ライフサイエンスコーパス: binding domain

1 its partial redundancy with an adjacent PARP-binding domain.

2 Another motif, DPHK, is in the DNA-binding domain.

3 ning a non-sense mutation within the AP2 DNA-binding domain.

4 at wrapped over a helix, typical of an FK506-binding domain.

5 lacking the Lap2, emerin, Man1 (LEM)-protein binding domain.

6 hey alter critical residues in the Sac3 mRNA binding domain.

7 ablishing UBA(Cez) as a functional ubiquitin-binding domain.

8 h C-terminal part instead of the last KH RNA binding domain.

9 y affects the conformation of N-terminal DNA-binding domain.

10 ve antibody titers specific for the receptor-binding domain.

11 -frame initiation codons upstream of the DNA binding domain.

12 djacent to the wing2 region of the FOXA1 DNA-binding domain.

13 ructurally unrelated to the E. coli McrB DNA-binding domain.

14 ues (human S183/S185, mouse S180) in the DNA-binding domain.

15 RP1S that contains only the C-terminal lipid binding domain.

16 for the phosphorylation of Vac17 in its Myo2 binding domain.

17 agarose microbeads functionalized with an Fc-binding domain.

18 r beads and we identified Spire's barbed-end binding domain.

19 nces outside of the conserved PUF family RNA-binding domain.

20 teins as well as small proteins fused to DNA-binding domains.

21 terior group paralogs that share similar DNA-binding domains.

22 could distinguish between IRF8 and IRF4 DNA-binding domains.

23 disordered regions in addition to folded RNA-binding domains.

24 esent in the binding pockets of methyllysine binding domains.

25 main-swapped dimers formed through their DNA-binding domains.

26 different mutations in regions encoding ion-binding domains.

27 cally disordered proteins (IDPs) and protein binding domains.

28 ave surface spikes and putative internal RNA-binding domains.

29 od is highly specific for the mapping of DNA binding domains.

30 states and decreases the mobility of the DNA-binding domains.

31 to other host receptors is mediated by both binding domains.

32 ions of the shell domain, including receptor-binding domains.

33 ical N-terminal domain (NTD), NTD-nucleotide-binding domain 1 (NBD1) linker, NBD1, and middle domain

34 rate-limited by ADP release from nucleotide-binding domain 1 (NBD1).

35 re of particular interest since the receptor-binding domain 1 lacks sequence homology to any other kn

36 its deaminase domain and double stranded RNA binding domain 2 (dsRBD2) bound to an RNA duplex as an a

37 y to any other known toxin, and the receptor-binding domain 2 is completely absent in other well-stud

38 SSBs share a conserved ssDNA-binding domain, a less conserved intrinsically disordere

39 the effect of adding a streptococcal albumin-binding domain (ABD) and a llama single-domain antibody

40 o attach drug leads to the G-related albumin-binding domain (ABD) to bind albumin and evade clearance

41 antimouse IgG1 nanobody (MG1Nb) and antibody-binding domain (ABD), individually or together, in a mix

42 pose, two different PBs derived from Albumin Binding Domain (ABDwt) of streptococcal protein G, so ca

43 ll as the presence of the adjacent anticodon-binding domain (ACB), influences the Nterm conformation.

44 entify the LOTUS domain as a specialized RNA binding domain across phyla and underscore the molecular

45 s obtained with constructs lacking the lipid-binding domain allowed a detailed characterization of th

46 ed high-resolution crystal structures of the binding domains alone and with purified trisaccharides.

47 We further showed that the putative membrane-binding domain also affected the nuclear localization of

48 urotoxin-like sequence motif on the receptor-binding domain also exhibits a high tendency to bind TCR

49 ind to the SARS-CoV-2 spike protein receptor binding domain and block spike protein interaction with

50 sense mutations cluster in the conserved DNA binding domain and disrupt MEF2C DNA binding.

51 However, STEAP1 lacks an intracellular NADPH-binding domain and does not exhibit cellular ferric redu

52 e-exposed proline residues in the nucleotide binding domain and linker of Arabidopsis ABCB1, mutation

53 C2 and KIFC3 lack the N-terminal microtubule binding domain and only have one microtubule-interacting

54 es developed against the MERS spike receptor-binding domain and S2 portion are ineffective in neutral

55 the functional activity of both the antigen binding domain and the luciferase.

