ライフサイエンスコーパス: beta-chain

1 ng with C3-fibrinogen interaction within the beta chain.

2 FGB (rs1800790; rs4220) encoding fibrinogen beta chain.

3 nation of the cytoplasmic tail of the mMHCII beta chain.

4 haI domain during activation, exerted by the beta chain.

5 t the interface with the betaI domain of the beta chain.

6 y specific (aa 9-23) epitopes of the insulin Beta chain.

7 ion and inability to associate with the HexA beta chain.

8 embrane-proximal N-terminal domain binds the beta-chain.

9 ed ubiquitination of a lysine residue in the beta-chain.

10 of C3b that lies near the C terminus of its beta-chain.

11 -T cells that have failed to rearrange their beta-chain.

12 essing a glutamic acid at position 69 of the beta-chain.

13 of physiologic innate responses of TCRalpha/beta chains.

14 t alpha domains, paired with an array of TCR-beta chains.

15 epertoire of T-cell receptor (TCR) alpha and beta chains.

16 CDR3) of the T-cell receptor (TCR) alpha and beta chains.

17 in humans), which pairs with an array of TCR beta-chains.

18 naling of PDGF-receptor (R)-alpha- and PDGFR-beta-chains.

19 ations in Lck, ZAP70, and the TCR alpha- and beta-chains abrogate Fas signaling.

20 pression of either preassembled VbetaDJbetaC beta-chain accelerated thymocyte development because of

21 interleukin-3 receptor, IL3Ra and the common beta chain, activated JAK2-V617F as well as STAT5 and ER

22 1.6 mum, only 8-fold weaker than the Met/HGF beta-chain affinity.

23 l receptor but exhibited a partial defect in beta-chain allelic exclusion and increased apoptosis.

24 ally use a conserved docking mode, the NKTcr beta-chain allows these cells to recognise unique aspect

25 between the peptide backbone and the HLA-DP2 beta-chain alpha-helix and containing three glutamic aci

26 C4BP isoforms containing beta-chain (alpha7beta1 and alpha6beta1; C4BP[beta(+)])

27 efined as those that expressed identical TCR beta-chain amino acid sequences and recurred in multiple

28 T-cell receptor variable beta-chain analysis was performed with the immunoSEQ ass

29 KDa for alpha1 and alpha2 chains, 226KDa for beta chain and 338.5KDa for gamma chain, respectively.

30 ic molecule Bcl-2 and interleukin-2 receptor beta chain and diminished IL-15-driven proliferation.

31 monoclonal tumors with a single, unique TCR-beta chain and diverse TCR-alpha chains, pinpointing mal

32 dom genomic integration of the TCR alpha and beta chain and expression from nonendogenous promoters r

33 er of this family, is related to the laminin beta chain and has recently been proposed to play an imp

34 ed elements of the T cell receptor alpha and beta chain and, surprisingly, dramatically affected by t

35 nterface with an antiparallel arrangement of beta chains and a unique tangential association of coile

36 rmed by the NH(2)-terminal regions of fibrin beta chains and revealed that the recombinant dimeric (b

37 ressing one of two different T cell receptor beta chains and various MHC alleles, we show that positi

38 The band intensity of beta-chain and alpha-chains increased as the extraction

39 CDR3 variable region of the T cell receptor beta-chain and an algorithm that detected significantly

40 capsular zone where they recombine their TCR beta-chain and gamma-chain gene loci.

41 amino acid residues derived from the HLA-DP2 beta-chain and peptide and showed that the TCR does not

42 the acute phase variant of C4BP lacking the beta-chain and protein S binds plasminogen much stronger

43 tronger than the main isoform containing the beta-chain and protein S.

44 ed in the N-terminal parts of the alpha- and beta-chains and common to multiple donors, in agreement

45 of invariant T cells is much higher than the beta-chain, and because the TCR alpha-chain V gene segme

46 ch encodes the interleukin 2 (IL-2) receptor beta-chain, and controlled the responsiveness to IL-15,

47 ing the ankyrin-binding site of the spectrin beta-chain, and covalent perturbation by treatment with

48 pha-chain, the heparin-binding domain on the beta-chain, and other functional domains remain elusive.

