ライフサイエンスコーパス: binding

1 al understanding of membrane-mediated ligand binding.

2 sition states and favors the enthalpy-driven binding.

3 hus explaining why H2 is necessary for tight binding.

4 insertions that are not correlated with H-NS binding.

5 showed weakening of actin-mutant tropomyosin binding.

6 e to MEK inhibition by enhancing interfacial binding.

7 ng conformational rearrangement upon initial binding.

8 s to identify residues involved in substrate binding.

9 ange in the DeltaH associated with substrate binding.

10 ngs, along with histological analyses of IAV binding.

11 ns in the PDE3A active site abolish compound binding.

12 in BBSome conformation induced by ARL6(GTP) binding.

13 ely small conformational changes upon target binding.

14 mediate the efficiency of reovirus host cell binding.

15 he inclusion of an auxiliary site capable of binding a Lewis acid (LA(II)); we used this unique featu

16 report that, in mammalian cells, NF2's lipid-binding ability is critical for its function in activati

17 (7)S-) were found to be critical to the PI5P-binding ability.

18 and anti-obesity drugs by inhibiting its DNA-binding activities.

19 ding region for EphA2, we compared the EphA2 binding activity of EBV gH/gL and the EBV gH/gL-N(69)L/S

20 st in Ca(2+)-release assays; its potency and binding affinity for Ins(1,4,5)P(3)R were similar to tho

21 or which we find that the predicted absolute binding affinity is predictive of immunogenicity.

22 We demonstrate a strategy to improve the binding affinity of aptamers by modifying their sequence

23 left region, (Sc)CRM1 exhibits 16-fold lower binding affinity than (Hs)CRM1 toward PKI-NES and signif

24 of A9 unspecific binding and to increase the binding affinity to the receptor.

25 tween disorder in H2 and its contribution to binding affinity, and that sequence variations in H2 tha

26 the wild type allele by measuring its ligand binding affinity, CCL2 scavenging efficiency, and cell a

27 The 2'-methylation uniquely enhanced binding and agonist potency at alpha7 receptors.

28 molecular determinants critical for agonist binding and biased signaling through PAR4.

29 ninflammatory because of reduced FcepsilonRI binding and enhanced CD23-dependent serum clearance.

30 couple the energy of nucleoside triphosphate binding and hydrolysis to mechanical movement along a po

31 ion, co-chaperone "helper" proteins, and ATP binding and hydrolysis.

32 the tendency of UPF1 to release RNA upon ATP binding and hydrolysis.

33 olutionarily more recent site diminishes p38 binding and made the phosphoswitch differently sensitive

34 2 active site, leading to blockade of RasGAP binding and optimal signaling by the two receptors.

35 to minimize the percentage of A9 unspecific binding and to increase the binding affinity to the rece

36 creased histone acetylation, increased c-Jun binding, and upregulation of nearby genes implicated in

37 cids) affording high-affinity lanthanide ion binding, and X-ray fluorescence microscopy (XFM).

38 The EBBINGHAUS (Evaluating PCSK9 Binding Antibody Influence on Cognitive Health in High C

39 ct, changes of NH protection during antibody binding are measured.

40 a recently established NanoBRET-based ligand binding assay.

41 rve separable effects of Na(+) and succinate binding at several positions suggesting distinct effects

42 results suggest that interfering with ZNF274 binding at the maternal SNORD116 locus is a potential th

43 ot change the level of disorder show similar binding behavior.

44 ABM300 was characterized in vitro (receptor binding, beta-arrestin2 recruitment, ERK1/2 phosphorylat

45 esigned two cyclic peptide mimics of the TAR-binding beta2-beta3 loop sequences present in two high-a

46 IP) and biochemical analyses revealed direct binding between endogenous TruB1 and the stem-loop struc

47 In both cases, the binding between MHC and antigenic peptides is the most s

48 did not affect surface expression and ligand binding but changed the susceptibility to heat denaturat

49 ing two-sided extrusion and stable chromatin binding by condensin II promotes compaction.

50 trate pTyr in EGFR and HER2 mediate specific binding by the SHP2 active site, leading to blockade of

51 ved through a hydrophobic trimethyl-L-lysine-binding 'cage' formed by BAHCC1(BAH), mediating colocali

52 Moreover, other Sirtuins share some DSB-binding capacity and DDR activation.

53 lular levels of anticancer drugs through ATP-binding cassette (ABC) pumps.

