ライフサイエンスコーパス: binding constant

1 BP), suggesting a reduction in the inhibitor binding constant.

2 at a near one-to-one ratio with a micromolar binding constant.

3 eads over several orders of magnitude of the binding constant.

4 ics, it also leads to a decrease in the zinc binding constant.

5 quences typically causes a large decrease in binding constant.

6 t containing tmphen results from its greater binding constant.

7 g and derived an integrative heterodimer DNA binding constant.

8 ls to adsorbate populations, via equilibrium binding constants.

9 se large compounds and their median Langmuir binding constants.

10 rs reveals ca. 10,000-fold variation Zur-DNA binding constants.

11 ellulose (NFC) and ranked according to their binding constants.

12 nd allowed the determination of the stepwise binding constants.

13 and combine them with a detailed analysis of binding constants.

14 immobilization artifacts and do not provide binding constants.

15 orporated into a new procedure for computing binding constants.

16 ds, respectively, lowering significantly the binding constants.

17 diffusion methodology is utilized to obtain binding constants.

18 omposition and have yielded widely different binding constants.

19 tration technique is applied to obtain their binding constants.

20 ge of specific values for rate constants and binding constants.

21 dues at the P-2 position with low micromolar binding constants.

22 o antibodies with a wide range of monovalent binding constants (0.1 microM to 0.1 nM).

23 equilibrium constant (~20 mum) and the CXCR2 binding constant (1 nm) indicate that WT CXCL1 is active

24 The binding constant (10(4) L mol(-1)), complex stoichiometr

25 Among them, the binding constant [(2.7 +/- 0.3) x 10(8) M(-1)] of 2 with

26 body-antigen interactions with low picomolar binding constants, 2 orders of magnitude lower than prev

27 The large binding constants (3.7-5.1x10(5)M(-1)) suggest that Res

28 rates as well as the calculated equilibrium binding constant, 3.0 +/- 1.3 x 10(6) M(-1) obtained fro

29 bited FLT3-internal tandem duplication (ITD; binding constant, 70 nmol/L) and the viability of five A

30 In solution, the binding constant affording 1@3 is exceptionally high.

31 For ubiquitin, the on-rate binding constant and binding affinity for a site located

32 geometry and orientation as revealed by the binding constant and computational optimized structure.

33 Using this technique, the binding constant and packing density of the model ligand

34 ogen bonds and van der Waals forces with the binding constant and stoichiometry ratio of 1.88 x 10(5)

35 retinol and retinoic acid binding sites, the binding constant and the effect of retinoid complexation

36 The binding constant and the kinetic constants of associatio

37 he effect of the dendrimer generation on the binding constant and the stoichiometry is discussed.

38 Both MOSCs show comparable binding constants and adsorb ca. 7 equiv of methylene bl

39 actions and a balance between the nucleotide binding constants and concentrations, complex I combines

40 oof of concept, we extract the thermodynamic binding constants and conformer distributions of analyte

41 he electrochemical assay demonstrated higher binding constants and dynamic range.

42 ration kinetics permitting determinations of binding constants and first-order oxidation rate constan

43 4 was also established and used to determine binding constants and kinetics of unlabeled ligands.

44 onal studies were performed to determine the binding constants and suggest 1:1 complexation stoichiom

45 complexation (CD-MUSIC) framework, chromate binding constants and the Stern Layer capacitance were o

46 re-associations exist in solution, for which binding constants and thermodynamic parameters have been

47 e trend well but underestimated the absolute binding constants) and a cocrystal featuring biaxial coo

48 t on the (i) concentration of MAbs, (ii) MAb binding constant, and (iii) IgG subclass.

49 ecific binding constant, the median Langmuir binding constant, and two global sorbent parameters; the

50 lts in a binding stoichiometry of 1:1 with a binding constant approximately 10(8) M(-1) at 100 mM KCl

51 The corresponding binding constants are 0.44(+/-0.05) M(-1) for Na(+) and

52 Measured PFAA binding constants are approximately 10% of those values

53 model of adduct formation is presented, and binding constants are calculated, which is based on a sp

54 The temperature at which the binding constants are determined can also be tuned, by a

55 At the first level, the apparent association binding constants are extracted from the measured intens

56 Binding constants are often measured by a series of expe

57 are different even though their steady state binding constants are similar.

