ライフサイエンスコーパス: binding affinity to

1 state, and exhibits a significantly enhanced binding affinity to 1-aminoadamantane in aqueous solutio

2 disulfide A10-A15 by a peptide bond reduced binding affinity to 32% and lowered potency to 7% but ma

3 mers derived from a monomer ( 3) showed high binding affinity to 5-HT 1D (for example, K i approximat

4 ligand physiochemical properties and ligand binding affinity to a biological transporter.

5 ning of this library to select aptamers with binding affinity to a desired small molecule.

6 ribonucleic acid (RNA) molecules with a high binding affinity to a large variety of target analytes.

7 lly profiled for the targeted and off-target binding affinity to a panel of 25 pre-selected protein k

8 nd deep sequencing, was used to optimize its binding affinity to a picomolar level, and X-ray co-crys

9 anges in SH2, the I568F mutant reduces SH2's binding affinity to a pTyr-containing peptide.

10 5 mutant EKLF proteins and quantitated their binding affinity to a range of EKLF-regulated genes.

11 oduces a complex with high sequence-specific binding affinity to a single-stranded capture oligonucle

12 ide greatly increases alpha-helical content, binding affinity to a target protein, cell penetration t

13 , where genes in a linear chain have ordered binding affinity to a transcription factor, suggesting a

14 three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K(d) of 0.14 nM to 20 nM) and

15 s discrepant residues resulting in different binding affinity to ABA.

16 clic 1,4-diphenyltriazoles showing excellent binding affinities to Abeta aggregates (Ki = 4-30 nM), w

17 (18)F-AV-45 displayed excellent binding affinity to Abeta plaques in the AD brain by ex

18 All bis-styryl-BTDs showed higher binding affinity to Abeta1-42 fibrils than to Abeta1-40

19 D3.3 possesses a larger binding affinity to Abeta42 and higher brain biodistribu

20 on toward the cell cytoplasm, diminishes its binding affinity to actin skeleton, and alters the numbe

21 stability than wild-type TRB3 and increased binding affinity to Akt.

22 at solvate H-bond donor solutes with similar binding affinity to alcohol monomers.

23 lutes, and these interactions have a similar binding affinity to alcohol monomers.

24 o properties of an ideal RAF inhibitor: high-binding affinity to all RAF paralogs and maintenance of

25 design enabled a 50-fold enhancement of the binding affinity to alpha(v)beta(3) integrin receptors w

26 soDGRFC, and CisoDGRC), which have different binding affinity to alphavbeta3 integrin, are reported f

27 ch solvate H-bond donor solutes with similar binding affinity to amide monomers.

28 , which displays enhanced hydrophobicity and binding affinity to amyloid fibrils.

29 ressed in BALB/c mice and exhibits increased binding affinity to and increased cytotoxic activity aga

30 The repeating H2A sequence enhances the binding affinity to anionic nucleic acids, forming more

31 omatic hypermutation (SHM) and selection for binding affinity to antigen via a process called affinit

32 t the juxtamembrane region of L1-CT has some binding affinity to AP2-mu2, although the specificity of

33 both time and resources spent in determining binding affinities to ASGP-R.

34 he additional glycosylation sequon increases binding affinity to avian-type alpha2-3-linked sialoside

35 lso have to cause an increase in calcium-ion-binding affinity to be effective therapeutically inside

36 ied a series of small molecules showing high binding affinities to BET proteins and low nanomolar pot

37 BD2 provides a structural basis for its high binding affinity to BET proteins.

38 rnazos et al., 2020) shows that modifying Fc binding affinities to better target FcyRIIa enhances the

39 Plin1 11mr peptide and a mutant with reduced binding affinity to both "naked" and phospholipid-coated

40 en prepared and evaluated for their apparent binding affinity to both Cu(I) and Cu(II).

41 emonstrate how these inhibitors achieve high binding affinity to both enzyme classes.

42 used N terminus (GST-sClC3-NT) exhibited low binding affinity to both G- and F-actin.

