ライフサイエンスコーパス: binding specificity

1 nteractions with the viral lipid membrane to binding specificity.

2 rated their power in predicting DNA- and RNA-binding specificity.

3 ritical residue dictating SCRIB:alpha(1D)-AR binding specificity.

4 ng architectures for predicting DNA- and RNA-binding specificity.

5 abundance of neoantigens and greater mutant-binding specificity.

6 ding, and ligand blot analysis confirmed the binding specificity.

7 2 complexes, while KIR2DL1 showed a broader binding specificity.

8 ligand, contributing an important aspect of binding specificity.

9 ognize and bind DNA with different levels of binding specificity.

10 and Oct1, a related protein with similar DNA-binding specificity.

11 uestion of what mechanism accounts for their binding specificity.

12 se findings and revealed avian-like receptor-binding specificity.

13 onal glycan-binding site, which broadens its binding specificity.

14 ith higher information content than the true binding specificity.

15 how adjacent fingers influence each other's binding specificity.

16 ced acute liver injury to determine its S1P1-binding specificity.

17 tly exhibit class I, class II, and class III binding specificity.

18 dentified PAD4 variants having enhanced TEM8 binding specificity.

19 e coiled-coil and perhaps contributes to the binding specificity.

20 TFBSs in order to achieve genome-wide TF-DNA binding specificity.

21 ith a few residues in the motif endowing the binding specificity.

22 antibodies that do not change their antigen binding specificity.

23 ive DIMM binding sites contribute to its DNA binding specificity.

24 t of the antibody fragment (64)Cu-DOTA-B-Fab binding specificity.

25 tant for allosteric activation from receptor binding specificity.

26 calization but only minimally by altered RNA binding specificity.

27 t to the non-sulfated hyaluronan, confirming binding specificity.

28 -end pairing is a general determinant of AGO binding specificity.

29 eing HLA-A2 and HLA-A3) carries some peptide-binding specificity.

30 (Cpf1) appears to be primarily driven by DNA-binding specificity.

31 on can be attributed to cleavage rather than binding specificity.

32 etween TcsL and TcdB switches their receptor-binding specificity.

33 fective affinity improvement and redesign of binding specificity.

34 ily, while co-binding could be key for their binding specificity.

35 4/CRAL-TRIO and GOLD domains govern membrane binding specificity.

36 uman heart specimen was conducted to confirm binding specificity.

37 tudies of the role of DNA shape in achieving binding specificity.

38 s in conferring host cell binding and ligand binding specificity.

39 weight of about 2 kDa with an antibody-like binding specificity.

40 arboxylate binding loop dictate alpha(1D)-AR binding specificity.

41 nd charge, which we suggest drives chemokine-binding specificity.

42 by biodistribution at 24 h to determine PSMA binding specificity.

43 e protein collaborate to create a unique RNA-binding specificity.

44 kely influenced by differential GAG receptor binding specificities.

45 homo- and heterodimers to measure their DNA binding specificities.

46 avior across viruses with different receptor binding specificities.

47 tifs, and allows for the analysis of in vivo binding specificities.

48 cessful design and prediction of C2H2-ZF DNA-binding specificities.

49 to determine, predict and engineer their DNA-binding specificities.

50 -throughput approach into the modeling of TF binding specificities.

51 ul means to enable accurate inference of DNA-binding specificities.

52 -occupancy sites have the expanded consensus binding specificity 5'-C(A/G)-CANNTG-3', with an added o

53 ents that translate into differential ligand-binding specificities across this protein family.

54 were synthesized and then characterized for binding specificity, affinity, cytotoxicity of drug-pept

55 able loop CBL2 is key for programming ligand binding specificity, albeit with limited predictability.

56 led to E2F1 cistrome expansion and different binding specificity, alterations distinct from those obs

57 key determinants for biological activity and binding specificity, although the nature of interactions

58 Moreover, variations in RNA-binding specificity among a panel of CG-binding pocket m

59 tibodies results in induction of new antigen binding specificities and acquisition of binding polyrea

60 ng HLA molecules for similarities in peptide binding specificities and binding pocket structure.