54 ATP-binding cassette (ABC) transporters constitute one of th

55 es, peroxisomal acyl-activating enzymes, ATP binding cassette (ABC) transporters, and central carbon

56 etion was not a consequence of increased ATP-binding cassette subfamily G member 5/8 activity given t

57 establishes multivalent, synergistic H3-tail binding causing distinct cellular localization and enhan

58 gest how changes in the association of lipid-binding caveolar proteins upon flattening of caveolae co

59 partially collapsed inward-facing substrate-binding cavity.

60 rvation and structural similarity in the NES-binding cleft region, (Sc)CRM1 exhibits 16-fold lower bi

61 DNA binding correlates with nucleotide occupancy: five MCM s

62 Fittings of NMR and ITC binding curves to the Hill model yielded n(Hill) ~2.9, n

63 ns, we demonstrate that cbEGF domain calcium binding decreases under mechanical stress (i.e. cbEGF do

64 le measurements of full length p53 tetramers binding DNA reveal the parameters that define the stabil

65 an extended loop in the C-terminal receptor-binding domain (HC) of BoNT/B (HC/B) has been proposed t

66 The receptor-binding domain (RBD) is immunodominant and the target of

67 gM, and IgA antibodies to the spike receptor binding domain (RBD), S1+S2, nucleocapsid, and ORF6 to O

68 However, STEAP1 lacks an intracellular NADPH-binding domain and does not exhibit cellular ferric redu

69 Cys2His2 zinc finger is the most common DNA-binding domain expanding in metazoans since the fungi hu

70 reatment of COVID-19 with high anti-receptor binding domain IgG titer convalescent plasma is efficaci

71 re, we report a crystal structure of the DNA-binding domain of a model ASO-binding protein PC4, in co

72 f the ankyrin repeat motifs in the substrate binding domain of cpSRP43 drives its activation.

73 se (NOX2) subunit, p67(phox), and to the RAC-binding domain of p21-activated kinase, consistent with

74 n July, 2020, using a spike protein receptor binding domain total antibody chemiluminescence assay (1

75 rsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site.

76 The binding domains of A. phagocytophilum adhesins A. phagoc

77 -binding surface exhibiting a preference for binding double-strand RNA (dsRNA) over single-strand RNA

78 as activity-based probes and as irreversibly binding drugs.

79 Newer formulations with carbohydrate cores binding elemental iron more tightly allow complete iron

80 -membrane interaction and fully map the site-binding energetics of Syt1 both in the absence and prese

81 te expressions for the prediction of optimal binding energies of important surface intermediates and

82 bstrate selectivity of ADAM17 toward Heparin-binding epidermal growth factor like growth factor (HB-E

83 In vitro DNA-binding experiments and structural prediction show that

84 ntaining polyglutamine tracts including core-binding factor alpha1, mediator subunit 12, transcriptio

85 The data show that S. gordonii binding force to the C. albicans surface is significantl

86 s, and experiments show that protein-protein binding free energies are sensitive to the extent of met

87 the effect of methylation on protein-protein binding free energies.

88 RA method is able to detect small changes in binding free energy with a sensitivity comparable to in

89 Our findings differentiate effector binding from biological function, which has ramification

90 inhibitors bearing two pharmacophores-a zinc binding group and a Cys-reactive warhead-were designed t

91 nists and heteromeric receptors that contain binding-impaired subunits, as we show for both kainate a

92 hanced phosphorylation (Ser73), and AP-1/DNA-binding in response to S. mansoni infection.

93 both a stabilized HA and alpha-2,6 receptor binding in tandem pose greater pandemic risk.

94 catechin gallate (ECGC) exhibited very rapid binding (in the order of seconds) with Human Salivary al

95 Loss of barbed-end binding increases nucleation by Spire and synergy with C

96 Biophysical insight into the binding interaction between the major whey protein, beta

97 ds high-affinity bonds by using several weak binding interactions simultaneously.