43 ximately 4- and 80-fold improvements in pH 6-binding affinity to both human and nonhuman primate FcRn

44 l series of ligands are known for their high binding affinity to both KOR and MOR, but efficacy at th

45 ational change, significantly increasing the binding affinity to BTE.

46 The aptamer BT10 exhibited the highest binding affinity to BTX-2, with a dissociation constant

47 were selected for experimental validation of binding affinity to C3d, using microscale thermophoresis

48 Binding affinity to CA-IX and other CA isoforms was dete

49 utant CAP (CAP-K26Bpy-Ala) showed comparable binding affinity to CAP-WT for the consensus operator se

50 rtificial glycosylation sites, can alter CBM binding affinity to carbohydrates and may thus be a gene

51 solvate H-bond donor solutes with a similar binding affinity to carboxylic acid monomers.

52 ly, we showed that ORG27569 enhances agonist binding affinity to CB1 but inhibits G protein-dependent

53 early HIV-1 Env to have high, medium, or low binding affinity to CD4, and we show that it loses the a

54 to test labeling efficiency, stability, and binding affinity to CD56.

55 To engineer CTLA4-Ig variants with altered binding affinity to CD80 and CD86, we employed a high-th

56 O-4-amino)propan-2-ol (TOTAPOL) has a strong binding affinity to cell wall polymers (peptidoglycan).

57 d with Eu(III)-DOTA was synthesized, and the binding affinity to cells overexpressing the human melan

58 ited by cello-oligosaccharides and displayed binding affinity to cellulose although no activity was o

59 BMs target specific polysaccharides, and CBM binding affinity to cellulose is known to be proportiona

60 ion reduces SIRT2 catalytic activity and its binding affinity to centrosomes and mitotic spindles, pr

61 s to increase the spanning space and overall binding affinity to chCD40ED.

62 rst, we developed DNA aptamers with specific binding affinity to chicken CD40 extra domain (chCD40ED)

63 tations that are predicted to reduce peptide binding affinity to chromosomes, suggesting that excessi

64 the sn-2 position suffices to generate high binding affinity to class B scavenger receptors.

65 HMGB1a in particular exhibits higher binding affinity to CP-GG adducts, and the extent of dis

66 ding by HMGB1a, which may explain its higher binding affinity to CP-GG adducts, while these conformat

67 oscillations that uses differential calcium binding affinities to create a robust molecular switch t

68 oth mutations significantly increased Ca(2+) binding affinity to cTn (KCa) and KC-I.

69 tion of truncated cTnI did not affect Ca(2+) binding affinity to cTn alone.

70 ion induced a significant increase in Ca(2+) binding affinity to cTn.

71 of the nitrogen atoms at lower pH causes the binding affinity to decrease, releasing the alpha-CD and

72 within a synthetic host, thus increasing the binding affinity to DeltaG= -15.5 kcal/mol upon formatio

73 Measurement of monoclonal antibody (mAb) binding affinity to DIII proteins, timed AID deletion, s

74 h separates histones based on their relative binding affinity to DNA and relative hydrophobicity.

75 The Zn2 domain exhibits high binding affinity to DNA compared with the Zn1 domain.

76 However, whereas the binding affinity to DNA of halophilic TBPs increases wit

77 heir spatial organization in nucleosomes for binding affinity to DNA.

78 re differences in the biological actions, in binding affinities to E-cadherin promoter, and in the ta

79 Among these, aptamer EF508 exhibited high binding affinity to E. faecalis cells (K(D)-value: 37 nM

80 dividual RAF family members exhibit distinct binding affinities to each RAS family protein, with CRAF

81 the flanking acidic residues "fine tune" the binding affinity to EHD1.

82 TNYL-RAW and its derivatives displayed high binding affinity to EphB4, with equilibrium dissociation

83 phorylation of LD4 results in a reduction of binding affinity to FAK.

84 2 and IgG4 isotypes have significantly lower binding affinity to Fcgamma receptors.