61 es that relate cell-cell organization to the binding specificities and energetics of adhesion recepto

62 ls of multiple CMV glycoprotein-specific IgG binding specificities and functions in mothers and infan

63 transcription factor concentrations and DNA binding specificities and predicts precise gene expressi

64 ntaining a variable Fab domain that mediates binding specificity and a constant Fc domain that bridge

65 orrectly identifies residues that confer DNA-binding specificity and accurately predicts binding moti

66 ure-based biophysical determinants for their binding specificity and affinity is of fundamental impor

67 y provides a basis for subtle differences in binding specificity and affinity to generate significant

68 fragments further improves the in vivo Abeta-binding specificity and brain uptake of the correspondin

69 ral infection is highly heterogeneous in its binding specificity and differs in both its reactivity t

70 atic probing with RNases illuminated how RNA binding specificity and dissociation after cleavage can

71 eotides is distinct and that it reflects the binding specificity and genome occupancy of methylcytosi

72 However, the detailed virus-glycan binding specificity and glycan chain length requirements

73 nd thermodynamics combine to modulate ligand-binding specificity and have implications for the evolut

74 lucidated the molecular basis underlying its binding specificity and high affinity.

75 s the molecular basis for pocket protein-E2F binding specificity and how cyclin-dependent kinases dif

76 to the study of in vivo transcription factor binding specificity and its relationship to cis-regulato

77 ly applicable strategy for investigating the binding specificity and molecular interactions of covale

78 Here we report the ligand binding specificity and physiological relevance of two D

79 the molecular prerequisites for higher level binding specificity and regulation, raising new question

80 f an epigenetic DNA modification on human TF binding specificity and reveals that many developmentall

81 in human cells using ChIP-seq to assess DNA-binding specificity and RNA-seq to measure the specifici

82 KAP-specific binding, thus demonstrating its binding specificity and selectivity in vivo.

83 of (11)C-LSN3172176, thus demonstrating its binding specificity and selectivity in vivo.

84 used as a blocking agent to investigate the binding specificity and selectivity of (18)F-CDKi.

85 at in the cerebellum, thus demonstrating the binding specificity and selectivity of (18)F-LY2459989 i

86 and 2 mg/kg) were obtained to assess tracer binding specificity and selectivity.

87 A structure ('shape') is a determinant of TF binding specificity and since DNA shape has a significan

88 the hydrophobic interactions to provide the binding specificity and strength in ribosome targeting o

89 the structural underpinnings of alphavbeta8 binding specificity and TGF-beta activation.

90 lipid bilayers, and therefore, questions on binding specificity and the effect of collective membran

91 dependent but convergent evolution of PUF4/5 binding specificity and the rewiring of the PUF4/5 regul

92 We also drive the intrinsic binding specificity and which correlation with amino aci

93 udicious strategies have blended design (for binding, specificity and active site modelling) with the

94 d its paralogue WelNDLY exhibit distinct DNA-binding specificities, and that, unlike WelNDLY, WelLFY

95 possibilities in terms of trimerization, DNA binding specificities, and transcriptional regulation.

96 able di-residues that determine TAL effector binding specificity, and is independent of the transcrip

97 11)C-GR103545 showed high brain uptake, good binding specificity, and selectivity for KOR, it display

98 nd PvRBP1a displayed a distinct reticulocyte-binding specificity, and their specific reticulocyte-bin

99 s and functional studies inform on substrate binding, specificity, and modulation of the AgcS family

100 This analysis revealed that TF binding specificities are highly conserved between Droso

101 nd that SH2 domain proteins with overlapping binding specificities are unlikely to compete with one a

102 trictly reflect the predictions arising from binding specificities at a molecular level, but instead

103 used ChIP-seq to examine genome-wide CRISPR binding specificity at gRNA-specific and gRNA-independen