58 F-actin binding constants are traditionally determined by centri

59 copy in the gas phase, computations, and its binding constant as a function of temperature in acetoni

60 Binding constants as high as 6 x 10(9) M(-1) have been m

61 e voltage-dependent response, we extract the binding constant, as well as the changes of the surface

62 of the mitochondrial matrix, weak nucleotide binding constants assist product dissociation.

63 From these observations, the apparent binding constant between a single-layer of Rituximab and

64 Evaluation of the binding constant between an aptamer and a small molecule

65 ntification of interaction stoichiometry and binding constant between bacteria (or other microorganis

66 ination of the interaction stoichiometry and binding constant between bacteria and (macro)molecules.

67 rates show a two orders of magnitude larger binding constant between DNA and T7 RNA polymerase, and

68 The binding constant between SEB and peptide-nanoparticle co

69 ophoresis (CE) is also used to determine the binding constant between the doxepin E and Z geometric i

70 (8) ITC-derived binding constants between 3 and DNA duplexes have the fo

71 used to create a device capable of measuring binding constants between a protein and a small ion base

72 We derived the equilibrium binding constants between DNA and Ag(+), the kinetic rat

73 However, precise determination of binding constants between partners is not highly reliabl

74 2:1 binding model, yielding estimates of 2:1 binding constants between some of the macrocycles and MA

75 The binding parameters such as binding constant, binding site size and diffusion coeffi

76 possible to compute the in vivo equilibrium-binding constant but not binding on- and off-rates.

77 hows charge disproportionation increases the binding constant by no less than approximately 5 orders

78 id species is able to change the equilibrium binding constant by orders of magnitude.

79 mg of Cu/mg of DOM, the measured conditional binding constant ((c)K(CuDOM)) decreased from 10(11.5) t

80 y bound pelargonidin at both pH 7.0 and 3.0 (binding constants ca. 1.0x10(5) at 25.0 degrees C).

81 p-LFER below the cutoff, the median Langmuir binding constants can be predicted with a root-mean squa

82 of pectic polysaccharide the copigmentation binding constants decreased.

83 Inhibitor binding constants derived from steady-state kinetic expe

84 The highest binding constant detected in this study was 3.3 x 10(6)

85 to study anion recognition processes (e.g., binding constant determination) and will furthermore pro

86 negative ion photoelectron spectroscopy and binding constant determinations with Cl(-).

87 Comparison between the macroscopic Ca(2+)-binding constants, directly measured by competition with

88 he residence times and, correspondingly, the binding constants dropped by more than an order of magni

89 Binding constants exceeding 10(14) M(-1) have been measu

90 The binding constant for A2E and purified RPE65 was calculat

91 The binding constant for CYP2B4 Compound I was about 1 order

92 itrocellulose filter binding reveal that the binding constant for I(1) at 25 degrees C is approximate

93 thyl viologen, MeV) suggests that the higher binding constant for intercalation of DAAQ may be partia

94 We find a high binding constant for iron(III) (log beta2=35).

95 ine the protein-induced Delta Lk and the DNA-binding constant for lambda O and GalR, but also we demo

96 s confirm that ExsA enhances the equilibrium binding constant for RNAP while having only a modest eff

97 In contrast, the binding constant for the active site docking step is str

98 hat explains the roughness dependence of the binding constant for the anchored proteins from membrane

99 eals a 3 orders of magnitude decrease in the binding constant for the capture of a free oligonucleoti

100 eraction in cell lysates and the equilibrium binding constant for the interaction in vitro.

101 The binding constant for the macrocycle-monomer complex (K =

102 In addition, the binding constant for the zein-calcium interaction was ca

103 a single NMR titration suffices to determine binding constants for all other detectable and resolvabl

104 R was also employed to evaluate the apparent binding constants for all the complexes.

105 Multiphoton FRAP provided the specific binding constants for alpha-synuclein's binding to synap

106 Metal binding constants for BDP, determined by competition iso

107 n had been previously shown to retain low nM binding constants for both the GDNF receptor and the mou

108 eezer behavior, albeit with slightly smaller binding constants for C(60) and C(70), suggesting that t

109 e first time, resulting in the estimation of binding constants for C4P with the ion pairs of A336(+)

110 Transition state binding constants for catalysts in the specific base rea

111 ion specific by comparing relative metal ion binding constants for Cd(2+) and Zn(2+).