56 age through a mechanism dependent on its DNA binding domain and, at least in part, on poly-ADP ribose

57 tructure and function of seventeen known RNA-binding domains and analyze the hydrogen bonds adopted b

58 tory expression that depends on the Xrp1 DNA binding domains and is necessary for cell competition.

59 eviously by our group, which contains murine binding domains and is used in axicabtagene ciloleucel.

60 etween M6A, an intrinsically disordered iron-binding domain, and an iron oxide particle was visualize

61 Spike protein subunits S1 and receptor binding domain, and nucleoprotein were coupled to micros

62 viral activity of DHX30 and contains a dsRNA-binding domain, and that the NS1-DHX30 interaction in vi

63 , excess of nonsynonymous changes in peptide-binding domains, and long gene genealogies.

64 part of the corona, contains two microtubule-binding domains, and physically associates with dynein m

65 nclear which residues in the UGT2B7 cofactor binding domain are responsible for the preferential bind

66 IgM, A, and G Ab responses against receptor-binding domain are significantly correlated to the disea

67 t the C-terminal filamentous actin (F-actin)-binding domains are responsible for Tarp-mediated invasi

68 ic domain, translocation domain and receptor binding domain) are targets for neutralizing antibodies.

69 mAbs in complex with the SARS-CoV-2 receptor-binding domain at 2.55 and 2.70 angstrom revealed a dire

70 MADS (MCM1, Agamous, Deficiens, and Srf DNA-binding domain)-box transcriptional co-regulator, Mkl-1

71 plicing and retains the extracellular ligand binding domain but lacks the intracellular signaling dom

72 I CaM in complex with the primary calmodulin-binding domain (CaMBD2) from RyR2 at 1.84-2.13 angstrom

73 mutations, which are located within the ATP-binding domain, cause ATP7B retention in the endoplasmic

74 e different TTD and PHD histone modification-binding domains causes distinct H3K9me3-binding behaviou

75 , this interaction did not require the cargo-binding domain (CBD) of TNPO3, which typically mediates

76 ride monooxygenase (LPMO), a family 5 chitin-binding domain (CBM5), and a family 18 chitinase (Chi18)

77 The prefusion trimer has three receptor-binding domains clamped down by a segment adjacent to th

78 iated by the intracellular cyclic nucleotide-binding domain (CNBD) connected to the pore-forming S6 t

79 n METTL2 forms a complex with DALR anticodon binding domain containing 3 (DALRD3) protein to recogniz

80 Here, the glycan interacts with the receptor-binding domain D of the toxin.

81 Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer ca

82 Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chroma

83 disordered AD2 motif and the structured DNA-binding domain (DBD).

84 operativity between the ligand (LBD) and DNA binding domains (DBD) of AR, and its autoinhibition by t

85 cycle is the dissociation of the nucleotide-binding-domain dimer, while ATP hydrolysis per se does n

86 rsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site.

87 DGCR8 core, contains two double-stranded RNA-binding domains (dsRBDs) and a C-terminal tail.

88 infect mice, and immunization against their binding domains elicits a protective immune response.

89 Cys2His2 zinc finger is the most common DNA-binding domain expanding in metazoans since the fungi hu

90 SpoIVFB has an ATP-binding domain exposed to the MC cytoplasm, but the role

91 B-dependent phosphorylation of the SAF-A DNA-binding domain; failure to execute this pathway leads to

92 switch, influencing the affinity of the PDZ binding domain for its binding partners.

93 at Hmx3a may not require its homeodomain DNA-binding domain for its roles in viability or embryonic d

94 these conformations, we decoupled the ligand-binding domains from specific transmembrane segments for

95 PPM models for 314 tested TFs (or their DNA-binding domains) from four families (bHLH, bZIP, ETS and

96 ter intravenous administration of a collagen-binding domain fused to IL-12 (CBD-IL-12) in mice bearin

97 ical studies identified that each of the two binding domains has a different selectivity profile.

98 ption factors that contain a homeodomain DNA-binding domain have crucial functions in most aspects of

99 an extended loop in the C-terminal receptor-binding domain (HC) of BoNT/B (HC/B) has been proposed t

100 reatment of COVID-19 with high anti-receptor binding domain IgG titer convalescent plasma is efficaci

101 This rigid arrangement of the putative DNA-binding domain imposed strong constraints on how TerS(P7

102 d the crystal structure of the CAR substrate-binding domain in complex with AMP and succinate and eng

103 rystal structure of the zebrafish VDR ligand-binding domain in complex with the ZK168281 antagonist,

104 shorter and the bilobed cleft of the glycine-binding domain in GluN1 is more closed when bound to gly

105 lf, and previously uncharacterized, the E6AP-binding domain in hRpn10 locks into a well-defined helic

106 RS-CoV-2 spike protein or the spike receptor binding domain in mice.

107 MEK-ERK-sensitive regulation of the peptide-binding domain in mortalin was critical to cell survival

108 cRNAs with high affinity through its HMG DNA-binding domain in vitro.

