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1  in knockout mice despite markedly decreased biliary excretion.
2 t in the mechanisms of sterol absorption and biliary excretion.
3 om high plasma protein binding and extensive biliary excretion.
4 oxorubicin and doxorubicinol elimination was biliary excretion.
5 e at the gut and blood-brain barrier and via biliary excretion.
6 from hepatocytes than from Kupffer cells, by biliary excretion.
7 n either E(2)17G-mediated cholestasis or its biliary excretion.
8 sA pretreatment was primarily due to lowered biliary excretion.
9  intestinal efflux transporter, and have low biliary excretion.
10                                  The percent biliary excretion (15.8 +/- 4.4%) and plasma half-life i
11 cromol/h) was similar to the total bile acid biliary excretion (286+/-84 micromol/hr, P = 0.06).
12 nto the liver for subsequent conjugation and biliary excretion, a key step in drug elimination from t
13 nd may compete with other organic anions for biliary excretion and 2) Mrp2 protein expression and fun
14  Knockdown of vipar in zebrafish resulted in biliary excretion and E-cadherin defects similar to thos
15 e low urinary recovery indicates substantial biliary excretion and supports the significant correlati
16           Unfortunately, liver accumulation, biliary excretion, and no tumor uptake were observed on
17 types and inhalation, intestinal absorption, biliary excretion, and plastic-associated chemical expos
18 n an ordinal 0-2 scale: hepatic enhancement, biliary excretion, and the signal intensity in the porta
19                       Intestinal absorption, biliary excretion, and urinary excretion of P-gp substra
20 he paracellular and transcytotic pathways of biliary excretion, assessed by horseradish peroxidase (H
21  on the rates of elimination (metabolism and biliary excretion) but also on the rates at which a drug
22 mechanism may involve direct competition for biliary excretion by PB and/or a PB metabolite.
23 sed to determine organ uptake (CLuptake) and biliary excretion (CLbile) clearances of radioactivity.
24            Compared with medications without biliary excretion, compounds with biliary excretion (n =
25 ired hepatic manganese uptake for subsequent biliary excretion has been proposed as the underlying di
26 egulated cholesterol transport genes for its biliary excretion, including scavenger receptor class B
27 lted in an approximately 45% decrease in the biliary excretion index of carboxydichlorofluorescein (C
28 nt with an approximately 60% increase in the biliary excretion index of carboxydichlorofluorescein.
29 sk of C difficile infection because of their biliary excretion into the gastrointestinal tract and di
30 ns and xenobiotics under conditions in which biliary excretion is impaired.
31                  Drug reabsorption following biliary excretion is well-known as enterohepatic recircu
32                                          The biliary excretion kinetics of sodium fluorescein reflect
33 ns without biliary excretion, compounds with biliary excretion (n = 50) had significantly higher freq
34 ed in auxiliary livers, including uptake and biliary excretion of (99m)Tc-mebrofenin in syngeneic rec
35 ole of Mrp2, Bcrp, and P-glycoprotein in the biliary excretion of acetaminophen sulfate (AS) and gluc
36 tion of Mrp2 expression may explain impaired biliary excretion of amphiphilic anionic conjugates in t
37             No differences were found in the biliary excretion of APAP, APAP-sulfate, and APAP-glutat
38 icient mouse livers, resulting in negligible biliary excretion of AS, 4MUS, and HS.
39 nterventions that targeted the synthesis and biliary excretion of bile acids prevented the rise in fe
40 important in the hepatic glucuronidation and biliary excretion of bilirubin and of this series of aci
41 se-1 (BUGT1)-deficient Gunn rats resulted in biliary excretion of bilirubin glucuronides and a 70% re
42  enzyme is essential for glucuronidation and biliary excretion of bilirubin, and its absence can be f
43  x 5 d) before liver isolation decreased the biliary excretion of both VPA (1.06E-04 +/- 0.27E-04 vs.
44  Laboratory animal studies have reported the biliary excretion of chemicals following exposure.
45                    Intestinal absorption and biliary excretion of cholesterol represent two major pat
46                The hepatic concentration and biliary excretion of conjugated and unconjugated BAs wer
47                                 As expected, biliary excretion of conjugates was not impaired in P-gl
48 ncreased intestinal absorption and decreased biliary excretion of dietary sterols, hypercholesterolem
49 r membrane and the recovery of bile flow and biliary excretion of DNP-SG.