112 ts into the large discrepancies reported for binding constants for cellulases and suggest that produc

113 copper to metal chelators such as EDTA, and binding constants for Cu(II) predict that copper-only SO

114 ematical modeling, we were able to determine binding constants for diacylglycerol-protein interaction

115 a seventh-order polynomial to calculate five binding constants for each of the individual steps in pr

116 g pH, permeability coefficients and membrane binding constants for each species of TPT were determine

117 l electrophysiology to measure independently binding constants for four different agonists, to both r

118 en constants for disassembly, and SNAP-SNARE binding constants for four different ternary SNARE compl

119 (pp-LFER) is able to predict median Langmuir binding constants for graphite, charcoal, and Darco gran

120 Substrate binding constants for P450 Compound I are important for

121 ion that are centred near the characteristic binding constants for polyacid interactions.

122 e polarization (FP) based assay and measured binding constants for the 25 most abundant human plasma

123 ng measurements of absorbance intensity, the binding constants for the 4a + Fe(3+) complex and 4a + C

124 Binding constants for the complexation between Na-Cas an

125 ally, determine by microscale thermophoresis binding constants for the interaction of A46 with the TI

126 The binding constants for the interaction of teicoplanin and

127 0 mM displayed saturation kinetics that gave binding constants for the substrate in the Compound I sp

128 the T state without affecting the intrinsic binding constants for the two Ca(2+) sites.

129 Higher binding constants for the Z isomer relative to the E iso

130 their N(3)H units provided greater apparent binding constants for their complexes with receptor 1a,

131 The chloride binding constants for thioureas and croconamides are sig

132 f the mutant on catalytic rate constants and binding constants for various substrates are the same as

133 a complementing set of cooperative networks, binding constants from approximately 0.1 nM to approxima

134 -state enzyme kinetic parameters and product binding constants from non-linear kinetic time courses w

135 /mH(4)R [pK(d) 8.78/7.75/7.18, comparable to binding constants from radioligand binding/flow cytometr

136 eloped, it is not straightforward to extract binding constants from the resulting data.

137 Although VEGF-VEGFR2 effective binding constants have been measured, these prior measur

138 almost independently of the ligand-receptor binding constant in a broad range of this parameter.

139 N53S showed a binding constant in the low micromolar range, similar to

140 al hydrophobic cavity of the channel, with a binding constant in the range of ~0.1-1 muM.

141 a1L-CTT forms oligomers cooperatively with a binding constant in the submicromolar range.

142 A binding constant in this range is necessary but not suff

143 al in primary structure but differ in oxygen binding constants in accordance with their distinct phys

144 ron spectroscopy, and determination of their binding constants in acetonitrile.

145 ing constant (Qax), a ratio of the substrate binding constants in the absence versus presence of an a

146 selectivity) and the calculation of apparent binding constants in the ISM.

147 ncompetitive nature of these inhibitors with binding constants in the low micromolar range.

148 Equilibrium binding constants in the micromolar to picomolar range w

149 evealed by (1)H NMR titrations, has produced binding constants in the order of 10(4) M(-1).

150 The binding constants in the surfactant were also measured a

151 The binding constant increases from glu(2-) to adi(2-) and t

152 on experiments reveal that the corresponding binding constant is about 3 orders of magnitude higher t

153 bserved in both cell lines that the PBAE-DNA binding constant is biphasic with the transfection effic

154 proximated by the Hill nonlinearity when the binding constant is near the ambient mean.

155 ITC is determined less by c (the product of binding constant K and titrand concentration [M](0)) tha

156 for template binding and a lower equilibrium binding constant K(d) for the template, leading to a tem

157 jor features of any enzymatic catalysis: the binding constant (K(D)) and the catalytic turnover rate,

158 intensity on the addition of glucose, with a binding constant (K(d)) of 11 mM, an operating range of

159 itration calorimetry experiments indicated a binding constant (K(d)) of 380 nM.

