ライフサイエンスコーパス: biaryl

1 atropselective transformation of an existing biaryl.

2 ovide an expedient route to multifluorinated biaryls.

3 functional groups leading to silicon-bridged biaryls.

4 enzyme in the biosynthesis of axially chiral biaryls.

5 ducts that are oxidized to the corresponding biaryls.

6 sly inaccessible electron-poor/electron-poor biaryls.

7 nder mild conditions to form polysubstituted biaryls.

8 pling of different tetraaryl borates to give biaryls.

9 ective synthesis of unsymmetrical oxygenated biaryls.

10 hylene bridge is developed from N-sulfonyl-4-biaryl-1,2,3-triazole derivatives via Rh-catalyzed denit

11 ature, the obtained allenes rearrange to 1,3-biaryl-1-trifluoromethyl-1H-indenes.

12 arrier study was performed on eight tertiary biaryl 2-amides using variable-temperature (VT) NMR and

13 using dihalobenzamides for the synthesis of biaryl 5-phenylisoindolin-1-ones.

14 lactamization for closure of the 12-membered biaryl AB ring system, and the defined order of CD, AB,

15 A biaryl acyl sulfonamide hit from this library was elabor

16 The biaryl acyl sulfonamides reported herein may also offer

17 st interaction is efficiently antagonized by biaryl alpha-d-mannopyranosides.

18 range of functional groups, and a variety of biaryl amide derivatives were successfully prepared in g

19 nzo[d]imidazole platform that evolved from a biaryl amide lead.

20 report efficient syntheses of axially chiral biaryl amides in yields ranging from 80-92%, and with en

21 ed design, two novel series of highly potent biaryl amine mitogen-activated protein kinase kinase (ME

22 nthesis of sterically hindered atropisomeric biaryl amines.

23 actical access to certain structures such as biaryl amino phenols known as NOBINs in enantiopure form

24 Truncation of the S3 substituent of the biaryl aminothiazine 2, a potent BACE1 inhibitor, led to

25 pensive, robust, and convenient synthesis of biaryl and heterobiaryl compounds.

26 ssing firefly luciferase, we prioritized the biaryl and N-arylpiperazine analogues by oral bioavailab

27 the resting states are unsymmetrical Ni(II)-biaryl and Ni(II)-bithiophene complexes.

28 of adequate pai-pai interactions between the biaryl and the phosphine.

29 A wide range of biaryls and derivatives has been obtained, and a mechani

30 ation, all Ni-catalyzed routes to functional biaryls and heterobiaryls are now easily accessible.

31 ee transformation, leading to functionalized biaryls and ultimately furnishing drug-like small molecu

32 the reactions (no side-formation of arenes, biaryls, and C2F5 derivatives) has allowed for the isola

33 -R-allylpalladium complexes containing bulky biaryl- and bipyrazolylphosphines with extremely broad l

34 n by arylsilanes (Ar(2)-SiMe(3)) to generate biaryls (Ar(1)-Ar(2)), with little or no homocoupling (A

35 t, thus offering access to unexplored chiral biaryl architectures.

36 Multifluorinated biaryls are challenging to synthesize and yet are an imp

37 Distinct approaches to synthesize bis-azine biaryls are in demand as these compounds have multiple a

38 Atropisomeric (hetero)biaryls are motifs with increasing significance in ligan

39 ration of the biaryl axis (stereochemistry), biaryls are notoriously difficult to synthesize.

40 Azine-containing biaryls are ubiquitous scaffolds in many areas of chemis

41 Selected examples involving allenes, biaryls, arylamides and transient axially chiral short-l

42 Axially chiral biaryls, as exemplified by 1,1'-bi-2-naphthol (BINOL), a

43 Non-biaryl atropisomers are valuable in medicine, materials,

44 After extensive optimization, biaryl Au(I) catalyst 21 was found to overcome the inher

45 pling was developed for the synthesis of the biaryl axes present in useful P-chiral dihydrobenzooxaph

46 rphenyls bearing 1,2-type or 1,3-type chiral biaryl axes was achieved by HPLC on a chiral phase.

