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1 Regional grey matter volumes, and regional binding of 18F-AV-1451 and 11C-PK11195 were derived from
6 ion of the motor switch protein FliM and the binding of a member of the CheY protein family to the ou
11 olar range (K (diss) ~ 17 and ~ 31 muM), but binding of a second molecule of profilin is negatively c
12 dpiece underlie PLB inhibition of SERCA, and binding of a single Ca(2+) ion is sufficient to shift th
15 revealed an overlap between LRP1 binding and binding of a small-molecule inhibitor of PAI-1, CDE-096,
16 ization of reactants induced by the bivalent binding of a specific IgG antibody to two antigen-conjug
20 either impaired RISC formation or increased binding of AGO2 to mRNA targets as mutation specific fun
21 he RIFIN disrupts the complex, blocks LILRB1 binding of all tested RIFINs and abolishes signalling in
22 nvestigate the effects of photolysis and the binding of amino acid residues in cytochrome c and neuro
24 of RSK2 on autophagy resulted from directly binding of AMPKalpha2 in nucleus and phosphorylating it
26 we demonstrate that fusion is abrogated when binding of an adaptor protein is prevented and that dire
28 ace coverage assays, including heterogeneous binding of analyte molecules on bead or sensor surfaces,
29 of apoptosis, which is characterized by the binding of Annexin V, demonstrates that programmed cell
31 f one ligand thermodynamically activates the binding of another, different ligand or substrate, is a
35 sults support the relevance of high-affinity binding of ARF transcription factors to uniquely spaced
38 ssays with newly replicated DNA revealed the binding of ATAD2, a bromodomain-containing posttranslati
42 lar response to external signals, such as in binding of B cell receptors (BCR) to antigen, which init
45 e of Apurinic/apyrimidinic (AP) site damage, binding of BER proteins, and G4 structures revealed that
46 the agonist, ATR, as well as the noncovalent binding of beta-ionone, an antagonist for G protein acti
47 nd-activated transcription factor that, upon binding of bile acids, regulates the expression of genes
48 role in the endothelial homeostasis and the binding of BMP-9 to the receptor activin-like kinase 1 (
49 itation experiments demonstrate preferential binding of both gephyrin and collybistin to WT and an S3
50 nt cells, however, can demonstrate increased binding of both MDM2 and MDM4 to p53 but in absence of c
51 show that PBRM1/Pbrm1 deficiency reduces the binding of brahma-related gene 1 (BRG1) to the IFNgamma
53 Taken together, these results show that the binding of calcium-calmodulin to the C-terminus has long
54 During small molecule screens, we observed binding of carbamazepine to the cysteine-rich domain (CR
55 We show that NVS-CECR2-1 inhibits chromatin binding of CECR2 BRD and displaces CECR2 from chromatin
57 conformational changes to GAFab induced upon binding of cGMP and the PDE6 inhibitory gamma-subunit (P
58 e Sec14-fold as scaffold for translating the binding of chemically distinct ligands to the control of
59 rial flagellar motility is controlled by the binding of CheY proteins to the cytoplasmic switch compl
62 gth of the reactant and product states: weak binding of CO is desirable from a selectivity perspectiv
64 E did not alter C1q interaction but affected binding of complement inhibitors factor H and C4b-bindin
66 via increased transcription, but instead via binding of CPEB4 to cytoplasmic polyadenylation elements
68 In conclusion, our results demonstrate the binding of CTRP6 to a variety of microbial and endogenou
72 out-coupled angle resulting from successful binding of d-biotin to streptavidin immobilized on funct
74 W mutation formed alternative holoenzymes by binding of different PP2A regulatory subunits compared w
76 ave been developed in recent years, but even binding of dinitrogen to an f-block metal cation is extr
83 don loop (nucleotides 32 and 38) to tune the binding of each tRNA to the decoding center in the ribos
84 ctivation promotes nuclear translocation and binding of Egr2 to SOCS1 promoter for its early inductio
85 efield-based refinement, we characterize the binding of eight analogues to the bacterial ribosome at
87 ct" in barium block experiments, whereby the binding of external K(+) impedes the forward translocati
90 at PF-PC synapses, and demonstrates that the binding of filamentous actin to CaMKII can enable the be
91 imulations reveal that the limiting step for binding of flexible molecules to ice is not the alignmen
96 ligands can contribute significantly to the binding of GBPs with multiple binding sites through a pr
98 We describe parameters known to control the binding of generic or gene-specific cofactors that regul
103 catalytic activity. We further show that the binding of GTP to the NADH-bound GDH activates a triangu
107 ommodation surfaces may assist high-affinity binding of HIV-1 MPER epitope at membrane interfaces.
