ライフサイエンスコーパス: binding selectivity

1 Ps and NC-OMCPs also possess different anion binding selectivity.

2 n mammalian cells by modulating trans-factor binding selectivity.

3 palmitoylation of RPE65 controls its ligand binding selectivity.

4 s play a general role in Gcn5/PCAF substrate binding selectivity.

5 last five residues of NR2b contribute to the binding selectivity.

6 regation is correlated with G-quadruplex DNA binding selectivity.

7 ed calixarenes was screened for alkali-metal-binding selectivity.

8 Scalloped to create a wing cell-specific DNA-binding selectivity.

9 core module and results in the loss of tRNA binding selectivity.

10 a homologous RNase P RNA maintains the tRNA binding selectivity.

11 esidues in this region in determining ligand binding selectivity.

12 osal of a mechanism for beta 1/beta 7 ligand binding selectivity.

13 -1, directs its remarkable PtdIns(3,4,5)P(3) binding selectivity.

14 e densities promote a switch in carbohydrate-binding selectivity.

15 e and were correlated with the thermodynamic binding selectivity.

16 as sensitive methods for determining cation-binding selectivity.

17 ved in the control of arrestin stability and binding selectivity.

18 a typical bZIP heterodimer with altered DNA binding selectivity.

19 sulted in a significantly increased receptor binding selectivity.

20 , implying that ionic radius is important in binding selectivity.

21 , can be used to predict reversible covalent binding selectivity.

22 tentially causing the peptides to lose their binding selectivity.

23 reported, less is known about hnRNP U's RNA-binding selectivity.

24 horylation and acetylation that may underlie binding selectivity.

25 quire the use of molecules with exclusive G4 binding selectivity.

26 se activity of MDA5 contributes to its dsRNA binding selectivity.

27 ic polarization and charge transfer to metal binding selectivity.

28 fic sulfate and epimerization patterns on HS binding selectivity.

29 fic, where polymorphisms within TraA dictate binding selectivity.

30 involved in endocytosis preserves interface binding selectivity.

31 ted to these data to measure (11)C-LY2795050 binding selectivity.

32 receptors and those reversing benzodiazepine binding selectivity.

33 s with two cysteines, demonstrating arsenite binding selectivity.

34 nd, we propose, the BRC repeats regulate DNA-binding selectivity.

35 , and Oct4 confirms their role in regulating binding selectivity.

36 ation states are distinct phases with unique binding selectivities.

37 Finally, the high binding selectivity, affinity, and fluorescence of yDNA

38 (2+) to be seven, thereby leading to reduced binding selectivity against Mg(2+).

39 ligands, exhibit differences in their guest-binding selectivities and reactivity with tris(2-aminoet

40 Binding selectivities and stabilities of the complexes w

41 ding domain goes beyond simply providing DNA-binding selectivity and affinity (10-100-fold enhancemen

42 By combining this unique binding selectivity and asymmetric catalysis, we are abl

43 gand-protein binding interfaces that predict binding selectivity and demonstrate its effectiveness fo

44 These results clearly demonstrate the binding selectivity and enhanced affinity of side-by-sid

45 for developing LC stabilizers with improved binding selectivity and enhanced physicochemical propert

46 y of current screening collections, improved binding selectivity and frequency.

47 nces between UL144 and HVEM that explain its binding selectivity and highlight it as a suitable scaff

48 Finally, the combined effect of binding selectivity and inactivation selectivity was ass

49 23 (Trp in PTH and Phe in PTHrP) determines binding selectivity and position 5 (Ile in PTH and His i

50 In general, the binding selectivity and potency of [(3)H]NE reuptake inh

51 veal the structural basis for doublecortin's binding selectivity and provide insight into its role in

52 finity cleavage for the establishment of DNA binding selectivity and provides the information at a hi

53 or 10-fold, reversing the PTH2/PTH1 receptor binding selectivity and resulting in a high affinity int

54 in acetamide 6, which showed CCK-A receptor binding selectivity and sub-micromolar agonist activity

55 resent study provides direct evidence of MPO binding selectivity and tests the relationship of select

56 Binding selectivity and the effects of beta have been in

57 How this range of affinities determines binding selectivity and virus motility remains largely u

58 >40-fold delta over mu and delta over kappa binding selectivity, and exhibits delta receptor antagon

59 by proteins: high binding affinity, superior binding selectivity, and extreme catalytic performance.

60 : D3R Ki = 6.84 nM, 1700-fold D3R versus D2R binding selectivity, and its metabolic stability in mous

61 ical properties such as the bioavailability, binding selectivity, and metabolic stability.