104 usly, we developed a method for modeling DNA binding specificities based on DNA shape features extrac

105 ession, we trained quantitative models of TF binding specificity based on protein binding microarray

106 Interestingly, PLB-binding specificity became more ambivalent for other SER

107 ntribution of each DNA strand to the overall binding specificity between DNA-binding proteins with di

108 yielded positive results, indicating a high binding specificity between the PNA used and the complem

109 We discovered mutual relationships among binding specificity, binding affinity, and structural pr

110 he 190V in HA does not affect virus receptor binding specificity but enhances binding affinity to hum

111 90V in the HA does not change virus receptor binding specificity but enhances virus binding affinity

112 8 virus has retained its avian-like receptor binding specificity, but could potentially establish inf

113 o All substitution mutants retained receptor binding specificity, but the substitutions frequently le

114 These approaches typically infer DNA-binding specificities by considering interactions for ea

115 e we introduce a framework for inferring DNA-binding specificities by considering protein-DNA interac

116 se and fly Gsx factors unexpectedly gain DNA binding specificity by forming cooperative homodimers on

117 6E) has been reported to alter the substrate-binding specificity by shifting Glut5-mediated transport

118 ports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface an

119 However, subtle differences in binding specificities can be detected in vitro with the

120 served, although underlying differential DNA binding specificity can dictate the recruitment of FOXK2

121 cally increased cleavage specificity but not binding specificity compared to wtCas9.

122 N37L in turn switches binding specificity: compared with the wild-type C. ther

123 ncreasing molecular size without loss of the binding specificity conferred by small cavity [Pd2(L)4](

124 f transcription factors with overlapping DNA-binding specificities, conferred by a C-terminal basic h

125 and shed light on Robo family member ligand binding specificity, conformational variability, diverge

126 istinct genomic regions, suggesting that DNA binding specificity contributes to functional difference

127 igate bsAbs, the physical linkage of the two binding specificities creates a dependency that can be t

128 on about the proteins and displays their DNA-binding specificity data in terms of k-mers, position we

129 cell differentiation, is critical for EBNA3C binding specificity; EBNA3A and EBNA3B specificities are

130 SAA through mechanisms involving DP peptide binding specificity, expression, and/or other factors af

131 inding profiles (FBPs) represent the average binding specificity for a group of structurally related

132 lity of small molecules while providing high binding specificity for biomolecular partners typically

133 me, approximately 24% of antibodies acquired binding specificity for divergent strains of HIV-1 gp120

134 is model enabled confirmation of altered DNA-binding specificity for FOXL2(C134W) and identification

135 ically, promoting DNA scanning and providing binding specificity for gapped DNA.

136 -lysine-binding domain (MBD) and demonstrate binding specificity for H4K20me2.

137 his study, we have established the WW domain binding specificity for Hippo pathway components and unc

138 we screened 20 widely used lectins for their binding specificity for major pancreatic cell types, and

139 We validate the importance of DNA binding specificity for organ-specific gene regulation b

140 brational spectra and provide perspective on binding specificity for small-molecule ligands in intact

141 our study not only elucidates the WW domain binding specificity for the Hippo pathway, but also reve

142 meric 'B' subunit made up of PltB, which has binding specificity for the N-acetylneuraminic acid (Neu

143 (64)Cu-LLP2A and LLP2A-Cy5 demonstrated binding specificity for VLA-4 in an immune-competent mur

144 In order to infer DNA-binding specificities from these data, numerous sophisti

145 supervised machine learning to predict probe binding specificity from genome-scale sequence alignment

146 allows ppGpp to bind to BipA and switch its binding specificity from ribosomes to small ribosomal su

147 orresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors.