109 s corresponding to the AipA, Asp14, and OmpA binding domains in alum followed by challenge with A. ph

110 ce for the critical role of the Tarp F-actin-binding domains in host cell invasion and for the Tarp e

111 es with minimal separation of the nucleotide-binding domains in the inward-facing conformation.

112 s by engaging cytoplasmically exposed dynein-binding domains in the outer nuclear membrane protein ne

113 of human SARS-CoV-2 Abs against the receptor-binding domain, including an Ag sandwich ELISA relevant

114 e for transcription factor tethering and DNA-binding domain-independent action.

115 2'-phosphate being pushed inside the NADP(+) binding domain instead of being stretched out in the sol

116 As (mRNAs) via a high-affinity stem-loop RNA binding domain interaction, enabling high-throughput ide

117 Using the RAS-RBD (CRAF RAS binding domain) interaction as a model system, we showed

118 apply it to the HCN4 ion channel, whose cAMP-binding domain is an archetypal conformational switch.

119 eta11-12 linker in the extracellular, ligand-binding domain is an integral component of the desensiti

120 ations in p53 protein, especially in the DNA-binding domain, is one of the major hallmarks of cancer.

121 Despite originally predicted as an RNA binding domain, its molecular binding activity towards R

122 lecular-weight (HMW) form of the E2 receptor-binding domain lacking three variable regions, Delta123-

123 iochemically reconstituted the GLR3.3 ligand-binding domain (LBD) and analyzed its selectivity profil

124 es harbor activating mutations in the ligand binding domain (LBD) of ER, which have been shown to con

125 cts and the ability to bind the Nurr1 ligand-binding domain (LBD).

126 y the presence of large extracellular ligand-binding domains (LBDs) and constitutive homo/heterodimer

127 ion and involves rearrangement of the ligand binding domains (LBDs).

128 Pm5e encodes a nucleotide-binding domain leucine-rich-repeat-containing (NLR) prot

129 Here, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-co

130 R, protease-activated receptor 2, nucleotide-binding domain, leucine-rich-containing family, pyrin do

131 lly flexible linker domain and a small metal-binding domain (MBD).

132 crease in positive charge in the microtubule binding domain (MBD).

133 er hGrx1 can act in Cu delivery to the metal binding domains (MBDs) of the P(1B)-type ATPase ATP7B an

134 TAS domain protein, binds the ABC nucleotide binding domain, MlaF, and is required for its stability.

135 copy, we have determined how three chromatin-binding domains (MTA1-BAH, MBD2/3 and RBBP4/7) are assem

136 oline-rich domain (PRD), not the microtubule binding domain (MTBD), drives LLPS and does so under the

137 ngineered a myristoylated 7 amino acid CCR10-binding domain (Myr-CBD7) peptide and showed that this c

138 utations located within the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembra

139 trated that neither the clathrin light chain-binding domain nor the clathrin heavy chain-binding moti

140 al upstream DNA over the RNA polymerase zinc-binding domain, NusA rotates underneath one capping rho

141 re, we report a crystal structure of the DNA-binding domain of a model ASO-binding protein PC4, in co

142 hat associate with the dimerization- and DNA-binding domain of ATF4 (the bZIP domain) in mouse skelet

143 hat expression of the extracellular integrin-binding domain of Basigin is sufficient to rescue periph

144 riguingly, Cep63 fused to a microtubule (MT)-binding domain of Cep57 functioned in concert with Cep15

145 f the ankyrin repeat motifs in the substrate binding domain of cpSRP43 drives its activation.

146 monoclonal antibodies targeting a conserved binding domain of DBP.

