ライフサイエンスコーパス: beta-alanine

1 f AMP serves as an anchor for the binding of beta-alanine.

2 s in the coenzyme A pathway, pantothenate or beta-alanine.

3 ular receptor for the itch-inducing chemical beta-alanine.

4 d gene E (rMrgE) receptor did not respond to beta-alanine.

5 on of pantothenate from ATP, D-pantoate, and beta-alanine.

6 ctly in the conversion of 3-aminopropanal to beta-alanine.

7 2b has been synthesized beginning with N-Cbz-beta-alanine.

8 es through condensation of these amines with beta-alanine.

9 that these mice exhibit normal responses to beta-alanine.

10 tizing GABA(A) receptor agonists taurine and beta-alanine.

11 sine's constituent amino acids histidine and beta-alanine.

12 rs, followed by amino acid compounds, mainly beta-alanine.

13 on of the unactivated beta-methylene bond of beta-alanine.

14 (PanD) enzyme that converts pantothenate to beta-alanine.

15 all zwitterions, such as glycine betaine and beta-alanine.

16 , injection of AOA in C57BL/6 mice placed on beta-alanine (0.1% w/v in drinking water) for 2 weeks le

17 h between the extended binding of the parent beta-alanine 1 (DbaPyPyPy-beta-PyPyPy) and the hairpin b

18 The pan D lines had increased levels of leaf Beta-alanine (1.2- to 4-fold), pantothenate (3.2- to 4.1

19 at alpha4beta2delta (gaboxadol, 10 muM, and beta-alanine, 10 muM-1mM), on surface expression of alph

20 These effects were replicated by beta-alanine (100 microM), but not by SKF 89976A (30 mic

21 We found that the conventional beta-alanine-3,3'-diamino-N-methyldipropylamine (betaDa)

22 -penicillamylglycine (6a) and D-penicillamyl-beta-alanine (6d), at 1/20 the molar concentration of et

23 )-oxoisoquinolin-2-yl ]acetyl]-3(S)- ethynyl-beta-alanine, 6d (L-767,679), is a potent fibrinogen rec

24 Fluoro-beta-alanine, a 5-FU catabolite, was not detected in pla

25 beta-Alanine, a popular supplement for muscle building,

26 the decarboxylation of aspartate to produce beta-alanine, a precursor of Coenzyme A (CoA).

27 ions within the laminar glial network causes beta-alanine accumulation in retinal pigment cells and i

28 The dB/dT values suggest that L-glycine and beta-alanine act as structure-breaker, while L-leucine a

29 that PKA serves as a downstream mediator of beta-alanine-activated MrgprD signaling to activate TRP-

30 netic mechanism that requires the binding of beta-alanine after the release of pyrophosphate from the

31 Beta-alanine (Ala) betaine, an osmoprotectant suitable u

32 the transaminase network by the amino acids beta-alanine, alanine, glycine, and serine as new amine

33 BOC-L-alanine alkyl esters and BOC-beta-alanine alkyl esters were tested as guests, and the

34 as well as the dihydroxyl, gem-dimethyl, and beta-alanine-amide moieties of pantetheine in dilute wat

35 beta-Alanine, an abundant non-proteinogenic amino acid,

36 plied capsaicin and intradermal injection of beta-alanine, an MrgprD agonist, excite vigorously all Q

37 y protein known to catalyze the synthesis of beta-alanine, an obligate intermediate in CoA synthesis.

38 decarboxylation of L -aspartate to generate Beta-alanine and carbon dioxide.

39 on the ratio of two NMR signals assigned to beta-alanine and carnosine + anserine, respectively.

40 oxyphenylalanine decarboxylase (DDC) provide beta-alanine and dopamine used in insect cuticle tanning

41 Abiotic amino acids such as beta-alanine and epsilon-aminocaprioc acid are detected

42 In contrast, buffers such as glycine, beta-alanine and gamma-amino-butyric acid (GABA) produce

43 Calcium imaging reveals that beta-alanine and histamine activate distinct populations

44 haracteristic muscle di-peptides composed of beta-alanine and histidine derivatives such as anserine

45 The important roles of beta-alanine and imidazole for 1:1 binding are discussed

46 e ATP-dependent condensation of pantoate and beta-alanine and is a direct precursor of coenzyme A.