160 PDGF receptors on VSMCs without altering the binding constant (K(d)), raising the possibility that ES

161 ction, but not to quantify the corresponding binding constant (K(d)).

162 The equilibrium O(2) binding constant (K(O(2)), DeltaH degrees , DeltaS degre

163 queous solutions containing 95% water with a binding constant (K) of 700+/-30 M(-1).

164 due to the formation of AR-BSA complex, with binding constant (K) ranging from 3.26+/-0.09 to 8.08+/-

165 The binding constant (K) value calculated for MTX was 3.821x

166 The binding constants (K(b)) of the para-substituted phenols

167 n kinetics, which permitted solution of both binding constants (K(bind)) and first-order oxidation ra

168 ribing triplex formation include equilibrium binding constants (K(eq)) and association/dissociation r

169 dinates Fe(3+) in a 1:2 stoichiometry with a binding constant, K(a) = 5.25 x 10(3) M(-1).

170 We evaluated the DNA binding constant, K(b), for each dye.

171 For both HWKK and KWKK, equilibrium binding constants, K(obs), and magnitudes of log-log sal

172 hort-armed" cryptand 3, did display a higher binding constant (Ka = 2.4 x 10(5) M(-1)) with paraquats

173 The binding constants (Ka) associated with the complexation

174 We report the measurement of the binding constants (Ka) for cucurbit[n]uril (n = 7, 8) to

175 t RA binds CD with a 1:1 stoichiometry and a binding constant Kb of 445 (+/-53) M(-1) or 465 (+/-81)

176 a comparison between these and experimental binding constants (Kb) for binding of a series of radica

177 ntate urea derivatives, in order to estimate binding constants (Kb) for the hydrogen-bonding process.

178 The copigmentation binding constants (KCP) for the interaction between malv

179 The measured binding constant (Kd = 5.645 x 10(3) M(-1)) indicated st

180 t, whose stoichiometry (1:1) and equilibrium binding constant (KD approximately 6.4 muM) were determi

181 The binding constant (Kd) discerned for the dye and HRP-II t

182 ty >800-fold lower (equilibrium dissociation binding constant [KD] = 7.56 x 10(-8)M) than its BoNT/F

183 logen, with high selectivity and equilibrium binding constants (Keq up to 10(14) M(-2)).

184 parameters, specifically the median Langmuir binding constants, KL, obtained utilizing the single-che

185 Relative binding constant (Krel) determinations revealed that the

186 ve analogue of Fe(III), provided conditional binding constant log beta(12)' = 13.3 +/- 0.2 for a [Ga(

187 A comparison of the binding constants measured by CLE-SPE with those measure

188 cy cannot be explained solely by the p53-DNA binding constants measured in vitro.

189 beginning of the curves using the inhibitor-binding constants measured under the same experimental c

190 ism are evidenced from emission, NMR, FT-IR, binding constant measurement, Job's plot, ICD spectra, E

191 cryptands, is responsible for the very high binding constants observed for their complexes with Grou

192 cific binding events are fit to the apparent binding constants obtained from the first level of model

193 Binding constants obtained via GFET and AFM were compara

194 A strong binding constant of 0.55x10(6) L mole(-1) between the HS

195 ly 1 binding site per casein molecule, and a binding constant of 0.6-5.6 x 10(4)M(-1).

196 The results demonstrate a binding constant of 1.1 muM for the Ca(2+)/CaM pair and

197 isotropy measurements yielded an equilibrium binding constant of 1.4 or 10.7 muM for the alkaline pho

198 r cage can encapsulate xenon in water with a binding constant of 16 M(-1).

199 uBAT mutant binds the SSRI sertraline with a binding constant of 18 nM and displays high-affinity bin

200 We determined the binding constant of 2-fluoro-5-aminophenyl boronic acid

201 in monomers per betaCaMKII holoenzyme with a binding constant of 2.4 x 10(5) m(-1).

202 ell based quartz-crystal microbalance, and a binding constant of 2.5 x 10(5) M(-1) was calculated on

203 a concentration-dependent manner, yielding a binding constant of 2.9 x 10(5) m(-1), consistent with t

204 ery high affinity for xenon in water, with a binding constant of 2.9(2) x 10(4) M(-1) as measured by

205 bands of the uranyl cation yielded a uranyl binding constant of 3(1) x 10(7) M(-1), corresponding to

206 d the highest affinity toward safranal, with binding constant of 3.196 x 10(3) M(-1).

