these residues by PP2A eliminates the SCF(beta-TrCP) recognition site and blocks beta-catenin ubiq

221 e substrate recognition component of the SCF(beta-TrCP) ubiquitin ligase complex.

222 Multiple components of the SCF(beta-TrCP)-based claspin degradation machinery were foun

223 volves deregulation of components of the SCF(beta-TrCP)-based claspin degradation machinery.

224 Thus, SCF(beta-TrCP)-dependent degradation of REST during G2 permi

225 Plk1 kinase activity and is mediated by SCF-beta-TrCP.

226 t interacts with the Plk1 kinase and the SCF-beta-TrCP ubiquitin ligase.

227 p1-Cdc53 / Cullin-F-box-protein complex (SCF/beta-TrCP).

228 By sequestering beta-TrCP away from other cellular substrates, Vpu leads

229 This Skp2-beta-TrCP-Sp1 feedback loop represents a novel crosstalk

230 reasoned that the human homologs of Slimb - beta-TrCP and its isoform beta-TrCP2 (KIAA0696) - might

231 sphodegron-mediated interaction with a Slimb/beta-TrCP SCF E3 ligase complex.

232 sphorylation of Ci and mediation of Ci-Slimb/beta-TrCP binding.

233 d for recognition by the F box protein SLIMB/beta-TrCP and proteasomal degradation.

234 ducin repeats-containing protein) (SCF(Slimb/beta-TrCP)) as the E3 ubiquitin ligase complex responsib

235 and genetic data strongly suggest that Slimb/beta-TrCP is the specificity determinant for the signal-

236 d phosphorylation and interaction with Slimb/beta-TrCP.

237 Targeting beta-TrCP to Cdc25A requires phosphorylation of serines

238 l cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also disc

239 rovide the proof of principle that targeting beta-TrCP might be beneficial for anticancer therapies.

240 Evidence indicates that Skp2 targets beta-TrCP for degradation via the cyclin-dependent kinas

241 We conclude that beta-TrCP is a component of an E3 ubiquitin ligase that

242 Our studies demonstrate that beta-TrCP has an important role in controlling H3K27 tri

243 We demonstrate that beta-TrCP interacts specifically with IkappaBbeta, and s

244 interference technique, we demonstrated that beta-TrCP is essential for NIK-induced p100 ubiquitinati

245 Therefore, these results indicate that beta-TrCP plays a critical role in the activation of NF-

246 Collectively, our data indicate that beta-TrCP regulates the transition from mitosis to meios

247 icantly, our pull-down assays indicated that beta-TrCP binds a phosphorylated version of DSGIS more t

248 vide an explanation for the observation that beta-TrCP can act as a tumor suppressor or an oncogene i

249 Here, we show that beta-TrCP, the substrate recognition component of an E3

250 These results suggest that beta-TrCP is an essential component of NIK-induced p100

251 The beta-TrCP-deficient male germ cells did not enter meiosi

252 ssociated with Cdc25A phosphorylation at the beta-TrCP docking site (DS82G motif) and physical associ

253 V3 was post transcriptional, mediated by the beta-TrCP ubiquitin E3 ligase and occurred via an endoly

254 ubsequent processing of p100 mediated by the beta-TrCP ubiquitin ligase and 26 S proteasome, respecti

255 Cysteine 308 in Blade 1 of the beta-TrCP beta-propeller region was found to be required

256 Transcription of the beta-TrCP gene is not required for JNK-mediated inductio

257 chanism for TRIM9-mediated regulation of the beta-TrCP SCF complex activity but also identifies TRIM9

258 Collectively, our data show that the beta-TrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppr

259 In addition, we show that the beta-TrCP-mediated degradation requires phosphorylation

260 rcPVT1 in the progression of NPC through the beta-TrCP/c-Myc/SRSF1 positive feedback loop, and circPV

261 ins, which promotes CHD1 degradation via the beta-TrCP-mediated ubiquitination-proteasome pathway.

262 nd 2-deoxyglucose, we demonstrated that this beta-TrCP accumulation resulted from decreased Skp2 expr

263 Moreover, we obtained evidence that this beta-TrCP-dependent degradation takes part in controllin

264 catenin-associated E-cadherin levels through beta-TrCP-dependent stabilization of the transcriptional

265 oteasomal degradation of c-Myc by binding to beta-TrCP, an E3 ubiquiting ligase.

266 ha and GSK3 promotes beta-catenin binding to beta-TrCP, leading to beta-catenin degradation through t

267 nics, effects that were overcome by siRNA to beta-TrCP and GSK-3beta or LPCAT1 gene transfer, respect

268 binding substrate, cdk2, can be tethered to beta-TrCP, ubiquitinated, and effectively degraded.

269 tified DSGIS(338) and DSAPGS(378) as the two beta-TrCP-binding motifs in Nrf2.

270 The ability of one of the two beta-TrCP-binding sites to serve as a degron could be bo

271 Overexpression of wild-type beta-TrCP in mammalian cells promoted the downregulation

272 Mechanisms underlying beta-TrCP regulation and their aberration in human and a

273 degradation in general, since the unrelated beta-TrCP target Snail is also stabilized by ORF61.

274 iquitination and degradation by upregulating beta-TrCP.

275 rolled at the level of protein stability via beta-TrCP-dependent, ubiquitin-based proteasomal degrada

276 ions were combined with mutations of the Vpu beta-TrCP binding site, resulting in Vpu proteins that i

277 rmore, USP47 deubiquitinates itself, whereas beta-TrCP promotes USP47 ubiquitination through interact

278 A forms a direct, Ras-regulated complex with beta-TrCP, the substrate recognition component of the SC

279 d an increased association of cyclin D1 with beta-TrCP, whereas no specific binding was noted with ot

280 Interaction with beta-TrCP is also necessary for ubiquitination of Ikappa

281 that partly depends on its interaction with beta-TrCP, a substrate adaptor for an SCF (Skp-Cullin 1-

282 on in Bora and promotes its interaction with beta-TrCP.

283 e protein by inhibiting its interaction with beta-TrCP.

284 er demonstrate that SVV ORF61 interacts with beta-TrCP, a subunit of the SCF ubiquitin ligase complex

285 loss of the known interaction of Rassf1 with beta-TrCP that usually mediates degradation of beta-cate

286 cells increased specific binding of Sp1 with beta-TrCP.