47 atropisomerism, with one or two stereogenic biaryl axes.

48 idative 2-naphthol coupling to establish the biaryl axial chirality.

49 regiochemistry) and the configuration of the biaryl axis (stereochemistry), biaryls are notoriously d

50 thesis (9a-11) hinted at the location of the biaryl axis and the presence of acetyl groups as importa

51 The presence of hindered rotation along a biaryl axis has conferred high selectivity to the compou

52 he introduction of hindered rotation along a biaryl axis has conferred high selectivity to the compou

53 was employed in the formation of the C9-C9' biaryl axis in 1.

54 coupling sequence for introduction of the AB biaryl axis of chirality (>20:1 dr), an essentially inst

55 ct to the configurational stability of their biaryl axis using dynamic chiral HPLC; subtle effects of

56 lling the otherwise configurationally labile biaryl axis.

57 xamples) can be synthesized from substituted biaryl azides at 60 degrees C using substoichiometric qu

58 stereoselective formation of carbazoles from biaryl azides.

59 we report the effect of force applied to the biaryl backbone of a bisphosphine ligand on the rate of

60 A catalyst that couples a photoswitch to the biaryl backbone of a chiral bis(phosphine) ligand, thus

61 tudy describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as potent anticancer agents

62 lpalladium complexes incorporated a range of biaryl/bipyrazolylphosphine ligands, while extremely bul

63 ring in N-phenylpyrazoles to afford either a biaryl bis-pyrazole (via dehydrogenative homocoupling) o

64 Specifically, we prepared the chiral biaryl bisphosphine ligand (TMG-SYNPHOS) containing 3,5-

65 bonylations, and two dehydrogenations, giant biaryl bisquinones (compounds 13, 14, 15, 18, and 21).

66 ly that this unusual mode of scission of the biaryl bond can occur in the C1,C1'-diprotonated form of

67 The congested N,C-biaryl bond establishes an axis of chirality that, for m

68 For example, NO(2) groups positioned over a biaryl bond exhibited similar influences as resonant ele

69 romobenzyltertiary alcohol to yield the homo-biaryl bond followed by intramolecular C-O bond formatio

70 The generation of 4 involves an unusual biaryl bond formation under reductive conditions.

71 , and a Suzuki homocoupling to forge the key biaryl bond.

72 restricted rotation about an axially chiral biaryl bond.

73 Biaryl bonds of the nonplanar p-terphenyl nuclei were co

74 n used to generate side chain to side chain, biaryl-bridged 14- to 21-membered macrocyclic peptides.

75 Biaryl bridges possessing three different configurations

76 nium salts in the synthesis of unsymmetrical biaryls, built around the seminal works of Pschorr, Gomb

77 ic method for the synthesis of atropisomeric biaryls by a cation-directed O-alkylation.

78 An efficient catalytic route to biaryls by employing (generally) only 0.25 mol % of Pd(O

79 Moreover, biaryl C-C coupling along with alkyl-aryl C-C coupling c

80 A range of bis-azine biaryls can be formed from abundant chloroazines using t

81 The leading biaryl carbamate demonstrated exceptional metabolic stab

82 Herein we demonstrate using a series of biaryl cation radicals with varying dihedral angles that

83 convergent syntheses utilize an enantiopure biaryl common intermediate, which is formed via an enant

84 ynthesis and evaluation of a guanidinomethyl biaryl compound {1-((4'-(tert-butyl)-[1,1'-biphenyl]-3-y

85 Axially chiral biaryl compounds are frequently encountered in nature wh

86 ides a useful method for the modification of biaryl compounds because the nitrile group can be readil

87 equential manner for the direct synthesis of biaryl compounds in excellent yields.