108 murine ISG15 of 2 aa recently implicated in binding of human ISG15 to LFA-1 in vitro were required f
109 Interestingly, our results suggest that binding of HVEM to gD may contribute to efficient upregu
110 virus (IAV) entry process, including initial binding of IAV to sialylated glycans, fusion between the
111 i-IFN-gamma-induced increase in the specific binding of IFN-gamma to its receptor in U937 cells, enha
112 II reduces bacterial clearance by decreasing binding of IgA to commensal and pathogenic bacteria.
115 or (Gal4-VP16) greatly stimulated reversible binding of individual RNApII molecules to template DNA.
116 e this repression is released indicates that binding of inhibited Rubisco to the C-terminal CbbO VWA
117 hat similar levels of Ca(2+) instead promote binding of inosine without cleavage and thus enable high
119 duction reaction (CO(2)RR), control over the binding of intermediates is key for tuning product selec
122 o results in monomerization of the receptor, binding of IT1t to this variant promotes receptor dimeri
123 by its intrinsically disordered regions and binding of its bromodomains to DNA and acetylated chroma
124 e the ncAA serves as an anchor to direct the binding of its peptides to the target's active site.
126 ystallographic observation of stereospecific bindings of l- and d-lysine (Lys) in achiral MFI zeolite
128 oters and found that while sequence-specific binding of late gene promoters requires ORF24, it additi
130 erial infections are frequently based on the binding of lectin-like adhesins to specific glycan deter
131 r membrane protein complexes and noncovalent binding of ligands and lipids to membrane proteins.
136 TA transferases provide new insight into the binding of lipid-linked WTA and enable assignment of the
137 exes are yielding valuable insights into the binding of lipids and their structural and functional ro
142 ction may occur on endothelial cells because binding of MBL to beta2-GPI was detected on the surface
143 he ORC5-depleted cells show normal chromatin binding of MCM2-7 and initiate replication from a simila
144 robustly detected DNA methylation-dependent binding of MeCP2 to mCG and mCAC, neither showed evidenc
145 o the main factors driving collaborative DNA binding of MEF2A and into its role in B cell-specific ge
148 ivalent binding of TNRC6 enables cooperative binding of miRNA-AGO complexes to target RNAs, thereby e
149 radigm for a lipid storage response in which binding of MLX transcription factors to LD surfaces adju
150 SA (g-iELISA) is based on the principle that binding of monoclonal antibodies to specific epitopes of
152 amics simulations also suggest that membrane binding of MreB double protofilaments induces a stable m
153 w these mitoribosomal proteins assist in the binding of mt-mRNA and to what extent they are involved
157 singly charged metals differ profoundly from binding of multiply charged ions, often leading to overa
161 tified, and the key residues involved in the binding of NADP(+) and L-AHG and the catalysis are revea
162 res show that either flavin reduction or the binding of NADP(H) is sufficient to drive the FAD to the
163 phB2-ephrinB1 boundary formation, as well as binding of Nck, RasGAP, and the chimaerins, respectively
171 hat oxidized base-derived AP site damage and binding of OGG1 and APE1 are predominant in G4 sequences
172 ion, while the other only requires substrate binding of OGG1--both resulting in conformational adjust
173 of in vitro selection, revealed that strong binding of OLE RNA by OapB requires a stem containing a
174 horetic mobility shift assays to examine the binding of OLE RNA fragments by OapB and found that OapB
177 imetric studies (ITC) show that the stronger binding of one enantiomer is accompanied by an increased
178 ric activation of protein function, in which binding of one ligand thermodynamically activates the bi
179 ace of the phagophore serve as scaffolds for binding of other core autophagy proteins and various eff
181 tein [RBP] yeast) two-hybrid assay to assess binding of our CEH mutant RNAs to TERT, we find that the
182 erization, thus enhancing insulin-stimulated binding of p110-p85alpha heterodimers to IRS1 and activa
185 t reaction selectivity arises from preferred binding of pairs through intermolecular interactions of
186 adaptive immune response triggered upon the binding of pathogenic superantigens to T cell receptors
187 currently available tools for predicting the binding of peptides to a selection of HLA-I allomorphs.
191 iochemical, and biologic work has shown that binding of PIP(3) to the pleckstrin homology (PH) domain
192 tor gamma (ESRRG), which results in stronger binding of pituitary-specific positive transcription fac
194 n sharp contrast, kinetic studies showed the binding of POT1 to an initially folded 24 nt G-quadruple
196 uch allosteric coupling leads to cooperative binding of proteasomal ATPases to 20S and promotes forma
197 ke only protein sequence as input to predict binding of protein to DNA, RNA, and other proteins.
