ライフサイエンスコーパス: beta-endorphin

1 nes, beta-lipotropic hormone (beta LPH), and beta endorphin.

2 he amyloid fiber formed by the human hormone beta-endorphin.

3 an altered cleavage profile for the peptide beta-endorphin.

4 alpha-neoendorphin, but not endomorphins or beta-endorphin.

5 elanocyte-stimulating hormone (beta-MSH) and beta-endorphin.

6 n of beta-lipotropin to gamma-lipotropin and beta-endorphin.

7 ation in the level of C-terminally processed beta-endorphin.

8 ere used for dual immunocytochemistry of Fos/beta-endorphin.

9 through the post-translational processing of beta-endorphin.

10 n (POMC), or PVN levels of Met-Enkephalin or beta-Endorphin.

11 peptide Y, vasoactive intestinal peptide, or beta-endorphin.

12 are derived from pro-opiomelanocortin as is beta-endorphin.

13 -stimulating hormone, and the opioid peptide beta-endorphin.

14 amic acid decarboxylase 67 (GAD67), NPY, and beta-endorphin.

15 )O-induced increases in nitrite, nitrate and beta-endorphin.

16 timulate an NO-dependent neuronal release of beta-endorphin.

17 O metabolites nitrite and nitrate as well as beta-endorphin.

18 yzed for their content of NO metabolites and beta-endorphin.

19 tisera against the endogenous opioid peptide beta-endorphin.

20 ient or lacking either pre-pro-enkephalin or beta-endorphin.

21 tobarbital-anesthetized rats pretreated with beta-endorphin (0.5 nmol i.c.v.).

22 a peptidase which converts beta-endorphin to beta-endorphin 1-17 (gamma-endorphin), beta-endorphin 1-

23 in to beta-endorphin 1-17 (gamma-endorphin), beta-endorphin 1-18, and their corresponding C-terminal

24 co-administration of morphine (1 microg) and beta-endorphin (1 microg) into either the amygdala alone

25 Co-administration of beta-endorphin (1 microg) into the amygdala and morphine

26 of morphine (1 microg) into the amygdala and beta-endorphin (1 microg) into the PAG failed to produce

27 he similar effects of intra-DVC injection of beta-endorphin (1 pmol) are inhibited by naloxone and no

28 psilon (epsilon)-opioid-receptor antagonist, beta-endorphin(1-27) prevents these effects of etorphine

29 ethadone (LAAM), morphine, meperidine, DADL, beta-endorphin(1-31), enkephalins, and dynorphin A(1-17)

30 ity to the suppressive actions of Gly-Gln or beta-endorphin-(1-27) injections that modulate voluntary

31 ficacy was shown to be comparable to central beta-endorphin-(1-27) or intraperitoneal (i.p.) naltrexo

32 In contrast, the opioid peptidergic agonist beta-endorphin (10 microgram/kg, i.p.) administered afte

33 Following intrathecal administration, beta-endorphin (10-100 nmol) and GRP (1-10 nmol) dose-de

34 rolysis of fluorogenic peptides based on the beta-endorphin 12-24 sequence, Abz-T-P-L-V-T-L-X(1)-X(2)

35 nto the rostral ventromedial medulla altered beta-endorphin (15 microg) analgesia elicited from the v

36 Both morphine (2.5-5 micrograms) and beta-endorphin (2.5-5 micrograms) microinjected into eit

37 Glycyl-L-glutamine (Gly-Gln; beta-endorphin 30-31) is an endogenous dipeptide that is

38 y, we investigated whether glycyl-glutamine (beta-endorphin(30-31)), an inhibitory dipeptide synthesi

39 ore effective in reducing morphine (60%) and beta-endorphin (79%) analgesia in the amygdala on the ju

40 essed pro-opiomelanocortin, the precursor of beta-endorphin (a known EOP), and constituted the majori

41 d in the DVC, whereas the similar effects of beta-endorphin, a peptide derived from the same precurso

42 egulated by, in part, the endogenous opioid, beta-endorphin, acting on mu-opioid receptors.