85 with a low amount of fucose displayed higher binding affinity to FcgammaRIIIa and FcgammaRIIIb, but n

86 hypersialylated glycans exhibited unchanged binding affinity to FcgammaRIIIA.

87 arginine at position 435, which reduces its binding affinity to FcRn in vitro.

88 sing CHO cells were only partly reflected in binding affinities to FRalpha and FRbeta or in the docki

89 MinC effects on FtsZ-GTP protofilaments and binding affinity to FtsZ-GDP were strongly dependent on

90 nd R379C mutants) showed reduced or impaired binding affinity to FZD5, suggesting a potential mechani

91 bazole conjugates and demonstrate their high binding affinity to G4 DNA.

92 resulted in five hits which exhibited strong binding affinities to GAB1 PH domain.

93 that a tight cavity can generate a stronger binding affinity to gas molecules than open metal sites.

94 lation by changing transcription factor (TF) binding affinities to genomic sequences.

95 at the exocyclic sulfur moiety improves tRNA binding affinity to GlnRS 10-fold compared with the unmo

96 AP is a tumor homing peptide exhibiting high binding affinity to glucose regulated protein 78 (GRP78)

97 tand in regard to human adaptation since its binding affinity to glycan receptors has not yet been qu

98 of the HIV-1 gp41 bNAb 2F5 for their antigen binding affinities to gp41 linear peptide and conformati

99 F750 and AF750-6Ahx-Sta-BBN showed a similar binding affinity to GRPR on HSC-3 cells.

100 l lobe of DmAgo1 and DmAgo2 had no effect on binding affinity to guide RNAs, we observed a loss of pr

101 Increasing the binding affinity to h-Syt II may improve botulinum neuro

102 es clonally related to known antibodies with binding affinity to H7 hemagglutinin could be identified

103 Individual somatic mutations that enhance binding affinity to hapten decrease the stability of the

104 pying the hCD1d F' channel in modulating TCR binding affinity to hCD1d-lipid complexes, the formation

105 Hx is the plasma protein with the highest binding affinity to heme and controls heme-iron availabi

106 pAcF IgG polymer conjugate, despite its high binding affinity to HER2 antigen, did not induce a signi

107 de toxin with known NMR structure and a high binding affinity to hERG.

108 s shown to destabilize pVHL and decrease its binding affinity to HIF.

109 Intriguingly, TCR binding affinities to HLA-C inversely correlated with th

110 enhanced altered peptide ligands (CPLs) for binding affinity to HLA-A*0201.

111 ee of 10 epitopes exhibited high-to-moderate binding affinity to HLA-A*02:01 molecules.

112 at possesses both anticoagulant activity and binding affinity to HMGB1, the inflammatory target, decr

113 This increases CHIP binding affinity to Hsc70, CHIP protein half-life, and c

114 e-fold higher promoter activity and stronger binding affinity to HSF1 than the C allele.

115 SNX-7081 showed strong binding affinity to Hsp90 and expected induction of Hsp7

116 -one derived 2-aminobenzamides showed strong binding affinity to Hsp90, and optimized analogues exhib

117 everal small 2-helix proteins with excellent binding affinities to human epidermal growth factor rece

118 The SEFL variants tested showed decreased binding affinity to human and cynomolgus FcgammaRs compa

119 activity against human iNKT cells in vitro, binding affinity to human and murine CD1d molecules, and

120 us receptor binding specificity but enhances binding affinity to human cells and lung tissues from mo

121 C-terminal octapeptide, has similar receptor binding affinity to human insulin.

122 ing site of H7 HA substantially increase its binding affinity to human receptor.

123 ategy to engineer DNA structures with strong binding affinity to human serum albumin (HSA).

124 These gull-origin viruses showed high binding affinity to human-like glycan receptors.

125 ull-origin virus showed significantly higher binding affinity to human-like glycan receptors.

126 ned through solid phase synthesis, and their binding affinity to hydroxyapatite, TiO2, ZrO2, CeO2, Fe

127 Consistent with its potent binding affinities to IAPs, 7 effectively antagonizes XI

128 nd evaluated for their monoamine transporter binding affinities to identify potent and selective comp

129 d FcalphaRI N-glycans significantly modulate binding affinity to IgA.