62 it demonstrates only modest G-quadruplex DNA binding selectivity, and PIPER in pH 8.5 buffer is both

63 of MAP-PTHrP(1-36) was a determinant of R/RG binding selectivity, and PTH(1-14) bound selectively to

64 e GR LBD/10 complex provides a new basis for binding, selectivity, and anti-inflammatory activity and

65 ates (to confirm brain penetration, specific binding, selectivity, and kinetics), and third in human

66 e-binding pockets that may influence peptide binding, selectivity, and presentation.

67 Ets DNA binding, selectivity, and regulation have been extensive

68 he molecular mechanisms underpinning histone binding, selectivity, and regulation of these highly dyn

69 onal studies, but the determinants of ligand binding, selectivity, and signaling are still poorly und

70 hts into the steric-pressure-enabled surface binding selectivity as well as its effect on the chemica

71 vide new insights into differences in ligand binding selectivity as well as unifying features of hist

72 ], have different levels of G-quadruplex DNA binding selectivity at pH 7 as determined by absorbance

73 t-antagonist benzodiazepine site ligand with binding selectivity at the alpha1 receptor.

74 protein can be designed that displays metal-binding selectivity based solely on coordination number

75 On the other hand, organic anion binding selectivity between Oat6 and Oat1 is influenced

76 were consistently greater (>2 muM), but the binding selectivity between symmetric and hemimethylatio

77 campus), and 14 (cerebellum), whereas in the binding selectivity (blockade) scan, all regional VT val

78 ificity is mediated in part through receptor binding selectivity brought about by alterations in the

79 ining duplexes or triplexes and on the metal binding selectivity but did not address the effect of th

80 termined that appropriate spacing can affect binding selectivity by 60-fold (20- x 3-fold).

81 ism underlying cyclic peptide's affinity and binding selectivity by combining X-ray crystallography,

82 ggest that DNA biosensors having only modest binding selectivity can also be used for fluorescence-ba

83 LXXLL motifs are the same and that receptor binding selectivity can be achieved by altering sequence

84 atterning assay, we demonstrate that NetrinG-binding selectivity can direct the sorting of a mixed po

85 design of reported inhibitors, their mode-of-binding, selectivity, cellular activity, and therapeutic

86 an telomeric RNA G-quadruplex and that their binding selectivity considerably differs depending on th

87 id inhibition potency and ex vivo plasma TTR binding selectivity data reveal that 2,6, 2,5, 2, 3,4,5,

88 of amyloid inhibition and ex vivo plasma TTR binding selectivity data reveal that direct connection o

89 ing fibril inhibition potency and plasma TTR binding selectivity data.

90 was an exception, displaying excellent delta binding selectivity (delta Ki = 7 nM, mu/delta = 1900, m

91 of the C terminus and altered client peptide-binding selectivity, demonstrating the functional signif

92 The exceptional binding selectivity enables these inhibitors to occupy t

93 076 suggests rational approaches to modulate binding selectivity, enabling the design of multifunctio

94 Remarkable binding selectivities, even for homologous steroid pairs

95 few agents that display some (ca. 1000-fold) binding selectivity for 5-HT2A versus 5-HT2C receptors a

96 e an explanation for RNA G-quadruplex ligand binding selectivity for a group of naphthalene diimide l

97 eads to large improvements of functional and binding selectivity for a5B3y2 over other axB3y2 GABA(A)

98 eads to large improvements of functional and binding selectivity for alpha5beta3gamma2 over other alp

99 s for Ca(2+), which is essential to the high binding selectivity for Ca(2+) over Mg(2+).

100 e, it has proven challenging to achieve high binding selectivity for different isoforms of this prote

101 Binding selectivity for dopamine versus norepinephrine t

102 Binding selectivity for ER alpha was as high as 50-70-fo

103 Surprisingly, both compounds showed higher binding selectivity for FKBP52 versus FKBP12, in contras

104 lly used AT1R blocker losartan exhibits high binding selectivity for kidney AT1R and rapid metabolism

105 trated that an inactive point mutant retains binding selectivity for mucin-domain glycoproteins.

106 el an AMFE reflects a channel's preferential binding selectivity for one ion species over another.

107 P4K2C binder TMX-4102, which shows exclusive binding selectivity for PIP4K2C.

108 Its use in generating a profile of DNA binding selectivity for several agents including distamy

109 e region in the delta receptor that confered binding selectivity for SUPERFIT by examining its bindin

110 and in the cloned transporter cells, and its binding selectivity for the DAT compared to the serotoni

111 transporter (NET) but in some cases retained binding selectivity for the DAT.