49 ocated near the C terminus of the fibrinogen beta-chain, and that the binding causes fibrinogen to ol

50 presence of a genetic variant in the HLA-DP beta chain appear to increase the risk.

51 onresponsive T-cell receptor variable region beta chain are nonresponsive to SEA in monoculture but d

52 The alpha and beta chains are similar, but are chemically and structur

53 The carbohydrate groups attached to beta chains are unusually prominent, the full sweep of 1

54 class II MHC molecules, where the alpha- and beta-chain are encoded on opposite chromosomes, can also

55 he cis-encoded variants where the alpha- and beta-chain are encoded on the same chromosome.

56 Namely, the iT(reg) TCR alpha-chain and beta-chain are overlaid with the alpha-chain and beta-ch

57 To determine whether such public beta-chains are advantaged during thymic selection, indi

58 The CDR3 regions of both the alpha- and beta-chains are encoded by either germline or nongermlin

59 rial biases, a small fraction of TCRalpha or beta-chains are shared by most individuals, or public.

60 ctivation pocket of the serine protease-like beta-chain as a "hot spot" for allosteric regulation of

61 Using both the TCR alpha- and beta-chains as tweezers to surround and grip the glucose

62 ces long-range allosteric changes in the TCR beta chain at conserved sites in both representative MHC

63 inhibiting hepatocyte surface expression of beta-chain ATP synthase, inhibits the removal of HDL-apo

64 es within the amino acid 9-23 peptide of the beta-chain (B:9-23).

65 es into two groups where any alpha-chain and beta-chain belonging to the same group are expected to f

66 e in the C-terminal region of the fibrinogen beta-chain (beta384-393).

67 d amino acid residue at position 57 of their beta chain (beta57); this results in the absence of a sa

68 ine residue at position 93 in the hemoglobin beta chain (beta93C) to form S-nitroso (SNO) hemoglobin

69 nding alpha chain (IL-5Ralpha), and a common beta chain, betac.

70 he conserved Cys93 residue of the hemoglobin beta-chain (betaCys93) and, specifically, for S-nitrosat

71 third conserved residue is a Cys within the beta-chain (betaCys93) that has been assigned a role in

72 that has been S-nitrosylated at Cys93 of the beta-chain (betaCys93) transitions from the oxygenated f

73 a glutamic acid at the 69th position of the beta-chain (betaGlu69).

74 glutamic acid residue at position 69 of the beta-chain (betaGlu69).

75 isplayed differential MR1 dependency and TCR beta-chain bias, consistent with possible divergent anti

76 1 hotspot that coincides with the known HGF beta chain binding site on blades 2-3 of the SEMA domain

77 fically by blocking HGF alpha-chain (but not beta-chain) binding to MET.

78 tin-2 that bundles actin fibers and spectrin beta-chain, brain 1 that links the plasma membrane to th

79 ption factors T-bet, the IL-2/IL-15 receptor beta chain CD122, and suppression of eomesodermin expres

80 ir expression of the signaling IL-2 receptor beta-chain CD122, forming with common gamma-chain functi

81 ignalling subunits of the IL-2 receptor, the beta chain (CD122) (mean decrease = 58.0%, SE = 2.8%, ra

82 omes) and the interleukin-2 and -15 receptor beta chain (CD122) and an enhanced ability to rapidly pr

83 n EPO receptor subunit (EPOR) and the common beta-chain (CD131).

84 erodimer, the alpha-chain interacts with the beta-chain coded by the same chromosome, while in a tran

85 eported possible limitation in the alpha and beta chain combinations that comprise the T cell reperto

86 spairing, simultaneous editing of alpha- and beta-chains combined with orthotopic TCR placement leads

87 ompare the global changes in T cell receptor beta chain complementarity determining region 3 (CDR3bet

88 nt TRAV9-2 or a histidine in their alpha- or beta-chain complementarity determining region 3 (CDR3) w

89 and germline-encoded residues in the second beta-chain complementarity-determining region (CDR2beta)

90 , several identical T-cell receptor variable beta-chain complementarity-determining region 3 sequence

91 r a heterodimer of EPOR and CD131-the common beta chain component of the GM-CSF, interleukin (IL)-3,

92 ds coated with the patient's own DQalpha- or beta-chain components.