98 ing regions of myosin assures a proper actin-binding interface and active site have formed before pro

99 dditional hIL-23p19 substitutions within its binding interface to hIL-23R and found that the combined

100 ases, our work demonstrates that drug-target binding is a major predictor of bacterial responses to a

101 Binding is concomitant with a significant wavelength shi

102 rmational selection mechanism, in which POT1 binding is coupled to an obligatory unfolding reaction,

103 Multivalent binding is essential to many biological processes becaus

104 concentration-dependent manner and that the binding is facilitated by the presence of phosphatidylse

105 Binding is sequence-independent with residues N13, R16,

106 g a protein binding motif will alter protein binding, it has been shown that single nucleotide polymo

107 C) and epigallocatechin (EGC) exhibited slow binding kinetics (in the order of minutes), epicatechin

108 Conversely, poly(A) binding KPAF4 shields the nascent A-tail from uridylatio

109 Additionally, high-mannose-binding lectins possess a broad capacity to neutralize a

110 teracting with lipid membranes (termed lipid-binding loop [LBL]).

111 exhibit irreversible or reversibly covalent binding mechanisms towards cysteine thiols and other ami

112 Based on the binding mode of adenosine 5'-(alpha,beta-methylene)dipho

113 face, which greatly influences Spike protein binding mode.

114 nel and systematically validated our menthol binding models with thermodynamic mutant cycle analysis.

115 o weak - or are disfavored compared to other binding modes - to be observed in typical host-guest com

116 evealing that proteins may exhibit different binding modes with different partners.

117 While it is clear that changing a protein binding motif will alter protein binding, it has been sh

118 f A, which we previously identified as a CDK-binding motif.

119 TAC") does so by rediscovering ab initio the binding motifs for known regulators and some unknown one

120 affect RNA-protein interactions from outside binding motifs through altered RNA secondary structure.

121 out evidence of donor and acceptor substrate binding obtained using a crystal engineering approach.

122 s by the KDEL receptor is pH dependent, with binding occurring under acidic conditions in the Golgi a

123 ning it in an "off" state until the specific binding of a true substrate.

124 four activation-loop threonine residues and binding of ATP-Mg(2+).

125 the agonist, ATR, as well as the noncovalent binding of beta-ionone, an antagonist for G protein acti

126 The binding of E. coli to the M13 phage on the cytosensor su

127 Binding of FH increases meningococcal resistance to comp

128 The binding of Fpr to various DNA motifs are mediated by its

129 ted STAT3 or GLI1 knockdown reduced promoter binding of GLI1 and STAT3, respectively.

130 ome buried at the complex interface, disrupt binding of hIL-23p19 to hIL-23R.

131 SA (g-iELISA) is based on the principle that binding of monoclonal antibodies to specific epitopes of

132 This process was likely accomplished by the binding of Mt2 ectodomain to Hjv and Hfe.

133 However, how the binding of multiple factors at any given locus is coordi

134 singly charged metals differ profoundly from binding of multiply charged ions, often leading to overa

135 Binding of NucC trimers to a cyclic tri-adenylate second

136 ations involving the strong and/or selective binding of O(2).

137 iochemical, and biologic work has shown that binding of PIP(3) to the pleckstrin homology (PH) domain

138 ke only protein sequence as input to predict binding of protein to DNA, RNA, and other proteins.

139 To detect any NR2B-specific binding of radioligand in brain, various preblocking or

140 resistance, probably owing to high-affinity binding of SAP2 to pyrethroid insecticides.

141 n of the WNT pathway, through preventing the binding of TCF4 to chromatin.

142 tion of the T cell receptor (TCR) results in binding of the adapter protein Nck (noncatalytic region

143 iosensors can be used to monitor equilibrium binding of the agonist, ATR, as well as the noncovalent

144 ctures in complex with HIV-1 RT/dsDNA showed binding of the conjugates at the polymerase active site,

145 by their typically low affinity and variable binding of the SIMs in parallel and antiparallel orienta

146 ERV into an A-repeat deficient Xist rescues binding of Xist RNA to Spen and results in strictly loca

147 The electrochemical measurements for glucose binding on the AuNP-MIP sensor revealed a high affinity

148 endoplasmic reticulum localization, kinesin-binding or phosphoinositide-binding properties abrogated

149 n protein-protein interactions to favor Cas2 binding over tetramerization; this in turn led to prefer

150 ygen transport and exchange by cooperatively binding oxygen with moderate affinity.

