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1 resence and absence of the osmolyte, glycine betaine.
2 xocobalamin, methylcobalamin, methionine and betaine.
3 s, was up-regulated during growth on glycine betaine.
4 miting the ability of most plants to produce betaine.
5 carry out corrinoid methylation with glycine betaine.
6 ts with severe MTHFR deficiency treated with betaine.
7 x S) plants showed increased accumulation of betaine.
8 e MCD diet, and these improved modestly with betaine.
9 pB catalyzes anoxic demethylation of proline betaine.
10 mechanism that is distinct from glycine and betaine.
11 nhanced sorption of long-chain fluorotelomer betaines.
12 s by deprotonation of heterocyclic mesomeric betaines.
13 in the iminophosphorane intermediate to give betaines.
14 ormation of cyclic intermediates rather than betaines.
15 t sizes: choline, 0.35 (95% CI: 0.12, 0.57); betaine, 0.29 (95% CI: 0.01, 0.58); methionine, 0.31 (95
16 3-yl)quinolinium derivative or the mesomeric betaine 2-(1-methylquinolinium-3-yl)-1,3-dioxo-2,3-dihyd
17 calculations on the structures of mesomeric betaine 22a, the carbene 23a, and the mechanisms of the
18 - and 4-substituted benzoates, the mesomeric betaines 3- and 4-[(1-methylquinolinium-3-yl)ethynyl]ben
19 proline betaine (stachydrine), beta-alanine betaine, 4-guanidinobutyric acid, trigonelline, N,N,N-tr
20 tinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernati
22 those of 6:2 fluorotelomer sulfonamidoalkyl betaine, 6:2 and 8:2 fluorotelomer sulfonates, and short
25 tion of either (a) a novel drink powder (4 g betaine, 800 mug folic acid, 5.2 mug vitamin B12, and 2.
26 ines (8:2-FTAB and 10:2-FTAB), fluorotelomer betaines (9:3-FTB, 11:3-FTB and 9:1:2 FTB) and 6:2 fluor
28 lamp association is also promoted by glycine betaine, a zwitterionic compound that accumulates intrac
34 betC genes, encoding choline dehydrogenase, betaine aldehyde dehydrogenase and choline sulfatase, re
35 ce-associated protein/B12D-related protein1, Betaine aldehyde dehydrogenase, and Unknown protein5.
37 establish for identifying and characterizing betaine aldehyde provides a framework for developing add
38 vitro assays and a crystal structure suggest betaine aldehyde targets the gut microbial enzyme cholin
41 esis and transport, respectively, of glycine betaine, an osmoprotectant used during osmotic stress.
42 s in chestnut, no one has appeared so far on betaines, an important class of nitrogen compounds ubiqu
43 iotracers are readily oxidized to respective betaine analogs, with metabolites detectable in plasma s
44 fore, the pre-harvest application of glycine-betaine and A. nodosum can be a good alternative to prom
46 rapid biosynthesis of predominantly glycine betaine and an increased root-to-shoot ratio to explore
47 ored partitioning of dietary choline between betaine and CDP-PC among NP (MTHFR rs1801133 and MTR rs1
50 free and bound phenolic acids (PAs) profile, betaine and choline contents were quantified in six diff
51 recombinant DSY3156 protein converts glycine betaine and cob(I)alamin to dimethylglycine and methylco
53 concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphisms with effe
55 nventional preferential solvation arguments, betaine and glycine both increase the surface tension at
58 ionally, PDX increased the levels of glycine betaine and L-carnitine in plasma samples, which correla
59 e-carbon metabolism, associated with glycine betaine and L-carnitine, and bile acid and tryptophan me
60 r database (MGDB) including folate, choline, betaine and methionine, for use in the European Prospect
63 se in production of osmoprotectants, such as betaine and polyols, and metal-chelating organic acids.