148 DNA-binding specificity has been proposed as a primary mecha

149 Knowledge of protein-DNA binding specificity has important implications in unders

150 he galectin interacting with Gal-3BP and its binding specificity has not been identified and structur

151 of influenza viruses (hemagglutinin receptor binding specificity, hemagglutinin pH of activation, and

152 n of three modes: Hox-cofactor dependent DNA-binding specificity; Hox-monomer binding sites; and inte

153 We also identified how binding specificities in LysM receptors can be altered t

154 TPase-activating protein (GAP), and effector-binding specificities in mixtures of GTPases and resolve

155 alog has almost a 10-fold higher IGF-1R/IR-A binding specificity in comparison with native IGF-II.

156 show that the ion binding sites switch their binding specificity in E1 and E2.

157 1)C]11e) were generated and tested for NMDAR binding specificity in ex vivo autoradiography and brain

158 rface experiment to successfully demonstrate binding specificity in kinetic analysis biomechanics in

159 implications for the evolutionary origins of binding specificity in multi-protein families.

160 ty, and specific radioactivity and possesses binding specificity in relevant models that indicate pot

161 Our structures define the basis of ligand-binding specificity in the CRF receptor-hormone system,

162 mutation assay experiments suggest that the binding specificity in the designs is essentially determ

163 de constitutes a key signature providing PIC binding specificity in the human genome.

164 ful pathway for drug development focusing on binding specificity in the initial high-throughput scree

165 To identify the determinants of Chd1 binding specificity in the yeast genome, we investigated

166 l specificity in vivo, they all show similar binding specificity in vitro and a satisfactory understa

167 However, CELF1's RNA binding specificity in vitro was not detectably altered

168 n vitro are not mutually exclusive, and that binding specificity in vivo remains to be demonstrated.

169 like factor-1 (KLF1) leads to degenerate DNA-binding specificity in vivo, resulting in ectopic transc

170 e number of Puf genes and alterations of RNA binding specificity including that: 1) Binding of Puf3 t

171 ubsequently, endocytic lectins with distinct binding specificities, including the Ashwell-Morell rece

172 ing with minimal interfaces, suggesting that binding specificity is an additional pressure for a scal

173 bstrates, including pre-rRNAs and pre-mRNAs, binding specificity is apparently conferred by Trf4 and

174 been reported, challenging the view that NR binding specificity is defined by half-site spacing.

175 It is widely believed that RBP binding specificity is determined by both the sequence a

176 Binding specificity is further modulated by different bi

177 ranscription factor dimerization impacts DNA-binding specificity is poorly understood.

178 though genogroup-dependent variation in HBGA binding specificity is structurally well characterized,

179 und in the human proteome, raising a "WW-PY" binding specificity issue in the Hippo pathway.

180 ns have been characterized for their histone binding specificities, many of these domains remain poor

181 est that polymorphisms that impact FOXP3 DNA-binding specificity may contribute susceptibility to aut

182 ant, we were able to build a heterodimer-DNA binding specificity model that has superior predictive p

183 improve the predictive power of quantitative binding specificity models across 27 transcription facto

184 ur collection containing 145 high-resolution binding specificity models for 86 RBPs is the largest sy

185 assessing cooperativity when generating DNA binding specificity models for heterodimers.

186 r partners and its impact on heterodimer DNA binding specificity models is still lacking.

187 rface of yeast, we show that SELEX can yield binding specificity motifs and identify cleavable LHE ta

188 Transcription factor (TF) binding specificities (motifs) are essential for the ana

189 solution chromatin accessibility, and TF-DNA binding specificities ('motifs').

190 HIV-1 binding specificities, neutralization potency, inhibitio

191 Substantial similarities in binding specificity, neutralization breadth and potency,

192 Regulation of protein-DNA binding specificity occurs through myriad mechanisms.

193 hensively by quantitatively assaying the DNA-binding specificities of 21 representative TALEs to appr

194 To address this, we determined the binding specificities of 242 Drosophila TFs, and compare

195 ein dimerization properties, we examined DNA binding specificities of 270 human bZIP pairs.