147 Surprisingly, we found that the eIF4E-binding domain of eIF4GI increases not only the binding

148 We further identified the binding domain of FAM20C in Periostin, which was mapped

149 2020) discover that the C-terminal substrate-binding domain of FBXL5 contains a redox-sensitive [2Fe-

150 Here, we show that the C-terminal substrate-binding domain of FBXL5 harbors a [2Fe2S] cluster in the

151 Here, we have characterized the DNA-binding domain of human FoxP1 by integrating single-mole

152 We also identified a distinct DNA-binding domain of human Orc6, named as HsOrc6-DBD.

153 SARS-CoV-2 uses the receptor-binding domain of its spike protein S1 to attach to the

154 Deletion of the beta-catenin-binding domain of LEF1 in HNF-1beta-deficient cells abol

155 ented here further defines the growth factor-binding domain of MAGP-1.

156 The microtubule-binding domain of MAP4 binds directly to the C2 domain o

157 In particular, the methyl-CpG-binding domain of MeCP2 shows preferential interactions

158 xtracellular binding domains with the ligand-binding domain of metabotropic glutamate receptor type 2

159 ptide mimetics derived from the phospholipid binding domain of Myristoylated alanine-rich C-kinase su

160 se (NOX2) subunit, p67(phox), and to the RAC-binding domain of p21-activated kinase, consistent with

161 which requires its interaction with the DNA-binding domain of PARP1.

162 d beta-sheet site of GB1, the immunoglobulin binding domain of protein G.

163 kemia fusion protein, which contains the DNA-binding domain of Runt-related transcription factor 1 (R

164 RyR1, or a peptide corresponding to the CaM-binding domain of RyR (RyRp).

165 The receptor-binding domain of SARS-CoV-2 has a 10- to 20-fold higher

166 roduction of a cysteine pair in the receptor-binding domain of sigma1 yielded a virus that replicates

167 esidue peptide M13, which represents the CaM binding domain of skeletal muscle myosin light chain kin

168 Replacing the PIP(2)-binding domain of STIM1 with that of STIM2 eliminated th

169 mapped primarily to the cytoplasmic, ligand-binding domain of STING.

170 a known functional polymorphism in the self-binding domain of the candidate gene DOG1.

171 knockout mouse, created by removing the DNA-binding domain of the ERbeta gene or interruption of the

172 The Ras-binding domain of the protein kinase c-Raf (c-Raf-RBD) i

173 nserved phosphorylation sites within the DNA-binding domain of the receptor.

174 thentic SARS-CoV-2, by engaging the receptor-binding domain of the S glycoprotein.

175 lizing activity and fully block the receptor-binding domain of the S protein (S(RBD)) from interactin

176 bodies that simultaneously bind the receptor binding domain of the spike protein, thereby providing i

177 that are specific to the SARS-CoV-2 receptor binding domain of the spike protein.

178 row or broad target specificity, and the DNA-binding domain of the transcription activator-like effec

179 -15 into the N-terminal extracellular ligand-binding domain of the umami (T1R) receptor was performed

180 Genetic disruption of the TEAD-binding domain of these oncogenic YAP1 fusions is suffic

181 t-1 bind to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with

182 Mutagenesis studies of the galabiose-binding domain of type P(N) SadP adhesin showed that the

183 ino-terminal region of Zta and the basic DNA binding domain of Zta in regulating Zta ubiquitination.

184 The binding domains of A. phagocytophilum adhesins A. phagoc

185 Roles played by 2 receptor-binding domains of activated CDTb were of particular int

186 iple binding events in the cyclic nucleotide binding domains of HCN pacemaker channel.

187 between the nucleotide-binding and substrate-binding domains of Hsp70.

188 and acts as a RAS mimetic by binding to Ras binding domains of RAS effectors.

189 Mutational analysis uncovered two dsRNA-binding domains of RHA that are necessary to tether JUND

190 yo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bo

191 We find that the microtubule-binding domains of the Ndc80 complex cluster at the micr

192 minal domain of the alpha-chain, the heparin-binding domain on the beta-chain, and other functional d

193 ed featuring a clustering of tRNA anti-codon binding domains on one MSC face.

194 osphatidylinositol 4,5-bisphosphate (PIP(2)) binding domains, or the entire C terminus, was without e

195 es a secreted trimerized SARS-CoV-2 receptor-binding domain; or BNT162b2, which encodes a membrane-an

196 that missense changes within or near the DNA-binding domain (p.Arg507His and p.Arg377Trp) reduce FAN1

197 alization patterns, often lack classical DNA-binding domains, presenting challenges in identifying me

198 1 version that carried the EspG(5) chaperone-binding domain, previously shown to redirect this substr

199 ith both the trimeric spike and the receptor-binding domain proteins.