47 is able to resolve sarcosine from alpha- and beta-alanine and is useful for quantifying sarcosine in

48 The densities and viscosities of L-glycine, beta-alanine and L-leucine have been determined in water

49 inose and d-ribose with glycine, alpha-l- or beta-alanine and l-valine in pH 7.0 phosphate buffer at

50 expected enzymes for the biosynthesis of the beta-alanine and pantoic acid moieties required for coen

51 d by FMS1, was found to be rate-limiting for beta-alanine and pantothenic acid biosynthesis.

52 G-protein-coupled receptor, member D ligand beta-alanine and PD123319, but not by the Mas antagonist

53 lipid diacylglyceryl-hydroxymethyl-trimethyl-beta-alanine and phosphatidyldimethylpropanethiol, both

54 HEK cells, reduced the potencies of glycine, beta-alanine and taurine by 9-, 6- and 3-fold respective

55 HDOC and classical glycine receptor agonists beta-alanine and taurine directly activated alpha6beta2d

56 he maximum responses to the partial agonists beta-alanine and taurine relative to the full agonist gl

57 and 0.66 to 0.93, 0.57 and 0.34 for glycine, beta-alanine and taurine, respectively, reflecting a thr

58 ansmitter glycine or other agonists, such as beta-alanine and taurine.

59 s such but is first degraded to pantoate and beta-alanine and then rebuilt.

60 h as alpha-benzyl-alpha-heterofunctionalized-beta-alanines and alpha-benzylnorlanthionine derivatives

61 ivated by GABA, 1400 s(-1) when activated by beta-alanine, and 50 s(-1) when activated by P4S.

62 s were 0.13, 0.8, and 2.6 mM for D-pantoate, beta-alanine, and ATP, respectively, and the turnover nu

63 ole, gamma = gamma-aminobutyric acid, beta = beta-alanine, and Dp = dimethylaminopropylamide), reveal

64 here gamma = gamma-aminobutyric acid, beta = beta-alanine, and Dp = dimethylaminopropylamide).

65 partic and glutamic acids, glycine, alanine, beta-alanine, and gamma-amino-n-butyric acid (gamma-ABA)

66 nDhp in complexes with hydantoin, N-carbamyl-beta-alanine, and N-carbamyl-beta-amino isobutyrate as w

67 easuring plasma uracil, urinary alpha-fluoro-beta-alanine, and peripheral-blood mononuclear cell (PBM

68 ites for several pairs of orthosteric (GABA, beta-alanine, and piperidine-4-sulfonic acid) and/or all

69 thways such as the metabolism of pyrimidine, beta-alanine, and purine.

70 e complexed with AMP and its last substrate, beta-alanine, and show that the phosphate group of AMP s

71 Only 40% of SCs respond to beta-alanine, and their response is only half that of QC

72 ivated by GABA, 1500 s(-1) when activated by beta-alanine, and too low to be determined when P4S was

73 ve predominantly trityl-protected alpha-iodo-beta-alanines, and hence norlanthionines, as the major p

74 fired a single action potential (AP) before beta-alanine application fired multiple APs during beta-

75 The actions on receptors activated by P4S or beta-alanine are also broadly consistent with this idea.

76 s, the primary sensory neurons responsive to beta-alanine are likely part of a histamine-independent

77 Pantothenic acid and beta-alanine are metabolic intermediates in coenzyme A b

78 hotolabile derivative of beta-alanine, caged beta-alanine, are described.

79 ity, low-capacity transporter of taurine and beta-alanine; ATB(0,+) (SLC6A14) is a Na(+)- and Cl(-)-d

80 spe2Delta, spe3Delta, and spe4Delta are all beta-alanine auxotrophs.