112 The unprecedented binding selectivity for the fetal muscle nAChR, coupled

113 riazolo[3,4-a]phthalazine 8 as a ligand with binding selectivity for the gamma-aminobutyric acid-A (G

114 the best compound features an unprecedented binding selectivity for the human telomeric DNA G-quadru

115 gonist ([D-Arg8]-inotocin) with a 3,000-fold binding selectivity for the human V1aR over the other th

116 Of those, eight exhibited excellent binding selectivity for TTR in human plasma (binding sto

117 es, we synthesize an inhibitor with >25-fold binding-selectivity for fungal Hsp90 NBD.

118 combinations that provided enhanced receptor binding selectivities (>100-fold) and affinities (as low

119 ly display an unforeseen pT205/pS197 peptide binding selectivity hierarchy.

120 x mimetics which reproduce their biophysical binding selectivity in a cellular context can be identif

121 idogenesis inhibitors that also display high binding selectivity in blood, it proves useful to system

122 have been established to govern RON2 ligand binding selectivity in other AMAs.

123 e indole ring did lead to improved CB 2/CB 1 binding selectivity in some cases (i.e., 7- 9, 15- 20).

124 mplex architectures of glycans can influence binding selectivity in unanticipated manners.

125 his precise variant to have altered receptor-binding selectivity in vitro.

126 We address ORC binding selectivity in vivo by mapping approximately 52,

127 We find that Hox proteins show considerable binding selectivity in vivo even in the absence of canon

128 ng with unlabeled MK-6240 to evaluate tracer binding selectivity in vivo.

129 ecific binding signals and confirmed its KOR binding selectivity in vivo.

130 e goal with the heterocycles is to design GC binding selectivity into heterocyclic compounds that can

131 Computationally, the prediction of binding selectivity is a challenge, and generally applic

132 dynamics calculations indicate that FTY720P binding selectivity is a function of the entropic contri

133 re than 500 SH3 domains in the human genome, binding selectivity is a key issue in understanding the

134 Binding selectivity is a requirement for the development

135 Thus, the in vitro KOR/MOR binding selectivity is about 36:1.

136 tRNA binding selectivity is affected in one but not in two ot

137 closely related molecules, it was shown that binding selectivity is an emergent property derived from

138 to bind less accessible chromatin, and high binding selectivity is associated with high-affinity bin

139 Structural comparisons indicate that this binding selectivity is determined by residues flanking t

140 Binding selectivity is determined by the nature of the s

141 We have observed that the substrate binding selectivity is more relaxed than the specificity

142 eceptors over alpha4beta2 receptors, but its binding selectivity is much greater at human than at rat

143 We further observed that the allosteric site binding selectivity is sensitive to inhibitor length as

144 Hox binding selectivity is strongly associated with chromati

145 One way to regulate dynein's cargo-binding selectivity is through the C-terminal domain (CT

146 subfamilies are incompletely understood, and binding selectivity is typically overlooked.

147 quester Ang2; however, the mechanism of Ang2-binding selectivity is unknown.

148 The binding selectivity may arise in part from aspartic acid

149 ining identical binding pocket residues, the binding selectivity may be influenced in an allosteric m

150 The TTR binding selectivity, modification yield, and reaction ch

151 CpA dinucleotides and that this alternative binding selectivity modifies gene expression in the deve

152 en thermodynamic contributions affecting the binding selectivity, molecular dynamics free energy simu

153 the various capping agents, including their binding selectivity, molecular-level interaction with a

154 the various capping agents, including their binding selectivity, molecular-level interaction with a

155 These data suggest that mAChR antagonist binding selectivity needs to be re-examined in intact ce

156 structure suggests a basis for the different binding selectivity observed for the alpha1I and alpha2I

157 s spectrometry is used to evaluate the metal-binding selectivities of an array of novel caged macrocy

158 duce an exchange model that accounts for the binding selectivities of different phases, which is like

159 trometry is used to evaluate the heavy metal binding selectivities of five caged crown ethers and two

160 A rapid method for the screening of metal binding selectivities of host compounds in mixtures is p

161 and the characterizations of the nucleotide-binding selectivities of individual motifs.

162 oping this method for the rapid screening of binding selectivities of new synthetic ligands.

163 e proteomics method, we assessed the ATP/GTP binding selectivities of nucleotide-binding proteins at

164 rinted as a glycan microarray to examine the binding selectivities of several HS-binding proteins.