130 to create a CL7 tag, which retained the full binding affinity to Im7 but was inactivated as a DNase.

131 dle of the protein exhibited higher apparent binding affinity to integrin-expressing tumor cells comp

132 r the design of linear epitopes of specified binding affinity to Intravenous Immunoglobulin (IVIg).

133 and (ii) a significant reduction of antigen-binding affinities to introduce dependence on bivalent i

134 Purified AbGSC90 showed a high binding affinity to isolated SQR.

135 ides with both high-binding affinity and low binding affinity to IVIg.

136 the KIAA1549-BRAF fusion displays increased binding affinity to kinase suppressor of RAS (KSR), an R

137 The isoforms varied in their binding affinities to known downstream targets and diffe

138 804M, N806D, I813L, S815K) reduces tadalafil binding affinity to levels characteristic of PDE6.

139 11H, on the other hand, had a slightly lower binding affinity to LF (dissociation constant of 7.4 nM)

140 Single-stranded (ss) DNA aptamers with binding affinity to Listeria spp. were selected using a

141 Although 13 showed potent binding affinity to LXRbeta (IC(50) = 53 nM), it had lit

142 s of m4-1BB disclosed a very tight nanomolar binding affinity to m4-1BBL with an unexpectedly strong

143 bridged compound 14 demonstrates very potent binding affinity to matriptase.

144 xplains how increasing disorder can tune the binding affinity to maximize the specificity of promiscu

145 ot transported by MalFGK2 despite their high binding affinity to MBP.

146 (ReCCMSH(Arg(11))), has shown high in vitro binding affinity to MC1R and excellent in vivo melanoma-

147 These novel inhibitors exhibit low nanomolar binding affinities to Mcl-1 and >500-fold selectivity ov

148 hibitors that exhibit single digit nanomolar binding affinity to Mcl-1 and greater than 1700-fold sel

149 nd bacterial evasion, we have calculated the binding affinity to MD-2 of agonistic and antagonistic L

150 ass of compounds has a major effect on their binding affinities to MDM2, with >100-fold difference be

151 B-231, and BT-549) viability, migration, and binding affinity to melatonin receptor 1 (MT1R) and estr

152 his mercury ion nucleation due to their high binding affinity to mercury.

153 ructure due to a mutation influences protein binding affinity to metabolites and/or drug molecules, a

154 e resulting antibody fusion exhibited strong binding affinity to Motavizumab, an RSV neutralizing ant

155 data demonstrated that L-Enano had a higher binding affinity to mouse peritoneal macrophages than En

156 ed in solution and significantly enhance the binding affinity to MTs as these regions contain the sec

157 RF-responsive transcription by enhancing its binding affinity to multiple different SRE sequences.

158 We assessed B. pseudomallei FliC peptide binding affinity to multiple HLA class II alleles and th

159 ion enhances 6PGD activity by increasing its binding affinity to NADP(+) and therefore activates the

160 ILC quantitatively predicts residue-specific binding affinities to nanoparticles and it expresses bin

161 sitively correlated with haemagglutinin (HA) binding affinity to NeuAcalpha2-6-Gal.

162 oximal AP-1 motif was found to have a higher binding affinity to nontypeable H. influenzae-activated

163 NRP/B mutations that resulted in low binding affinity to NRF2 were unable to activate NRF2-mo

164 lacement of Trp-97 with tyrosine reduced the binding affinity to NTP and the catalysis step.

165 concentrations through its calcium-dependent binding affinities to numerous target proteins.

166 -linking of whole IgG, result in the greater binding affinity to OAPs.

167 mismatch sites with high specificities; DNA binding affinities to oligonucleotides containing single

168 h transcription factor, we measured relative binding affinities to oligonucleotides covering all poss

169 tivities of the modified substrates or their binding affinities to other proteins.