81 Insertion of 6-aminohexanoic acid (X) or beta-alanine (B) residues into oligoarginine R8 decrease

82 ine, lysophosphatidic acid, trypsin, SLIGRL, beta-alanine, BAM8-22), and scratching was assessed usin

83 = 69).Of the 10 dietary biomarkers analyzed, beta-alanine (beef) (P-raw < 0.001), alkylresorcinols C1

84 uents disrupt DNA binding, (R)-alpha-methoxy-beta-alanine (beta((R)-OMe)) maintains strong binding af

85 hylhydroxypyrrole (Hp) amino acids linked by beta-alanine (beta) bind the minor groove of DNA in 1:1

86 A series of alpha-substituted beta-alanine (beta) linked polyamides (DbaPyPyPy-beta*-P

87 improve our understanding of the effects of beta-alanine (beta) substitution and the number of heter

88 (Im), pyrrole (Py), hydroxypyrrole (Hp), and beta-alanine (beta), are synthetic ligands that form hig

89 beta-Alanine (beta-Ala) betaine is an osmoprotective com

90 ethylproline, proline betaine (stachydrine), beta-alanine betaine, 4-guanidinobutyric acid, trigonell

91 erevisiae, ALD2 and ALD3 are specialized for beta-alanine biosynthesis and are consequently involved

92 AD-containing amine oxidases and its role in beta-alanine biosynthesis suggested that its substrates

93 To identify the gene(s) for beta-alanine biosynthesis, we have established the pathw

94 polyamine pathway in yeast are necessary for beta-alanine biosynthesis; spe1Delta, spe2Delta, spe3Del

95 related gene D (rMrgD) receptor responded to beta-alanine but not L-alanine by elevating intracellula

96 nity, low-capacity transporter which accepts beta-alanine but not taurine.

97 were differentially induced by Spd, DAP, and beta-alanine but showed no apparent response to Put, Cad

98 Metabolism of 3-AP to beta-alanine by aldehyde dehydrogenase was also evaluate

99 Photolysis of 2-methoxy-5-nitrophenyl-beta-alanine by irradiation with a 600-ns laser pulse at

100 racterization of a photolabile derivative of beta-alanine, caged beta-alanine, are described.

101 beta-Alanine can activate the glycine receptor, a major

102 inefficient, by demonstrating that exogenous beta-alanine can be effectively routed toward oxidation.

103 The beta-alanine carrier was characterized functionally in t

104 e encodes the transport protein known as the beta-alanine carrier which, due to its broad substrate s

105 s, the key functional characteristics of the beta-alanine carrier, identified previously in situ in i

106 is the molecular correlate of the intestinal beta-alanine carrier, perhaps the last of the classical

107 beta-Alanine carrier-like function has not been demonstr

108 Oligoglycine and oligo(beta-alanine) chains underwent oligomerization by 1,3-di

109 m; the 2-methoxy-5-nitrophenyl derivative of beta-alanine combined with a laser-pulse photolysis meth

110 The beta-alanine component was prepared using Davies' asymme

111 The intracluster open durations elicited by beta-alanine could be described by the sum of two expone

112 zin-3-one chromogens and their corresponding beta-alanine derivatives were synthesized and evaluated

113 dase activity in bacteria known to hydrolyze beta-alanine derivatized substrates.

114 and that bauABCD are essential for growth on beta-alanine derived from DAP (or Spd) catabolism via th

115 A beta-alanine-derived embedded urea and amide group-conta

116 beta-alanine disrupts lactate binding to AARS1, reduces

117 an GABA-T and AGXT2 are able to transaminate beta-alanine efficiently.

118 Here we show that, in mice, beta-alanine elicited itch-associated behavior that requ

119 diacylglycerylhydroxymethyl-N,N,N-trimethyl-beta-alanine, esterified with 13-methyl-tetradecanoic (i

120 These inhibitors are functionalized beta-alanines, exemplified by 2a.

121 lanine application fired multiple APs during beta-alanine exposure.

122 binding conformation differing from both the beta-alanine (extended) or gamma-aminobutyric acid (hair

123 ntoate binding, release of PP(i), binding of beta-alanine, followed by the release of pantothenate an

124 showed an equivalent dependence on exogenous beta-alanine for growth in liquid medium.

125 inactive carcinine through conjugation with beta-alanine for transport.

