ライフサイエンスコーパス: beta1 integrin

1 ng electrotaxis via electric field-activated beta1 integrin.

2 between AR and TrkA, which is controlled by beta1 integrin.

3 tion, likely via downregulation of NCAM1 and beta1 integrin.

4 s by dampening the RhoA pathway or silencing beta1 integrin.

5 involves loss of RAP1-mediated activation of beta1 integrin.

6 s downstream of cleaved CDCP1 complexed with beta1 integrin.

7 ) signaling and downstream activation of the beta1 integrin.

8 ing following normal endocytosis of inactive beta1-integrin.

9 ilin promotes the internalization of surface beta1-integrin.

10 nd with E353 to mediate its high affinity to beta1-integrin.

11 ation of Akt and the recruitment of talin to beta1 integrins.

12 onformationally active population of surface beta1 integrins.

13 l adhesion kinase (FAK) and ligand-activated beta1 integrins.

14 were eliminated by neutralizing antisera for beta1-integrins.

15 sts with QHREDGS was found to be mediated by beta1-integrins.

16 nia, which enables uptake via mammalian host beta1-integrins.

17 eling correlated with increased staining for beta1 integrin, a component of adhesion receptors that r

18 Here, we asked whether beta1 integrin, a mechanosensory protein in endothelial

19 We observed that beta1-integrins accumulate on the luminal membrane of up

20 beta1-integrin accumulation is due to increased ceramide

21 n activation in talin-deficient cells with a beta1-integrin activating antibody normalized both VE-ca

22 icking mutant talin1(S425D) led to increased beta1 integrin activation and generated biologic effects

23 showed that KRIT1 functions as a switch for beta1 integrin activation by antagonizing ICAP1-mediated

24 ta3 in human erythroleukemia (HEL) cells and beta1 integrin activation in macrophage-like RAW264.1 ce

25 ediated phosphorylation of talin1 leading to beta1 integrin activation is a novel mechanism that incr

26 ession, reduced Vegfr2 expression, decreased beta1 integrin activation, and disrupted downstream FAK/

27 that talin1, but not talin2, is important in beta1 integrin activation.

28 is study, we identified a novel mechanism of beta1 integrin activation.

29 le for talin1 phosphorylation and subsequent beta1 integrin activation.

30 2 and Tie2 expression with an enhancement in beta1 integrin activation.

31 ts from these mice show unaltered beta3- and beta1-integrin activation and consequently normal adhesi

32 Restoring beta1-integrin activation in talin-deficient cells with

33 resses result in a transcellular gradient in beta1-integrin activation with vinculin, focal adhesion

34 Notably, SCs in aged mice show altered beta1-integrin activity and insensitivity to Fgf2.

35 Augmenting beta1-integrin activity with a monoclonal antibody resto

36 Loss of AMPK promotes beta1-integrin activity, the formation of centrally loca

37 Transient expression of tensins increases beta1-integrin activity, whereas tensin silencing reduce

38 g either talin or kindlin failed to activate beta1 integrins, adhere to fibronectin (FN) or maintain

39 ontrols surface topology of nanometer-scaled beta1 integrin adhesion domains in cis, whereas its liga

40 Among the identified hits, we confirmed an beta1-integrin agonist, pyrintegrin, as a podocyte-prote

41 ex and is not a function of either alpha5 or beta1 integrin alone.

42 ) was required for the induction of integrin beta1, integrin-alpha V, and integrin-alpha 5 for adhesi

43 Indeed, inhibition of beta1 integrins also leads to loss of electrotaxis in ke

44 i-dependent glycosylation and trafficking of beta1 integrin and decreased phosphorylation of focal ad

45 CD47 loss is linked to decreased epithelial beta1 integrin and focal adhesion signaling, as well as

46 zed that the collaborative signaling between beta1 integrin and gp130 (IL-6 beta receptor, IL-6 signa

47 izes with and regulates the levels of active beta1 integrin and of phosphorylated FAK and ERK.