207 tom frustule biosilica had a half-saturation binding constant of 6.4 +/- 2.4.10(-8)M and statisticall

208 o which it binds in 1:1 stoichiometry with a binding constant of approximately 1.0 x 10(5)M(-1).

209 The binding constant of APSAL for H(2)AsO(4)(-) has been det

210 ith each other, and UV titrations revealed a binding constant of ca. 10(3) for the guest Pd(II) ions,

211 The binding constant of chemosensor HMBP with Al(3+) from th

212 Cl(-) anions can be attributed to the higher binding constant of Cl(-) with the anion receptor and th

213 ght but significant (p=0.05) increase in the binding constant of curcumin to processed PC, which may

214 The apparent binding constant of curcuminoids to whole buttermilk was

215 xceptionally high substrate affinity, with a binding constant of K = 5.0 x 10(6) M(-1) for its best s

216 omposed of SiO2 NPs of 300nm diameter with a binding constant of k=1.7(pM)(-1), sensitivity of 6.9nm/

217 The result was a binding constant of Ka >10(5) M(-1) from ammonium-carbox

218 esults provide a useful route to compute the binding constant of membrane-anchored receptor and ligan

219 n calorimetry measurements revealed that the binding constant of NADPH to the C298S mutant is decreas

220 nimal fluorescence-quenching effect and weak binding constant of nucleozin to the swine-origin influe

221 y fluorescence correlation spectroscopy, the binding constant of purified AKAP18delta fragments to la

222 The binding constant of RecF protein, in the presence of the

223 Because the binding constant of soluble proteins is readily accessib

224 nement and that relates this constant to the binding constant of soluble proteins without membrane an

225 orescence spectroscopy is used to obtain the binding constant of the analog intermediate, equilenin.

226 We find that the binding constant of the anchored proteins strongly decre

227 adhesion processes depend sensitively on the binding constant of the membrane-anchored receptor and l

228 showed saturation kinetics with an apparent binding constant of Zn(II) to the [enzyme-TPPS] complex

229 ry (ITC) and UV/vis spectroscopy, leading to binding constants of (5.0 +/- 0.6) x 10(4) M(-1) and (7.

230 +, Ca2+, and the unprotonated ionophore with binding constants of 10(3.5), 10(1.8), 10(6.8), and 10(4

231 Binding constants of 10(5)-10(7) M(-1) magnitude and 1:1

232 The equilibrium binding constants of 1a-h to SZO(300) are related to the

233 ibution, it is possible to determine all the binding constants of a ligand to a highly multimeric coo

234 The Hammett plot for the binding constants of AcO(-) with 3- and 4-substituted ph

235 The values of the 14 binding constants of ATP to GroEL were determined, and t

236 here is no comparative data available on the binding constants of Concanavalin A (Con A) and glycogen

237 The overall binding constants of DNA-theophylline = 3.5x10(3) M(-1),

238 ing specificity of cyclase activation, tuned binding constants of effector proteins, and physical int

239 ution assay method based on BSI to determine binding constants of GCAP1 and GCAP2 to the full-length

240 es a powerful approach to accurately measure binding constants of interactions between membrane bound

241 anes of the endoplasmic reticulum, obtaining binding constants of k(on) approximately 255/s and k(off

242 philic and hydrophobic contacts with overall binding constants of K(retinol-)(alpha)(-caseins)=1.21 (

243 plateau is observed for the median Langmuir binding constants of larger molecular volume sorbates.

244 In a single experiment, the binding constants of one protein interacting with all li

245 We report the direct measurement of ligand-binding constants of organolithium complexes using a (1)

246 is approach allowed direct comparison of the binding constants of prothrombin, factor X, activated fa

247 o monitor receptor activity and characterize binding constants of small-molecule antagonists spanning

248 form, BSI, we then studied the effect on the binding constants of the ConA-carbohydrate interactions

249 Furthermore, the binding constants of the host guest complexes were estim

250 The 1:1 binding constants of the indicator dyes are in the range

251 While the binding constants of the metal cations to the XFs were l

252 tion rates and specific-nonspecific relative binding constants of the restriction nuclease EcoRI enab

253 The binding constants of these triols with zero to three CF3

254 g force to the association, and resulting in binding constants of up to 10(6) M(-1) for aromatic anal

255 Binding constants of up to 90 300+/-8700 m(-1) were obta

256 to a Langmuir isotherm yielded a calculated binding constant on the order of approximately 10(7) M(-

257 binding strength have generally not measured binding constants over the same Cu:DOM ratios.