170 ated FcgammaRIII isoforms, without affecting binding affinity to other FcgammaRs.

171 backbone flexibility, mechanical stability, binding affinity to other interacting ligands and enzyma

172 ded RTA's active site, but lacked sufficient binding affinities to outcompete RTA-ribosome interactio

173 characterization of ssDNA aptamers with high binding affinity to P4.

174 body (H3L2) maintained similar structure and binding affinity to parental MMGZ01 after back mutation

175 Binding affinities to peanut agglutinin and human galect

176 This mature PfPM1 showed comparable binding affinity to peptide substrates and inhibitors wi

177 f the Q1L mutant showed that the increase in binding affinity to PfPM2 was due to improvements in bot

178 ficantly higher antibody titers, with higher binding affinity to Pfs47, than mice that received two i

179 oreover, Akt phosphorylation enhances merlin binding affinity to phosphatidylinositols and inhibits i

180 dy showed that bis-DOTA-hypericin had higher binding affinity to phosphatidylserine and phosphatidyle

181 Merle 46 and Merle 47 exhibited binding affinity to PKC alpha with Ki values of 7000 +/-

182 iple motifs are used combinatorially to tune binding affinity to PP1.

183 ucleotide addition and that it exhibits weak binding affinity to PPi relative to NTP, suggesting a me

184 promising new compounds by estimating their binding affinity to proteins.

185 provide novel evidence that LIL3 shows high binding affinity to protochlorophyllide, the substrate o

186 LEDGF PWWP exhibits nanomolar binding affinity to purified native MNs, but displays ma

187 Because of their high binding affinity to pyrin's B-box, PAPA-associated PSTPI

188 ranslocation to lysosomes via increased mTOR binding affinity to Rag GTPases in an Akt-independent ma

189 a cell lines were generated and compared for binding affinities to recombinant human IL13Ralpha2 (rhI

190 oalloying Pt7 with boron modifies the alkene-binding affinity to reduce coking.

191 sphorylated by CDK2-cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), and

192 nt of reconstituted powdered milk has a high binding affinity to ricin.

193 havior in addition to providing an increased binding affinity to RNA.

194 d on Thr199 by CDK2-cyclin E acquires a high binding affinity to ROCK II kinase.

195 channel open probability and showed enhanced binding affinity to RyR2.

196 coli GusR's preferential DNA and glucuronide binding affinity to S. enterica GusR.

197 r sequencing of the pool showing the highest binding affinity to S. enteritidis, a DNA sequence of hi

198 inding domain, we demonstrate low micromolar binding affinity to S100A1.

199 peptide, MSal 020417, demonstrated a higher binding affinity to Salmonella spp. than the commerciall

200 Its binding affinity to selectins is modulated by posttransl

201 tracyclic butyrophenones that exhibit potent binding affinities to serotonin 5-HT(2A) and dopamine D2

202 The new ligands displayed high binding affinities to SERT (Ki ranging from 0.03 to 1.4

203 acid moieties that are known to exhibit high binding affinities to serum albumin.

204 e PRL promoter, and it selectively increases binding affinity to sites within the hGH-LCR.

205 Binding affinities to sKLB and cellular stimulatory acti

206 Moreover, SUMO-RhoGDI had a much higher binding affinity to small Rho GTPase compared with the u

207 that alpha2,6-linked sialosides exhibit high binding affinity to SNA, while alteration in sialyl link

208 They exhibited high binding affinities to somatostatin receptor-positive tum

209 hy purification, exhibited unexpectedly high binding affinity to somatostatin receptor subtype 2, and

210 lls express inhibitory receptors with varied binding affinities to specific major histocompatibility

211 udies, the clicked bioconjugates showed high binding affinities to sstr2, with Kd values ranging from

212 st assay and exhibited about a 10-fold lower binding affinity to Ste2p.

213 e half-sites, as shown by decreased PrrA DNA binding affinities to synthetic DNA sequences without sp

214 27q, 27r, and 27t, which have low-nanomolar binding affinity to TcCYP51 and significant activity aga

215 ations, the Vgll4-4A mutant possessed higher-binding affinity to TEAD1 than wild-type Vgll4.