48 tosis, as monitored using antibody-clustered beta1 integrin and previous studies on other proteins, w

49 B1 cells constitutively expressed activated beta1 integrin and relocated from the peritoneum to the

50 nalling via controlling its interaction with beta1 integrin and thus ensures proper development of ly

51 ar matrix (ECM) also converge on GIV-GEF via beta1 integrins and that focal adhesions (FAs) serve as

52 ression by influencing the crosstalk between beta1 integrins and Twist to increase VEGF production.

53 confirmed that level of bisecting GlcNAc on beta1-integrin and N-cadherin was increased in Fut8(-/-)

54 cal adhesions, cadherin-11 co-localizes with beta1-integrin and paxillin and physically interacts wit

55 d a novel subset of vesicles containing both beta1-integrin and Rab13.

56 Expression of the modified CLC reduces beta1-integrin and transferrin receptor recycling, as we

57 rimary human TM cells induces aggregation of beta1-integrin and upregulation of alpha-smooth muscle a

58 ned by estradiol-mediated transactivation of beta1-integrins and tropomyosin receptor kinase B (trkB)

59 beta1D integrin and other costameric proteins were lost

60 ional beta-catenin, stimulates clustering of beta1 integrins, and enhances the conformationally activ

61 eptor-beta, transactivates synaptic TrkB and beta1-integrin, and via mechanisms dependent on integrin

62 Here we show that Thy-1 supports beta1 integrin- and syndecan-4 (Syn4)-mediated contracti

63 Altogether, our findings demonstrate that beta1-integrin- and KV1.3 channel-dependent signaling st

64 y, the formation of centrally located active beta1-integrin- and tensin-rich mature fibrillar adhesio

65 face beta1-integrin internalization via anti-beta1-integrin antibodies or the RGD peptide ligand-or b

66 ignificantly inhibited in cells treated with beta1 integrin antibody or Rap1A siRNA.

67 A functional-activating beta1-integrin antibody rescued Hcy-suppressed adhesion

68 We previously showed that beta1 integrins are activated in metastatic prostate can

69 However, how beta1 integrins are activated in PCa cells is unknown.

70 In sum, developmental beta1-integrins are indispensable for OFC function later

71 hile that thinned Ld lipid domains increased beta1-integrin-Arg-Gly-Asp-peptide affinity and valency,

72 human aortic endothelial cells, BA increased beta1-integrin-Arg-Gly-Asp-peptide affinity by 18% with

73 hmidtea mediterranea as a model, we identify beta1-integrin as a crucial regulator of blastema archit

74 the PKC- and CaMKII-dependent activation of beta1-integrins, as well as their exocytosis.

75 promoted cell migration and colocalized with beta1 integrin at sites of cell adhesion and at the lead

76 rphogenesis and promotes the accumulation of beta1 integrin at sites of failed angiogenic sprouting.

77 dy or endothelial cell-specific depletion of beta1 integrin attenuated FMD of the femoral artery, and

78 arly endosome disrupts eventual recycling of beta1 integrins back to the cell surface, resulting in d

79 nockdown retarded the efficient recycling of beta1-integrin back to the plasma membrane following nor

80 beta1 integrins (beta1) transduce mechanical signals in

81 rming growth factor-beta1 precursor (pro-TGF-beta1), integrins bind to the prodomain, apply force, an

82 h frequency ultrasound, we demonstrated that beta1 integrin-blocking antibody or endothelial cell-spe

83 Notably, injection of beta1 integrin-blocking antibody or tamoxifen-induced en

84 aA directly affected the amount of host cell beta1 integrin but not other cellular integrins.

85 plasma membrane expression and activation of beta1 integrins, but not alpha4, alpha5, or alpha6 integ

86 e hydrogen bonds were not observed in talin1/beta1-integrin, but did exist in talin1(C336S)/beta1-int

87 ip binding and reduces surface expression of beta1-integrin by interference with recycling following

88 alpha-actinin promote talin association with beta1-integrin by restricting the motion of the cytoplas

89 Here the authors develop beta1 integrins carrying traceable tags in the extracell

90 tion by sema3E in trans regulates individual beta1 integrin catch bonds.