151 also show that SIM interacts with CYCA2;3, a binding partner of CDKB1;1, via SIM motif A, which we pr

152 ceptor kinase-1 (IRAK-1) as a Nck1-selective binding partner, demonstrating that IRAK-1 activation by

153 This spurs interest in simulations of (un)binding pathways of TSPO ligands, which could reveal the

154 no comprehensive survey of genome-wide CTCF binding patterns across different human cancers.

155 e closely related species to assess how CTCF binding patterns stably fixed by evolution in each speci

156 ty in a panel of variants of the Car9 silica-binding peptide (DSARGFKKPGKR) fused to the C-terminus o

157 with rhIGF-1 (recombinant human IGF-1)/BP3 (binding peptide 3) improves lung growth and prevents PH

158 ay-based platform yields high-quality MHC-II-binding peptide datasets that can be used to improve the

159 suggests the existence of an optimal ligand-binding pocket conformation for capsaicin-mediated TRPV1

160 ealed a large, membrane-accessible substrate-binding pocket that alternately faced the ER lumen and c

161 metabolites within the ATP and D-cycloserine binding pockets of Ddl.

162 an be used to improve the accuracy of MHC-II binding prediction algorithms, and potentially enhance o

163 However, current MHC-binding prediction methods lack an analysis of the major

164 rusen, and can compete with FH/FHL-1 for C3b binding, preventing FI-mediated C3b cleavage.

165 We found that folding-upon-binding primarily occurred through induced-folding pathw

166 s between cardiotoxicity risk and structural/binding profiles of individual KIs.

167 ization, kinesin-binding or phosphoinositide-binding properties abrogated the regenerative effects.

168 We further show that those different binding properties directly translate to distinct biolog

169 ently suggests that the knowledge of the DNA-binding properties of the proteins is in itself not suff

170 e transcription factor cAMP response element-binding protein (CREB) to enhance the expression of prot

171 strained, and enriched for cis-eQTLs and RNA-binding protein (RBP) interactions.

172 rotein (GFP), siderocalin (Scn), and retinol-binding protein 4 (RBP4) as model proteins and screened

173 TAR DNA-binding protein 43 (TDP-43) has emerged as a key player

174 tent with adipogenesis, and the phospholipid-binding protein annexin A3 (AnxA3), a negative regulator

175 ogin (SCGN) is a recently discovered calcium-binding protein belonging to the group of EF-hand calciu

176 lysaccharide monooxygenase (LPMO) and copper binding protein CopC share a similar mononuclear copper

177 show that the phosphorylation of the RNA-DNA binding protein fused in sarcoma (FUS) is higher in Itga

178 Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central nervou

179 ure of the DNA-binding domain of a model ASO-binding protein PC4, in complex with a full PS 2'-OMe DN

180 Mental Retardation Protein (FMRP) is an RNA binding protein that regulates translation and is requir

181 teracts with the TRFH domain of the telomere binding protein TRF2.

182 t the promoter, recruits the C/EBPbeta (CREB-binding protein) and CBP transcription factors and activ

183 excitement around ProQ as a novel global RNA-binding protein, and its potential to serve as a matchma

184 ned to the filament domain containing myosin binding protein-C, the "C-zone." Myosin motors in domain

185 transcriptional coactivator CBP and TATA-box binding protein.

186 rands and crosslink them: class A penicillin-binding proteins (aPBPs) and complexes of SEDS proteins

187 he endoplasmic reticulum (ER) immunoglobulin binding proteins (BiPs) are molecular chaperones involve

188 ition for binding sites among protective RNA-binding proteins and decay factors, PTBP1 promotes displ

189 Targeting the actin-binding proteins LIMK1 and LIMK2 significantly diminishe

190 To identify RNA binding proteins potentially driving these patterns, we

191 for calcium management (calmodulin, calcium-binding proteins), pH regulation (V-type proton ATPase),

192 organic matter, such as hydrophobic surface binding proteins, laccases (AA1_1), xylanases (GH10, GH1

193 f TRAMP components with multiple nuclear RNA binding proteins, revealing preferential colocalization

194 Here we have developed monobodies, synthetic binding proteins, that bind the N-terminal four-helix bu

195 in belonging to the group of EF-hand calcium-binding proteins.

196 mine the binding selectivities of several HS-binding proteins.

197 y correlates with EGFR numbers available for binding, rather than specific signalling events.

198 defined as less than 65% of putamen striatal binding ratio expected for the individual's age.

