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1 ant levels of recently proposed 'off target' binding sites for [(18)F]AV-1451, such as neuronal monoa
4 additional plant families and identified 715 binding sites for 501 genes conserved in dicots, monocot
8 st that this may represent an as-yet-unknown binding site for a partner protein required for tumorige
9 as it took 10-20 s on average to predict the binding site for a protein complex whereas the state-of-
10 nding pocket in BGT1, which accommodates the binding site for a series of novel noncompetitive inhibi
11 incorporates competition between neighboring binding sites for a local pool of TF molecules explains
12 q analysis was used to determine genome-wide binding sites for a range of different TFs in multiple c
16 scan" approach, we show that the orthosteric binding sites for acetylcholine and nicotine in the two
19 specific RpL4 extension harbours overlapping binding sites for Acl4 and the nuclear transport factor
21 on, docking calculations around the observed binding site for all three states of the receptor, inclu
26 loss of hyaluronan, which harbors a specific binding site for angiopoietin and a key regulator of end
27 during infection without the need to evolve binding sites for antisilencing proteins at each foreign
29 open sites at active enhancer regions and at binding sites for AP1-complex components, including c-Fo
34 es ASIC1a, identify the acidic pocket as the binding site for BigDyn, and thus highlight this cavity
35 his assay allows distinction of two separate binding sites for BODIPY-cyclopamine on the SMO transmem
36 AZ resistant isolates involved AmpC, a known binding site for both ceftolozane and ceftazidime, and D
37 ecause DapF (Ct) utilizes a shared substrate-binding site for both racemase and epimerase activities,
38 5-bp consensus sequence GGC(GC)|(CG) as the binding site for both TGF-beta and BMP-activated Smads a
39 d TRPM8 structures have uncovered unforeseen binding sites for both cooling agonists and membrane lip
41 rved scaffold protein TOPBP1(Dpb11) provides binding sites for both pro- and anti-resection factors a
47 (TnC) as the Ca(2+)-binding moiety, has two binding sites for calcium ions, providing a linear respo
48 that the presence of high-nanomolar affinity binding sites for CaM at its universal gating brake and
49 harboring a weak SigA-dependent promoter and binding sites for cap repressors such as SaeR, CodY and
50 his SNP is on chromosome 8q24, adjacent to a binding site for CCAAT/enhancer-binding protein beta, a
52 tu neutron powder diffraction studies on the binding sites for CD4 within MFM-132a and MFM-115a revea
55 tor (GPCR) to be swept rapidly for potential binding sites for cholesterol at the bilayer interfaces
56 g WS-12 and PIP(2) Our structures reveal the binding sites for cooling agonists and PIP(2) in TRPM8.
61 site ligands identify an additional membrane binding site for diazepam and suggest an allosteric mech
62 rials with sensitive nanospace and selective binding sites for discriminating the subtle structural d
63 of the genome can be genetically encoded by binding sites for DNA-binding proteins and can also invo
65 ibodies neutralize P. vivax by targeting the binding site for Duffy antigen receptor for chemokines (
69 on, and the regions that close contain known binding sites for effectors of mitogenic signaling pathw
70 ta(1-40) oligomers with multiple independent binding sites for EGCG with a Kd approximately 10-fold l
72 e show that the fourth helix constitutes the binding site for FlhA, a membrane protein at the export
74 thin the previously determined fVa-dependent binding site for fXa (amino acid region 473-487 of FII).