91 ke serine proteases with aprotinin prevented beta1 integrin/CDCP1 complexing and downstream FAK/Akt s

92 X4, reduced monocyte migration and decreased beta1-integrin cell surface expression.

93 In addition, analysis of beta1 integrin clustering by super-resolution imaging de

94 Loss of plexinD1 expression reduces beta1 integrin clustering, thereby diminishing avidity,

95 d beta1-integrin receptors, resulting in Met/beta1-integrin co-internalization and co-accumulation on

96 Thus, c-Met and beta1-integrin co-internalize and become progressively r

97 Additionally, beta1 integrin-cofilin signaling was triggered by the ex

98 ta1-integrin, but did exist in talin1(C336S)/beta1-integrin complex.

99 in cell cultures and in live animals, active beta1 integrin complexed preferentially with functionall

100 Further, using beta1 integrins containing a HaloTag in combination with

101 Importantly, beta1 integrins containing an extracellular pH-sensitive

102 These beta1 integrins control distinct antifungal effector fun

103 We further show that beta1-integrin cooperates with fibroblast growth factor

104 in and the membrane-distal NPxY motif in the beta1 integrin cytoplasmic domain.

105 1-integrin R760, and between talin2 K327 and beta1-integrin D759.

106 corrected reward-related decision making in beta1-integrin-deficient males.

107 Remarkably, beta1 integrin deletion, specifically in MKs, restores t

108 not observed in mice with neuronal-targeted beta1-integrin deletion, supporting the hypothesis that

109 We found that beta1 integrin-dependent cell adhesion is critical for s

110 mesenchymal cells both in vivo and in vitro beta1 integrin-dependent cell adhesion relied on the rel

111 hed Galpha13-beta1 interaction and inhibited beta1 integrin-dependent cell spreading and migration.

112 These complexes are involved in promoting beta1 integrin-dependent directional migration in undiff

113 We also found that this phenotype relies on beta1 integrin-dependent local activation of the small G

114 o Tie2 increases Tie1-Tie2 interactions in a beta1 integrin-dependent manner and that Tie1 regulates

115 that the Galpha13-beta1 interaction mediates beta1 integrin-dependent Src activation and transient Rh

116 LPA initiates EMT in ovarian tumors through beta1-integrin-dependent activation of Wnt/beta-catenin

117 This beta1-integrin-dependent c-Met-sustained signalling on A

118 ion was also identified as a novel target of beta1-integrin-dependent TUDC action, which is frequentl

119 diminished VEGF production, and knockdown of beta1 integrins diminished Twist and VEGF production by

120 mmunoprecipitation studies demonstrated that beta1-integrin directly interacts with the bone morphoge

121 cal correction of ceramide levels-normalizes beta1-integrin distribution and sphingosine levels in CF

122 beta1-integrins downregulate acid ceramidase expression,

123 Whether beta1 integrin ectodomains visit conformational states s

124 Silencing beta1 integrin efficiently inhibited RCP-induced Slug ex

125 In the absence of Ift20 function, beta1 integrins endocytosed during FA disassembly are no

126 Moreover, beta1 integrin engagement and mechano-sensitive cues, su

127 emodeling of the perineuronal network, and a beta1-integrin/ERK pathway.

128 echanotransducers (focal adhesion kinase and beta1-integrin) ex vivo A 3-week low-energy shockwave re

129 ngs in other organs, loss of JAM-A decreased beta1 integrin expression and impaired filamentous actin

130 Differences in the chemokine receptor and beta1 integrin expression profiles of progenitors betwee

131 rular tuft and their acquisition of CD44 and beta1 integrin expression.

132 tion, adhesion, and migration and suppressed beta1-integrin expression and activity in human CD34(+)

133 This study suggested that COX-2 upregulates beta1-integrin expression and cell invasion in NSCLC by

134 nt study investigated the effect of COX-2 on beta1-integrin expression and cell invasion in NSCLC.

