ライフサイエンスコーパス: binding affinity

1 complexes (89 increasing and 153 decreasing binding affinity).

2 in which the N terminus contributes only to binding affinity.

3 different protein target with a unique drug binding affinity.

4 ed to predict the effects of mutations on Ab binding affinity.

5 st one mismatch was found that increased the binding affinity.

6 features of SARS-CoV-2 RBD increase its ACE2-binding affinity.

7 ptor to agonists without changing the ligand binding affinity.

8 over, but is nonlinearly correlated with its binding affinity.

9 m resulted in compounds with improvements in binding affinity.

10 to modulate their membrane permeability and binding affinity.

11 sequence of multi-point mutations on antigen binding affinity.

12 dodecameric duplexes spanning >10(3)-fold in binding affinity.

13 resulted in a lead with submicromolar VISTA binding affinity.

14 s and is inversely related to divalent metal binding affinity.

15 maturation may contribute to increased MuSK-binding affinity.

16 acokinetic (PK) properties and improved TLR8 binding affinity.

17 of an enlarged binding cavity that enhances binding affinity.

18 as attributed to over 100-fold loss of CXCR4 binding affinity.

19 is impaired by mutations that reduce its RNA-binding affinity.

20 n of the C-tail greatly increases Mtf1's DNA binding affinity.

21 cRn with a considerable heterogeneity in the binding affinity.

22 e TH on PPARgamma with nanomolar potency and binding affinity.

23 of divalent ions leads to a reversal of the binding affinity.

24 sponse without substantially altering ligand binding affinity.

25 al contributions to RNA-binding, but not DNA-binding, affinity.

26 hore protein Spc105/KNL1 and their Bub3-Bub1 binding affinities.

27 drug stimulation of ATP hydrolysis and drug binding affinities.

28 n C-patches reveals an unexpected breadth of binding affinities.

29 that of 2, affecting guest scope as well as binding affinities.

30 and hydrophobic interactions are crucial for binding affinities.

31 cture element is insufficient to obtain high binding affinities.

32 network features such as network size and TF-binding affinities.

33 inding groove of 14-3-3, resulting in varied binding affinities.

34 ce between the sequences' rankings and their binding affinities.

35 ABP ligands in which eight of them have high binding affinities.

36 Excellent binding affinities (150-fold higher versus control parti

37 Consequently, a low-DNA-binding-affinity acetylation-mimetic MITF mutation suppo

38 silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, -B, and -C genotypes

39 Differential binding affinities among closely related protein family

40 The cA4 binding affinities and activities of the two constituent

41 teractions must account for their often weak binding affinities and also the biochemical challenges i

42 Quantitative modeling of MEF2B binding affinities and computational simulations exposed

43 nto a powerful tool for the determination of binding affinities and demonstrate the promising pharmac

44 ound target RNAs and substantially increased binding affinities and Hill coefficients.

45 , cell, and tissue scales by predicting drug-binding affinities and rates from simulation of ion chan

46 ine antibodies was measured by SHG, allowing binding affinities and rates of dissociation to be obtai

47 We also combined analysis of binding affinities and structures of 27 diverse NESs for

48 these PBDs (over 1,800 are known), their low binding affinities and the sensitivity of binding proper

49 d a humanized monoclonal IgG that has a high binding affinity and a relatively high specificity towar

50 al assays reveal key factors that may define binding affinity and agonist potency of formyl peptides.

51 ith metal ions correlate with their specific binding affinity and capacity.

52 Rs and uncover features that determine their binding affinity and editing efficiency.

53 contain capsid mutations that increase Dicer binding affinity and enhance pathogenicity.

54 wo forms: trans Pro300 SthK with high ligand binding affinity and fast activation, and cis Pro300 Sth

55 n of key interactions critical for nanomolar binding affinity and high selectivity of A9g for human P

56 The binding affinity and kinetics of target engagement are f

57 50% of neoantigens with high predicted MHC-I binding affinity and led to enhanced tumor clearance.

58 agments that dramatically improves the Abeta-binding affinity and lipophilicity for favorable blood-b

59 lysis, as heterodimeric ENZ-PRO mutants lack binding affinity and methyltransferase activity toward t

60 African strains responsible for differential binding affinity and neutralization potency (E393D).

61 0 results in a substantial reduction in both binding affinity and neutralization potential indicating

62 , where the allosteric modulator affects the binding affinity and operational efficacy of the agonist

63 es, and that HCI can be used to evaluate mAb binding affinity and potential functional efficacy again

64 In this work, we studied the binding affinity and specificity for a series of TALE pr

65 of gene expression noise depending on their binding affinity and stability of the bound TF.