64 ied surfactants with functionalities such as betaine and quaternary ammonium was improved with the Me
65 ract of C. sapidus, while homarine, lactate, betaine and taurine characterized E. verrucosa and C. pa
66 ylates Co(I)-MtqC in the presence of proline betaine and that other quaternary amines are much less p
67 tus was low and that the association between betaine and tHcy depended on folate status at 24-27 and
68 choline and its closely related metabolites, betaine and TMAO, with linear growth and stunting in you
71 tnut cultivated in Italy, the composition of betaines and ammonium compounds intermediates of their b
72 ccurs around neutral pH, while the two other betaines and PFOAAmS have pK(a) values that are outside
74 eous solution, the N-methyl-6-oxyquinolinium betaine, and analyze it in terms of far IR and THz frequ
76 f labile methyl groups (choline, methionine, betaine, and folate) is important for normal liver funct
77 flours, whereas an uncommon betaine, valine betaine, and glutamine betaine were present only in flou
78 ee osmolytes, trimethylamine N-oxide (TMAO), betaine, and glycine, on the hydrophobic collapse of an
80 rbon cofactors vitamins B6 and B12, choline, betaine, and methionine and neural tube defect (NTD) out
84 edian (25th, 75th percentile) serum choline, betaine, and TMAO concentrations were 6.4 (4.8, 8.3), 12
85 tion coefficients of age with serum choline, betaine, and TMAO were -0.57 (P < 0.0001), -0.26 (P < 0.
86 ound that concentrations of the methyl donor betaine are decreased in MS cortex and are correlated wi
92 hylation of homocysteine to methionine, with betaine as the methyl donor, and has previously been tho
93 ach to preventing diabetes, and increases in betaine at 2 years were also associated with lower diabe
95 s that followed the accident, as did several betaine-based PFASs (8:2-FTAB, 10:2-FTAB, 9:3-FTB, 11:3-
100 nd biomarker-derived intake (urinary proline betaine biomarker) data from participants (n = 565) as p
102 tudies using two UCST-type TRILs, protonated betaine bis(trifluoromethyl sulfonyl)imide ([Hbet][Tf2N]
104 er-deficit stresses which de novo synthesize betaine by the stepwise methylation of glycine, catalyze
107 d, inosine, inosine monophosphate, creatine, betaine, carnosine and hypoxanthine) out of eighteen met
108 We have developed a new class of cinchonium betaine catalysts bearing both a base moiety and an arom
109 ed circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal s
112 illatory production of S-adenosylmethionine, betaine, choline, phosphocholine, glyceophosphocholine,
114 1, aflatoxin G1, aspergillic acid, aspyrone, betaine, chrysogine, deacetyl parasiticolide A, flufuran
115 rvest application of salicylic acid, glycine-betaine complex and seaweed extract (Ascophyllum nodosum
116 identified, and non-fluorinated zwitterionic betaine compounds, which are considered to be replacemen
118 We included 955 pregnant women whose plasma betaine concentrations were measured at 26-28 wk of gest
120 our knowledge, DSY3156 is the first glycine betaine:corrinoid methyltransferase described, and a des
121 evelopment, we hypothesized that choline and betaine could also be positively related to academic ach
122 t than after the RG diet, whereas melatonin, betaine, creatine, acetylcholine, aspartate, hydroxyprol
123 monstrate that the oxidative choline-glycine betaine degradation pathway can operate in a fully rever
125 tood about the importance of the alternative betaine-dependent methylation pathway-catalyzed by betai
128 a biomarkers of choline metabolism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TM
129 oassay and plasma concentrations of choline, betaine, dimethylglycine, retinol, essential fatty acids
130 f organic compatible solutes such as glycine betaine does not perturb the functioning of cytoplasmic
131 ed in conjunction with the methylation agent betaine, dramatically increased survival in mice fed a n
132 ine, acetylcholine, L-carnitine, and glycine betaine effectively.The choline-binding protein ChoX exh
134 diastereoselectivities are determined in the betaine forming step and are more variable as a result.