43 ted by opioids, leading to the proposal that beta-endorphin acts to provide feedback inhibition.

44 d respiratory depression produced by central beta-endorphin administration.

45 sor proopiomelanocortin (POMC) gives rise to beta-endorphin, adrenocorticotropic hormone, beta-lipotr

46 We found that beta-endorphin aggregation and dissociation occur in vit

47 ght carbohydrates exhibit the same effect on beta-endorphin aggregation as phosphate.

48 point as well as more rapid dissociation of beta-endorphin amyloid fibrils at lower pH indicate the

49 In contrast, beta-endorphin amyloid fibrils obtained in the presence

50 In the beta-endorphin amyloid, every layer of the beta-solenoid

51 l factors on the assembly and disassembly of beta-endorphin amyloids in vitro.

52 ning exercise increases blood levels of both beta-endorphin (an opioid) and anandamide (an endocannab

53 However, the A118G variant receptor binds beta-endorphin, an endogenous opioid that activates the

54 beta-Endorphin, an endogenous opioid, is synthesized in

55 e PAG significantly reduce both morphine and beta-endorphin analgesia elicited from the amygdala.

56 sary for the full expression of morphine and beta-endorphin analgesia elicited from the amygdala.

57 PAG significantly reduced morphine, but not beta-endorphin analgesia in the amygdala on the tail-fli

58 the multiple modulatory mechanisms mediating beta-endorphin analgesia in the PAG, and in terms of whe

59 The opioid mediation of beta-endorphin analgesia in the ventrolateral periaquedu

60 Whereas mecamylamine failed to reduce beta-endorphin analgesia on either measure, scopolamine

61 l (11%) and transient (30 min) reductions in beta-endorphin analgesia on the jump test, MK-801 produc

62 al (9%) and transient (30 min) reductions in beta-endorphin analgesia on the tail-flick test.

63 l (23%) and transient (30 min) reductions in beta-endorphin analgesia on the tail-flick test.

64 Glycosylated beta-endorphin analogues of various amphipathicity were

65 esidues in the helical address region of the beta-endorphin analogues without destroying mu-, delta-,

66 py showed colocalization of cathepsin L with beta-endorphin and alpha-MSH in the intermediate pituita

67 addiction, mediated by the hedonic action of beta-endorphin and anhedonic effects of withdrawal, may

68 these neurons produce the endogenous opioid beta-endorphin and are heavily regulated by opioids.

69 As the opioid peptides beta-endorphin and enkephalin increase splenic NK cell f

70 the measurement of instrumental behavior of beta-endorphin and enkephalin knock-out mice that both o

71 We conclude that both beta-endorphin and enkephalin positively contribute to t

72 y granules yet expresses endogenous opioids (beta-endorphin and Met-enkephalin) and uroguanylin in ap

73 eceptors (MOR, OPRM1) mediate the effects of beta-endorphin and modulate many biological functions in

74 In addition, we have shown that beta-endorphin and mu-opiate receptor are expressed at t

75 The expression of both beta-endorphin and mu-opiate receptor correlated positiv

76 hemistry and immunoelectron microscopy using beta-endorphin and mu-opiate receptor specific antibodie

77 ed the brain-to-blood transport of morphine, beta-endorphin and other opioids.

78 udy reveals decreases in endogenous opioids, beta-endorphin and perhaps Met-enkephalin in the thalamu

79 (POMC) neurons release the endogenous opioid beta-endorphin and POMC neuron activity is inhibited by

80 f the infiltration of immunocytes containing beta-endorphin and the consequent decrease of the beta-e

81 y structural differences between melittin or beta-endorphin and their respective synthetic analogs.

82 Moreover, neurons triple-labeled with c-Fos, beta-endorphin and VGLUT3 were noted in this region foll

83 affinity for both endogenous opioids such as beta-endorphins and exogenous opioids such as fentanyl.