88 E as the catalyst system affords the desired biaryl compounds in good yields with excellent rates and

89 rylation of benzene enables the formation of biaryl compounds in the presence of aryl iodides.

90 oaryl bromides furnishes 1,2-azaborine-based biaryl compounds including 6-[pyrid-2-yl]-1,2-azaborines

91 lefination, acetoxylation, and iodination of biaryl compounds is reported.

92 a sustainable alternative for preparing N,O-biaryl compounds that are widely used as ligands and cat

93 ses of coherent charge-transfer mechanism in biaryl compounds the rates follow a squared cosine trend

94 amides for the synthesis of widely occurring biaryl compounds through N-C amide bond activation is re

95 ve synthesis that delivers chiral nonracemic biaryl compounds with excellent optical purity and good

96 ion of secondary alcohols and axially chiral biaryl compounds with selectivity factors of up to 37 an

97 been extended to intermolecular synthesis of biaryl compounds.

98 nature for the formation of atroposelective biaryl compounds.

99 pling of arenes provides efficient access to biaryl compounds.

100 n-2,1'-cyclohexa[2,5]diene]-3,4'-diones, and biaryl compounds.

101 rine content to systematically build complex biaryls containing between two and five Caryl-F bonds vi

102 ctive for the synthesis of heterobiaryls and biaryls containing electrophilic functionalities sensiti

103 med the foundation for the assembly of novel biaryls containing pyridine moieties with differently su

104 e direct formation of a variety of unnatural biaryl-containing amino acids in good to excellent yield

105 This same feature also enables biaryl-containing medium-sized rings to be prepared with

106 anthone scaffold followed by copper-mediated biaryl coupling allowed for efficient access to these co

107 Interestingly, this biaryl coupling also works in the presence of potassium

108 nd six steps, including a key Suzuki-Miyaura biaryl coupling and a directed remote metalation (DReM)-

109 loped employed an enantioselective oxidative biaryl coupling and a double cuprate epoxide opening, al

110 enzylamines undergo a one-pot N-deprotection/biaryl coupling followed by oxidation, thus offering an

111 he Suzuki-Miyaura coupling, an unprecedented biaryl coupling ortho to the borono group was observed.

112 complete stereocontrol observed in this key biaryl coupling step is due to the asymmetric induction

113 venture include a catalytic enantioselective biaryl coupling, a PIFA-induced naphthalene hydroxylatio

114 cal biaryls, indicative of a net Kumada-like biaryl coupling.

115 s macrocyclizations conducted using a Suzuki biaryl coupling.

116 is formed via an enantioselective catalytic biaryl coupling.

117 ing a "transition metal-free" intramolecular biaryl-coupling of o-halo-N-arylbenzylamines has been de

118 nough to mediate hindered, ortho-substituted biaryl couplings but mild enough for use on peptides and

119 The SET-induced biaryl cross-coupling reaction is established as the fir

120 sulting aryl radicals are engaged in (hetero)biaryl cross-coupling, borylation, and hydrogenation in

121 Biaryl cyclohexene carboxylic acids were discovered as f

122 In this process, three cyclopalladated biaryl derivatives have been isolated and characterized

123 itution reaction which yields axially chiral biaryl derivatives in excellent yields with e.r. values

124 boronic esters, leading to the synthesis of biaryl derivatives in good yields.

125 More lipophilic biaryl derivatives mostly displayed similar or reduced p

126 a 'one-pot' fashion to afford functionalized biaryl derivatives that, upon subsequent 'one-pot', high

127 ts, benzo-fused tetrahydroisoquinoline-based biaryl derivatives were obtained in overall high to exce

128 directing groups leading to functional biaryl derivatives, polyheterocycles and polydentate lig

129 palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination w

130 efficient access to chiral ortho-substituted biaryl diamines.

