ライフサイエンスコーパス: binaphthyl

1 g from chiral NOBIN (2-amino-2'-hydroxy-1,1'-binaphthyl).

2 substituents are linked to 6,6'-positions of binaphthyl.

3 e to tolyl-phenylmethanes and naphthalene to binaphthyl.

4 ctions rather than from the primarily formed binaphthyls.

5 and-BINAP [2,2'-bis(diphenylphosphino)-1,1',-binaphthyl].

6 ture, the observed equilibrium ratio of 1,1'-binaphthyl, 1,2'-binaphthyl, and 2,2'-binaphthyl is <1:3

7 nd 7b results in the clean formation of 1,1'-binaphthyls 13a and 13b, respectively, their higher homo

8 chiral (P)-catenane upon binding to (R)-1,1'-binaphthyl 2,2'-disulfonate, with a diastereomeric exces

9 antiopure ditopic initiator (R)- or (S)-1,1'-binaphthyl-2,2'-bis-(2-bromoisobutyrate).

10 ea organocatalysts derived from (S)-(-)-1,1'-binaphthyl-2,2'-diamine ((S)-BINAM).

11 inaphthalen-2-ol (R-NOBIN) from (R)-(+)-1,1'-binaphthyl-2,2'-diamine (R-BINAM) is reported.

12 rogen phosphate, 1,1'-bi-2-naphthol, and 1,1-binaphthyl-2,2'-diamine, are investigated.

13 ch was applied to chiral separations of 1,1'-binaphthyl-2,2'-dihydrogenphosphate (BNP), 1,1'-bi-2-nap

14 acil-conjugated enantiopure (R)- or (S)-1,1'-binaphthyl-2,2'-diol (BINOL) and a hydrophobic oligo(p-p

15 el identified the dihedral angle of the 1,1'-binaphthyl-2,2'-diol (BINOL) subunit of the IDPi to be s

16 piroconjugated absorber molecules using 1,1'-binaphthyl-2,2'-diol (BINOL) units on the donor part.

17 folds, as well as the versatile reagent 1,1'-binaphthyl-2,2'-diol and a precursor to the heterobiaryl

18 inaphthyl-2,2'-diyl hydrogen phosphate, 1.1'-binaphthyl-2,2'-diol, and Troger's base, and several neu

19 ethylthiolate) clusters and enantiopure 1,1'-binaphthyl-2,2'-dithiol (BINAS) was monitored in situ us

20 dithiogermanes have been prepared from 1,1'-binaphthyl-2,2'-dithiol and 3,3'-bis(trimethylsilyl)-1,1

21 s of 3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate (TRIP) allows th

22 RIP (3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate) was investigate

23 ed by the fact that three atropisomers, 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate, 1.1'-binaphthyl

24 RIP: 3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogen phosphate).

25 3,3-Bis(2,4,6-triisopropylphenyl)-1,1-binaphthyl-2,2-diyl hydrogenphosphate (TRIP) catalyzes t

26 ilyloxy)-5,5',6,6',7,7',8,8'-octahydro-1, 1'-binaphthyl-2-olate), were generated through addition of

27 d divergent synthesis of chiral bifunctional binaphthyl-2-ylphosphines is developed to allow rapid ac

28 4,4'-bis(3,3,3-tri-d(5)-phenylpropynyl)-1,1'-binaphthyl 5 were prepared via a Sonogashira coupling of

29 s determined by bis-ANS (4,4'-dianilino-1,1' binaphthyl-5,5' disulfonic acid) binding study.

30 Binding of 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonate (Bis-ANS) dye (a probe commo

31 ere, we demonstrate that 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (bis-ANS) and similar co

32 imitations in the use of 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (bis-ANS) to examine unf

33 of the fluorescent probe 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (bis-ANS) to hydrophobic

34 drophobic probe binding (4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (bis-ANS)), competition

35 lerosis (ALS), we used a 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (BisANS) photolabeling a

36 polar fluorescent probe, 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid (BisANS), to monitor cha

37 nitoring the increase in 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt fluores

38 omatography and bisANS (4,4'-dianilino-1, 1'-binaphthyl-5,5'-disulfonic acid) labeling studies provid

39 p120-gp41 in situ using 4,4'-dianilino-1, 1'-binaphthyl-5,5'-disulfonic acid, a fluorescent probe tha

40 hobic fluorescent probe, 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid, dipotassium salt (bis-A

41 The obtained binaphthyl alcohols represent potentially useful synthon

42 nantiopure Lewis acid organocatalysts: i.e., binaphthyl-allyl-tetrasulfone (BALT) and imidodiphosphor

43 The binaphthyl amine containing two triazole rings shows hig

44 The triazolyl binaphthyl amine shows cytotoxicity for cancer cells by

45 Two novel binaphthyl amines have been designed and synthesized usi

46 The resulting chiral azobenzenes bearing binaphthyl and naphthyl/phenyl backbones undergo reversi

47 do[3]rotaxane containing axially chiral 1,1'-binaphthyl and photoresponsive azobenzene moieties.