66 ith both R1 and R2, bind to KLA with similar binding affinity and stimulate FGFR1 activation and MAPK

67 n histone paralogs vary substantially in DNA binding affinity and tetramer stability.

68 d the three small subunits increased the DNA binding affinity and the base substitution fidelity.

69 rary data improves the prediction of peptide-binding affinity and the identification of pathogen-asso

70 cations for specific sites, 3) estimates of binding affinities, and 4) testable hypotheses of the mo

71 hromatin accessibility and transcript factor binding affinities, and calculating the distribution of

72 cell-wall modules with drastically different binding affinities, and with distinct and mutually exclu

73 delineate the pMHCII intrinsic stability, DM-binding affinity, and catalytic turnover, independent ki

74 ired a protein-loading approach in which the binding affinity, and hence the surface diffusivity, is

75 Agonist potency, binding affinity, and relevant pharmacological parameter

76 tween disorder in H2 and its contribution to binding affinity, and that sequence variations in H2 tha

77 assessment of the physical and thermodynamic binding affinity, and the determination of the PXR-garci

78 ned properties of biological stability, high binding affinity, and thermal stability make TNA aptamer

79 ties can be major determinants of RNA-ligand binding affinity as well as a source of binding cooperat

80 thods, antibacterial activities and relative binding affinities, as well as physicochemical propertie

81 Through a competitive binding affinity assay and a number of physiochemical pr

82 Binding affinity assays showed that ACKR2-V41A has a low

83 CCL2 scavenging results aligned with binding affinity assays, with ACKR2-V41A cells scavengin

84 -tetramer transition, and (iv) calculate the binding affinities associated with the four Ca(2+)-bindi

85 ere designed, synthesized, and evaluated for binding affinities at DAT, as well as the serotonin tran

86 of the protein structure, and change of the binding affinity at a remote site are not well understoo

87 ile speciofoline does not exhibit measurable binding affinity at the u-, delta- or k-opioid receptors

88 to investigate viral genome replication, RNA-binding affinity, ATP hydrolysis activity, and helicase-

89 in hand, sdAbs can be engineered to improve binding affinity, avidity, target specificities, and bio

90 screen for ionizable molecules with high HSA binding affinity based on pK(a) shifts using UV-pH titra

91 technique we developed to calculate relative binding affinities between metal cations and the protein

92 ng, whereby an indicator of the differential binding affinity between a TF and its cognate DNA exhibi

93 ding domain of eIF4GI increases not only the binding affinity but also the selectivity among these mR

94 ntirely of TMO linkages also show higher RNA binding affinity but do not recruit ribonuclease H1 (RNa

95 We show that the enantiomers have similar binding affinities, but RR-RJW100 stabilizes both recept

96 These compounds display high binding affinity, but have poor physicochemical properti

97 er, and the resulting 61-nt aptamer enhanced binding affinity by 19 times (K(d) = 1.2 nM).

98 ch in part accounts for differences in EphA2 binding affinity by KSHV.IMPORTANCE Virus entry into tar

99 SEMpl estimates transcription factor-binding affinity by observing differences in chromatin i

100 for second-site mutations in S, decreasing S binding affinity by orders of magnitude.

101 hed state-of-the-art small-molecule relative binding affinity calculations, which have been shown to

102 Specific point mutations that decrease drug binding affinity can produce TKI resistance, and second-

103 the wild type allele by measuring its ligand binding affinity, CCL2 scavenging efficiency, and cell a

104 Quantitative estimation of the binding affinity changes (DeltaDeltaGbind) caused by mut

105 ulfono-gamma-AApeptides reveal much-enhanced binding affinity compared to the p53 peptide.

106 The mutant Tpm exhibited enhanced actin-Tpm binding affinity, consistent with overlap stabilization.

107 Increased PFAS binding affinities correlate with stronger responses in

108 used to explain the acidity versus chloride binding affinity correlations recently reported for some

109 s quantify protein diffusion and DNA-protein binding affinity, dependent on macromolecular density.