199 ion by NMR spectroscopy, we identify the SAM-binding region and observe changes in the dynamics of th

200 e whether this glycosylation site may be the binding region for EphA2, we compared the EphA2 binding

201 ormed, using CRISPR-Cas9 to delete MafK-int6 binding region in IRF8 expression-restrictive cells.

202 binding restricts the dynamics in the Ca(2+)-binding region.

203 ent at the central transcription factor (TF) binding regions and at the flanking eRNA initiation regi

204 mall changes outside of highly conserved DNA-binding regions can lead to profound changes in protein

205 munication between the actin- and nucleotide-binding regions of myosin assures a proper actin-binding

206 that increase the surface area of the actin-binding regions promoting myosin interaction with actin,

207 a-interface, mapped to Switch I and effector-binding regions, (ii) alpha-interface at the allosteric

208 ion, some fundamental aspects of protein-DNA binding remain poorly understood(1,2).

209 diated by lysine residues in the microtubule-binding repeat region of tau.

210 Knowledge of protein-binding residues (PBRs) improves our understanding of pr

211 sease-causing sequence variants often affect binding residues.

212 Ca(2+) binding restricts the dynamics in the Ca(2+)-binding reg

213 n the microtubule-bound state by slowing ATP-binding, resulting in high-force production at both homo

214 For MN4, ligand-binding results in the reduction of dynamics that are lo

215 rinted as a glycan microarray to examine the binding selectivities of several HS-binding proteins.

216 hanism of the Ealpha and its downstream CTCF binding site (here named EACBE) in dynamic chromatin reg

217 injury) and their effects on the ubiquinone-binding site and a connected cavity in ND1.

218 The structure reveals a composite binding site bridging over three domains of one capsid p

219 d or in chromosomal DNA, containing the same binding site but with a different reporter.

220 nal repression of Wapl through a single Pax5-binding site by recruiting the polycomb repressive compl

221 tyrosine to phenylalanine substitution at a binding site could be detected.

222 To date, a binding site for P on L had not been described.

223 ering such a selective multivalent metal ion binding site into target macromolecules for structural a

224 ctivity when targeting the peptide substrate binding site of NTMT1/2.

225 hylated context, either deletion of the CTCF binding site or depletion of RAD21 cohesin complex prote

226 Disruption of the NAD(+)-binding site or the ARM-TIR interaction caused constitut

227 bound MHB can be correlated to the change of binding site polarity and that a tyrosine to phenylalani

228 tides ('msR4Ms') designed to mimic the CXCR4-binding site to MIF, selectively bind MIF with nanomolar

229 n the DNA-binding domain, distal to the zinc-binding site.

230 uction of dynamics that are localized to the binding site.

231 ures required for optimal interaction at the binding site.

232 n happens at a position far from the antigen binding site.

233 e MITF as a model, we show that low-affinity binding sites act as a competitive reservoir in vivo fro

234 zation that depend on direct competition for binding sites among protective RNA-binding proteins and

235 ture.ORG for further investigation of glycan-binding sites and glycan structures.

236 lycomb repressive complex occupancy and CTCF binding sites are associated with cancer-specific gene d

237 nalysis of the data allowed pinpointing CodY-binding sites at close to single-nucleotide resolution.

238 ally identify ZMAT3-regulated RNAs and their binding sites at nucleotide resolution in intact colorec

239 RT forms a symmetric dimer with two (p)ppGpp binding sites at the dimer interface.

240 Modeling studies unveil the specific binding sites for acetylene capture as well as the inter

241 during infection without the need to evolve binding sites for antisilencing proteins at each foreign

242 reporter assay (MPRA) libraries composed of binding sites for SOX2, POU5F1 (OCT4), KLF4, and ESRRB.

243 We identify binding sites for substrate K(+) and Cl(-) ions, demonst

244 of both the allosteric ligands and receptor binding sites important for these allosteric activities.

245 PSF30-hFip1 complex in vitro, and both hFip1 binding sites in CPSF30 can support polyadenylation.

246 e searches resulted in only 13 similar metal binding sites in other proteins, indicative of the raren

247 We compared binding sites of TRAMP components with multiple nuclear

248 ed in this way often contain multiple ligand binding sites or modification sites, which can operate t

249 t for smaller oligonucleotides the number of binding sites remained unchanged with pressure rise whil

250 We also identified two distal quinone-binding sites with bound quinones.

251 8 forms a dimeric structure with four Zn(2+) binding sites within each subunit: a highly conserved pr

252 Using TR ChIP-seq peaks or imputed TR binding sites, Lisa probes the chromatin models using in

253 been proposed to be mediated by their lysine-binding sites.