93 Detailed analysis of TCRalpha and -beta chain composition is consistent with positive selec

94 In this study, we demonstrate that TCR beta-chain composition can dramatically influence lipid

95 y flexible regions) and the N termini of the beta-chain, confirm these models with known structural a

96 -3C8 that indicate long-range effects on TCR beta chain conformation and dynamics.

97 ally exclusive expression of T cell receptor beta-chain constant domains 1 and 2 (TRBC1 and TRBC2).

98 Both alpha- and beta-chains constituted as major components.

99 TCR beta-chain contacts are mostly through the variable CDR3

100 ch TCR is a heterodimer, and both alpha- and beta-chains contribute to determining TCR antigen specif

101 ites in the constant regions of TCR alpha or beta chains could increase the functional avidity of T c

102 n bond with bound O(2) in both the alpha and beta chains (DeltaG(His(E7)H-bond) approximately -8 kJ/m

103 Integrins domain (MET Sema-PSI), and the HGF beta-chain demonstrate that onartuzumab acts specificall

104 ges in clonal composition were TCRalpha- and beta chain-dependent and were directly related to the av

105 n and reveal unexpected redundancy of common beta chain-dependent cytokines previously thought to pos

106 nd that expression of these preassembled TCR beta-chains did not downregulate recombinational accessi

107 These findings indicate that NKT TCR beta-chain diversity results in differential and nonhier

108 uses diverse T-cell receptor (TCR) alpha-and beta-chains, does not recognize alpha-galactosylceramide

109 The TRBV17 beta-chain dominated the interaction and, whereas the co

110 structures, NMR characterization of the TCR beta-chain dynamics reveals significant chemical shift e

111 with extracellular regions of the alpha and beta chains each comprising a V-type domain and a C-type

112 types that use the same alpha chain but have beta chains encoded by other genes.

113 sed and frequently dominated by a public TCR beta-chain encoded by the variable gene segment TRBV4-3.

114 I molecules, prevalent HLA-DP molecules with beta-chains encoding Gly84 (DP(84Gly)) constitutively pr

115 ++) in the natural TCR ligand and that MHCII beta-chain flexibility in the area around the peptide p7

116 HLA class II alpha and beta chains form receptors for antigen presentation to C

117 ) and an in vitro selection study on the TCR beta chain (four mutations).

118 Here, we conditionally deleted the MHC-II beta-chain from myelinating Schwann cells in mice and in

119 epertoires based on TCRseq of the alpha- and beta-chains from glioma tissue, nonneoplastic brain tiss

120 detail, raising provocative questions about beta chain function.

121 Assembly of a functional TCR beta-chain gene triggers feedback inhibition of V(beta)-

122 T-cell function, we cloned the TCR alpha and beta chain genes from one effective and two ineffective

123 The TCR alpha- and beta-chain genes from a tumor-infiltrating lymphocyte, w

124 prehensive knockout of HLA class II (HLA-II) beta-chain genes is complicated by their high polymorphi

125 Mice that lack the GM-CSF receptor beta chain (GM-CSFRbeta) developed invasive hyphal growt

126 Tyrosine phosphorylation of the beta chain has been studied extensively.

127 mer interface (either solely alpha or solely beta chains) has been corrupted.

128 of the TCR-alpha chain with the MHC class II beta chain helix.

129 in O(2)-binding affinity of the alternative beta-chain hemoglobin isoforms were entirely attributabl

130 n E, (iii) globin Y, and (iv) the alpha- and beta-chain hemoglobins of gnathostomes.