84 y completely prevented carboxy-shortening of beta-endorphins and greatly diminished conversion of bet

85 of neuroendocrine peptides (dynorphin A-17, beta-endorphin, and alpha- melanocyte-stimulating hormon

86 hormones adrenocorticotropic hormone (ACTH), beta-endorphin, and alpha-melanocyte stimulating hormone

87 e for cathepsin L in the production of ACTH, beta-endorphin, and alpha-MSH peptide hormones in the re

88 ock-out mice showed major decreases in ACTH, beta-endorphin, and alpha-MSH that were reduced to 23, 1

89 mone, alpha-, beta-, and gamma-melanotropin, beta-endorphin, and beta-lipotropin.

90 nadotropin-releasing hormone (GnRH), VP, OT, beta-endorphin, and dopamine neurons, are responsive to

91 proopiomelanocortin (POMC), the precursor to beta-endorphin, and endomorphin 1 and 2 on sectioned rat

92 mu-opioid receptor agonists (e.g., morphine, beta-endorphin, and enkephalin) inhibit luteinizing horm

93 gonadotropin-releasing hormone-I, dopamine, beta-endorphin, and gonadotropin-releasing hormone-II ne

94 analgesic responses induced by morphine and beta-endorphin, and indicate that the latter response is

95 prolactin, corticotropin-releasing hormone, beta-endorphin, and somatotropin release-inhibiting fact

96 tein as well as its derivatives beta LPH and beta-endorphin, and that this process is modulated by TP

97 ructures of EOP-OR-G(i) complexes, including beta-endorphin- and endomorphin-bound muOR, deltorphin-b

98 deprived feeding states but were reduced in beta-endorphin- and enkephalin-deficient mice only when

99 0-100 nmol) dose-dependently attenuates both beta-endorphin- and GRP-elicited robust scratching witho

100 The same pathway produces beta-endorphin, another POMC derivative, which potential

101 selected for three different receptors: anti-beta-endorphin anti-body, streptavidin, and thrombin, an

102 nsulin, growth hormone releasing factor, and beta-endorphin are nearly equivalent substrates for the

103 Enkephalins and beta-endorphin are nonselective endogenous MOR ligands.

104 ide (POMC), and its opioid cleavage product, beta-endorphin, are expressed in the mouse retina.

105 Using a monoclonal antibody (3E-7) against beta-endorphin as a target, we selected a single peptide

106 These data implicate beta-MSH and beta-endorphin as important in determining hunger and mo

107 fferential affinity to the endogenous ligand beta-endorphin as well as alterations in pain sensitivit

108 Wild type IDE cleaved beta-endorphin at Leu(17)-Phe(18) and Phe(18)-Lys(19), w

109 Nardilysin cleaves beta-endorphin at the monobasic site, Phe(17)-Lys(18), w

110 olved in pain modulation-metenkephalin (ME), beta-endorphin (BE), and substance P (SP)-in patients un

111 Within 36 h after TPA stimulation, beta-endorphin became undetectable in cell extracts, coi

112 To enhance beta-endorphin (BEP), the endogenous opioid polypeptide

113 halamic NSCs differentiated these cells into beta-endorphin (BEP)-producing neurons in culture.

114 The endogenous peptides beta-endorphin (beta-END) and neuropeptide Y (NPY) have

115 in-releasing hormone (CRH), urocortin (Ucn), beta-endorphin (beta-END), ACTH, and corticosterone (COR

116 role also exists for the endogenous opiate, beta-endorphin (beta-END).

117 The enzymatic cleavage products of beta-endorphin (beta-endorphin1-27 and Gly-Gln) reduce v

118 The role of beta-endorphin (beta-EP) in ethanol-altered NK cell cyto

119 The mechanism by which ethanol induces beta-endorphin (beta-EP) neuronal death during the devel

120 cAMP system is involved in ethanol-regulated beta-endorphin (beta-EP) release from rat hypothalamic n

121 induced by the mu-sensitive opioid peptide, beta-endorphin (betaEND, 10 microg, i.c.v.) was signific

122 CB1R activation selectively increases beta-endorphin but not alpha-melanocyte-stimulating horm

123 elanocyte-stimulating hormone (beta-MSH) and beta-endorphin but not alpha-MSH; humans, similar to dog

124 pin hormone (ACTH), alpha-MSH, beta-MSH, and beta-endorphin by immunoassay.