254 hrough octarepeat and nonoctarepeat (non-OR) binding sites.

255 on of the protein depending on the preferred binding sites.

256 ides were printed as a microarray to examine binding specificities of lectins, anti-ganglioside antib

257 VP4 [P] genotype binding specificities of rotaviruses and differential ex

258 ffold with basic patches constituting an RNA-binding surface exhibiting a preference for binding doub

259 ious DNA motifs are mediated by its flat DNA-binding surface, which is centered on a short loop spann

260 nding to the same consensus motif, their DNA-binding syntax is different, suggesting discriminatory f

261 stigated using voltage-clamp and radioligand binding techniques.

262 ivision machinery by hijacking NuMA from LGN binding, thereby favoring TIC self-renewal.

263 a conformational change that mediates stable binding to a non-canonical DNA motif.

264 sites enabled chemoselective and reversible binding to acetylene through the formation of metastable

265 n vitro, both tracers displayed preferential binding to activated hPBMCs.

266 which functions as a stabilizer of MEILB2 by binding to an alpha-helical N-terminus of MEILB2 and pre

267 ) changes significantly, consistent with BVM binding to an internal ring of hydrophobic side chains o

268 We find that RAC2(E62K) retains binding to an NADPH oxidase (NOX2) subunit, p67(phox), a

269 SidI binding to eEF1A and Lpg2505 is not mutually exclusive,

270 , multivalent interactions couple productive binding to efficient deacetylation of histones on endoge

271 tides (EP1, -2, -3, -7 or EP9) showed strong binding to EpiSCs but not to blood immune cells.

272 dium containing eGFP-Wnt-3a to visualize its binding to FZD and to quantify Wnt-FZD interactions in r

273 We compared plasma antibody binding to HIV antigens between 51 nontransmitting mothe

274 Binding to Ins(1,4,5)P(3) receptors [Ins(1,4,5)P(3)R] an

275 changes in PCSK9 required for high-affinity binding to LDL particles.

276 as been proposed to also contribute to toxin binding to neurons by interacting with lipid membranes (

277 blast HS genetically to make it incapable of binding to OPG.

278 rved for estradiol but not testosterone, IPI binding to SHBG was reduced by ~20-fold in the presence

279 t is involved in DNA replication by directly binding to specific motifs within their promoters.

280 enza IgG monoclonal antibodies for selective binding to the activating Fcgamma receptor FcgammaRIIa r

281 ently by promoting oligomerization involving binding to the C-terminal region.

282 otes immunostimulatory secondary necrosis by binding to the phagocytic marker phosphatidylserine on d

283 While binding to the same consensus motif, their DNA-binding s

284 thambutol inhibits arabinosyltransferases by binding to the same site as both substrates in EmbB and

285 1 and MdGH3-2, respectively, by specifically binding to their promoters.

286 s, which bind NC with exothermic energetics, binding to these sites occurs endothermically due to con

287 Results: LW223 binding to TSPO was not susceptible to the rs6971 geneti

288 ulin); 5) is competitive with paclitaxel for binding to tubulin but not with vinblastine, crocin, or

289 and pro-metastatic effects through directly binding to Vimentin and competitively abrogating Trim16-

290 Besides binding to well-established receptors, an extended loop

291 This biases binding toward lower methylated states.

292 experiments, and inhibition analysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjug

293 of four highly conserved Trp residues in the binding tunnel had been replaced with Ala.

294 How integrin binding under shear stress mechanosignals a functional s

295 New pS22-Lamin A/C binding was accompanied by increased histone acetylation

296 20-fold in the presence of zinc, whereas DVT binding was almost completely lost.

297 Cooperative binding was retained when the two sites were for two dif

298 ation between raphe and hippocampal 5-HT(1A) binding which was more pronounced in HV.

299 We measured eosinophil binding with a Sykes-Moore adhesion chamber.

300 inst non-specific, adventitious nanoparticle binding, without the need for complex surface chemistrie