131 10, which bound to the recombinant human HGF beta-chain (HGF beta) and competitively inhibited bindin

132 teric activation of the serine protease-like beta-chain (HGF beta), which binds Met to initiate signa

133 ly identical TCR alpha chain but a different beta chain, highlighting the likely dominance of the con

134 The hydrogen bond (H-bond) between beta-chain His(81) and the peptide backbone at the -1 po

135 The L(beta) chains, however, lack the tilt of the L(beta') pha

136 dentify human interleukin-2 receptor (IL-2R) beta chain (IL2RB) gene defects as a cause of life-threa

137 Using TCR beta-chain immunosequencing, we observed that the propor

138 Expression of IL3Ra or the common beta chain in BaF3 cells also enhanced the ability of JA

139 served lysine in the cytoplasmic tail of the beta chain in dendritic cells (DCs) and B cells.

140 reduced expression of T cell receptor (TCR) beta chain in DN4 thymocytes.

141 fined native T cells expressing an alpha and beta chain in their TCR can only sense antigen when pres

142 ing the optimal orientation of the alpha and beta chains in the expression cassette; 9/10 TCRs favore

143 vered a putative new sequence variant of the beta-chain in dog (T38 -> A).

144 tochemistry identified hemoglobin alpha- and beta-chains in both rat and human brains, and hemoglobin

145 Sequencing of the T-cell receptor beta-chains in purified T cells revealed clonal expansio

146 mited TCR gene usage for both TCR alpha- and beta-chains in type II NKT cells reflects specific antig

147 and containing three glutamic acids from the beta-chain, including betaGlu69.

148 However, these cells have diverse TCR beta-chains, including Vbeta8, Vbeta7, and Vbeta2 in mic

149 In mice expressing single, rearranged TCR beta-chains, individual mutation of amino acids in the c

150 nd riboflavin cross-links collagen alpha and beta chains into larger polymers.

151 alpha- and gamma-chain sequences (the native beta chain is blocked).

152 y studied human MHCII isotype, HLA-DR, whose beta chain is encoded by the HLA-DRB1 locus, several oth

153 Diversity of the TCR beta chain is generated in part by a random yet intrinsi

154 We show that the influence of the TCR beta-chain is due to a combination of Vbeta-, Jbeta-, an

155 e alpha-chain of the NKTcr is invariant, the beta-chain is more diverse, but how this diversity enabl

156 Using clonotypic TCR beta-chain length and sequence analysis we confirmed tha

157 cDNA-TCR beta-chain libraries were sequenced from 2 million perip

158 th a focus on studies of the T-cell receptor beta chain locus.

159 Both TCR alpha-chains and TCR beta-chains made contact with the CD1d molecule with a d

160 ut decreased numbers of NKT (T-cell receptor beta chain + mCD1d tetramer(+)) and CD4(+)FoxP3(+) cells

161 ant domains of the T-cell receptor alpha and beta chain mRNAs.

162 or recognition is mediated by binding of MSP beta-chain (MSPbeta) to the RON Sema.

163 kably, the catalytic potency of DM with each beta-chain mutant was equal to or greater than that obse

164 Complement component C1q, beta-chain, nonspecific cytotoxic cell receptor protein

165 C3 identified two peptide motifs within the beta chain of fibrinogen (residues 424-433, 435-445) tha

166 hat adhiron A6 binds to similar areas on the beta chain of fibrinogen.

167 rring murine hybrid cytokine of IL-7 and the beta chain of hepatocyte growth factor (rIL-7/HGFbeta) t

168 We hypothesize that the 12-20 peptide of the beta chain of insulin is responsible for activation of t

169 We show that the common beta chain of the GM-CSF receptor (betac) is dispensable

170 gen interaction, in which both the alpha and beta chain of the NKT TCR is required for ligation above

171 of antigen-presenting cells and the variable beta chain of the T-cell receptor but also to the dimer

172 pping constant domains between the alpha and beta chains of a therapeutic TCR.

173 The proteases cleaved alpha and beta chains of C3 and work in synergy with host regulato

174 d by a mutation in the gene encoding for the beta chains of hemoglobin.

175 ompatibility complex class II and specific V-beta chains of the T-cell receptor, thus forming a terna

176 s similar to that detected previously in the beta chains of two MHC class I-restricted TCRs, thereby

177 reover, we demonstrate that the cytoplasmic (beta) chain of LRP1 suffices to limit cholesterol accumu

178 severely reduced or absent expression of the beta-chain of adult hemoglobin (alphabeta;HbA).