125 s opiates with the same receptor activity as beta-endorphin can cause fatigue.

126 Thus, beta-endorphin cell therapy may offer some therapeutic v

127 A recognized beta-endorphin cleavage product, Gly-Gln, inhibits volun

128 tion of cell bodies containing enkephalin or beta-endorphin, colchicine (90-100 microg/kg) was inject

129 A118G) may have higher receptor binding for beta-endorphin compared with AA homozygotes that may con

130 evels of oxidation products of NO as well as beta-endorphin, compared to levels in fractions collecte

131 fall in arterial pressure elicited by i.c.v. beta-endorphin, consistent with evidence that cyclic dip

132 The results suggest that although beta-endorphin-containing fibres are absent in many part

133 bility, CB(2) immunolabeling was detected on beta-endorphin-containing keratinocytes in stratum granu

134 endorphin and the consequent decrease of the beta-endorphin content in the inflamed tissue.

135 vital organs, we tested whether skin-derived beta-endorphin contributes to radiation-induced fatigue.

136 CSF beta-MSH is increased and CSF beta-endorphin decreased in RLS patients with painful sy

137 Although conversion of beta-lipotropin to beta-endorphin decreased, the lack of PC2 activity cause

138 Adult male beta-endorphin deficient and wild type mice were subject

139 Overall, the beta-endorphin deficient mice and wild type mice had fai

140 After the conflict, the beta-endorphin deficient mice had higher corticosterone

141 th the aggressive conspecific several of the beta-endorphin deficient mice showed clear signs of coun

142 In this experiment beta-endorphin deficient mice were used to study the rol

143 re returned to baseline levels faster in the beta-endorphin deficient mice.

144 In this study, we used the beta-endorphin deficient mutant mouse line C57BL/6-Pomc1

145 tion in proenkephalin knockout (PENK KO) and beta-endorphin-deficient (BEND KO) mice, and how the bod

146 Herein we demonstrate that morphine and beta-endorphin disrupt this long-range synchrony of gamm

147 so challenge the dogma that shorter forms of beta-endorphin do not exhibit receptor activity; we show

148 ed NO activity and the stimulated release of beta-endorphin during exposure of rats to N(2)O.

149 at mu and kappa opioid receptors as well as beta-endorphin each produce analgesia elicited from the

150 studies have demonstrated that morphine and beta-endorphin employ different anatomical and neurochem

151 f a rat's hindpaw elicits an accumulation of beta-endorphin-(END) containing immune cells.

152 ls and neurons double-labeled with c-Fos and beta-endorphin, enkephalin or VGLUT3 in the ARC were sig

153 however, growth hormone releasing factor and beta-endorphin exhibit a 40-fold higher kcat, but a 10-f

154 ansgenic mice with a selective deficiency of beta-endorphin exhibit normal analgesia in response to m

155 UVB stimulated beta-endorphin expression was higher in D2 than in B6.

156 king beta-endorphin), heterozygous mice (50% beta-endorphin expression) and sibling wildtype mice fro

157 ule has an acidic pH but, on exocytosis, the beta-endorphin fibril would encounter neutral pH conditi

158 We find that beta-endorphin fibrils are in a beta-solenoid conformati

159 We find that beta-endorphin fibrils are in a beta-solenoid conformati

160 ) receptor activation induces the release of beta-endorphin from keratinocytes and the activation of

161 mutant POMC cDNA produced a mutant beta-MSH/beta-endorphin fusion protein.

162 s with the rank order of etorphine > DAMGO = beta-endorphin > morphine > butorphanol, and the affinit

163 beta-Endorphin had an LOD of 5 nM when detected directly

164 Functional studies showed that beta-endorphin has potent melanogenic, mitogenic, and de

165 imulating hormone; and the endogenous opioid beta-endorphin) have a diverse array of biological activ

166 Homozygous knockout mice (entirely lacking beta-endorphin), heterozygous mice (50% beta-endorphin e

167 that hemorrhage increased Fos expression by beta-endorphin immunoreactive neurons significantly.