135 onamide alkylbetaines (FTABs), fluorotelomer betaines (FTBs), 6:2 fluorotelomer mercaptoalkylamido su
137 tSs), zwitterionic fluorotelomer sulfonamido betaines (FtSaBs), and cationic 6:2 fluorotelomer sulfon
141 ve extraordinarily high affinity for glycine betaine (GBT), with half-saturation (K (s) ) values arou
143 we also detected several metabolites (e.g., betaine, guanidine acetic acid, and 2-aminoheptanoic aci
144 oline, and methionine and moderate intake of betaine had approximately half the risk of an NTD-affect
146 arnitine, such as trimethylamine N-oxide and betaine, have recently been identified as novel risk fac
147 ine levels of betaine, also known as glycine betaine (hazard ratio 0.84 per SD log metabolite level,
152 AM from betaine (N,N,N-trimethylglycine) via betaine-homocysteine methyltransferase (BHMT), which is
153 e-dependent methylation pathway-catalyzed by betaine-homocysteine methyltransferase (BHMT)-for establ
155 A (Mat1a), adenosylhomocysteinase (Achy) and betaine-homocysteine S-methyltransferase (Bhmt) mRNA and
156 small heterodimer partner [SHP]-null mice), betaine-homocysteine S-methyltransferase (Bhmt), or both
161 first time the occurrence of pipecolic acid betaine (homostachydrine) and its precursor 1,2-N-methyl
163 The cyclizations involve the formation of betaines (imidazoliumylpyrrolides) under basic condition
164 oligopeptide importer (oppABCDF) and glycine betaine importer (gbuABC) allowed DeltadacA mutants to g
165 ittle literature available on the content of betaine in cereal products, nor on betaine intake from c
171 ed maturing oocytes autonomously synthesized betaine in vitro in the presence of choline, whereas thi
172 cereal foods provide approximately 60-67% of betaine in Western diets, and 20-40% of betaine in South
173 We report the LC-ESI-MS/MS determination of betaines in commercial flours of cereals and pseudocerea
174 Together, these data indicate that dietary betaine increases Fgf21 levels to improve metabolic heal
175 bolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understand
178 be due to improved liver metabolism because betaine is a methyl-donor in liver methylation but is no
181 ntify genetic factors associated with plasma betaine levels and determine their effect on risk of cor
185 ol-to-sulfolipid and a phosphatidycholine-to-betaine lipid replacement followed by a late accumulatio
190 both de novo synthesis and uptake of glycine betaine, matching the biosynthesis and transport systems
193 the nanomolar range for choline and glycine betaine, micromolar Kd for stachydrine and trigonelline
195 described, in which an imidazolium-aryloxide betaine moiety cooperates with a Lewis acidic metal cent
199 but only a few cell types generate SAM from betaine (N,N,N-trimethylglycine) via betaine-homocystein
200 that glycine betaine, trigonelline, proline betaine, N(epsilon)-trimethyllysine were metabolites com
201 ycerophosphocholine, phosphocholine, glycine betaine, N-methylproline, proline betaine (stachydrine),
203 s acute intake biomarkers of citrus (proline betaine), oily fish (methylhistidine), coffee (dihydroca
205 hat LuxR activates expression of the glycine betaine operon betIBA-proXWV, which enhances growth reco
208 the maximal current amplitudes achieved with betaine or choline, making monepantel a superagonist.