200 g the lysine-rich insertion, or the membrane-binding domain provided similar cell survival ratio as t

201 We thus name the hRpn10 AZUL-binding domain RAZUL.

202 The RAS-binding domain (RBD) and cysteine-rich domain (CRD) of R

203 ptor human ACE2 (hACE2) through its receptor-binding domain (RBD) and is proteolytically activated by

204 between the SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-c

205 tein variants with mutations in the receptor-binding domain (RBD) and N-terminal domain that confer r

206 fragment (Fab) with the SARS-CoV-2 receptor-binding domain (RBD) and negative-stain electron microsc

207 detection of SARS-CoV-2 Abs to the receptor-binding domain (RBD) and nucleocapsid protein in additio

208 between those directed against the receptor-binding domain (RBD) and those directed against the N-te

209 odies (nAbs) to two epitopes on the receptor binding domain (RBD) and to distinct non-RBD epitopes on

210 dies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics

211 these antibodies with the S protein receptor-binding domain (RBD) are compared with those between ang

212 Whereas its RAS-binding domain (RBD) contains the main binding interface

213 t (DPSO), whereas the salivary anti-receptor binding domain (RBD) IgG response yielded 100% specifici

214 h the highly immunogenic and mobile receptor binding domain (RBD) is either locked in the all-RBDs 'd

215 The receptor-binding domain (RBD) is immunodominant and the target of

216 re susceptible to neutralization by receptor-binding domain (RBD) monoclonal antibodies and convalesc

217 search for antibodies targeting the receptor-binding domain (RBD) of CoV-2.

218 l antibody (MAb), which targets the receptor-binding domain (RBD) of Middle East respiratory syndrome

219 t neutralizing mAbs recognizing the receptor-binding domain (RBD) of S.

220 sing electrodes was pre-coated with receptor binding domain (RBD) of SARS-CoV-2 spike protein, and su

221 his study, we engineered variants of the Ras-binding domain (RBD) of the C-Raf proto-oncogene, Ser/Th

222 nt complexes formed by ACE2 and the receptor-binding domain (RBD) of the S-protein.

223 The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotei

224 The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein is

225 sorbent assay utilizing recombinant receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was

226 side-modified mRNA that encodes the receptor binding domain (RBD) of the SARS-CoV-2 spike protein(1).

227 the virus into cells depends on the receptor-binding domain (RBD) of the spike (S) protein of SARS-Co

228 vaccine that encodes the trimerized receptor-binding domain (RBD) of the spike glycoprotein of SARS-C

229 The SARS-CoV-2 receptor binding domain (RBD) of the spike protein binds to the h

230 ing surface (ACE2IS) located in the receptor-binding domain (RBD) of the spike protein can neutralize

231 rmined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2

232 ffinity and high specificity to the receptor-binding domain (RBD) of the spike protein.

233 ly used IGHV gene for targeting the receptor-binding domain (RBD) of the spike protein.

234 EY6A Fab binds the receptor binding domain (RBD) of the viral spike glycoprotein tig

235 st cells via a trimeric spike whose receptor binding domain (RBD) recognizes angiotensin-converting e

236 Notably, residues of receptor-binding domain (RBD) showing crucial interactions with a

237 Notably, IgG against the spike receptor binding domain (RBD) was predictive of survival and IgA

238 ty by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme

239 he Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are

240 gM, and IgA antibodies to the spike receptor binding domain (RBD), S1+S2, nucleocapsid, and ORF6 to O

241 lular spike glycoprotein and at the receptor-binding domain (RBD)-receptor interface, suggesting a ro

242 verting enzyme 2 (ACE2) through its receptor-binding domain (RBD).

243 onal expansion, and three bound the receptor-binding domain (RBD).

244 ion between ACE2 and the SARS-CoV-2 receptor binding domain (RBD).

245 avirus 2 (SARS-CoV-2) spike protein receptor binding domain (RBD).

246 enome-scale collection of RBPs and their RNA-binding domains (RBDs) and assessed their specificities

247 of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessib

248 The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the human ACE2 receptor

249 Nucleolin, through its RNA-binding domains (RBDs), binds to and maintains the cytos

250 d as interconnected complexes (nodes) of RNA-binding domains (RBDs), whose integrated RNA-binding cap

251 cterized phosphorylation in the p53 core DNA-binding domain regulates the DNA binding cooperativity a

252 d amino acid substitutions in the penicillin-binding domain relative to R497.