168 The proportion of beta-endorphin immunoreactive neurons that expressed Fos

169 e for beta-endorphin immunostaining, whereas beta-endorphin-immunoreactive neurons were absent in ret

170 ell extracts, coinciding with an increase of beta-endorphin-immunoreactive protein in the culture med

171 aused significant increases in POMC mRNA and beta-endorphin immunoreactivity in both ipsilateral and

172 d-expressing amacrine cells was positive for beta-endorphin immunostaining, whereas beta-endorphin-im

173 t with nerve fibers containing enkephalin or beta-endorphin in both the rVLM and vlPAG.

174 A physiological role for beta-endorphin in endogenous pain inhibition was investi

175 gulated secretion of both chromogranin A and beta-endorphin in response to the usual secretagogue, co

176 lanocyte-stimulating hormone (alpha-MSH) and beta-endorphin in RLS patients and controls.

177 s and/or dendrites) containing enkephalin or beta-endorphin in specific regions of the brain stem.

178 These findings implicate skin-derived beta-endorphin in systemic effects of radiation therapy.

179 oid analgesia elicited by either morphine or beta-endorphin in the amygdala could be altered by eithe

180 roopiomelanocortin (POMC) neurons to release beta-endorphin in the arcuate nucleus (ARC) of the hypot

181 exin A, orexin B, and a novel isoform of rat beta-endorphin in the arcuate nucleus.

182 own that enhancement of endogenous levels of beta-endorphin in the hypothalamus via beta-endorphin ne

183 tration of AAS also increased the content of beta-endorphin in the midline thalamus, suggesting a pos

184 est, but decreased the potency of the opioid beta-endorphin in the periaqueductal gray region of the

185 AtT-20 cells resulted in increased ACTH and beta-endorphin in the regulated secretory pathway.

186 let radiation, to date a functional role for beta-endorphin in the regulation of human epidermal mela

187 ta-melanocyte-stimulating hormone (MSH), and beta-endorphin in the regulation of skin pigmentation, a

188 but the data do not support a major role for beta-endorphin in the regulation of sleep or social stre

189 s activates neurons containing enkephalin or beta-endorphin in the rVLM as well as in the periaqueduc

190 -endorphin were used to study the release of beta-endorphin in the urethane anaesthetized rat followi

191 neuronal structures containing enkephalin or beta-endorphin in these regions.

192 oxidation of epidermal ACTH, alpha-MSH, and beta-endorphin in vitiligo owing to oxidation of methion

193 halin, leu-enkephalin, dynorphin A(1-8), and beta-endorphin in vivo.

194 Over a 6-week radiation regimen, plasma beta-endorphin increased in rats, paralleled by opiate p

195 Beta endorphin-induced constriction was enhanced followi

196 tion produced a dose-dependent inhibition of beta-endorphin-induced hypotension, but not bradycardia,

197 beta-endorphin inhibition of tumor progression also invo

198 ere active toward the physiological peptides beta-endorphin, insulin, and amyloid beta peptide 1-40.

199 Co-administration of subthreshold doses of beta-endorphin into both structures also results in a pr

200 hold doses of morphine into both structures, beta-endorphin into both structures, morphine into one s

201 in into the other structure, or morphine and beta-endorphin into one structure.

202 tions of morphine, mu-selective agonists and beta-endorphin into the amygdala.

203 structures, morphine into one structure and beta-endorphin into the other structure, or morphine and

204 Beta-endorphin is an endogenous opioid peptide that is r

205 beta-Endorphin is an opioid peptide cleaved from the pre

206 Furthermore, beta-endorphin is approximately three times more potent

207 The cancer-preventive effect of beta-endorphin is mediated through the suppression of sy

208 hermal stimulus was applied, suggesting that beta-endorphin is necessary for CB(2) receptor-mediated

209 Whereas plasma beta-endorphin is reported to increase after exposure to

210 t an important mechanism of the transport of beta-endorphin is the cerebrospinal fluid.