131 ct spectroscopy NMR studies suggest that the biaryl dihedral angle and the electronic nature of ortho

132 ki coupling and cycloreversion deliver a key biaryl dihydrodiol intermediate, which is rapidly conver

133 Studies on a model biaryl diol substrate shows that the high product er obs

134 ncluding a challenging tetraorthosubstituted biaryl diol, led to highly enantioenriched products (14

135 pselective acylation of a range of symmetric biaryl diols is investigated using isothiourea catalysis

136 gly, reheating a dimethoxy-substituted giant biaryl (e.g., 21) in nitrobenzene at 260 degrees C does

137 isclose a detailed SAR study that led to the biaryl ether 6.

138 id-catalyzed hydrolysis of oxygen (O)-linked biaryl ether 8-2'-deoxyguanosine (dG) adducts produced b

139 lly, chrysophaentin A features a macrocyclic biaryl ether core incorporating two trisubstituted chlor

140 stitution reaction for macrocyclization with biaryl ether formation completed the assemblage of the c

141 In this approach and with the ABCD biaryl ether ring system in place, the key Larock cycliz

142 es with phenols has been achieved to provide biaryl ethers that are prevalent in biologically active

143 While attempting to synthesize biaryl ethers we discovered the inadvertent formation of

144 Biaryl ethers were recently reported as potent NNRTIs.

145 linking oxygen for nitrogen (or piperazine), biaryl extension, and replacement of phenyl rings by pyr

146 The design of four new fluorinated biaryl fluorescent labels and their attachment to nucleo

147 n constitute a reliable alternative tool for biaryl formation.

148 The synthesis of biaryls from benzyne intermediates offers an alternative

149 While the synthesis of biaryls has advanced rapidly in the past decades, cross-

150 PdL(2)(C(6)F(5))(2)] to form polyfluorinated biaryls has been a challenge for over 50 years.

151 technique to generate highly functionalized biaryls has been demonstrated via the synthesis of chira

152 gy for increasing the barrier to rotation in biaryls has been developed that allows for the incorpora

153 rnative method for the resolution of vaulted biaryls has been developed.

154 the field of the atropisomeric synthesis of biaryls have hence been undertaken over the past decade.

155 An intramolecular biaryl Heck coupling reaction, catalyzed using the Herma

156 lts reveal a new method for the synthesis of biaryls, heteroaryls, and dienes, as well as a general m

157 al methodology for the chemical synthesis of biaryl, heterobiaryl, and polyaryl molecules by the cros

158 ture of its structure, the 5-membered chiral biaryl heterocyclic scaffold represents a departure from

159 and the structurally diverse 2,2'-dihydroxy biaryl (i.e., BINOL-type), as well as 2-amino-2'-hydroxy

160 oxygenated and functionalized unsymmetrical biaryls in good to excellent yields by the direct oxidat

161 table catalyst NiCl(2)(PCy(3))(2) to furnish biaryls in good to excellent yields.

162 benzyl lactones, 3-arylacetals (ketals), and biaryls in moderate to good yields.

163 visible-light irradiation, the synthesis of biaryls in moderate-to-high yields.

164 uki-Miyaura cross-coupling to axially chiral biaryls, in particular for the most challenging reaction

165 to the cutting-edge strategies for creating biaryls; in particular the 2-fold C,H activation is of s

166 ure water leads to symmetrical/unsymmetrical biaryls, indicative of a net Kumada-like biaryl coupling

167 When substituents in the biaryl inhibit rotation about the linking bond, stable n

168 e or byproduct of the synthesis of the giant biaryls is a reagent or catalyst necessary for the conve

169 an efficient access to atropisomeric (hetero)biaryls is reported.

170 The synthesis of pyridine-containing biaryls is therefore limited, and methods for the format

171 native approach to selective fluorination of biaryls is to couple an arene that already possesses C-F

172 eveloped for the synthesis of seven-membered biaryl lactams involving Pd-catalyzed, native amine-dire

173 he potential for synthesizing eight-membered biaryl lactams.