253 In fact, the ERRbeta ligand-binding domain remains the last unsolved ERR structure a

254 with the same carboxyl-terminal microtubule-binding domain repeats, isoforms with four microtubule r

255 tect the full-length S protein or S receptor-binding domain (S-RBD); and an IgG avidity assay.

256 e of polypeptide substrates at the substrate-binding domain (SBD) of Hsp70s.

257 d that three fru isoforms with different DNA binding domains show a division of labor on male aggress

258 terminal J domain and a C-terminal substrate binding domain, similar to type II cellular J proteins.

259 tral and posterior groups based on their DNA-binding domain similarity.

260 um neutralization assays as well as receptor binding domain-specific IgA; however, the frequency of p

261 The N protein contains two RNA-binding domains surrounded by regions of intrinsic disor

262 YAP/transcriptional co-activator with a PDZ-binding domain (TAZ) silencing results in reduced ZIKV r

263 rminal region a previously unappreciated DNA-binding domain that exhibits specific binding to G-quadr

264 ng site was discovered in the first receptor-binding domain that is important for its stability, and

265 that the Timeless protein has a G-quadruplex binding domain that works together with the DDX11 helica

266 a translocation pathway, and two nucleotide-binding domains that hydrolyze ATP.

267 DNA polymerase beta has two DNA-binding domains that interact with the opposite sides of

268 ty and stability of an active ERRbeta ligand-binding domain, thereby providing a protein tool enablin

269 le the two McrBC complexes use different DNA-binding domains, these contribute to the same general GT

270 h plasma with an anti-spike protein receptor binding domain titer of >=1:1350.

271 that CITCO binds directly to the hPXR ligand-binding domain to activate hPXR.

272 le rescue factor CLIP-170 in its microtubule-binding domain to increase its rescue-promoting activity

273 of riboswitches that utilize the same ligand-binding domain to regulate transcription or translation.

274 Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduces te

275 llustrate the benefits of linking an albumin-binding domain to the single-domain ADCs.

276 PRC1/Ase1 proteins use distinct microtubule-binding domains to control the spindle elongation rate.

277 with two different types of C-terminal ssDNA binding domains to form diverse bacterial topoisomerase

278 n July, 2020, using a spike protein receptor binding domain total antibody chemiluminescence assay (1

279 ultivalent association of the entire cognate binding domains, two WW sequences and five PPXY motifs r

280 ot in the chromatin); requires the ubiquitin-binding domains (UBA1/2) of USP13; and occurs preferenti

281 icity and the third binds a unique ubiquitin-binding domain (UBD).

282 ducing conformational flexibility of F-actin-binding domains via interdomain cross-talk and consequen

283 t for its stability, and the second receptor-binding domain was found to be critical for host cell to

284 antibodies targeting the S protein receptor-binding domain was not attenuated.

285 A construct lacking an albumin-binding domain was rapidly cleared, leading to lower tum

286 immunization against only the AipA or Asp14 binding domain was sufficient to reduce the bacterial pe

287 ucture guided design of the murine STING CDN binding domain, we engineer a Forster resonance energy t

288 ing an affinity maturation of the RLIP76 Ral-binding domain, we identified several sequence substitut

289 he inositol phospholipid-binding and F-actin-binding domains were essential.

290 gets is dominated by the contribution of one binding domain, whereas the binding to other host recept

291 formations of the estrogen receptor's ligand-binding domain, which in turn produces differential recr

292 omain (XPA DBD) and the RPA70AB tandem ssDNA-binding domains, which is likely to influence the orient

293 es the process of optimization of an antigen binding domain with desirable properties and allows the

294 Subsequent interaction of the RAF1 RAS binding domain with KRAS does not significantly change G

295 e receptors by replacing their extracellular binding domains with the ligand-binding domain of metabo

296 ers host cells through binding of a receptor-binding domain within its trimeric spike glycoprotein to

297 Moreover, disruption of a PDZ binding domain within PKCalpha led to impaired Rac1 acti

298 owever, a second contact between the XPA DNA-binding domain (XPA DBD) and the RPA70AB tandem ssDNA-bi

299 istinct architecture in which the beta' zinc-binding domain (ZBD) of RNAP stretches out from its cano

300 ich has multiple domains: an N-terminal zinc-binding domain (ZBD), a 1B domain, and helicase core dom