110 We find that the rituximab binding affinity depends sensitively and nonmonotonously

111 ct the binding poses, hot-spot residues, and binding affinity differences of a set of perfluoroarene

112 assays confirmed that E4(x12)-Cy7 has a high-binding affinity (dissociation constant, Kd, 4.6 +/- 0.8

113 bout their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity.

114 bserved, an observation substantiated by the binding affinities exhibited by the compounds in 5-HT(2A

115 during the immune response but whose antigen binding affinity failed to support further clonal expans

116 successfully predicts differences in overall binding affinities, fine details of IDP-SNP affinity pro

117 By native MS, the binding affinities for five ligand-DNA and DNA-DNA inter

118 This order largely reflected AgcA's binding affinities for the different guaiacols and was t

119 ins of paramyxoviruses have vastly different binding affinities for their cognate receptors, which th

120 Ds were monomeric and they exhibited similar binding affinities for their Cu cofactor.

121 (18)F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic fe

122 Despite a 12-fold loss of binary binding affinity for Brd4, macroPROTAC-1 exhibited cellu

123 acylation rate and, paradoxically, improves binding affinity for carbapenems.

124 ty assays showed that ACKR2-V41A has a lower binding affinity for CCL2 and CCL4 than ACKR2-WT.

125 in NPC1-deficient cells in spite of its low binding affinity for cholesterol.

126 eal that the PKLPPKTYKREH peptide has strong binding affinity for cSH3, but very weak for nSH3.

127 ound that EBV gH/gL-N(69)L/S(71)V had higher binding affinity for EphA2, indicating that the EBV gL N

128 acid substitution at E367 enhanced the viral binding affinity for glycosaminoglycans (GAGs) and reduc

129 modified loops, exhibited a 100 times higher binding affinity for HBeAg (K(d) = 0.4 nM) than the unmo

130 ing the semaphorin domain, confers exquisite binding affinity for HER2 and enables MET(N375S) to inte

131 r the Rb so as to significantly increase its binding affinity for hIgG1 as well as redesign its speci

132 st in Ca(2+)-release assays; its potency and binding affinity for Ins(1,4,5)P(3)R were similar to tho

133 including A, T, C, and G) had the strongest binding affinity for labeling of the administered GO (di

134 f this study show that (i) mimosine has high binding affinity for metallic cations at alkaline pH, Fe

135 Currently, predicted peptide binding affinity for MHC-I is often the major criterion

136 alogues of biphalin with excellent to modest binding affinity for mu-, delta-, and kappa-receptors we

137 phosphorylation of serine 298 decreased the binding affinity for MUPP1, a known scaffolding partner

138 e R101Q mutation in NLGN4 did not affect its binding affinity for NRXNs or its capacity to form homod

139 hibit an acute reduction in haemoglobin (Hb) binding affinity for oxygen that facilitates adaptation

140 adapted to high altitude through enhanced Hb binding affinity for oxygen.

141 ently, a PEDF receptor has shown an elevated binding affinity for PEDF.

142 To identify such compounds with binding affinity for polyQ aggregates, we embarked on sy

143 el that enables estimates of the equilibrium binding affinity for rapidly disassociating compounds fr

144 Compound 10 exhibited potent binding affinity for S1R, high selectivity over S2R and

145 bstitution substantially (76-fold) increased binding affinity for SETD3 and inhibited SETD3 activity

146 In contrast, resveratrol, which has a low binding affinity for site(s) on the surface of the BLG,

147 ular domain can be engineered to enhance its binding affinity for T-cadherin.

148 abolic flux control by fine-tuning substrate-binding affinity for the key enzymes in the competing re

149 icular eQTL that significantly decreases the binding affinity for the repressor Broad, driving differ

150 s to both proteins indicate a 17-fold higher binding affinity for the SA-N2 bond with respect to that

151 Grb2 nSH3/cSH3 domains have strong binding affinity for the SOS1 proline-rich (PR) domain t

152 ing partner of connexin36, and increased the binding affinity for two different 14-3-3 proteins.

153 , SBP-7455 (compound 26), displayed improved binding affinity for ULK1/2 compared with SBI-0206965, p

154 lical motif in full-length PCSK9 lowered LDL binding affinity >5-fold.