196 tions to analyze the dual GlcNAc- and MurNAc-binding specificities of BsPdaC and compared them with t

197 numbers of the DNA codes represent relative binding specificities of corresponding glycan structures

198 nsights concerning mechanisms underlying the binding specificities of FGF21 and FGF23 to beta-Klotho

199 ctors, and highlights the multiple substrate-binding specificities of its adaptor subunit.

200 ides were printed as a microarray to examine binding specificities of lectins, anti-ganglioside antib

201 their central role in RNA function, the RNA-binding specificities of most RBPs remain unknown or inc

202 The distinctive binding specificities of PGHS subunits permit different

203 VP4 [P] genotype binding specificities of rotaviruses and differential ex

204 n as another feature that fine-tunes the DNA binding specificities of some transcription factor famil

205 tide-binding assay and use it to analyze the binding specificities of the endoplasmic reticulum Hsp70

206 se findings are consistent with the measured binding specificities of these proteins for ganglioside

207 DNA binding specificities of transcription factors (TFs) are

208 Characterizing the binding specificities of transcription factors (TFs) is

209 Purpose To determine the binding specificity of (18)F-16alpha-17beta-fluoroestrad

210 lated transcription factors have a consensus binding specificity of 5'-TTG-CG-CAA-3', with a central

211 define the glycan binding specificity of a variant of typhoid toxin produc

212 alendronate confirmed the microcalcification binding specificity of alendronate derivatives.

213 Effector Design (SIFTED), to predict the DNA-binding specificity of any TALE.

214 n the conserved motif LXXXXD, pivotal to the binding specificity of BH3 domains of pro-apoptotic BCL-

215 ng could explain the ppGpp regulation of the binding specificity of BipA.

216 Binding specificity of Cas9-guide RNA complexes to DNA i

217 We show that binding specificity of DIP/Dpr subgroups is controlled b

218 intrafamily protein interactions affect DNA binding specificity of floral MADS domain proteins.

219 ified by each study, suggesting that the RNA-binding specificity of FMRP is still unknown.

220 To further investigate the RNA-binding specificity of FMRP, we developed a new method c

221 loping limb as a model system to compare the binding specificity of HOXA13 and HOXD13 (HOX13 hereafte

222 an sulfate (HS) 3-O-sulfation determines the binding specificity of HS/heparin for antithrombin III a

223 s recently been used to deeply probe the DNA binding specificity of hundreds of eukaryotic transcript

224 The binding specificity of individual PC's Ig was determined

225 ed protein-protein docking tools to identify binding specificity of individual tropomyosin pseudorepe

226 ound that homo-trimerization defines the DNA binding specificity of Myrf N-terminal fragments.

227 The binding specificity of P47Rec from distant anophelines (

228 Early works suggested binding specificity of PRC2 to certain long non-coding R

229 Rapid evolution of the DNA-binding specificity of PRDM9 and gradual erosion of PRDM

230 e first strategy to exhaustively explore the binding specificity of protein domain-peptide interactio

231 nstrate that the CTR domain confers receptor-binding specificity of RELN.

232 ffects both the expression and the chromatin binding specificity of REX1.

233 rotein histochemistry showed that the tissue binding specificity of S1 proteins of turkey, quail, and

234 -chain variable fragment (scFv) retained the binding specificity of the 3H3 IgG and, when expressed i

235 Modulating LIR binding specificity of the centriolar satellite protein

236 ts they regulate is not fully known, and the binding specificity of the CPEB2 subfamily is a matter o

237 , particularly of sites corresponding to the binding specificity of the overexpressed SH2 domain.

238 Our result shows that the binding specificity of the PHD-finger domain of VIN3 pla

239 An alteration in the binding specificity of the PHD-finger domain of VIN3 res

240 However, the DNA-binding specificity of the regulatory factors that orche

241 Of these processes, the binding specificity of the TCR is a key component.

242 It has been recently proposed that the binding specificity of the yeast mitochondrial ADP/ATP c

243 Analysis of the binding specificity of their bromodomains suggests that

244 Uncovering the mechanisms that affect the binding specificity of transcription factors (TFs) is cr

245 n cis-regulatory elements or by altering the binding specificity of transcription factors (TFs).

