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1                                          The bigenic ampullary glands and vas deferens were extremely
2                                              Bigenic and control mice were evaluated prospectively fr
3                                The resulting bigenic animals (i6A-/Tag) and control WT/Tag mice were
4 PC synapses in comparison to vehicle-treated bigenic animals and tamoxifen-treated PrP-floxed-SCA7-92
5              Differentiating chondrocytes in bigenic animals could be ablated at different developmen
6                     Brca1-/-; TgN x BRCA1GEN bigenic animals develop normally and can be maintained a
7 sgenic strain prone to mammary gland cancer, bigenic animals develop tumors with greatly accelerated
8 ading carcinoma cells in both MMTV-DNIIR and bigenic animals showed loss of DNIIR transgene expressio
9 elayed time to neu-mediated tumorigenesis in bigenic animals.
10 c beta(2)-AR x DNp38alpha MAPK mice, but not bigenic beta(1)-AR x DNp38alpha MAPK mice, and failed to
11  beta(2)-AR Tg mice and was still present in bigenic beta(1)-AR x DNp38alpha MAPK mice, but not bigen
12 d LVEF and reduced apoptosis and fibrosis in bigenic beta(2)-AR x DNp38alpha MAPK mice, but not bigen
13 c beta(1)-AR x DNp38alpha MAPK mice, but not bigenic beta(2)-AR x DNp38alpha MAPK mice.
14 reveal fine structural details of podocytes, bigenic Coll1alpha1GCE;Gt(ROSA)26Sor(tm9(CAG-tdTomato))
15 enin (Pro-Cat and Ubi-Cat, respectively) and bigenic crosses between these lines (Pro-Cat x JOCK1 and
16 el deficiency and the molecular mechanism of bigenic disease.
17                      In K5.TGFbeta1/K5.Smad7 bigenic (double transgenic) mice, Smad7 transgene expres
18 PRDX3 with the LRRK2 kinase mutant G2019S in bigenic Drosophila ameliorated the G2019S mutant-induced
19 d in response to irradiation, we generated a bigenic EC-SOD mouse model (OE mice) that expressed high
20                                    Moreover, bigenic expression of caBmpr1a rescued the differentiati
21 l fibrillary acidic protein (GF)-IL-12 mice, bigenic for the p35 and p40 genes, developed neurologic
22                                        Using bigenic Gli1-CreER(t2); R26tdTomato reporter mice, we ob
23 mance developed significantly more slowly in bigenic HD knock-in/Snell dwarf mice.
24 igral neuropil aggregates were diminished in bigenic HD knock-in/Snell dwarf mice.
25 th weight loss blunted significantly in male bigenic HD knock-in/Snell dwarf mice.
26                       This demonstrates that bigenic heterozygosity can lead to FSGS and suggests tha
27                                    Moreover, bigenic heterozygosity for synaptopodin and CD2AP is suf
28 ther combinations of genetic heterozygosity (bigenic heterozygosity) that alone do not result in clin
29 d to determine the potential for deleterious bigenic interactions; approximately 4800 complex hemizyg
30                                           In bigenic L126Z/WT-hSOD1:YFP mice, disease was not acceler
31 a by crossing the moAPP transgenic mice to a bigenic line expressing human APPswe with PS1dE9.
32                            We also generated bigenic mice (MHC-cyclin T1/CLP-1(+/-)) by crossing MHC-
33 last cell-fate determinant OSX compared with bigenic mice (Osx(f/f)/SCID).
34                                              Bigenic mice (termed GFAP-IL6/sgp130 mice) were generate
35                      MMTV/Wnt-1 x MMTV/GPNMB bigenic mice also exhibit a significant increase in the
36 orter in the WT/ERE-Luc and REA(+/-)/ERE-Luc bigenic mice and by the higher expression levels of estr
37 -inducible recombination was demonstrated in bigenic mice at age 3 and 6 weeks, using each of 3 indep
38 d precursor protein + presenilin-1 (APP+PS1) bigenic mice attenuates AD pathogenesis.