179 gle point mutation (beta6 Glu -> Val) on the beta-chain of adult hemoglobin (HbA) that results in sic

180 g the dysfunction to a point mutation in the beta-chain of C3 (c.1180T > C; p.Met(373)Thr).

181 e immune cytokine interleukin (IL)-7 and the beta-chain of hepatocyte growth factor (HGF) aggregate t

182 ovel hybrid cytokine containing IL-7 and the beta-chain of hepatocyte growth factor (HGF) in the supe

183 ine consisting of interleukin (IL)-7 and the beta-chain of hepatocyte growth factor (HGF) that had ly

184 alpha-chain of HLA-DQ2 (DQA1*05:01) and the beta-chain of HLA-DQ8 (DQB1*03:02).

185 Using high-throughput sequence data from the beta-chain of human T-cell receptors, we infer factors t

186 -chain are overlaid with the alpha-chain and beta-chain of MHC class II, respectively.

187 on, we showed that the T-cell receptor (TCR) beta-chain of our nTreg model was not only sufficient to

188 these conformers are similar to those in the beta-chain of oxyferrous hemoglobin A (HbA) and oxyferro

189 ts a wedge-like position when binding to the beta-chain of TCR, allowing for an interaction between t

190 Here, the TRBV29-1 beta-chain of the D462-E4 TCR binds over the F'-pocket o

191 he uterus of mice and humans, expressing the beta-chain of the IL-15R complex (CD122) and responding

192 egion from a mAb directed against CD79B, the beta-chain of the invariant signal-transducing dimer of

193 ted with decreased sialic acid levels on the beta-chain of the IR and reduction of IR signaling.

194 ansgenic mouse that expresses the alpha- and beta-chains of a myelin oligodendrocyte glycoprotein (MO

195 ved in balanced expression of the alpha- and beta-chains of MHC class II, whereas rs7192 was predicte

196 on with 200 umol/L NiSO(4) ., TCR alpha- and beta-chains of sorted nickel-specific and control cells

197 sed on the dimeric feature of the alpha- and beta-chains of the human major histocompatibility comple

198 or Hb isoform) and HBB-T2 (which encodes the beta-chains of the minor Hb isoform).

199 in a trans heterodimer it interacts with the beta-chain on the other chromosome.

200 of positional isomers of glycated alpha- and beta-chains on the intact level.

201 after called C4BP[beta(-)] [C4BP lacking the beta-chain]), overexpressed under acute-phase conditions

202 , the importance of complementary alpha- and beta-chain pairing in determining TCR specificity and T

203 Most GIL-specific TCRs utilize alpha/beta chain pairs encoded by the TRAV27/TRBV19 gene combi

204 ous work has shown that both alpha-chain and beta-chain phosphorylations of CD11a/CD18 and CD11b/CD18

205 he acute-phase C4BP isoform C4BP lacking the beta-chain plays a pivotal role in the modulation of the

206 rum expected for NO bound to the heme in the beta-chain plus that of a thiyl radical.

207 MHC class II molecules, in particular around beta-chain position-57 (beta57), afford susceptibility/r

208 d of its carboxyl-terminal NPXY motifs, LRP1 beta-chain positively regulates the expression of ATP bi

209 ould otherwise be sterically hindered by the beta-chain, primarily mediates this interaction.

210 tic of the R and T states, for both alpha or beta chains, prior to the quaternary R-T and T-R shifts.

211 this study, we characterized the global TCR beta-chain profile in human T cells isolated from placen

212 Three alpha-chain and three beta-chain public TCR sequences were shared between indi

213 pertoires focus solely on an analysis of TCR beta-chains, rather than the combined TCRalphabeta heter

214 ative selection of thymocytes expressing TCR beta-chains reactive against several retroviral superant

215 egration site sequencing and T-cell receptor beta-chain rearrangement sequencing, correlated signific

216 hese three cytokines signal through a common beta-chain receptor but yet differentially affect protei

217 eosinophil gene expression program among the beta-chain receptor cytokines.