76 GIRK2-4, and located within their C-terminal binding sites for Gbetagamma proteins that mediate membr
77 kinase homology domain harbored an exclusive binding site for GCAP1 with similar affinities as the fu
79 ke SS4, SS5 has a conserved putative surface binding site for glucans and also interacts with MYOSIN-
80 omplexes and a competitive loss of available binding sites for glyphosate-functionalized poly(ethylen
82 g the CD33 IgV domain, which is the antibody-binding site for GO, as well as diagnostic immunophenoty
83 ciency (Mac-1(-/-)) or mutation of the Mac-1-binding site for GPIbalpha have delayed thrombosis after
84 ble chromatin regions, as well as sex-biased binding sites for growth hormone-regulated transcription
90 lutionary paths to (i) optimize their glycan binding site for higher glycan binding function and (ii)
91 401W, places a bulky tryptophan opposite the binding site for HMG Box A at both 12- and 23-spacer rec
92 tes HSR, and heat shock elements (HSEs), the binding sites for HSF1 - between Antarctic fishes and th
95 and mutagenesis analysis identified specific binding sites for hypoxia-inducible factors (HIF) and TG
97 heterodimer (IL-2Rbetagamma(c)) but have no binding site for IL-2Ralpha (also called CD25) or IL-15R
98 eostat positions located near the allosteric binding sites for inhibitor alanine (Ala) and activator
100 rates how mRNA junctions can create specific binding sites for interacting RNAs of prescribed sequenc
101 extremely hydrophobic, but in complex I the binding site for its redox-active quinone headgroup is a
103 The major groove of this helix provides the binding site for L-glutamine, which is extensively hydro
106 entification and characterization of protein-binding sites for ligands are crucial for the understand
108 cost and demonstrated to possess sufficient binding sites for LPS adsorption and removal with ~100%
109 hat contains the following two high affinity binding sites for LRP1: one is located within domains 1
112 view the regulatory roles of the 3'UTRome as binding sites for microRNAs or RNA binding proteins, or
113 factor 1 (MACF1), a scaffolding protein with binding sites for microtubules (MT) and actin, is concen
115 ever, only one, possessing multiple putative binding sites for miR-145, was highly conserved between
116 nce that repression of egl-1 is dependent on binding sites for miR-35 and miR-58 family miRNAs within
117 s of CYCLIN D1 and c-MYC mRNAs revealed that binding sites for miR33b, miR96, and miR503 are critical
120 ed a preference in the enzyme's second metal binding site for Mn(II) over Mg(II), suggesting that T7
121 mers, study of flexibility of side chains in binding site for molecular docking preparations, use of
124 ined the roles of RNA elements identified as binding sites for NC, a Gag-derived RNA-binding protein.
126 n B7-H6 that is completely distinct from the binding site for NKp30, such that 17B1.3 does not block
130 w that most Ribi gene promoters also contain binding sites for one or more General Regulatory Factors
137 ction of channels presenting a high-affinity binding site for PF-05089771 and suggesting that combina
138 roscopy (cryo-EM) structures reveal that the binding sites for PF 06882961 and GLP-1 substantially ov
139 iching specific lipids and forming essential binding sites for phosphoinositides and cholesterol that
141 hromatin in hSSCs was strikingly enriched in binding sites for pioneer factors (NFYA/B, DMRT1, and ho
142 elements (CREs) comprised of combinations of binding sites for pluripotency TFs and measured their ex
144 sis and electrophysiology, we identified the binding site for potentiating dFBr on the top half of a
145 tified using the polyclonal antisera overlap binding sites for previously reported monoclonal antibod
146 with other amino acid residues in the GERAMT-binding site for proper chaperone-dependent regulation o
147 o gain insight into the number of functional binding sites for propofol and the energetic contributio
148 ne or two additional functionally equivalent binding sites for propofol, other than those modified by
150 ional analysis and molecular modeling of the binding site for prototypical NAMs to provide new molecu
152 ysis of both RBDs suggests that the receptor-binding site for QX is located at a different location o
153 ational change of the ELMO1 subunit, exposes binding sites for RAC1 on DOCK2(DHR2), and RHOG and BAI
154 in of PLCepsilon was proposed to the primary binding site for Rap1A, we first confirmed using purifie
155 RNA, an extension of MotifMap which predicts binding sites for RBP motifs across human and mouse geno
156 n transcribed into RNA, as they serve as the binding sites for RBPs that control post-transcriptional
157 omain (Delta1-147), suggesting an allosteric binding site for recifin A on the regulatory domain of T
159 s may result in presence or absence of miRNA binding sites for regulatory miRNAs with consequences on
162 expression, we identified transcriptome-wide binding sites for RNA polymerase II and the exosome cofa