174 tate, B(OPh)(3), and a molecule of a vaulted biaryl ligand (VAPOL or VANOL).

175 d involves the reaction of a racemic vaulted biaryl ligand with one equivalent of BH(3).SMe(2) and on

176 talysts were assembled in situ from a chiral biaryl ligand, an amine, water, BH3.SMe2, and an alcohol

177 tion process was not observed for the linear biaryl ligands BANOL and BINOL, although the new deracem

178 ead use of axially chiral, or atropisomeric, biaryl ligands in modern synthesis and the occurrence of

179 d deracemization of the C2-symmetric vaulted biaryl ligands VANOL and VAPOL has been investigated.

180 amic thermodynamic resolution of the vaulted biaryl ligands with this method in combination with a no

181 hod has been applied to 16 different vaulted biaryl ligands, including 10 whose preparation is descri

182 copper complexes of these diamines with the biaryl ligands.

183 a representative example of the enantiopure biaryl-like CATPHOS class of diphosphines, (S)-9,9'-dime

184 representative example of the electron-rich biaryl-like KITPHOS class of monophosphine, 11-dicyclohe

185 er bearing an sp(2)-nitrogen adjacent to the biaryl link.

186 as exploited to conformationally constrain a biaryl linkage and allow contact with key residues in GK

187 Biaryl linkage, C(1) linkage, and aromatic sulfide linka

188 /dimerization to generate the requisite 2,2'-biaryl linkage.

189 des of reactivity, allowing the formation of biaryl linkages, were revealed and here exploited for th

190 We have reported that compounds containing a biaryl linked unit (Ar-X-Ar') modulated Na(+) currents b

191 polymerization of propylene oxide (PO) using biaryl-linked bimetallic salen Co catalysts was investig

192 A catalytic synthesis of novel biaryl-linked divalent glycosides was achieved using an

193 was optimized for the synthesis of divalent biaryl-linked mannopyranosides that was subsequently gen

194 hieved with unstrained enones that contain a biaryl linker.

195 y structure-based design and optimization of biaryl mannoside FimH inhibitors.

196 The photophysical properties of the biaryl-modified nucleosides, dNTPs, and DNA were studied

197 ps of small compounds (including adenine and biaryl moieties) were identified as cN-II binders and a

198 ail-cyclized RGD peptides, for example, with biaryl moieties, providing a new dimension of structure-

199 y relevant halogen, oxygen, heterocyclic and biaryl moieties.

200 Bioisosteric replacement of this biaryl moiety by arylpiperazine resulted in a soluble, o

201 of the aromatic A-ring, (2) a heteroaryl or biaryl moiety, or (3) multiple substituents on the aroma

202 somerization mechanism of a complex, bridged biaryl molecule with imbedded biphenyl, amine, and lacta

203 A new biaryl monophosphine ligand (AlPhos, L1) allows for the

204 pared [LPd(II)Ar(F)] complexes, where L is a biaryl monophosphine ligand and Ar is an aryl group, and

205 ia ortho-deprotonation of a L.Pd(Ar)OTf (L = biaryl monophosphine) species by CsF and thus competes d

206 s-coupling (SMC), resulting in new-to-nature biaryl motifs.

207 The enantioenriched biaryl N-oxide compounds catalyze the asymmetric allylat

208 4-Aryl-3-bromo-N-benzylmaleimides and 3,4-biaryl-N-benzylmaleimides have been synthesized by a mod

209 ic access to a wide variety of unsymmetrical biaryls of pharmaceutical, agrochemical and optoelectron

210 ki coupling provides rapid access to diverse biaryls of unprecedented topology.

211 in one-pot to form a 2-amino-2'-hydroxy-1,1'-biaryl or 1-amino-1'-hydroxy-4,4'-biaryl, respectively.