48 stand for (2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and trimethylsilyl respectively).

49 dynamics on the racemization kinetics of the binaphthyls and allow the important demonstration, via t

50 ffer from both canonical atropisomers (e.g., binaphthyls) and topoisomers (i.e., molecules that have

51 d equilibrium ratio of 1,1'-binaphthyl, 1,2'-binaphthyl, and 2,2'-binaphthyl is <1:3:97.

52 enic center adjacent to the nitrogen atom in binaphthyl- and biphenyl-derived azepinium salt organoca

53 (2b)AuCl [2b = 2-di-tert-butylphosphino-1,1'-binaphthyl] and AgSbF(6) in dioxane at 100 degrees C for

54 The 1,1'-binaphthyl anion radical is found to undergo a cyclodehy

55 tch 2, are designed and prepared with an (R)-binaphthyl azo group as a chiral photosensitive moiety a

56 An enantiopure aluminum salen catalyst with binaphthyl backbone facilitates the regioselective ring-

57 ongestion imparted by the 3,3'-disubstituted binaphthyl backbone of the borane catalyst as well as th

58 ed first generation ligands bearing a chiral binaphthyl-based amino alcohol.

59 The optimal binaphthyl-based catalyst 1g features a large aryloxytri

60 atalyst derived from HB(C(6) F(5) )(2) and a binaphthyl-based chiral diene to give rise to enantioenr

61 ed remote amide group in the designed chiral binaphthyl-based ligand plays the essential role of a ge

62 s regarding general synthetic procedures for binaphthyl-based mono- and bidentate phosphites and phos

63 A series of well-defined enantiopure 1,1'-binaphthyl-based oligomers linked through their 6,6'-pos

64 Particularly, a great variety of chiral binaphthyl-based phosphorus compounds, herein represente

65 pecial attention to the functionalisation of binaphthyl-based phosphorus ligands for use in alternati

66 Among these materials, the binaphthyl-based polymers such as (R)-451 developed by P

67 F), racemic-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (BINAP), and diphenylethylphosphine (PPh(2)Et

68 gand containing a resolved 2,2-dihydroxy-1,1-binaphthyl (BINOL) group and a diastereomerically and en

69 The 2,2'-dihydroxy-1,1'-binaphthyl (BINOL) phosphoric acid ligand, Cs2 CO3 , and

70 distance between the phosphonic acid and the binaphthyl chiral units significantly impact the transfe

71 show on the example of the racemizations of binaphthyl compounds that pure unmodified graphene can d

72 including those made of cyclodextrins, 1,1'-binaphthyl compounds, and nanomaterials, and uses them t

73 he area of the monolayer and modification of binaphthyl conformation.

74 ptically active dendrimers containing a 1,1'-binaphthyl core and cross-conjugated phenylene dendrons

75 Using an axially chiral binaphthyl derivative and a borane photosensitizer as pr

76 eta-blockers, labetalol and sotalol, and the binaphthyl derivatives, 1,1'-bi-2-naphthyl-2,2'-dihydrog

77 hesis of several new 2-diphenylphosphino-1,1-binaphthyl derivatives, prepared to probe the effect of

78 r descriptors from five different asymmetric binaphthyl-derived catalyst families with the propensity

79 trans-dibenzylideneacetone) and chiral 2,2'-binaphthyl diamine (BINAM)-derived phosphoric acids (BDP

80 (BINAM)-derived phosphoric acids (BDPA, 2,2'-binaphthyl diamine-derived phosphoric acids) is presente

81 nt chiral components, i.e., an atropisomeric binaphthyl-diamine backbone and two stereochemically ide

82 al photosensitive moiety and two (S)- or (R)-binaphthyl fluorescent molecules with opposite or the sa

83 the insertion of axially chiral enantiomeric binaphthyl fluorophores into the constitutions of pyridi

84 ., the substituents on 4,4'-positions of the binaphthyl framework and the methyl groups on the bis(xy

85 f the torsion angle of an amphiphilic chiral binaphthyl, from -90 degrees to -80 degrees , was achiev

86 with two BINOL (BINOL = 2,2'-dihydroxy-1,1'-binaphthyl) groups has been prepared in two enantiomeric

87 hosphino)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl (H(8) -BINAP) and its derivatives without los

88 zed isomerization of 1,1'-binaphthyl to 2,2'-binaphthyl has been noted previously.