163 hare common sequence motifs and overlap with binding sites for RNA-binding proteins crucial for neuro
164 nic frameworks allows design of well-defined binding sites for selective molecular adsorption, which
165 ieval method, here we comprehensively define binding sites for Semliki Forest virus (SFV) Cp on the g
166 epigenetic inheritance of silencing requires binding sites for sequence-dependent activating transcri
167 revealed that the exon 11 sequences contain binding sites for serine/arginine-rich splicing factor 2
168 12-amino-acid region of VP1 that is also the binding site for several previously identified monoclona
169 ition model was used to determine overlap of binding sites for several inhibitory and potentiating st
170 with the established views of the overlap of binding sites for several pairs of orthosteric (GABA, be
171 AngII-induced enhancers/SEs are enriched in binding sites for signal-dependent transcription factors
173 st that the loops and tails may offer unique binding sites for small micropollutants which are overse
175 izing antibodies (bNAbs) but can also expose binding sites for some types of nonneutralizing antibodi
177 reporter assay (MPRA) libraries composed of binding sites for SOX2, POU5F1 (OCT4), KLF4, and ESRRB.
178 nsupervised method that accurately annotates binding sites for specific TFs automatically with no req
182 ferentially expressed genes have a known DNA binding site for SR1, suggesting that they are likely di
184 form of Strep-Tactin that harbours a unique binding site for Strep-tag II and a single cysteine that
187 p in telomeric repeats, the longest reported binding site for synthetic, non-nucleic-acid-based, sequ
189 s containing replication origins proximal to binding sites for Taz1, a component of the Shelterin tel
190 ment of single nucleotide variants in active binding sites for TEAD4 (P = 6 x 10-11) and its binding
192 signature encompasses and better defines the binding site for TFIID and is surprisingly invariant ove
193 uPol(A) bound to the cRNA template reveals a binding site for the 3' cRNA at the dimer interface.
194 ctural studies have identified a new surface binding site for the 3' vRNA and cRNA promoters on FluPo
196 SNP rs2227473 is located within a putative binding site for the aryl hydrocarbon receptor, a master
197 gene island and having a predicted promoter binding site for the As(III) oxidation regulator AioR.
200 nformational changes that create a potential binding site for the CaM binding domain of a target prot
201 l from the enzyme active site, namely at the binding site for the cellular cofactor lens epithelium-d
202 hing data revealed the existence of the same binding site for the compounds on the enzyme molecule.
203 CATAC consensus sequence resembles the E-box binding site for the core circadian transcription factor
205 In contrast, resistance mutations in the HR1-binding site for the fusion inhibitors did not cause cro
206 fic modulators acting via the C1 domain, the binding site for the lipid second messenger diacylglycer
207 that the class M epitope overlapped with the binding site for the major histocompatibility complex.
210 t site, which was previously identified as a binding site for the NAM/ATAF1/CUC2 78 (NAC78) transcrip
211 dure in which DNA containing one copy of the binding site for the neural-inducing factor Ascl1 is inj
212 a representative ligand of the high-affinity binding site for the neuroactive substance gamma-hydroxy
213 omes, removing the glycan cap and exposing a binding site for the Niemann-Pick C1 (NPC1) receptor.
216 the presence of low levels of H3K9me3 at the binding site for the PF3D7_1466400 AP2 transcription fac
217 se they bind to the sAC-specific, allosteric binding site for the physiological activator bicarbonate
219 model in which the POTRA domains serve as a binding site for the preprotein as it emerges from the T
220 tion between slower dynamics of water at the binding site for the protein in solution and stronger fr
221 otein by a conserved kinase, DDK, provides a binding site for the Scc2/4 cohesin loading complex, the
222 I and III in two different CaV isoforms as a binding site for the SH3 domains and report a crystal st
225 r function, however, required evolution of a binding site for the spatially restricted potent repress
226 Notably, SNP rs17651213 created a putative binding site for the splicing factor RBFOX2 and was asso
228 chemical experiments have indicated that the binding site for the substrate eEF-2 is located in the C
229 nstead, these promoters are enriched for the binding site for the TALE-class homeodomain transcriptio
230 f the ternary complex reveals a noncanonical binding site for the toxin that adopts a novel conformat
231 2149092 was predicted to disrupt a consensus binding site for the transcription factor ETS within an
232 ion in the BALB promoter creates a consensus binding site for the transcription factor MZF1 (myeloid
233 through rs7278468, which lies in a consensus binding site for the transcription repressor KLF10.