155 Of these compounds, 13 exhibits potent binding affinity (IC(50) = 7.6 +/- 0.9 nM), positive all

156 d 45 (ZL0516) have been discovered with high binding affinity (IC(50) values of 67-84 nM) and good se

157 While all factors showed greater binding affinities in the presence of PS and PE, the mos

158 ves rise to 10-30 unique sybodies exhibiting binding affinities in the range of 500 pM-500 nM.

159 er" model, and the mechanisms underlying the binding affinities in vivo, have remained elusive.

160 al binding site (site 2), which enhances the binding affinity in combination with site 1 by many orde

161 etry pores are thus required to maximise the binding affinity in host-guest complexes.

162 nding protein (PBP) 5 (PBP5) and beta-lactam binding affinity in HOU503 versus R497.

163 Ms showing predicted allelic variation in TF binding affinity in human lymphoblastoid cell lines and

164 The potassium binding affinity in the selectivity filter of this mutan

165 cgammaRs) for full effect and increasing the binding affinity increases efficacy.

166 binding to hairpin RNAs is weak but that the binding affinity increases significantly upon covalent a

167 methyltransferase (MTase) domain reduced SLA-binding affinity, indicating that they each are part of

168 we show that the dependence is solely on the binding affinity, irrespective of pH, IS, and resin liga

169 bution of conformational energies toward the binding affinities is revealed, which explains why the d

170 talysts a greater than 10-fold modulation in binding affinity is achieved upon photoisomerization.

171 Binding affinity is consequently lost if these changes a

172 or which we find that the predicted absolute binding affinity is predictive of immunogenicity.

173 pha-P or pregnanolone reduced to a hydroxyl, binding affinity is reduced by 1,000-fold, whereas bindi

174 We find that Engrailed binding affinity is strongly amplified by the DNA region

175 We developed variants with varying binding affinities (K(D) as low as 216 pM), co-crystalli

176 lowing the determination of essential ligand binding affinities (K(D)).

177 g proteins but also revealed the strong PI5P-binding affinity (K(d) = 1.81 x 10(-7) M) of the Walker

178 parameters for Signal Amplification (gamma), Binding affinity (K(d)), Receptor activation Efficacy (e

179 p90 inhibitor, independent of the reversible binding affinity (K(i)) or the intrinsic electrophilicit

180 two competing substrates with very different binding affinities (low nanomolar to millimolar) for an

181 t to accurately reproduce experimental guest binding affinities (MAD = 1.9 kcal mol(-1)) and identify

182 r signaling, but sequence degeneracy and low binding affinities make them difficult to identify.

183 ational approach, combined with experimental binding affinity measurements, to reveal how specificity

184 ing small molecule binding, measuring ligand-binding affinity, monitoring protein folding and unfoldi

185 ion in vitro and in cell culture models with binding affinities of 0.5 muM to alpha-syn fibril seeds.

186 lation (IR) was correlated with differential binding affinities of A-class and B-class ARFs, respecti

187 ments in vivo, and suggest that differential binding affinities of ARF subfamilies underlie diversity

188 Therefore, the binding affinities of candidate drugs to their targets a

189 molecular tool to determine hH(3,4)Rs/mH(4)R binding affinities of ligands binding to these receptors

190 oteins, we examined both the occupancies and binding affinities of miRNA-AGO2 complexes and target RN

191 ntal verification has been difficult because binding affinities of neurotransmitters to the lipid bil

192 assess effects of ligand orientation on the binding affinities of NOD-like receptors (NLRs).

193 erality of our method to characterize target-binding affinities of protein-binding aptamers.

194 Different binding affinities of these proteins for the endocytic r

195 approach is successful at rank-ordering the binding affinities of these stapled peptides with respec

196 eled conjugate allowed measurement of ligand binding affinities of unlabeled hA(2A)AR antagonists usi

197 is process, a comparison was made of the DNA binding affinities of WT pol beta, pol lambda, and pol m

198 esearch is illustrated by (i) increasing the binding affinity of a consensus pentapeptide motif towar

199 ons and it appears to be predicting the mean binding affinity of a ligand for its protein targets.

200 We further examined the binding affinity of a naturally occurring GQ stabilizing

201 set of residues that contribute most to the binding affinity of a protein-nucleic acid interaction.

202 se strategies have either exploited the high binding affinity of a receptor for its corresponding bio

203 (D23N), resulted in up to a 50-fold stronger binding affinity of Abeta for fibrinogen.