126 other prokaryotes where the enzyme producing beta-alanine from l-aspartate is a pyruvoyl-containing l

127 inating other known and proposed pathways to beta-alanine from malonate semialdehyde, l-alanine, sper

128 ydrogenase-mediated step is required to make beta-alanine from the precursor aldehyde, 3-aminopropana

129 e of alanine analogues, including d-alanine, beta-alanine, glycine and l-serine, but not d-serine, tr

130 ents with an order of potency (hypotaurine > beta-alanine > GES > GABA) similar to that reported for

131 and the order of agonist potency was GABA > beta-alanine > glycine.

132 ic gamma 2L receptors were also activated by beta-alanine > taurine > glycine, and, like some types o

133 uch architecture, the beta-peptoids (N-alkyl-beta-alanines), has found use in a variety of biological

134 s exclusively innervate the skin, respond to beta-alanine, heat, and mechanical noxious stimuli but d

135 This work underscores the importance of beta-alanine homeostasis for proper growth and developme

136 beta-amino acid beta-glycine (also known as beta-alanine); however, the potential of these species t

137 2-Methoxy-5-nitrophenyl-beta-alanine hydrolyzes in aqueous solution at neutral p

138 cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine, and taurine, respectively.

139 on of pantothenate from ATP, D-pantoate, and beta-alanine in bacteria, yeast, and plants.

140 xylation of aspartate was the only source of beta-alanine in cell extracts of M. jannaschii.

141 hich is in turn controlled by degradation of beta-alanine in liver and kidney.

142 This structure confirms that binding of beta-alanine in the active site cavity can occur only af

143 n the lamina, we detected both carcinine and beta-alanine in the fly retina, where they are found in

144 antothenate formation from the adenylate and beta-alanine in the second half reaction could not be me

145 established the pathway for the formation of beta-alanine in this organism after experimentally elimi

146 nthesis via conversion of 3-aminopropanal to beta-alanine in vivo.

147 a-cholesterylamine derivatives bearing fewer beta-alanines in the linker region or N-acyl derivatives

148 thyl]-2-oxopiperidinyl ]acetyl]-3(R)- methyl-beta-alanine) in which the lactam chiral center has been

149 ignificant quantitative trait loci (QTL) for beta-alanine, including the AGT2 locus associated in bot

150 In humans, intradermally injected beta-alanine induced itch but neither wheal nor flare, s

151 We tested TrpC3 null mice for beta-alanine induced itch, and found that these mice exh

152 Here too, beta-alanine-induced activation of endogenous MrgD inhib

153 Finally, we assessed the consequence of beta-alanine-induced activation of MrgD in phasic neuron

154 onstrate that mouse TrpC3 is dispensable for beta-alanine-induced acute itch.

155 he ion channel downstream of MrgprD, and the beta-alanine-induced calcium signal was attributed mostl

156 se effects, the presence of rMrgE restricted beta-alanine-induced internalization of rMrgD.

157 Knockout of TRPA1 also attenuated the beta-alanine-induced pain behavior in CCI models.

158 Finally, we found that the beta-alanine-induced pain behavior was increased, wherea

159 chanically insensitive C-fibres (C-MIAs) are beta-alanine insensitive but vigorously respond to capsa

160 renal beta-alanine transamination upon oral beta-alanine intake.

161 Reverse isotope exchange of [(14)C]-beta-alanine into pantothenate in the presence of AMP wa

162 cellular level, calcium influx triggered by beta-alanine is also unchanged in cultured DRG neurons f

163 t strong and direct evidence indicating that beta-alanine is an efficient substrate for the mammalian

164 The amino acid beta-alanine is an intermediate in pantothenic acid (vit

165 beta-Alanine is conjugated with dopamine to yield N-beta

166 le of pantothenic acid biosynthesis, and the beta-alanine is derived from methionine via a pathway in

167 The metabolic fate of orally ingested beta-alanine is largely unknown.

168 only a small fraction (3-6%) of the ingested beta-alanine is used for carnosine synthesis.