209 THFR deficiency, of whom at least 1 received betaine, or (2) single patients with severe MTHFR defici
210 tration (~10 mM) at which the KCl to glycine betaine osmoprotectant switch in H. halophila occurs is
213 taines, yet perfluorooctane sulfonamidoalkyl betaine (PFOSB) showed strong sorption in selected soils
216 ic analysis indicates this NRPS-like glycine betaine reductase is highly conserved and widespread in
217 immunoprecipitation experiments showed that betaine regulates metabolic genes in human SH-SY5Y neuro
222 nd methylation potential, higher creatinine, betaine, S-adenosylhomocysteine (SAH), and S-adenosylmet
223 oil increased several metabolites (glycine, betaine, serine and methionine) that are essential to th
224 ring a virus-mimetic zwitterionic surface, a betaine side chain and an ultralow critical micelle conc
225 e, glycine betaine, N-methylproline, proline betaine (stachydrine), beta-alanine betaine, 4-guanidino
227 to examine the association between maternal betaine status and neonatal birth size and adiposity in
231 ve metabolic health in mice and suggest that betaine supplementation merits further investigation as
233 lel with these beneficial metabolic effects, betaine supplementation robustly increased hepatic and c
236 gue-Dawley rats a control diet, MCD diet, or betaine-supplemented MCD (MCD+B) diet for 8 wk and colle
237 nine, N1-acetylspermidine, xanthine, uracil, betaine, symmetric dimethylarginine, and asymmetric-dime
239 hate (CDP)-choline pathway at the expense of betaine synthesis even when use of betaine as a methyl d
241 vel sulfating reagent, TriButylSulfoAmmonium Betaine (TBSAB), we developed a 3-step procedure using t
245 ze tetrahydrofolate methylation with proline betaine, thereby forming a key intermediate in the Wood-
246 A), alpha-linolenic acid (ALA), or ratios of betaine to choline and LA to ALA.The findings supported
250 sic conditions and the tautomerizaton of the betaines to the corresponding NHCs, which are the reacti
251 ars, amino acids, organic acids, choline and betaine) to determine whether the composition had change
252 eptides act as osmolytes, similar to glycine betaine, to disrupt intracellular osmotic pressure.
254 f height-for-age z score with serum choline, betaine-to-choline ratio, and TMAO-to-choline ratio were
256 ions were in opuD, encoding the main glycine-betaine transporter, and alsT, encoding a predicted amin
258 ificantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine beta
262 imal lowering of Hcy levels during long-term betaine treatment with a concomitant normalization of in
265 to all examined flours, whereas an uncommon betaine, valine betaine, and glutamine betaine were pres
266 s, polyunsaturated fatty acids, carotenoids, betaine, vitamins, fibre, minerals and polyphenols.
267 The mean +/- SD plasma concentration of betaine was 13.2 +/- 2.7 mumol/L (range: 5.3-25.0 mumol/
269 nitric oxide donor sodium nitroprusside, and betaine was able to rescue H3K4me3 levels and respirator
270 tment for covariates, higher maternal plasma betaine was associated with lower birth weight (beta: -5
272 (0.93-6.40); P trend = 0.08], whereas plasma betaine was inversely associated with colorectal cancer
274 velopment in surviving patients treated with betaine was normal in all 5 early-treated patients but i
276 es N-methyl proline during growth on proline betaine, we demonstrate that MtpB catalyzes anoxic demet
277 Using uptake experiments with (14) C-glycine betaine, we discovered that two strains of SAR11, Candid
278 Conversely, higher concentrations of plasma betaine were associated with a favorable cardiometabolic
279 ses in the concentration of the methyl donor betaine were correlated with decreases in histone H3 tri
280 wed that by 24-27 GW, both plasma folate and betaine were inversely associated with tHcy when folate
282 ommon betaine, valine betaine, and glutamine betaine were present only in flours of barley, rye, oat,
283 roposed piezolytes glutamate, sarcosine, and betaine were used, as well as solutions containing the d
284 graphy (TOF-CIC) revealed that fluorotelomer betaines were a substantial portion of the organofluorin
286 relatively stable ring-opened oxyphosphonium betaines were isolated for the first time from the Ph(3)
287 O and carnitine, and lower concentrations of betaine, were associated with greater insulin resistance
289 ), who presented with low plasma choline and betaine, were studied to determine the metabolic charact
290 intakes for each one-carbon cofactor except betaine, where the starkest contrast occurred in the mid
291 utyric-acid, hydroxy-hydrocinnamic acid, and betaine whereas Bifidobacterium was negatively associate
293 r along with diethanolamines and alkyl amido betaines, which were not found in the eight archived AFF
294 tions were the best overall common source of betaine, while the pseudocereal quinoa had the highest a
296 iense was found capable of growth on glycine betaine with electron acceptors such as nitrate or fumar
297 and its precursors (choline, carnitine, and betaine) with inflammatory and cardiometabolic risk biom
298 sed frequency of reactions to cocamidopropyl betaine, wool alcohol, lanolin, tixocortol pivalate, and
300 monium group is mitigated in polyfluoroalkyl betaines, yet perfluorooctane sulfonamidoalkyl betaine (