198 article characterization can directly detect binding of proteins to functionalized colloidal probe pa
200 r, we generated a knock-in mouse model where binding of Pygo2 to H3K4me(2/3) was rendered ineffective
201 ivating protein (GAP) activity, and effector binding of RAC2(E62K) Our findings indicate the E62K mut
208 Furthermore, our results showed increased binding of RNA-binding protein CUGBP1 with occludin and
211 This inactive conformation is stabilized by binding of SARM1's own substrate NAD+ in an allosteric l
214 y of the SM22alpha promoter by hindering the binding of serum response factor (SRF) to the proximal C
216 the terminator to uridines strengthened the binding of several ProQ-specific RNAs to the Hfq protein
217 lementation technology, we characterized the binding of several SHP2 allosteric inhibitors in intact
218 ne is presented, exploiting the preferential binding of silver nanoparticles (AgNPs) with sulfur-cont
220 cyanine chromophores controlled by selective binding of small-molecule "anchor" groups to a specific
221 vealed that the active-site structure and Cu binding of SOD5 strongly deviate from those of Cu/Zn-SOD
223 ntifies the ability of plasma to inhibit the binding of spike protein to angiotensin-converting enzym
224 pre-mRNA splicing by sterically blocking the binding of splicing factors to the pre-mRNA, are a promi
225 cooperation of heteroduplex pairing with the binding of ssDNA to the secondary site, to extend dsDNA
229 osteric systems is defined as a ratio of the binding of substrate in the absence of effector to the b
231 Arg/Lys residues play critical roles in the binding of suramin to the "AT-hook" DNA-binding motifs.
234 n of either gene did not alter the low-level binding of T3SA(-), which does not engage sialic acid.
235 t transactivation in microglia by disrupting binding of Tat to CDK9, a process key to HIV transcripti
236 it in a range of assays that measured direct binding of Tau to glycosaminoglycans and inhibition of T
237 immunoprecipitation assays confirmed direct binding of TCF/LEF factors to the promoter and putative
239 Activating beta-catenin signaling increased binding of Tcf4/beta-catenin complex and upregulated its
240 tion of the T cell receptor (TCR) results in binding of the adapter protein Nck (noncatalytic region
241 iosensors can be used to monitor equilibrium binding of the agonist, ATR, as well as the noncovalent
248 ctures in complex with HIV-1 RT/dsDNA showed binding of the conjugates at the polymerase active site,
249 th a model in which eS25 facilitates initial binding of the CrPV IGR IRES to the 40S while ensuring t
250 tion of the DH/PH-DEP1 fragment, it inhibits binding of the DEP1 domain to liposomes containing phosp
251 faces due to the difficulties with selective binding of the developing agents to the fingermark ridge
252 ation regulated EZH2 expression by enhancing binding of the E2F1 transcriptional activator to the EZH
254 We found that activation was initiated by binding of the gamma9delta2TCR to BTN2A1 through the reg
256 protein targets of herbicides, affecting the binding of the herbicide either at or near catalytic dom
257 low cytometry analysis demonstrated specific binding of the IgG1 format to cells expressing membrane-
262 MMTV share common features such as membrane binding of the MA via hydrophobic interactions and exhib
263 network of flexible interactions, including binding of the N domain of betaarr1 to phosphorylated re
264 a ligand-gated ion channel that converts the binding of the neurotransmitter serotonin (5-HT) into a
267 olecule of protein is extremely slow and the binding of the primary substrate, CO(2), is competitivel
268 ted in capsule alterations that affected the binding of the probe, as reducing ends were exposed and
270 by their typically low affinity and variable binding of the SIMs in parallel and antiparallel orienta
271 s in solution, it also demonstrates that the binding of the std20S or i20S subtype to any of its PA28
272 substrate in the absence of effector to the binding of the substrate in the presence of a saturating
273 e cyclic compound within this series blocked binding of the Tat-ARM peptide to TAR in solution assays
275 system of cell entry, which is triggered by binding of the viral spike protein to angiotensin-conver
276 The first step in SARS-CoV-2 infection is binding of the virus to ACE2 (angiotensin-converting enz
279 Our investigation uncovered differential binding of these NPC subunits, where Nup107 preferential
280 e is still debate over what triggers the (un)binding of this transient third ion during catalysis and
284 l calculations were consistent with a strong binding of trans-resveratrol to the CpLIP2 catalytic sit
285 tures of active enhancers that accompany the binding of transcription factors and local opening of ch
288 truncated Drosophila TnT (TpnT-CD70) retains binding of tropomyosin, troponin I, and troponin C, indi
289 s that have been discussed as central to the binding of trypsin and BPTI and protein complex formatio
293 We hypothesize that during nuclear budding, binding of UL25 situated at the pentagonal capsid vertic
294 measured in patient sera to characterize the binding of unconjugated bilirubin (B(T) ) to albumin (A)
295 mposition and miscibility, while competitive binding of unconnected proteins disengages networks and
297 igh affinity of the EhActn2 CaMD for Ca(2+), binding of which can only be regulated in the presence o
298 ERV into an A-repeat deficient Xist rescues binding of Xist RNA to Spen and results in strictly loca
300 scanning fluorimetry analyses confirmed the binding of YjhC to the substrates 2,7-anhydro-Neu5Ac and