135 FoxC2 siRNA suppressed beta1-integrin expression and EP1-mediated cell invasion

136 Thus beta1-integrin expression by EZCs reduces movement of BM

137 Prostaglandin E2 (PGE2) treatment increased beta1-integrin expression in NSCLC cell lines.

138 EP1 siRNA blocked PGE2-mediated beta1-integrin expression.

139 2 and p38 inhibitors suppressed EP1-mediated beta1-integrin expression.

140 ts show that CM Tln2 is essential for proper beta1D-integrin expression and that Tln1 can substitute

141 Furthermore, our data implicates beta1 integrin, FAK, and paxillin in mediating the obser

142 down-regulated under normoxic condition; (2) beta1 Integrin/FAK signaling pathway was activated in my

143 t CDCP1 cleavage, occurring at the apex of a beta1 integrin/FAK/PI3K/Akt signaling cascade, may repre

144 Blocking endocytosis or endosomal Met/beta1-integrin/FAK signaling profoundly inhibits the onc

145 ECM signals through a beta1-integrin/FAK/p190RhoGAP complex to downregulate a

146 Surprisingly, however, the major leukocyte beta1 integrin family member, alpha4beta1, was only part

147 uction of beta1D integrin isoform and active beta1 integrin from the buoyant domains in the heart; (4

148 Ablation of beta1-integrin from EZCs in vivo reduced the number of E

149 ant role for beta4GalT1 in the regulation of beta1 integrin function and signaling during thrombopoie

150 d FMD of the femoral artery, and blocking of beta1 integrin function did not further decrease FMD in

151 KCa1.1 channels regulate beta1-integrin function and cell adhesion in rheumatoid

152 ignaling mechanism by which KCa1.1 regulates beta1-integrin function and therefore invasiveness of RA

153 of KIND1, a cytoskeletal protein involved in beta1-integrin function, causes Kindler syndrome, a gene

154 a independent and dependent on regulation of beta1-integrin gene expression by NR4A1 which can be inh

155 We show that although short-term loss of beta1-integrin has no obvious consequences for normal li

156 Contrary to beta1 integrins, high tension increases beta3 integrin r

157 yocyte Cav3 correlates with increased active beta1 integrin in adult CM; (5) in vivo pressure overloa

158 stal NPxY motif in the cytoplasmic domain of beta1 integrin in early endosomes.

159 We show that AP-1B colocalized with beta1 integrin in focal adhesions during cell migration

160 In this study, the functional importance of beta1 integrin in lung epithelium during mouse lung deve

161 administration reduced the levels of active beta1 integrin in the podocytes, which was prevented by

162 nd to impede interactions between VEGFR3 and beta1 integrin in vitro and in vivo, and endothelial cel

163 Herein, we investigated the role of beta1 integrins in regulating this process.

164 Mechanistically, loss of beta1-integrin in hepatocytes impairs ligand-induced pho

165 First, loss of beta1-integrin in hepatocytes with liver injury triggere

166 rucial role and novel mechanism of action of beta1-integrins in liver regeneration and demonstrate th

167 Loss of beta1-integrin increased SMAD1/5/8 and p38 signaling, su

168 oop required for rapid recycling of EGFR and beta1 integrins, increased focal adhesion turnover, and

169 Conditional knock-out of beta1-integrin increases GFAP expression and astrocytic

170 We demonstrate that expression of beta1-integrin increases in EZCs following SCI in mice.

171 ization and homing to the injured vessel via beta1-integrin inhibition, which partially contributes t

172 sor AMP-activated protein kinase (AMPK) as a beta1-integrin inhibitor in fibroblasts.

173 beta1- and beta3-integrins, and unlike other beta1-integrin inhibitors which induce prometastatic bet

174 iated protein-1) to the cytoplasmic tails of beta1 integrins inhibits integrin activation.