218 /macrophage-colony stimulating factor common beta-chain receptor.

219 During infection, T cell beta chain repertoire continues to contract while the di

220 DR1beta- and CDR2beta-MHC binding to broaden beta-chain repertoire diversification before alphabetaTC

221 Using immune profiling of the T cell beta-chain repertoire in 16 patients with early-stage br

222 Sequencing of the TCR beta-chain repertoire reveals that the DEJ CD8alphaalpha

223 agnitude of the CD8(+) T cell responses, TCR beta-chain repertoires did not significantly differ amon

224 Two beta-chain residues, located near the proposed Be bindin

225 uated underneath the TCR alpha-chain and TCR beta-chain, respectively.

226 cation could be identified on the alpha- and beta-chain, respectively.

227 PSI in complex with hepatocyte growth factor beta-chain reveals the receptor-ligand selectivity deter

228 quencing of paired T cell receptor alpha and beta chain sequences show pronounced CD8 T cell clonal e

229 ndicating that pairing of certain alpha- and beta-chain sequences is key for determining TCR specific

230 taining and clonotypic T cell receptor (TCR) beta-chain sequencing in multiple anatomic regions isola

231 We applied single-cell TCR alpha- and beta-chain sequencing to peripheral blood GAD65-specific

232 7 Vbeta3 transgenic mice, which have a fixed beta-chain specific for pigeon cytochrome c peptide I-Ek

233 e engineered to express single TCR alpha- or beta-chains specific for the D(b)NP366 or D(b)PA224 epit

234 Chimeric analysis indicates that integrin beta chain-specific impacts on induction are dictated by

235 How the IL-2 receptor beta-chain specifically shapes immunity has remained eni

236 10 residues of the cleaved N terminus of the beta-chain stimulate Met phosphorylation by pro-HGF to l

237 The B:Y16A Beta chain substitution has been previously shown to be

238 a-globin paralogs, HBB-T1 (which encodes the beta-chain subunits of the major Hb isoform) and HBB-T2

239 disorder characterized by altered hemoglobin beta-chain synthesis amenable to allogeneic HSC transpla

240 seven identical alpha chains and one unique beta chain synthesized in liver and pancreas.

241 xpanded populations of T cells, we amplified beta-chain TCR transcripts by the nonpalindromic adaptor

242 Multiple identical copies of beta-chain TCR transcripts were identified in these pati

243 ity had no lung disease, and T-cell receptor beta chain (Tcrb)(-/-) STING N153S animals only had mild

244 ified an allele of the T-cell receptor (TCR) beta-chain, Tcrb-V13S1A1, as a candidate gene.

245 que phenotypic traits of CD8(+) TILs and TCR beta chain (TCRbeta) clonotypic frequency in melanoma tu

246 tional profiling and T-cell antigen receptor beta-chain (TCRbeta) genotyping on sequential genital sk

247 We studied the T-cell receptor beta-chain (TCRbeta) usage and phenotypes of peanut-acti

248 first expressing the T cell antigen receptor beta-chain (TCRbeta).

249 stimulation and mRNA sequencing of their TCR beta-chains (TCRbeta).

250 cells bearing receptors made up of alpha and beta chains (TCRs) usually react with peptides bound to

251 inant I-A(k) class II molecules possessing a beta-chain-tethered hen egg lysosome peptide lack the Ia

252 We created mice expressing a transgenic TCR-beta chain that confers high affinity for self-lipid/CD1

253 hese cells express a range of TCR alpha- and beta-chains that show differential recognition of glycol

254 For alpha but not for beta chains, the frequency of the nu(4) porphyrin breath

255 In CD4 thymocytes expressing a fixed Tg TCR beta-chain, the associated TCRalpha sequences in wild-ty

256 le CDR3 region of human CD4+ T-cell receptor beta chains to infer the statistical properties of these

257 re MSPalphabeta (disulfide-linked alpha- and beta-chains) to RON ectodomain modulates receptor dimeri

258 nfants, the diversity of the T cell receptor beta chain (TRB) expressed in cord blood samples from HE

259 for the generation and selection of the TCR beta chain (TRB) from sequenced repertoires of 651 indiv

260 ts to the CDR3 domain of the T-cell receptor beta chain (TRB).