204 Sulfation significantly improved the binding affinity of ACA-01 for a range of proinflammator

205 he N-terminal acetylation is to regulate the binding affinity of alphaS for synaptic vesicles without

206 We demonstrate a strategy to improve the binding affinity of aptamers by modifying their sequence

207 We measured the binding affinity of c-Raf-RBD(RKY) using a bio-layer int

208 Detection strategy is based on higher binding affinity of citrinin with diammonium citrate, an

209 est FOXL2(C134W) drives AGCT by altering the binding affinity of FOXL2-containing complexes to engage

210 correlates with the experimentally observed binding affinity of H1 subtypes, suggesting an important

211 from the DM-pMHCII catalytic complex and the binding affinity of HLA-DM for a pMHCII.

212 Functional analysis demonstrated that Ca(2+)-binding affinity of P4H-TM is within the range of physio

213 The ultratight binding affinity of P[5]AS and P[6]AS toward quaternary

214 lin derivative, showed increased beta-lactam binding affinity of PBP5 of HOU503 compared with that of

215 modifications, and buffer environment on the binding affinity of PC4.

216 me A is a ligand for the PvrA, enhancing the binding affinity of PvrA to its target promoters.

217 The binding affinity of recombinant WT FH and the FH variant

218 As a consequence, the overall binding affinity of RNA to its binding partners depends

219 The enhanced binding affinity of S. mutans to glucan-coated C. albica

220 lable, additional curated information on the binding affinity of the complex and the effects of mutat

221 s control sfRNA formation by maintaining the binding affinity of the corresponding xrRNAs to Xrn1.

222 Second, paradoxically, the hACE2 binding affinity of the entire SARS-CoV-2 spike is compa

223 osphodiester could explain the decreased RNA-binding affinity of the G301D-substituted protein.

224 in agreement with an increased apparent RNA-binding affinity of the N196K-substituted protein.

225 e allosteric coupling controls the potassium binding affinity of the prototypical potassium channel K

226 The high hACE2 binding affinity of the RBD, furin preactivation of the

227 pH gate allosterically affects the potassium binding affinity of the selectivity filter.

228 governed by different parameters, including binding affinity of the targeting signal to the cargo fa

229 he principal route of metabolism because the binding affinity of UDP-GlcUA is higher than that of UDP

230 We then determine the binding affinity of Wnt3 to its receptor, Frizzled1 (Fzd

231 MHC binding prediction tools are trained on binding affinity or mass spectrometry-eluted ligands.

232 onal studies suggest that the changes in the binding affinity originate from the stabilization of the

233 These measurements determine binding affinities over four orders of magnitude at equi

234 tuned by the addition of ligands of varying binding affinity, particularly preQ1, guanine, and 2,6-d

235 earning scoring functions for protein-ligand binding affinity prediction have been found to consisten

236 rts several major histocompatibility complex binding affinity prediction tools.

237 med that decreasing transcription factor DNA-binding affinity reduces transcription initiation by dim

238 l EF-Tu-tRNA interactions, which lowers tRNA binding affinity, representing the first step of tRNA re

239 YoeB-YefM2-YefM2-YoeB) with low and high DNA-binding affinities, respectively.

240 the EBD, the evolved biosensors display DNA-binding affinities similar to BenM, and are functional w

241 tions at the peptide C terminus modulated DM-binding affinity, suggesting distal communication betwee

242 s varied substantially, but not in step with binding affinity, suggesting distinct modes of interacti

243 left region, (Sc)CRM1 exhibits 16-fold lower binding affinity than (Hs)CRM1 toward PKI-NES and signif

244 First, SARS-CoV-2 RBD has higher hACE2 binding affinity than SARS-CoV RBD, supporting efficient

245 epigenetic states, transcription factor-DNA binding affinity thresholds and influences of given tran

246 lling the effects of mutations on Ab-antigen binding affinity, through the inclusion of evolutionary

247 rnazos et al., 2020) shows that modifying Fc binding affinities to better target FcyRIIa enhances the

248 Intriguingly, TCR binding affinities to HLA-C inversely correlated with th

249 and (ii) a significant reduction of antigen-binding affinities to introduce dependence on bivalent i

250 ILC quantitatively predicts residue-specific binding affinities to nanoparticles and it expresses bin

251 concentrations through its calcium-dependent binding affinities to numerous target proteins.

252 ded RTA's active site, but lacked sufficient binding affinities to outcompete RTA-ribosome interactio

253 acid moieties that are known to exhibit high binding affinities to serum albumin.