258 g only yield minor changes in rate until the binding constant passes a threshold value.

259 ), which compares favorably to the intrinsic binding constant presented in the literature for the mon

260 he bilirubin-albumin equilibrium association binding constant (R(2) = 0.69), which varied 10-fold amo

261 h a serine hydrolase probe (with equilibrium binding constants ranging from 4 to 120 muM).

262 terface in the homotetrameric structure with binding constants relative to dioleoylphosphatidylcholin

263 ration calorimetry, the determination of the binding constants requires a significant amount of time

264 ent cations, such as Cs(+) and Tl(+), with a binding constant significantly lower than its congeners

265 og-log salt concentration derivatives of the binding constants (Sk(i)) even though their binding site

266 purposes, reacted with benzphetamine with a binding constant that was nearly an order of magnitude s

267 mbrane surface, displays considerably larger binding constants that are largely attributed to loss of

268 ion factors bound to a DNA promoter, (2) the binding constants that describe the affinity of the prot

269 A single sorbate-specific binding constant, the median Langmuir binding constant,

270 uch as the stoichiometry of the complex, the binding constant, the relative degrees of occupancy of t

271 e complicating temperature dependence of the binding constant; the resulting constant-temperature sys

272 cal temperature and decreases the ring-stalk binding constant, thereby unblocking the pore and releas

273 tra and molecular modeling increase the BPDE binding constant to G in codon 248 consistent with a pat

274 utions, which enables a determination of the binding constant to the diamine via luminescence quenchi

275 ous DMSO and pure water correlate with their binding constants to 4-nitrophenyl phosphate dianion (K(

276 ork yielded new peptide leads with picomolar binding constants to FZD7 as measured by biophysical met

277 propagation velocity on the ligand receptor binding constant under influence of the convective trans

278 affinity of SA to BSA was demonstrated by a binding constant value (1.09x10(3) at 310 degrees K).

279 conjugate Fc-5 featured the highest apparent binding constant value among all the complexes tested.

280 inside the CD cavity, which is evident from binding constant values and molecular modeling studies.

281 umin (BSA) were bound to beta-C with overall binding constant values of 1.31 x 10(7), 1.80 x 10(4), a

282 on, but experimental measurements of product-binding constants vary significantly, and there is littl

283 25 degrees C)(0)=-29.35 kJ mol(-1)), and the binding constant was 1.39 x 10(5) M(-1), at 25 degrees C

284 The CN- binding constant was 2.3 x 10(6) (mol/kg)(-1), which is

285 N:P of 2 and was positively cooperative; the binding constant was calculated in the range of 10(5) M(

286 mplex was determined by a Job's plot and the binding constant was estimated from a linear regression

287 atrol interacted with both proteins, but the binding constant was higher for zein than for gliadin at

288 The binding constant was of the order of 10(5)L.mol(-1) by f

289 degrees C for 10min; a similar trend in the binding constants was also observed with casein micelles

290 Comparison of these binding constants was used to establish positive coopera

291 To decrease the enzyme binding constant, we propose to shield the substrate bin

292 y and the standard deviation of the Langmuir binding constant were employed.

293 Although significant differences in binding constant were not observed between surfaces with

294 cting" hydroxyl groups on the structures and binding constants were also explored, and surprisingly t

295 For COS ligands with a DP of 2-3 the binding constants were around 10(5) m(-1), and for longe

296 o investigate the underlying thermodynamics, binding constants were determined at 25.0, 35.0, and 45.

297 s of pH and structure of anthocyanins on the binding constants were studied.

298 of the film broadens the range of the cation-binding constants, which leads to wide sensitivity range

299 efficacy and that the optimal values of the binding constant with respect to the transfection effica

300 ns, analytical methods that can characterize binding constants with individual plasma proteins in a r