169 der physiological conditions, the DANP-caged beta-alanine is water-soluble and stable and can be used

170 y of 1 as an enolate synthon of homoglycine (beta-alanine) is illustrated by the efficient synthesis

171 ation but did not impair mechanosensation or beta-alanine itch-stimuli associated with nonpeptidergic

172 uced acidification (using glycylsarcosine or beta-alanine) led to Na(+)-dependent, EIPA-inhibitable p

173 ining glutamic acid, glycine, aspartic acid, beta-alanine, leucine, and phenylalanine residues, maxim

174 eks lead to a 3-fold increase in circulating beta-alanine levels and to significantly higher levels o

175 MINOTRANSFERASE2 (AGT2, AT4G39660) linked to beta-alanine levels in Arabidopsis under normal conditio

176 vealed that the regulatory pathway involving beta-alanine levels, AGT2, and ALDH6B2 connects the bran

177 uscle and heart is controlled by circulating beta-alanine levels, which are suppressed by hepatic and

178 hat AICAR inhibited the activity of pantoate beta-alanine ligase in vitro (PanC, EC 6.3.2.1).

179 Beta-alanine-linked pyrrole-imidazole polyamides bind GA

180 ed tubular assemblies, are tethered by oligo(beta-alanine) linkers to give tubular stacks MC-2 and MC

181 e as the major product (>99%) and (R)-styryl-beta-alanine (<1%).

182 changes in the citric acid cycle (jejunum), beta-alanine metabolism (skeletal muscle), and purine me

183 ges established the critical role of AGT2 in beta-alanine metabolism.

184 ponents, a tetrahydronaphthyridine moiety, a beta-alanine moiety, and a central imidazolidone moiety.

185 yl radicals and cation radicals derived from beta-alanine N-methylamide, N-acetyl-1,2-diaminoethane,

186 riments demonstrated that neither DANP-caged beta-alanine nor its byproducts inhibit or activate the

187 Neither the 2-methoxy-5-nitrophenyl-beta-alanine nor the 2-methoxy-5-nitrophenol photolysis

188 ferentially on basic dipeptides derived from beta-alanine or gamma-aminobutyrate, PM20D2 also acted a

189 he medium, whereas deletion mutants required beta-alanine or pantothenic acid for growth.

190 The receptors were activated by GABA, beta-alanine or piperidine-4-sulfonic acid (P4S), and th

191 terial isolates, suggesting a preference for beta-alanine over pantothenate utilization in CoA synthe

192 istidine and lower glutamic acid, glutamine, beta-alanine, phenylalanine, tyrosine, and proline, an e

193 ide surfactant poly(sodium undecyl-L-leucine-beta-alanine) (poly L-SULbetaA).

194 rting from inexpensive and readily available beta-alanine precursors in moderate to excellent yields.

195 Although beta-alanine-producing activity was not detected in the

196 ue samples were incubated with aspartate, no beta-alanine production was observed.

197 study, we aimed to deepen our insights into beta-alanine regulation by conducting mGWAS under two co

198 In contrast to bacteria, yeast derive the beta-alanine required for pantothenic acid production vi

199 A conjugate containing a beta-alanine residue at the C terminus of the polyamide

200 A beta-alanine residue was coupled to the main-chain (alph

201 n, whereas an analogous compound lacking the beta-alanine residue was strongly localized in the nucle

202 ariation within the seco-cryptophycin unit C beta-alanine residue, but strict structural requirements

203 itrate-derived fatty acid and a rare dehydro-beta-alanine residue.

204 ee functionally distinct subpopulations with beta-alanine responsive QC fibres likely corresponding t

205 hat bath application of the ligand for MrgD, beta-alanine, resulted in robust inhibition of KCNQ2/3 a

206 In this report, a combination of beta-alanine scanning mutagenesis and kinetic measuremen

207 leus and enantiospecific substitution on the beta-alanine side chain attached to N4.

208 zinebenzylamine attached with a N,N-dimethyl-beta-alanine side chain.

209 ess the conformational preferences about the beta-alanine side chain.