39  in terms of AR function, we further derived bigenic mice by crossing AR activity indicator mice with
40                    Analyses of the resultant bigenic mice by in vivo imaging and luciferase assays sh
41              Neither APP47 nor APP48 nor the bigenic mice develop extracellular amyloid plaques.
42 /Abeta, although only APP(E693Q) X PS1Delta9 bigenic mice developed amyloid plaques.
43                   Both single transgenic and bigenic mice developed intraneuronal accumulation of APP
44                                        These bigenic mice displayed exacerbated Abeta-induced cogniti
45                                          The bigenic mice exhibit enhanced susceptibility to hypertro
46                                              Bigenic mice exhibited an age-dependent increase in BLI
47 dification of tau in cultured neurons and in bigenic mice expressing Abeta and human tau.
48                       We generated a tet-off bigenic mice expressing either a WT (wild type) or a mut
49 ertrophic cardiomyopathy (HCM) by generating bigenic mice in which expression of the mutant transgene
50 , the Abeta amyloid plaques in the brains of bigenic mice inoculated with Abeta42 prions prepared in
51 TBK1 on tauopathy in vivo, we have developed bigenic mice overexpressing full-length TTBK1 and the P3
52                                          The bigenic mice presented with an elevated accumulation of
53                                          The bigenic mice provide a model with cooperative aberration
54 f cyclin D2 level in the cyclin D3/cyclin D2 bigenic mice results in a complete reversion of the inhi
55                                          The bigenic mice show enhanced tau phosphorylation at multip
56                                          The bigenic mice show significant locomotor dysfunction as d
57 t with the reduction in spheroid number, the bigenic mice showed delayed accumulation of insoluble ta
58 rlier disease, and spinal cords of paralyzed bigenic mice showed YFP fluorescent inclusion-like struc
59 ion of alpha-synuclein neurotoxicity in such bigenic mice to the ability of beta-synuclein to reduce
60 on was evaluated in Pdx1(lacZ/+)/MT-TGFalpha bigenic mice treated with zinc.
61 erally to the hippocampi of APP+presenilin-1 bigenic mice via an adenoassociated virus serotype 2/1 h
62  of metastatic lesions was widespread in old bigenic mice we did not detect IGF-1(des) in poorly diff
63         PrP-floxed-SCA7-92Q BAC;CAGGS-Cre-ER bigenic mice were treated with a single dose of tamoxife
64 Myc-induced cell growth on CycD2, we created bigenic mice where Myc can be selectively activated in C
65 ely 4 times greater than those of TRAMP/SSAT bigenic mice, and by 36 weeks, they were approximately 1
66 protein is absent in tumors from Nrdp1/ErbB2 bigenic mice, and real time PCR analysis indicates that
67  two transgenic lines were mated to generate bigenic mice, and TGFbeta1 transgene expression was cont
68 rn granule neurons are unaffected in the APP bigenic mice, despite abundant amyloid pathology and rob
69                                       In the bigenic mice, iFGFR1 activation dramatically enhanced ma
70  increase in SSAT activity in the TRAMP/SSAT bigenic mice, prostatic N(1)-acetylspermidine and putres
71               In either combination of these bigenic mice, the severity of fibrillar inclusion pathol
72                We generated ligand-inducible bigenic mice, turned on and off expression of cardiac tr
73               Within 6 d of induction in the bigenic mice, we observed significantly altered ambulati
74 ta40 and Abeta42 in the brains of inoculated bigenic mice, whereas synthetic Abeta42 prions stimulate
75 /Neu + MMTV/transforming growth factor alpha bigenic mice.
76 et of clinical IDDM was not present in these bigenic mice.
77 to self-propagate following inoculation into bigenic mice.
78 essing APP(E693Q) or APP(E693Q) X PS1DeltaE9 bigenic mice.
79 racteristic of AD, were also reversed in the bigenic mice.
80 c Min/+ S1p3r(-/-), and Apc Min/+ S1p1r(+/-) bigenic mice.