50 rotubule destabilizer, nocodazole, decreased biliary excretion of DNR.
51             In the presence of GF120918, the biliary excretion of doxorubicin and doxorubicinol was d
52 data supported the hypothesis that decreased biliary excretion of doxorubicin in the isolated perfuse
53            In the presence of quinidine, the biliary excretion of doxorubicin was reduced significant
54 ht) gave a similar degree of cholestasis and biliary excretion of E(2)17G-equivalents in wild-type an
55 Neither Taxol nor daunorubicin decreased the biliary excretion of E(2)17G.
56                Additionally, PCA reduced the biliary excretion of FL-Glu by 55%.
57 ndependent bile flow primarily by inhibiting biliary excretion of glutathione and to a lesser extent
58 this dislocation of apical transporters, the biliary excretion of glutathione-methylfluorescein and c
59                                              Biliary excretion of intact as well as partially degrade
60                                     However, biliary excretion of intravenously infused TC was signif
61 mechanism of inhibitory effect of CsA on the biliary excretion of irinotecan and its metabolites.
62 nalicular membrane by P-glycoprotein, on the biliary excretion of irinotecan and its metabolites.
63 cy and kinetics of food- and hormone-induced biliary excretion of L. monocytogenes from the murine ga
64 e microtubule inhibitor colchicine inhibited biliary excretion of LPS in WT mice, indicating that LPS
65 Taurolithocholate (TLC) acutely inhibits the biliary excretion of multidrug-resistant associated prot
66 that limit intestinal absorption and promote biliary excretion of neutral sterols.
67 patic synthesis of lecithin was similar, but biliary excretion of newly synthesized lecithin was sign
68 esistance-associated protein 2 (Mrp2) in the biliary excretion of PB and metabolites was studied usin
69       The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibi
70 ificantly increased, suggesting that reduced biliary excretion of PhIP and PhIP metabolites leads to
71                                          The biliary excretion of rosuvastatin was very fast, with 60
72 ea, which is believed to be secondary to the biliary excretion of SN-38, the extent of which is deter
73 ese data support two mechanisms for impaired biliary excretion of some organic anions by PB treatment
74     Phenobarbital (PB) treatment impairs the biliary excretion of some organic anions.
75 o limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of
76 itive inhibition of P-gp transport may alter biliary excretion of substrates.
77 edominantly by Mrp2, mouse Bcrp mediated the biliary excretion of sulfate metabolites and also played
78 cluded that EFA deficiency leads to impaired biliary excretion of taurocholate, lecithin, and water,
79                                          The biliary excretion of the bile acid, taurocholate ([3H]-l
80 cells to study the cellular localization and biliary excretion of the fluorescent cation, daunorubici
81 abolites and also played a major role in the biliary excretion of the glucuronide metabolites, with s
82 iver ratios remained >1, due to fairly rapid biliary excretion of the label.
83                       The 120-min cumulative biliary excretion of the Mrp2 substrate 5-(and-6)-carbox
84 ing the transporter MRP2 contributing to the biliary excretion of the reactive metabolite.
85  activity of 80 +/- 30 s, followed by prompt biliary excretion of the tracer.
86                        A label showing rapid biliary excretion only after delivery to hepatocytes, (1
87  from kinetic modeling of sodium fluorescein biliary excretion, showed a significant inverse correlat
88 icantly blocked both E(2)17G cholestasis and biliary excretion, such that 16 micromol E(2)17G decreas
89 MOAT in E(2)17G-mediated cholestasis and its biliary excretion using the isolated perfused rat liver.
90                                  The percent biliary excretion was significantly lower for the phosph
91 trointestinal absorption, hepatic uptake, or biliary excretion were observed in these animals.
92 droxy-tert-butyl carbamate (HDTX) metabolite biliary excretion, were best fit by a two compartment mo
93 ites, SN-38 and SN-38G, by possibly reducing biliary excretion, which in turn could lower irinotecan