216 rboring both TRF2 and POT1 has the strongest binding affinity to telomeric DNA substrates comprised o

217 caused by gp2-mediated decrease of the RNAP binding affinity to template and non-template strand seg

218 teraction is highly similar in structure and binding affinity to that between SNX17 and P-selectin.

219 between H1(0) and H1c changed their overall binding affinity to that of the other variant.

220 e intensity of the chromophore upon binding, binding affinities to the chromophore in nanomolar to lo

221 The binding affinities to the classical AATT sequence were s

222 M, 3-5 orders of magnitude higher than their binding affinities to the corresponding mature protease.

223 incubation mixture were prioritized by their binding affinities to the FIXa protein.

224 ecules as model systems and determined their binding affinities to the hD2 receptor.

225 ic Fe(II) helicates-which have similar anion binding affinities to the metalated Star of David catena

226 gions showed no striking difference in their binding affinities to the most frequent HLA-DR alleles.

227 es that HF2(-) and Cl(-) should have similar binding affinities to the parent triazolophane in the ga

228 nding peptide PIFtide, suggesting comparable binding affinities to the PIF pocket.

229 In addition to reporting their binding affinities to the sigma-1 and sigma-2 receptors,

230 ng substituents and have characterized their binding affinities to the sigma-1 receptor.

231 horylation of KLF13 by PRP4 results in lower binding affinity to the A/B site of the CCL5 promoter, c

232 standard antiandrogen, bicalutamide, in both binding affinity to the AR and inhibition of AR-mediated

233 The DNA sequence showing the highest binding affinity to the bacteria was further integrated

234 t-PA, the results being used as measures of binding affinity to the betaC hole.

235 mutations (E141K and E141V) impaired Ca(2+) binding affinity to the C-domain of CaM.

236 of phosphorylation of the LD4 peptide on its binding affinity to the C-terminal domain of FAK.

237 Its structure, location and high binding affinity to the capsid indicate that the gp10 di

238 Although RsmA exhibited the highest binding affinity to the cfcR transcript, single deletion

239 Cyclic azapeptides have shown unprecedented binding affinity to the cluster of differentiation 36 re

240 d23 proteins demonstrate approximately equal binding affinity to the damaged DNA duplex (K(D) approxi

241 ISX that interact epistatically to increase binding affinity to the dosage compensation complex.

242 odynamic availability of the peptide and its binding affinity to the enzyme are important for TPST su

243 o potency and in vivo efficacy, although its binding affinity to the EPOR was lower than that of the

244 The order of the metabolites' binding affinity to the Factor IXa protein from the ALIS

245 These analogues were tested for their binding affinity to the five human somatostatin receptor

246 Furthermore, after PEGylation, ConA's binding affinity to the fluorescent competing ligand pre

247 We link this differential binding affinity to the free energy of deforming (bendin

248 and Lys78Ala showed little if any change in binding affinity to the FVIII substrates.

249 te show that the s(2)U modification enhances binding affinity to the glutamine codons CAA and CAG and

250 IGF-2R with high affinity but which has low binding affinity to the IGF-1R and to the A isoform of t

251 ted ProINS-Tf exhibited significantly higher binding affinity to the insulin receptor compared with t

252 ppearance of new oncogenic species with high binding affinity to the insulin-like growth factor 1 (IG

253 Importantly, a large difference in binding affinity to the interchangeable isomers is obser

254 nity to human and murine CD1d molecules, and binding affinity to the invariant t cell receptor of hum

255 ift assay indicated that P-RhpR has a higher binding affinity to the IR motif than RhpR.