211 t, in rodents, another POMC-derived peptide, beta-endorphin, is coordinately synthesized in skin, ele

212 eptive and behavioral effects were absent in beta-endorphin knockout mice and in mice lacking p53-med

213 nist treatment and were undetected in either beta-endorphin knockout mice or mice lacking keratinocyt

214 An antibody that selectively recognized beta-endorphin labeled fibers and neurons in the ventral

215 ty caused an increase in beta-lipotropin and beta-endorphin levels in the mutant animals, but no incr

216 beta-endorphin levels increased in the inflamed paw, and

217 ription, and plasma interleukin-1 (IL-1) and beta-endorphin levels measured.

218 fe-threatening episodes implicates increased beta-endorphin levels resulting from acid-mediated esoph

219 Resting plasma beta-endorphin levels were significantly higher in the H

220 r women, dyadic satisfaction correlated with beta-endorphin levels, depression, and perception of ill

221 ' dyadic satisfaction scores correlated with beta-endorphin levels.

222 Moreover, we show that oxidized beta-endorphin loses its function in the promotion of pi

223 Solitary chemosensory cells that coexpress beta-endorphin, Met-enkephalin, uroguanylin, and Trpm5 e

224 In conclusion, the results suggest that beta-endorphin modulates the acute endocrine, thermoregu

225 These data support the hypothesis that beta-endorphin modulates the response to EtOH.

226 e causal links for itch-eliciting effects by beta-endorphin-MOP receptor and GRP-BB2 receptor systems

227 0 microM concentrations of etorphine, DAMGO, beta-endorphin, morphine, and butorphanol, DAMGO-stimula

228 s designed to examine the involvement of the beta-endorphin/mu-opiate receptor system in human epider

229 elanocortin-1 receptor, we conclude that the beta-endorphin/mu-opiate receptor system participates in

230 rmal melanocytes express a fully functioning beta-endorphin/mu-opiate receptor system.

231 ls of beta-endorphin in the hypothalamus via beta-endorphin neuron transplantation suppresses stress

232 in the ethanol-induced neuronal death of the beta-endorphin neuron.

233 deposition of the complement protein C1q in beta-endorphin neuronal cells in both in vitro and in vi

234 regulates exosome-mediated, ethanol-induced beta-endorphin neuronal death.SIGNIFICANCE STATEMENT Neu

235 anol treatments increased the number and the beta-endorphin neuronal killing activity of microglial e

236 0 +/- 2.6%, depending on neuronal location), beta-endorphin neurons (68.3.0 +/- 4.4%), and VP neurons

237 production; and ultimately cellular death of beta-endorphin neurons.

238 ds to hyperpolarize guinea pig hypothalamic (beta-endorphin) neurons.

239 rast to traditional mu and kappa opioids and beta-endorphin, none of the OFQ/N fragments in the amygd

240 beta LPH and beta-endorphin of keratinocyte origin may thus be involv

241 ls of epinephrine and norepinephrine but not beta-endorphin or cortisol.

242 t rat dynorphin1-13 but not antisera against beta-endorphin or methionine-enkephalin.

243 the cardiorespiratory depression produced by beta-endorphin or morphine.

244 CD+CID can improve the sequence coverage for beta-endorphin over performing ECD alone (i.e., from 72

245 networks) to show that three neuropeptides (beta-endorphin, oxytocin, and dopamine) play particularl

246 Glycopeptides related to beta-endorphin penetrate the blood-brain barrier (BBB) o

247 s (PVN) (P<0.05), but did not have lower PVN beta-endorphin peptide levels (0.05).

248 proopiomelanocortin (POMC) neuron-producing beta-endorphin peptides in the hypothalamus in a postnat

249 The opioid peptide beta-endorphin plays a critical role in bringing the str

250 )), an inhibitory dipeptide synthesized from beta-endorphin post-translationally, inhibits IL-1beta a

251 c-rAAV8 expressing the analgesic gene prepro-beta-endorphin (ppbetaEP) led to significant (P < 0.0001

252 role for insulin-degrading enzyme as both a beta-endorphin-processing and -inactivating enzyme is im

253 et of experiments tested the hypothesis that beta-endorphin-producing neurons, that is, proopiomelano

254 mes when introduced into primary cultures of beta-endorphin-producing POMC neurons, increased cellula

255 utyric acid (GABA), neuropeptide Y (NPY), or beta-endorphin receptor blockade in the ipsilateral hypo

256 rdiovascular reflexes through enkephalin- or beta-endorphin-related opioid receptors in the rostral v

257 emperature, at least in part, by stimulating beta-endorphin release from pro-opiomelanocortin neurons

258 AM1241 stimulated beta-endorphin release from rat skin tissue and from cul

259 u-opioid receptors (MORs) and an increase in beta-endorphins released into the VTA and the plasma.