254 e intensity of the chromophore upon binding, binding affinities to the chromophore in nanomolar to lo

255 ic Fe(II) helicates-which have similar anion binding affinities to the metalated Star of David catena

256 pically relies on extremely strong chelating/binding affinities to UO(2)(2+) using chelating polymers

257 D3.3 possesses a larger binding affinity to Abeta42 and higher brain biodistribu

258 s to increase the spanning space and overall binding affinity to chCD40ED.

259 rst, we developed DNA aptamers with specific binding affinity to chicken CD40 extra domain (chCD40ED)

260 within a synthetic host, thus increasing the binding affinity to DeltaG= -15.5 kcal/mol upon formatio

261 Measurement of monoclonal antibody (mAb) binding affinity to DIII proteins, timed AID deletion, s

262 Among these, aptamer EF508 exhibited high binding affinity to E. faecalis cells (K(D)-value: 37 nM

263 nd R379C mutants) showed reduced or impaired binding affinity to FZD5, suggesting a potential mechani

264 F750 and AF750-6Ahx-Sta-BBN showed a similar binding affinity to GRPR on HSC-3 cells.

265 at possesses both anticoagulant activity and binding affinity to HMGB1, the inflammatory target, decr

266 This increases CHIP binding affinity to Hsc70, CHIP protein half-life, and c

267 C-terminal octapeptide, has similar receptor binding affinity to human insulin.

268 promising new compounds by estimating their binding affinity to proteins.

269 ted ProINS-Tf exhibited significantly higher binding affinity to the insulin receptor compared with t

270 linked to a peptide ligand in a way that its binding affinity to the PDZ2 domain changes upon switchi

271 of A9 unspecific binding and to increase the binding affinity to the receptor.

272 Modified PS ASOs display better binding affinity to the target RNAs and increased bindin

273 tional docking simulations predict a greater binding affinity to the TrxR active site in comparison t

274 d that the T allele of rs17079281 had higher binding affinity to transcription factor YY1 than the C

275 inated pyridine derivatives and tested their binding affinities toward CB2 and CB1.

276 pared using a multistep synthesis, and their binding affinities toward GluN2B subunits and selectivit

277 co analysis predicted the peptides possessed binding affinity toward a broad range of divalent metal

278 presence of Ag(CN)(2)(-), which has a lower binding affinity toward alpha-cyclodextrin.

279 coordination and has only a minor impact on binding affinity toward Ca(2+) and on other biophysical

280 ating TMO and DNA-pS subunits exhibit higher binding affinity toward complementary RNA relative to th

281 hemically synthesized compounds had in vitro binding affinity toward galectin-8N in the range of 5-33

282 Fv to a bivalent scFv-Fc format improved its binding affinity toward native CD44 on human breast canc

283 It showed >10 muM binding affinity toward the ganglionic alpha3beta4 recep

284 ligase for the target protein, improving the binding affinities towards the target protein and the E3

285 conjugates demonstrated similar (nanomolar) binding affinity towards HER2-positive ovarian carcinoma

286 vity studies; lead optimization of aggregate-binding affinity, unbound fractions in brain, permeabili

287 2-domain target exhibits a 330-fold shift in binding affinity upon illumination.

288 of 242 experimentally determined changes in binding affinity upon multiple point mutations in antibo

289 Results: The binding affinity values for OF-NB1 and MF-NB1 toward the

290 can not only quantify the GNP-glycan-lectin binding affinities via a new fluorescence quenching meth

291 The improved binding affinity was attributable primarily to a reduced

292 ic contacts and an increased Tpm troponin T1 binding affinity, was also observed.

293 gnitude in the discrepancies of experimental binding affinities, we introduce topological data analys

294 wn to correlate with ionic strength (IS) and binding affinity, we show that the dependence is solely

295 (1)] or low [E1-7 (2)] medulloblastoma cell binding affinity were synthesized.

296 pectrum of binding modes and highly variable binding affinities when interacting with both biological

297 Quantitative experimental binding affinities with synthetic silica nanoparticles (

298 each of which results in ~1000 fold loss of binding affinity with a concomitant reduction in antivir

299 phthalate and Dactylorhin-A showed a higher binding affinity with CCR5 co-receptor than the standard

300 abel-free method for studying sub-micromolar binding affinities, with potential for extension towards