81 Ep2-/- mice and studied tumor development in bigenic mice.
82 model is ameliorated in BACE1(-/-).Tg2576(+) bigenic mice.
83 h KDNR mice to generate ARR2PBi-caFGFR1/KDNR bigenic mice.
84 ressing mice did not develop mammary tumors, bigenic MMTV-Alk(T204D) x Neu mice developed cancers tha
85 tumors arising in MMTV-TGF-alpha compared to bigenic MMTV-DNIIR/MMTV-TGF-alpha was the marked suppres
86                                              Bigenic MMTV-MAT/neu female offspring developed primary
87                    Expression of eYFP in the bigenic mouse brain was observed only in neuronal mitoch
88            We tested this hypothesis using a bigenic mouse in which transgenic expression of APP was
89            We have created a new fluorescent bigenic mouse model of AD by crossing "H-line" yellow fl
90 tate cancer development, and present a novel bigenic mouse model that mimics the human condition, whe
91                              Using the GT-tg bigenic mouse model, where brain-selective Tat expressio
92  address this question, we developed a novel bigenic mouse that overexpresses both amyloid precursor
93  from HG type 7, which further validates the bigenic nature of this resistance.
94 ified mammary epithelial cells isolated from bigenic NIC-PRMT1 (Tg) and NIC-PRMT6 (Tg) mice revealed
95 ore, a progesterone receptor (PR)-Cre Notch1 bigenic (Notch1(d/d)) confirmed a Notch1-dependent hypom
96                                              Bigenic (NT) and Neu-induced mammary tumors developed wi
97 analysis using heterozygous Pdx1(lacZ/+) and bigenic Pdx1(lacZ/+)/MT-TGFalpha mice.
98                                              Bigenic PRAI-SRC-1(-/-) mice revealed that SRC-1 modulat
99 e that recognize the hemoglobin epitope, the bigenic progeny developed dense, pseudo-follicular lymph
100 ion resulted in exuberant hyperplasia of all bigenic prostatic lobes typified by epithelial stratific
101      PiggyBac or Sleeping Beauty transposase bigenic rats bred with wild-type albino rats yielded off
102                                              Bigenic rats carrying single-copy transposons at known l
103                     Pdx1(lacZ/+)/MT-TGFalpha bigenics showed up-regulated Pdx1 expression in premalig
104 s of isolated tubular epithelia by FACS from bigenic SLC34a1-CreERt2; R26tdTomato proximal tubular-sp
105 this uncertainty, we developed an innovative bigenic system for the doxycycline-inducible expression
106                                 In this PRKO bigenic system, acute doxycycline-induced expression of
107 xpressed in all chondrocytes by the UAS-GAL4 bigenic system.
108  amyloid precursor protein (Tg2576) leads to bigenic (TAPP) mice with enhanced neurofibrillary pathol
109 luminescence imaging signal in the brains of bigenic Tg(APP23:Gfap-luc) mice, indicative of astrocyti
110 of Abeta trimers in vivo, we created a novel bigenic Tg-Abeta+Tau mouse line by crossing Tg2576 (Tg-A
111 rons and elevated activated microglia in the bigenic Tg-SwDI/Tg-5xFAD mice.
112 enance of genome stability) and showing that bigenic Tg.AC/Wrn(Deltahel/Deltahel) mice experience an
113                    Harlequin patterning is a bigenic trait, resulting from the interaction of the mer
114                         NeuYD;MMTV-VEGF(164) bigenic, tumor-bearing animals resulted in an average of
115                                          The bigenic tumors and their metastases were less proliferat
116 ly, in spite of their more malignant nature, bigenic tumors are more secretory and differentiated.
117 e data revealed that MMTV/Wnt-1 x MMTV/GPNMB bigenic tumors exhibit a pro-growth signature characteri
118 mo*) specifically in the cartilage using the bigenic UAS-Gal4 system, we demonstrate that activation
119  these phenotypes, profound disorders of the bigenic Wolffian duct derivatives were observed.

 
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