175 nd C4-2B4 PCa cells, decreased activation of beta1 integrins, integrin-mediated adhesion, motility an

176 CagA translocation by Hp is mediated by beta1 integrin interaction of the cag-T4SS.

177 ing this vicious cycle by triggering surface beta1-integrin internalization via anti-beta1-integrin a

178 egrin by competing with talin for binding to beta1-integrin intracellular domain.

179 Upon ligand binding in various cells, the beta1 integrin is internalized, traffics to early endoso

180 Our data suggest that endothelial beta1 integrin is required for both acute and chronic wi

181 Here we show that beta1-integrin is an essential niche molecule that maint

182 e hypothesized that the cell adhesion factor beta1-integrin is essential to OFC function, anticipatin

183 reveal that a cell adhesion protein termed "beta1-integrin" is necessary for OFC neuronal maturation

184 veolae; (3) loss of Cav3 caused reduction of beta1D integrin isoform and active beta1 integrin from t

185 tion, although levels of the muscle-specific beta1D-integrin isoform were reduced by 50%.

186 elial cell-specific deletion of the gene for beta1 integrin (Itgb1) inhibited both arteriogenesis and

187 On laminin, which binds APP and beta1 integrins (Itgb1), DS neurons formed enlarged and

188 c astrogliosis after conditional deletion of beta1-integrin (Itgbeta1).

189 nt inhibition of hepatocyte proliferation by beta1-integrin knockdown or p21 overexpression, resultin

190 integrin activation, and restore adhesion in beta1 integrin knockout fibroblasts.

191 ic responses were also absent in conditional beta1-integrin knockouts, and with inhibition of matrix

192 nt study, we demonstrate that RCP stabilizes beta1 integrin leading to increased beta1 integrin level

193 tion and downstream activation/clustering of beta1 integrin, leading to AML cell survival via activat

194 isrupting TPC function halted trafficking of beta1-integrin, leading to its accumulation in EEA1-posi

195 abilizes beta1 integrin leading to increased beta1 integrin levels and activation of a signaling casc

196 n stress fibers, focal adhesions, and active beta1-integrin levels in cultured cells.

197 latelets lacking beta4GalT1 adhere avidly to beta1 integrin ligands laminin, fibronectin, and collage

198 A activity is critical for cell migration on beta1 integrin ligands.

199 were resilient to OFC (but not hippocampal) beta1-integrin loss.

200 brotic skin by activating an LTbeta receptor/beta1 integrin (LTbetaR/beta1 integrin) pathway on ADSCs

201 f the molecular brightness of mCherry-tagged beta1-integrins measured using fluorescence correlation

202 the loss of TGF-beta signaling and elevated beta1-integrin mechanosignaling engaged a positive feedb

203 P1GAP levels in injured podocytes maintained beta1 integrin-mediated adhesion and prevented cellular

204 e shown that collaborative signaling between beta1 integrin-mediated adhesion to fibronectin and inte

205 ncogenic signaling pathways, including EGFR, beta1 integrin, MEK, and AKT, leading to loss of tissue

206 2 expression promotes the formation of dense beta1 integrin membrane clusters.

207 icipating developmental windows during which beta1-integrins might be more influential than others.

208 bitors, we define here a MAP4K4-moesin-talin-beta1-integrin molecular pathway that promotes efficient

209 own or treatment with OS2966, a neutralizing beta1 integrin monoclonal antibody, attenuated aggressiv

210 hanism of developmental failure in implanted beta1 integrin-null blastocysts and found that primitive

211 segregation phenotype was also reproduced in beta1 integrin-null embryoid bodies, in which primitive

212 Targeting this mechanosensing alpha6(beta1)-integrin offers a novel anti-fibrotic strategy ag

213 requires multimerization and associates with beta1 integrin on the cell surface.

214 he formation of ceramide platforms that trap beta1-integrins on the luminal pole of bronchial epithel

215 Importantly, beta1-integrins operate during a critical period equival

216 of beta3 integrin or FAK inhibitor, but not beta1 integrin or integrin-linked kinase inhibitor, prev

217 g in stimulatory or inhibitory ways with its beta1 integrin or Plexin C1 receptors, respectively.