261 inatorial diversity of human T-cell receptor beta-chain (TRB locus) was measured in peripheral blood.

262 In this study, we examined the TCR beta-chain (TRB) diversity of the CD8(+) T cell response

263 Here, we sequenced T-cell receptor beta-chain (TRB) gene rearrangements from immunodominant

264 the gene encoding the T cell receptor (TCR) beta-chain (Trb, also known as Tcrb) using CDR3 sequence

265 f one of two mutually exclusive TCR constant beta chains, TRBC1 and TRBC2.

266 KF11) and identified common usage of the TCR beta-chain TRBV7 in eight of nine HLA B57 subjects exami

267 s likely to be Tcrb-V13, indicating that TCR beta-chain usage is a determinant of susceptibility to a

268 rate here that NKTcrs, which varied in their beta-chain usage, recognised diverse glycolipid antigens

269 The coexpressed beta-chain used a Vbeta segment homologous to the semiva

270 buried hydroxymethyl that forms a common TCR beta-chain V region variant.

271 ligoclonality and restricted T-cell receptor beta-chain V-J pairing in CD8(+) but not CD4(+) T cells,

272 class II molecules and T-cell receptor (TCR) beta-chain variable domains (Vbetas).

273 ted a TCR motif in humans defined by the TCR beta-chain variable gene 4-1 (TRBV4-1) region.

274 CTL receptor TCR beta-chain variable gene subfamilies were polyclonal, wi

275 ining region 3 (CDR3) regions containing the beta-chain variable region (Vbeta) demonstrated a more d

276 was found irrespective of the member of the beta-chain variable region (Vbeta) family present in the

277 CR) alpha-chain variable region (Valpha) and beta-chain variable region (Vbeta).

278 expressing the T cell antigen receptor (TCR) beta-chain variable region 11 (TRBV11-2) were 'preferent

279 y one or two clones typically expressing TCR beta-chain variable TRBV-15.

280 s was a T cell-intrinsic and T cell receptor beta-chain variable-dependent phenomenon.

281 tive roles of the CDR loops within the NKTcr beta-chain varied as a function of the antigen.

282 hat utilizes only the variable domain of the beta chain (Vbeta).

283 troduction of T-cell receptor (TCR) variable beta-chain (Vbeta) monoclonal antibodies has facilitated

284 eage, but we also demonstrated that this TCR beta-chain was able to provide stronger TCR signals.

285 ormalized to vector copy, the vector-encoded beta-chain was expressed at a level approximating normal

286 silonRI alpha-chain with the gamma-chain and beta-chain was markedly reduced.

287 ncing of the T-cell receptor variable-region beta-chain was performed on peripheral blood from PHTS p

288 Consistently, in the absence of beta-chains, we found a direct interaction between the c

289 Individual residues within the MAIT TCR beta chain were dispensable for the interaction with MR1

290 the alpha-helices of the HLA-DP2 alpha- and beta-chains were also mutated to alanine.

291 ary DNA for T cell receptor (TCR) alpha- and beta-chains were cloned into a retroviral vector.

292 MAGE-A3-specific TCR alpha- and beta-chains were isolated and cloned into a retroviral v

293 is composed of two polypeptides (alpha- and beta-chains), which form three plasma oligomers with dif

294 receptors for these cytokines use the common beta chain, which serves as the main signaling unit link

295 the most variable part of the TCRalpha and -beta chains, which govern interactions with peptide-MHC

296 ules are composed of one alpha-chain and one beta-chain whose membrane distal interface forms the pep

297 g ligand promiscuity to favor development of beta chains with self-reactivity but is occluded by alph

298 Rhinocetin was shown to comprise alpha and beta chains with the molecular masses of 13.5 and 13 kDa

299 We created chimeras of alpha- and beta-chains with the NR2A and NR2B C termini and evaluat

300 uman HC1 has a structure similar to integrin beta-chains, with a von Willebrand factor A domain conta