234 the ribosomal protein uL23 form a composite binding site for the transmembrane domain (TMD) on the n
236 that these phosphorylations create potential binding sites for the adaptor protein 14-3-3 that links
237 poptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic proteins Bcl-XL and
238 acement strategy, we found that multimerized binding sites for the architectural proteins Pita, Su(Hw
239 mputational analysis of single-cell data and binding sites for the CD4(+)-lineage transcription facto
240 s and identify accurate transcription factor binding sites for the core regulatory complexes in the t
241 the docking factors that specify the unique binding sites for the different dynein isoforms on the s
242 entromeric alpha-satellite repeats harboring binding sites for the DNA sequence-specific binding prot
246 ence motifs enriched in the PREs are cognate binding sites for the identified transcription factors a
247 boxyl dopants of graphene were the efficient binding sites for the immobilization of NapCo through ax
249 NA binding by PPR repeats to infer candidate-binding sites for the maize protein PPR103 and its ortho
250 ctra for each isomer, clearly indicating the binding sites for the major conformers in the presence o
251 f microRNA promoters revealed enrichment for binding sites for the MAPK-driven ETS1 transcription fac
253 led to the acquisition of hundreds of novel binding sites for the MSL complex in different species.
254 advances to rapidly mutate 10 high-affinity binding sites for the nucleoid occlusion protein SlmA an
255 and de-methylesterified pectin presents more binding sites for the protein-pectin interaction than to
256 complex as a tethering complex with just two binding sites for the Rab7-like Ypt7 protein to determin
258 A, adjacent to the guide region, function as binding sites for the snoRNP proteins including the enzy
262 We found that robustness is encoded by many binding sites for the transcriptional activator Arrowhea
263 or transport and are candidates for possible binding sites for the two H(+) that are exchanged for on
264 molecular docking studies revealed that the binding site for these compounds overlaps with the site
268 o regulate PTEN and identify high-confidence binding sites for these miRNAs on the 3' UTR of protein
269 ), we have identified pathways that link the binding sites for these modulators to the Cys loop, a re
271 during active disease, in order to assemble binding sites for these TFs into synthetic promoters, wh
273 h was recently identified as a mitochondrial binding site for thiazolidinediones, including MSDC-0602
274 of use in clinical practice, the prototypic binding site for this class of drugs within pLGICs is ye
278 , leaving a cavity suggestive of a potential binding site for transcription-promoting small molecules
279 ontains several high-affinity non-functional binding sites for transcription factors (TFs) creating a
281 ls and determine the energetic properties of binding sites for transcription factors and RNA polymera
284 red common cis-acting elements may represent binding sites for transcription factors responsible for
285 ation, mediated by DNA sequences that harbor binding sites for transcription factors, which can up- o
286 oxidation) and lack methylation at specific binding sites for transcription factors; 83% of samples
287 terminal (AF-1) domain of AR, which contains binding sites for transcription regulators, is not requi
291 different timing classes each associate with binding sites for two transcription factors, GAGA-factor
293 to Tx7335 as wild-type, indicating that the binding site for Tx7335 is distinct from that of canonic
294 The data suggest that there is only one binding site for ubiquinol in cyt bo3 and that site corr
297 near the N-terminal Arg and the carbohydrate-binding site, for which the potential function is curren
298 nt-response elements, and we also discovered binding sites for XBP1, a transcription factor of endopl