210 luoro-beta-ureidopropionic acid and a-fluoro-beta-alanine signals in the tissues of mice that receive

211 luoro-beta-ureidopropionic acid and a-fluoro-beta-alanine signals in tumors treated with EU and a dra

212 ermore, the application of the Mrgprd ligand beta-alanine significantly reduced the rheobase and incr

213 PASTSAPG was conjugated to biotin using a di-beta-alanine spacer arm.

214 Taurine, gamma-aminobutyric acid, and beta-alanine (substrates of the SLC6 gamma-aminobutyric

215 Insertion of two beta-alanine subunits between a DNP derivative and 3beta

216 Chronic oral beta-alanine supplementation is a popular ergogenic stra

217 Chronic beta-alanine supplementation is becoming increasingly po

218 The present study can partly explain why the beta-alanine supplementation protocol is so inefficient,

219 beta-Alanine supply for this pathway is independent of e

220 ependent of enzymatic synthesis by Black and beta-alanine synthase Pyd3.

221 ssue protein extracts, its potential role in beta-alanine synthesis cannot be excluded.

222 2; OAT1; Oatp1; mdr 1a and 1b; MRP 1 and 5; beta-alanine, system L and system y+L amino acid carrier

223 y, high-capacity transporter for taurine and beta-alanine; TauT (SLC6A6) is a Na(+)- and Cl(-)-depend

224 ted an amino acid sequence including several beta-alanines that occurred in a repeating alphaalphabet

225 ctivated by the orthosteric agonists GABA or beta-alanine, the allosteric agonist propofol, or combin

226 Upon photolysis of DANP-caged beta-alanine, the caging group is released within 5 micr

227 Injection of beta-alanine, the expected product of ADC, into dsTcADC-

228 pecific activity modes, including the use of beta-alanine to achieve increased efficacy with alphabet

229 ERK2 as well as maintaining the capacity of beta-alanine to elevate intracellular [Ca(2+)], which wa

230 finate salts is accomplished using catalytic beta-alanine to form a transient imine.

231 ATP-dependent condensation of D-pantoate and beta-alanine to form pantothenate in bacteria, yeast and

232 e ATP-dependent condensation of pantoate and beta-alanine to form pantothenate.

233 visual signal transduction, Ebony conjugates beta-alanine to histamine, forming beta-alanyl-histamine

234 These interactions increased the potency of beta-alanine to phosphorylate ERK1 and ERK2 as well as m

235 investigate the putative contribution of two beta-alanine transamination enzymes, namely 4-aminobutyr

236 s, which are suppressed by hepatic and renal beta-alanine transamination upon oral beta-alanine intak

237 t the pauA3B2 operon and the bauABCD operon (beta-alanine utilization).

238 to target genes in four metabolism pathways: beta-alanine; valine, leucine, iso-leucine; aminoacyl-tR

239 However, when beta-alanine was applied for a sufficient duration to pr

240 ntioselective synthesis of these substituted beta-alanines was also developed.

241 -yl)-1H-pyrazol-1-y l]ethyl}phenyl)carbonyl]-beta-alanine, was discovered by optimization of a previo

242 nd the concentration of the third substrate, beta-alanine, was increased.

243 Sarcosine (N-methylglycine) and beta-alanine were also accepted as substrates, albeit wi

244 logues of gamma-aminobutyric acid (GABA) and beta-alanine were designed as conformationally rigid ana

245 ites, nutrients as taurine, nicotinamide and beta-alanine, were found.

246 metabolites, fluorouracil, and alpha-fluoro-beta-alanine, were not meaningfully altered by coadminis

247 ter linkage to the carboxyl functionality of beta-alanine, which activates the inhibitory glycine rec

248 uscle depends on circulating availability of beta-alanine, which is in turn controlled by degradation

249 aminopropanal is further oxidized to produce beta-alanine, which is necessary for the biosynthesis of

250 with a 600-ns laser pulse at 333 nm releases beta-alanine, which then activates glycine receptor-chan

251 Replacement of one beta alanine with Py to afford PyImPyIm-gamma-PyImbetaIm

252 can transport non-alpha-amino acids such as beta-alanine with low affinity, and has a higher affinit

253 ), synthesized using diethylated alanine and beta-alanine with N-hydroxysuccinimide.

254 of constitutional isomers alpha-alanine and beta-alanine with ratios determined to ~4% measurement u

255 photolyzed by a laser pulse to release free beta-alanine within 3 microseconds and with a product qu