218 In contrast, in vivo blocking of beta1 integrins or alpha4 integrins did not affect lung

219 Knockdown of beta1-integrins or inhibition of cellular contractility

220 motion and metastasis of tumor cells through beta1 integrin partnering.

221 llectively, these findings implicate a Rap1A/beta1 integrin pathway, activated downstream of G-protei

222 Targeting the COX-2/EP1/PKC/MAPK/E2F-1/FoxC2/beta1-integrin pathway might represent a new therapeutic

223 g an LTbeta receptor/beta1 integrin (LTbetaR/beta1 integrin) pathway on ADSCs.

224 Thus, beta1 integrins promote resistance to antiangiogenic the

225 In cells growing in suspension, beta1-integrin promotes sustained c-Met-dependent ERK1/2

226 er, ZNF304 is a transcriptional regulator of beta1 integrin, promotes cancer cell survival and protec

227 Furthermore, beta4 and beta1 integrin protein and mRNA expression is elevated i

228 ophage chemoattractant via activation of the beta1 integrin-PYK2 pathway in macrophages.

229 g key hydrogen bonds between talin2 N326 and beta1-integrin R760, and between talin2 K327 and beta1-i

230 The binding of Inv to beta1 integrins rapidly induces IL-18 mRNA expression, s

231 agen and lymphangiogenesis via activation of beta1-integrin receptor.

232 riants enhance interactions with the Met and beta1-integrin receptors, resulting in Met/beta1-integri

233 id-induced epithelial MV miR-17/221 promoted beta1 integrin recycling and presentation back onto the

234 miR-17/221 that in turn modulates macrophage beta1 integrin recycling, promoting macrophage recruitme

235 ha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane.

236 kdown of STXBP4 also substantially inhibited beta1-integrin recycling in human monocytes.

237 ubiquitin-mediated degradation and promoting beta1-integrin recycling.

238 Ablation of beta1-integrin reduced overall levels of BMP receptors b

239 stimulation disrupts the assembly of ILK and beta1 integrin, releasing the integrin to enable its int

240 The paraoxon-induced beta1 integrin response was targeted to synapses, and th

241 extent of synaptic decline and the level of beta1 integrin responses.

242 beta1-integrin(RNAi) animals formed small head blastemas

243 ls and progenitor cells were mislocalized in beta1-integrin(RNAi) animals without significantly alter

244 Therefore, beta1-integrin senses the SC niche to maintain responsiv

245 beta1 integrins signal through the Abl2/Arg (Abl-related

246 the resulting lack of glycosylation enhances beta1 integrin signaling leading to dysplastic MKs with

247 ein kinase (MAPK) downstream of PKCalpha and beta1 integrin signaling when CD82 is overexpressed.

248 Sig1R promoted the formation of hERG/beta1-integrin signaling complexes upon extracellular ma

249 well as short-hairpin RNA downregulation of beta1 integrin significantly reduced FAK/Akt phosphoryla

250 We discovered that OFC-selective beta1-integrin silencing before adolescence, but not lat

251 beta1-integrin silencing suppressed COX-2-mediated tumou

252 ted gene deletion or intravenous delivery of beta1-integrin siRNA formulated into nanoparticles that

253 e marrow stromal cells (BMSC) showed similar beta1 integrin-specific enhancement of PYK2 and STAT3 si

254 probability density plots thus revealed that beta1-integrin-specific interactions are predominately a

255 Correspondingly, YAP1-LOX and beta1 integrin-SPP1 signaling correlates positively with

256 ly, survival signaling in melanoma cells via beta1-integrin, Src, and FAK.

257 ancer cell aggressiveness through sequential beta1 integrin stabilization, activation of an ILK/EGFR/

258 Talin-dependent activation of EC beta1-integrin stabilizes VE-cadherin at endothelial jun

259 extend beyond those requiring binding to the beta1 integrin subunit NPxY motif.