212 ied to investigate other, similarly hindered biaryl or teraryl systems either derived from natural so

213 an be subsequently transformed into phenols, biaryls, or dihydrobenzofurans via oxidation, Suzuki-Miy

214 lkynylation using the chiral imidazole-based biaryl P,N ligand StackPhos to establish the absolute st

215 os, a newly developed imidazole-based chiral biaryl P,N ligand, and copper bromide to effect a three-

216 Using this concept, an imidazole-based biaryl P,N-ligand has been designed and prepared as a si

217 bicyclo-aliphatic analogues of zwitterionic biaryl P2Y(14) receptor (P2Y(14)R) antagonists were synt

218 temperature coupling of deactivated/hindered biaryl partners.

219 eric crowding at the Pd catalyst by either a biaryl phosphine ligand and/or substrate.

220 A copper catalyst and electron-rich biaryl phosphine ligand facilitate the formation of ally

221 ligated L.Pd(II)(Ar)X complexes (L = dialkyl biaryl phosphine) have been prepared and studied in an e

222 of in situ prepared L.Pd(Ar)X complexes (L = biaryl phosphine) with [(11)C]HCN.

223 oped in recent decades, since nonsymmetrical biaryls play an evident role in natural product synthesi

224 The use of a racemic biaryl precursor allowed for the synthesis of both hibar

225 These features expedite biaryl preparation, as demonstrated by synthesis of the

226 This strategy allows the preparation of biaryls previously inaccessible via decarboxylative meth

227 The alkoxy/alkyl/halogen-substituted biaryls produced are useful precursors for accessing sub

228 The biaryl product forms via C-H activation of two arenes to

229 hylphenylacetylene gave much poorer yield of biaryl product.

230 ethylsilanolates and aryl bromides result in biaryl products with the same configuration and similar

231 nalization of unactivated arenes to form the biaryl products.

232 cribed, which vary in the linker between the biaryl pyrazole and imidazole/triazole group.

233 is of structural comparison with a different biaryl pyrazole template and supported by dozens of high

234 Atropisomeric biaryl pyridine and isoquinoline N-oxides were synthesiz

235 azine-diarylplatinum(II) complex accelerates biaryl reductive elimination by a factor of 64,000.

236 eactions for the synthesis of nonsymmetrical biaryls represent one of the most significant transforma

237 droxy-1,1'-biaryl or 1-amino-1'-hydroxy-4,4'-biaryl, respectively.

238 Dimeric analogues linked through the biaryl ring show an impressive 8-fold increase in potenc

239 lization closure of the strained 16-membered biaryl ring system found in complestatin (1, chloropepti

240 Diverse modifications to the biaryl ring to improve druglike physical and pharmacokin

241 lignment of the acetoxy group with the other biaryl ring, and places the smallest substituent on the

242 of a chiral Bronsted acid and a C1-symmetric biaryl saturated-imidazolium precatalyst was required to

243 selectivity with a new tailored C1-symmetric biaryl-saturated imidazolium-derived NHC catalyst.

244 rovide a swift and tuneable route to related biaryl scaffolds.

245 convenient procedure for the construction of biaryl scaffolds.

246 bstrate and one of the aromatic rings of the biaryl section of the chiral auxiliary with a good align

247 potencies to these in contrast to the parent biaryl series.

248 itrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175

249 c heterocycles, or (iii) generating extended biaryl side chains.

250 Enantioenriched aryne atropisomers having a biaryl stereogenic axis vicinal to the reactive triple b

251 of aryne chemistry to access a huge range of biaryl structures from a versatile and highly customizab

252 ormation is described that affords versatile biaryl structures without recourse to transition-metal c

253 On the basis of our observation that the biaryl substituent of iminopyrimidinone 7 must be in a p

254 d that (i) DAGL-alpha tolerates a variety of biaryl substituents, (ii) the sulfonamide is required fo

255 for the transformation of a variety of ortho-biaryl substituted alkynes into polycyclic homo- and het

256 These results suggest that biaryl substituted aminopyrimidines represented by compo

257 the biaryl substrate 4/7/9/11 and not by the biaryl substrate 2a.