260 The time-integrated beta-endorphin response to CRH was greater in the patien

261 Depolarization-mediated beta-endorphin secretion was greatly enhanced in the GAP

262 tone, sensation, plasma levels of cortisol, beta-endorphin, selected gut neuropeptides, norepinephri

263 ng in keratinocytes, subsequently increasing beta-endorphin signaling at opioid receptors, and produc

264 During this period, beta-endorphin stimulates PRL secretion by regulation of

265 phine (tail-flick: 70-75%; jump: 60-81%) and beta-endorphin (tail-flick: 100%; jump: 93%) analgesia e

266 des alpha-melanocyte-stimulating hormone and beta-endorphin, the glucocorticoids; and the catecholami

267 ting hormone (alpha-Msh) and carboxy-cleaved beta-endorphin, the products of Cpe-dependent processing

268 have shown the distribution of dynorphin and beta-endorphin throughout social behavior circuits withi

269 ell line contains a peptidase which converts beta-endorphin to beta-endorphin 1-17 (gamma-endorphin),

270 cial attachment, binding of the neuropeptide beta-endorphin to mu-opioid receptors in the central ner

271 al tone regulating feeding behavior, whereas beta-endorphin underlies orosensory reward in high need

272 Analyses of beta-endorphin variants carrying mutations in Glu8 suppo

273 A functional role for beta-endorphin was assessed in epidermal melanocyte cult

274 125I-beta-Endorphin was cross-linked to preparations enriched

275 Little immunoreactive-beta-endorphin was detected in the areas of brain sample

276 e of the amyloid fibril of the human hormone beta-endorphin was determined by solid-state NMR.

277 Basal secretion of beta-endorphin was first observed at Embryonic Day 13.5

278 of the sum of CSF alpha- and beta-MSH to CSF beta-endorphin was highest, intermediate, and lowest in

279 vented in rats when naloxone or antiserum to beta-endorphin was injected in the hindpaw where the nox

280 Hindpaw injection of beta-endorphin was sufficient to produce antinociception

281 proximity to fibers containing enkephalin or beta-endorphin, was observed in the rVLM and ventrolater

282 timulate an NO-dependent neuronal release of beta-endorphin, we conducted a ventricular-cisternal per

283 Given the powerful analgesic properties of beta-endorphin, we tested this hypothesis using pain tol

284 n Western blot analysis, POMC, beta LPH, and beta-endorphin were detected in cell extracts under base

285 n the PAG, while no cell bodies labeled with beta-endorphin were identified in either region.

286 Met-Enkephalin and beta-Endorphin were not affected by dietary treatment.

287 Plasma ACTH, alpha-MSH, and beta-endorphin were similar between groups.

288 ilized antibodies to the carboxy-terminus of beta-endorphin were used to study the release of beta-en

289 is mechanism allows for the local release of beta-endorphin, where CB(2) receptors are present, leadi

290 tially to inflamed sites, where they release beta-endorphin which activates peripheral opioid recepto

291 ion stimulates release from keratinocytes of beta-endorphin, which acts at local neuronal mu-opioid r

292 emia and exercise both induce the release of beta-endorphin, which plays an important role in the mod

293 Unlike beta-endorphin, which produces itch and attenuates infla

294 from keratinocytes of the endogenous opioid beta-endorphin, which then acts at opioid receptors on p

295 There was no correlation of IL-1 or beta-endorphin with any psychosocial or behavioral compl

296 icroscopy studies revealed an association of beta-endorphin with melanosomes.