260 Knocking down DDR2, but not the beta1 integrin subunit, a common subunit for all collage

261 ide or with a monoclonal antibody binding to beta1-integrin subunit and binding assays in different c

262 subunit of KCa1.1 coimmunoprecipitates with beta1 integrins, suggesting that this physical associati

263 oss of AMPK up-regulates tensins, which bind beta1-integrins, supporting their activity and promoting

264 wever, this effect was not due to changes in beta1 integrin surface expression or activation.

265 , which also elicited enhanced beta2 but not beta1 integrin surface expression, suggesting increased

266 Furthermore, expression of SNX31 rescues beta1 integrin surface levels and stability in SNX17-dep

267 Similarly like SNX17, binding of SNX31 with beta1 integrin tails in early endosomes occurs between t

268 ly diminished the interaction of talin2 with beta1- integrin tails.

269 ow here that talin2 has a higher affinity to beta1-integrin tails than talin1.

270 -/-) mice exhibited reduced levels of active beta1 integrin that were responsible for reduced RhoA ac

271 Complexing of beta1 integrin the 70-kDa with CDCP1 fragment induced in

272 h of activating and inhibitory antibodies to beta1 integrins, the conformational states that these an

273 ate that GMFG mediates the ubiquitination of beta1-integrin through knockdown or overexpression of GM

274 lted in aberrant trafficking of internalized beta1 integrin to late endosomes and its ultimate degrad

275 pecifically the B isoform (alpha6B), couples beta1-integrin to mediate MMP-2-dependent pericellular p

276 nd trafficking-relevant site Thr(788/789) of beta1-integrin to stimulate the PKC- and CaMKII-dependen

277 tamine dependent and triggered by binding of beta1-integrin to vascular cell adhesion molecule 1 (VCA

278 vitro and in vivo, at least in part through beta1-integrin translocation leading to fibronectin asse

279 oreover, the binding of Abeta42 oligomers to beta1-integrin triggers the cofilin activation, and in t

280 f GMFG in monocyte chemotaxis, adhesion, and beta1-integrin turnover.

281 ctivated forms of the BDNF receptor TrkB and beta1-integrins, two synaptic receptors that engage acti

282 Dysregulation of beta1-integrin underlies Kindler syndrome skin fragility

283 y, but rather by matrix architecture-induced beta1-integrin upregulation.

284 silencing suppressed EP1-mediated FoxC2 and beta1-integrin upregulation.

285 duces membrane recruitment and activation of beta1 integrin via the low density lipoprotein receptor-

286 y beta2-integrin (CD11c/CD18) that activates beta1-integrin (VLA-4) to bind endothelial VCAM-1.

287 resulting in differential regulation of the beta1 integrins VLA3 (alpha3beta1) and VLA5 (alpha5beta1

288 Here we show that beta1 integrin was dependent on AP-1B and its coadaptor,

289 ed to synapses, and the two-fold increase in beta1 integrin was selective as other synaptic adhesion

290 Conversely, ectopic expression of beta1 integrin was sufficient to induce Slug expression.

291 Conversely, eCRT induction of alpha5 and beta1 integrins was not mediated by TGF-beta signaling n

292 ol-I binding molecules, an antibody-blocking beta1-integrin was used.

293 ial adhesins invasin and YadA with host cell beta1 integrin, we compared the sterol dependence of wil

294 COX-2 and beta1-integrin were co-expressed in NSCLC tissues.

295 FlnA loss leads to diminished expression of beta1-integrin, whereas FlnB loss promotes integrin expr

296 ment membrane extracellular matrix (ECM) via beta1 integrins which activate both ILK and Rac1 and are

297 ZNF304 transcriptionally regulates beta1 integrin, which subsequently regulates Src/focal a

298 rolling the affinity states of two different beta1 integrins, which in turn elicit distinct effector

299 parallel, NR4A1 also regulated expression of beta1-integrin, which with PAX3-FOXO1A, contributed to t

300 ort the generation of functional recombinant beta1 integrins with traceable tags inserted in an extra