89 xially chiral phosphoric acids, achiral N,N'-binaphthyl hydrazines undergo a facile [3,3]-sigmatropic

90 PO (BINPO = 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) in the presence of NaSbF6.

91 f 1,1'-binaphthyl, 1,2'-binaphthyl, and 2,2'-binaphthyl is <1:3:97.

92 In the molecular structures, binaphthyl is covalently linked to ortho-positions of az

93 l and reversible formation of 1,2'- and 2,2'-binaphthyl isomers.

94 The 1,1'-binaphthyl macrocycle (S)-2 is found to be an excellent

95 halene-2,2'-diol (BINOL) into 2'-substituted binaphthyl monoalcohols under mild conditions are report

96 The copolymerization of the chiral binaphthyl monomer with the achiral biphenyl monomer dem

97 larenes, 2-diphenylphosphino-2'-methoxy-1,1'-binaphthyl (MOP) is among the most accessible.

98 ple, (R)-2-methoxy-2'-diphenylphosphino-1,1'-binaphthyl, MOP) and a highly dissociated counteranion (

99 ccessible starting materials using palladium binaphthyl nanoparticles (Pd-BNPs) has been developed.

100 ally enriched (R(a))-2-amino-2'-hydroxy-1,1'-binaphthyls (NOBINs) with exceptional yields and enantio

101 hrough mixing a metal Lewis acid and a metal binaphthyl phosphate (MLA/M[P]3) in solution.

102 the Y(Yb)(III)/Y[P]3 complexes with bridging binaphthyl phosphate ligands.

103 Study of the binaphthyl polymers in the asymmetric organozinc additio

104 E compared to their neutral optically active binaphthyl precursors.

105 i; BINAP is 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl) revealed subtle but significant differences

106 genic and axially chiral phosphorylated 1,2'-binaphthyl ring system.

107 The binding site on the binaphthyl salt has been determined using computer model

108 Axially chiral binaphthyl salts are shown to bind chiral analytes in a

109 of ephedrine-substituted quaternary ammonium binaphthyl salts as molecular receptors is demonstrated.

110 These ligands combine the axial chirality of binaphthyl scaffolds with the bifunctional and bidentate

111 zation catalyst for fundamental biphenyl and binaphthyl scaffolds, as well as the versatile reagent 1

112 , phenylacetylene, and secondary amine using binaphthyl stabilized palladium nanoparticles (Pd-BNP) a

113 The binaphthyl stabilized palladium nanoparticles (Pd-BNP) c

114 f the aryl group at the 3,3'-position on the binaphthyl system using aryl boronic acid through a pall

115 n we report the synthesis of two enantiopure binaphthyl systems: an open and a methylene-bridged 1,1'

116 A series of chiral binaphthyl titanium alkoxide complexes were synthesized.

117 Acid-catalyzed isomerization of 1,1'-binaphthyl to 2,2'-binaphthyl has been noted previously.

118 rted the AlCl3-catalyzed cyclization of 1,1'-binaphthyl to perylene.

119 nomer demonstrates that the chirality of the binaphthyl unit is not propagated along the biphenyl pol

120 the structural properties of the chiral 1,1'-binaphthyl unit, suggest strongly that two distinct bina

121 chirality present in the chiral enantiomeric binaphthyl units and the fine-tuning of their electronic

122 ased on conformationally restricted transoid binaphthyl units direct preferential facial binding of t

123 n the dihedral angle induced a switch of the binaphthyl units from the cisoid to the transoid form up

124 ed substituents to the 6,6'-positions of the binaphthyl units in the macrocycles leads to greatly amp

125 f the N* organization due to the presence of binaphthyl units in the polymeric structure, which are k

126 mpounds that bear two axially chiral bridged binaphthyl units were developed as photodynamic chiral d

127 ructure and conformational properties of the binaphthyl units: a robust, persistent helical handednes

128 -diarylation of the racemic 2,2'-diiodo-1,1'-binaphthyl which proceeds with deracemization via a pall

129 ing in polymer glasses atropisomeric bridged binaphthyls with appended oligophenyl paddles of varying