256 oximately 10.5 has been determined for sugar-binding affinity to the lactose permease of Escherichia

257 idylcholines (PC) found on oxLDL, has a high binding affinity to the macrophage scavenger receptor CD

258 in, which has been associated with increased binding affinity to the mammalian alpha2,6Gal-linked sia

259 Receptor specific changes in binding affinity to the melanocortin receptors were obse

260 tive biochemical properties in terms of cAMP binding affinity to the N-terminal cyclic nucleotide bin

261 ntagonists displaying not only low nanomolar binding affinity to the P2Y(1)(2) receptor but also a lo

262 linked to a peptide ligand in a way that its binding affinity to the PDZ2 domain changes upon switchi

263 cetylation of HNF4alpha, which decreased its binding affinity to the PEPCK-C gene promoter.

264 VP30 showed low binding affinity to the predicted stem-loop alone or to

265 of A9 unspecific binding and to increase the binding affinity to the receptor.

266 nylpyridin-2-one series exhibited comparable binding affinity to the reference compound, 1-(4-methoxy

267 hanced voltage-sensor trapping via increased binding affinity to the resting state, whereas L1439A in

268 a point substitution mutations decreases the binding affinity to the Rev arginine-rich motif (ARM) by

269 nd a glycoprotein VI (GPVI) domain with high binding affinity to the SDF-1 receptor CXCR4 and extrace

270 Because fenpropimorph has high-binding affinity to the sigma-1 receptor, we have synthe

271 ega6) with mutant omega showed a decrease in binding affinity to the sigma-factors (sigma(70), sigma(

272 cid (S77D) in the PDZ I domain decreased the binding affinity to the sodium-dependent phosphate trans

273 l predicts that a reduction in the effective binding affinity to the substrate coupled with an increa

274 the basic side chains to alanine lowered the binding affinity to the surface but did not perturb the

275 for its increased infection may be a higher binding affinity to the surface of airway epithelia than

276 Modified PS ASOs display better binding affinity to the target RNAs and increased bindin

277 orresponding unconstrained MP derivatives in binding affinity to the three transporters.

278 tional docking simulations predict a greater binding affinity to the TrxR active site in comparison t

279 Specifically, we quantify C16-KGGK's binding affinity to the two types of membrane by umbrell

280 ne fragment was found to have low micromolar binding affinity to the zinc metalloenzyme carbonic anhy

281 By comparing germinant apparent binding affinities to their known in vivo concentrations

282 t the end of the 3'-(dT)n tail increases the binding affinities to their maximum values (i.e. the sam

283 ns were evaluated for surface expression and binding affinity to their HLA-C group 1 and 2 ligands.

284 ibodies modified using the pi-clamp retained binding affinity to their targets, enabling the synthesi

285 f both mutations (HA190+HA212) increased the binding affinity to those glycans recognized by the HA19

286 with selectivity from 3-folds difference in binding affinity to total discrimination (K(D) of 50 nM

287 d that the T allele of rs17079281 had higher binding affinity to transcription factor YY1 than the C

288 ctors harboring RT mutants with reduced dNTP binding affinity to transduce human lung fibroblasts (HL

289 type was demonstrated to be important in its binding affinity to TRH receptors; the most potent stere

290 ot (knottin) miniproteins with low-picomolar binding affinity to tumor cells.

291 The probe also shows in-gel binding affinity to two lactate dehydrogenase isozymes a

292 , the N-terminal helix of Arl3 increases the binding affinity to UNC119a.

293 pically relies on extremely strong chelating/binding affinities to UO(2)(2+) using chelating polymers

294 ects, yielded a 2000-fold improvement in the binding affinity to VEGFR with IC(50) value of 25 pm.

295 All three mutants show similar metal binding affinities to wild type TbetaM in the oxidized e

296 subset of 16 representative inhibitors with binding affinities to wild-type protease ranging from 58

297 For the TRTK-12 complexes, the Ca(2+)-binding affinity to wild type ((WT+TRTK)K(D)=12+/-10 muM

298 Sera of MS patients exhibited similar binding affinity to wild-type and GrB-cleaved TAL.

299 thinylestradiol) correlated with their known binding affinities to zebrafish androgen receptor.

300 renal epithelial cells because of diminished binding affinity to ZO-1.