165 lexes in the mass spectra correlate with the binding selectivities of the hosts.

166 m and have been shown to retain the distinct binding selectivities of the receptors from which they d

167 We also examined the binding selectivities of these proteins toward (S)GTP an

168 luorescence polarization to characterize the binding selectivity of 157 mouse PDZ domains with respec

169 ate reductase (DHFR) that combine the enzyme-binding selectivity of 2,4-diamino-5-(3',4',5'-trimethox

170 d classified the cell lines according to the binding selectivity of 26,031 recovered tripeptide motif

171 ase content and placement also show a higher binding selectivity of 3 toward continuous AT-rich than

172 a possible structural interpretation for the binding selectivity of 4a and the lack of selectivity of

173 additional charge clamp that determines the binding selectivity of a coactivator and a distinct liga

174 us a major step closer to understanding the binding selectivity of AHs to lipid membranes.

175 The binding selectivity of antithrombin-III (AT-III) compare

176 We show that the binding selectivity of Bauhinia purpurea lectin switches

177 The F(-), Cl(-), and Br(-) binding selectivity of bis(p-nitroanilide)s of dipicolin

178 nsively, much less is known about the actual binding selectivity of BLM, that is, the obligatory step

179 N-SH2 domain, results in a change in peptide binding selectivity of C-SH2 towards that demonstrated b

180 M) free energy simulations to understand the binding selectivity of Ca(2+) and Mg(2+) in the wild-typ

181 m channel is used to study the energetics of binding selectivity of Ca(2+) versus monovalent cations.

182 eted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal part

183 We present structural insights into the binding selectivity of CELF member 1 (CELF1) for GU-rich

184 Insufficient binding selectivity of chemosensors often renders biorel

185 the basis of molecular modeling, the ERbeta binding selectivity of compounds in this series appears

186 tihypertensive agent spironolactone, and the binding selectivity of cortisol over cortisone.

187 The phosphoinositide binding selectivity of Golgi coatomer COPI polypeptides

188 The in vitro binding selectivity of HuR is indicative of an ARE seque

189 veal that the hnRNP U RBD attenuates the RNA binding selectivity of its core RGG motifs to achieve an

190 ubstrates and is not inhibited, indicating a binding selectivity of LS for the catalytic site and OS

191 Our results highlight that the binding selectivity of metal ions depends on both the st

192 the structural and biochemical basis for the binding selectivity of NHERF1 PDZ domains.

193 hromatin structure in directing the promoter binding selectivity of Pdx1 in beta-cells and non-beta-c

194 Although binding selectivity of procyanidin B3 towards peptides c

195 g of Vestigial to Scalloped switches the DNA-binding selectivity of Scalloped.

196 We investigated the G-quadruplex (G4) binding selectivity of short aromatic oligoamide helical

197 y-based protein profiling platform to assess binding selectivity of small-molecule inhibitors against

198 for RNC binding, and in doing so, tunes the binding selectivity of SRP.

199 We established in vivo binding selectivity of the anti-Abeta42 and anti-Abeta40

200 disclosed model where it is the noncovalent binding selectivity of the compounds, and not the alkyla

201 itively charged amino acids alters the sugar binding selectivity of the domain so that it now binds H

202 ur approach captures, in a single model, the binding selectivity of the PDZ domain family.

203 )) forms an integrated module, maintains the binding selectivity of the PHD6 finger toward acetylated

204 ntributions of carboxyl-terminal residues to binding selectivity of the prototypic interactions of th

205 (methyl and ethyl) increased the A(2B) AdoR binding selectivity of the xanthine derivatives while re

206 A method is presented here to evaluate the binding selectivity of these inhibitors to TTR in human

207 receptor domain specifies the signaling and binding selectivity of TIP39 for the PTH2 receptor over

208 ously, they provide a powerful way to assess binding selectivity on a proteome-wide scale and provide

209 h K(i) = 6 nM to STAT6 and at least >85-fold binding selectivity over STAT5.

210 d double-stranded DNA (ds-DNA) show that the binding selectivity pattern is similar when examined acr

211 -yloxy)butan-2-amine (7), showed an improved binding selectivity profile in favor of alpha(4)beta(2)

212 nist activity (IC(50) = 1.8 nM) and improved binding selectivity profile mu/kappa and mu/delta, when

213 No improvement in the binding selectivity ratio (SERT/DAT and NET/DAT) was fou

214 wed improvements in mu/delta and kappa/delta binding selectivity ratios as well as in the delta antag

215 C/N domain binding selectivity ratios ranged from 1 to 350, while r

216 I3K (EC(50) = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinase

217 ted aromatic region of GO, resulting in high binding selectivity relative to larger apolar compounds.