258 C-H bond was possible and facilitated by the biaryl substrate 4/7/9/11 and not by the biaryl substrat

259 kinetic asymmetric transformation of racemic biaryl substrates on the basis of axial-to-central chira

260 volving a synthetic tripeptide known to bind biaryl substrates through tailored hydrogen bonding to c

261 or the dynamic kinetic resolution of racemic biaryl substrates.

262 and represent tetrahedral equivalents to the biaryl substructures that overpopulate synthetic librari

263 us other fused 6,5-heterocyclic moieties and biaryl sulfone or sulfonamide motifs.

264 ions of these molecules afforded many potent biaryl sulfone-containing Nampt inhibitors which also ex

265 and offers facile access to a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reage

266 6,7-dihydro-5H-dibenzo[c,e]azepines over the biaryl sultam formation.

267 Using an appropriate substrate, a biaryl sultam has been obtained exclusively.

268 lfonanilides, providing a workable access to biaryl sultams annulated into a six-membered ring that a

269 was largely controlled over the formation of biaryl sultams containing a seven member ring.

270 of this protocol including the synthesis of biaryl sultams containing a seven-membered ring and anal

271 p as new benzyne precursors enable inventive biaryl syntheses under mild conditions.

272 th aryl halides (Ar-X; X = I, Br, Cl) toward biaryl syntheses underwent smoothly in the presence of o

273 A new biaryl synthesis via silver-catalyzed hydroarylation of

274 thways and reaction conditions, the scope of biaryl synthesis with arenediazonium salts has enormousl

275 iew will cover all aryne methods relevant to biaryl synthesis, drawing together key ideas from the ol

276 ons at various evolutionary stages of modern biaryl synthesis.

277 The strained and distorted l-tyrosine-based biaryl system characteristic for mycocyclosin is selecti

278 C(sp(2))-H bonds using heteroaryl-aryl-based biaryl systems.

279 difications to arrive at the simple achiral, biaryl target structures.

280 hesis of halogenated 2-amino-2'-hydroxy-1,1'-biaryls that are currently either inaccessible or challe

281 tly than either tetrahedral carbon or chiral biaryls, they may create complementary chiral environmen

282 den if they include a particular sequence of biaryl torsional states that causes excessive steric str

283 lbiaryl junctures, only slightly relaxes the biaryl twist angle from 89.6 degrees to approximately 80

284 Biaryls (two directly connected aromatic rings, Ar(1)-Ar

285 A class of biaryl-type compounds that is assembled by convenient sy

286 g group-free or minimized total synthesis of biaryl-type phytoalexins.

287 Subsequent directed remote metalation of biaryls under standard conditions and at elevated temper

288 A biaryl urea group, prone to self-aggregation, was functi

289 The axial chirality of the biaryls was determined using TDDFT ECD and VCD calculati

290 he preparation of 1,1'-linked functionalized biaryls was developed.

291 The different substitution pattern of the biaryls was used for tuning of emission maxima in the br

292 A wide range of biaryls were synthesized by palladium-catalyzed Negishi

293 Biaryls were synthesized via a novel visible-light-promo

294 of cyclopentadienones, to afford substituted biaryls, were studied using an expanded substrate base.

295 lings of benzoates with aryl halides to give biaryls, which is cooperatively catalyzed by copper/pall

296 he experimental data and DFT calculations of biaryls with different dihedral angles unequivocally sup

297 photoinduced metal-free synthesis of (hetero)biaryls with no need of a (photo)catalyst or of other ad

298 an aryl Truce-Smiles rearrangement to afford biaryls with sulfur dioxide extrusion.

299 key improvement for achieving nonsymmetrical biaryls with superb selectivity and synthetic attractive

300 opos P,N) ligands require a specific type of biaryl, with one component carrying a pendant phosphine