218 the isolated aromatic region of GO enhanced binding selectivity relative to similar-sized apolar aro

219 )-27 showed > 2659- and > 2105-fold delta/mu binding selectivity, respectively.

220 otency and dramatically increased plasma TTR binding selectivity resulted.

221 the estradiol A-ring binding pocket and that binding selectivity results from differences in the inte

222 This binding selectivity revises the dogma in the field.

223 By coupling protein folding with RNA binding selectivity, RIG-I distinguishes RNA molecules t

224 Comparison of ligand binding selectivity showed resemblance to that by the C1

225 te the structural features that confer CRTH2 binding selectivity, structure-activity relationship ana

226 Binding selectivity studies with the most potent (alpha/

227 phorylation of the cadherin reverses the TCF binding selectivity, suggesting another potential layer

228 ses, with 6 and 7 exhibiting somewhat higher binding selectivities than 8-10.

229 that demonstrate significantly higher D(3)R binding selectivities than the reference compounds.

230 d lower binding potencies and delta receptor binding selectivities than their pyridine counterparts.

231 ve agents showed in many cases less dramatic binding selectivity than anticipated from published repo

232 (15a-d) displaying generally higher subtype binding selectivity than the bisphenolic analogues (15f-

233 t1 is similar to human IFIT1 in its cap0-RNA-binding selectivity, the roles of Ifit1b and Ifit1c are

234 Consistent with this binding selectivity, the signature domain of thrombospon

235 e domains; the use of induced fit to enhance binding selectivity; the imposition of fidelity at the l

236 The large binding selectivities, therefore, do not influence cleav

237 leading to a model where Hox proteins derive binding selectivity through affinity-based competition w

238 e easily extended to evaluate small molecule binding selectivity to any protein in a given biological

239 the D-Au nanoparticle shows a 2-fold higher binding selectivity to D-glucose substrates, attributed

240 Selected polyphenols exhibited binding selectivity to different cellulose-based composi

241 ERs, three of which displayed over 100-fold binding selectivity to ERbeta over ERalpha.

242 aromatic ring is the prerequisite to display binding selectivity to Pt(111), while a neutral to posit

243 ering this cooperativity of Lrp binding, the binding selectivity to specific sites may increase to a

244 ion within this triplet, W976R, restored the binding selectivity to the general consensus sequence fo

245 A expression, degree of target shedding, and binding selectivity to tumor cell surface TAAs over shed

246 g affinity, the adsorbent shows high uranium binding selectivity to uranyl against not only the inter

247 ion of the other residue involved in agonist binding selectivity, to the corresponding residue in the

248 48-linked chains, UQ1-UBA shows little or no binding selectivity toward a particular chain linkage or

249 ge internal cavity, the cage exhibits a high binding selectivity toward C70 (K = 3.9x10(3) L mol(-1))

250 A 120-fold binding selectivity toward C70 (Kassoc = 1.81 x 10(7) M(

251 y and tertiary structures, MTs show distinct binding selectivity toward different MAChRs.

252 inverse agonist and antagonists that display binding selectivity toward the alpha5beta2gamma2 isoform

253 ds' terminal substituent correlated with its binding selectivity toward the alpha5beta2gamma2 versus

254 DCX's exquisite binding selectivity uncovers important insights into reg

255 TA buffer also demonstrated G-quadruplex DNA binding selectivity under these buffer conditions.

256 This binding selectivity was determined by the non-conserved

257 Binding selectivity was determined to a large part by th

258 10 with 2-pyridylmethoxy (compound 29), but binding selectivity was not enhanced (K(i): alpha 2 = 1.

259 zepine selectivity was reversed, yet peptide binding selectivity was unaffected.

260 veral compounds with combined D3/D4 receptor binding selectivity were also identified.

261 ially, this mechanical bond effect induces a binding selectivity which directly opposes Hofmeister bi

262 cture has a significant effect on the halide binding selectivity, which is further amplified upon K(+

263 gree of polymerization of 10 (dp10) had high binding selectivity, while dp10 heparin and dp10 6-desul

264 lting, affect ssDNA binding: Y184A decreases binding selectivity, while Y189A and W193A decrease the

265 contrast, the enantiomers show only moderate binding selectivity with lysozyme.

266 entify pH-regulated transcription factor-DNA binding selectivity with relevance to how pHi dynamics c