246 networks are reconfigured by changes in the binding specificity of transcription factors and their c

247 e specific gene expression by modulating the binding specificity of transcription factors to chromati

248 Finally, we show that the DNA-binding specificity of ZFP809 is evolutionarily conserve

249 Combining cleavage rates and binding specificities on the same target libraries, we b

250 To evaluate the impact of RT-aptamer binding specificity on replication, we engineered provir

251 eering proteins for thermodynamic stability, binding specificity, or enzymatic activity in a 'single

252 ed; however, questions still arise regarding binding specificity outside the core GGA recognition seq

253 oped an algorithm, SelexGLM, that quantifies binding specificity over a large (31-bp) binding site by

254 ge, which allows on-the-fly visualization of binding specificity over a wide range of affinity intera

255 chine learning revealed that the accuracy of binding specificity predictions improves by adding shape

256 Likewise, models of its DNA binding specificity remain error prone due to a lack of

257 e 3Q fibril structure, but the origin of the binding specificity remained obscure.

258 et transcripts, but precisely defining their binding specificity remains challenging.

259 he influence of the chromatin context on HOX binding specificity remains elusive.

260 e of the resulting corona phases demonstrate binding specificity remarkably similar to that of phosph

261 imilar features, they exhibit distinct lipid-binding specificities signifying their various biologica

262 complex induced transient Ab responses with binding specificity similar to the CD4bs-directed bNAbs.

263 tro assays to systematically measure the DNA-binding specificity (Spec-seq), catalytic activity speci

264 the structural determinants of the shift in binding specificity suggests that qualitative rather tha

265 The binding specificity suggests that the most likely Grb2-S

266 ly of transcription factors with similar DNA binding specificities that control animal differentiatio

267 interaction permits fine tuning of CBC:HapX binding specificities that could support adaptation of p

268 how the partnering of RBPs evokes changes in binding specificity that underlie regulatory network dyn

269 RRM domains act in concert to determine RNA-binding specificity: the PUM-HD dictates binding to UAAU

270 Because Hox proteins have notoriously low binding specificity, they are believed to bind with cofa

271 n to providing new insights into viral Bcl-2 binding specificity, this study will inform future work

272 We show that human CENP-N confers binding specificity through interactions with the L1 loo

273 ining AMPARs, regardless of receptor subunit binding specificity, through increased internalization a

274 lready characterized, increasing coverage of binding specificities to 292 C. elegans TFs ( approximat

275 and a control case to assess the 18F-AV-1451 binding specificity to Alzheimer's and non-Alzheimer's t

276 conformational space, causing this dual DNA-binding specificity to be selectively enhanced in the GR

277 All three antibody formats showed high binding specificity to CoV-2 RBD and the spike antigens

278 Like Stau1, PKR displayed binding specificity to domain IIId of HCV-IRES.

279 f the IgG subclasses without altering target binding specificity to generate R-mAbs useful in simulta

280 rticoid receptor (GR), which has similar DNA-binding specificity to the androgen receptor (AR).

281 , a single amino acid polymorphism-underpins binding specificity to the substrate PexRD54 by shaping

282 HTB1M displayed high binding specificity toward SOD1 mutants, inhibited their

283 QBiC-Pred uses regression models of TF binding specificity trained on high-throughput in vitro

284 ed here is the development of an altered DNA-binding specificity variant of Rap1 (Rap1(AS)).

285 samples had antibodies with multiple epitope binding specificities, viz.

286 Binding specificity was assayed in CD-1 and sEH knock-ou

287 EMI-137 binding specificity was assessed by fluorescence microsc

288 Binding specificity was demonstrated using a non-binding

289 on live rat insulinoma INS-1E cells, and the binding specificity was validated by a CRISPR/Cas9 media

290 ls have been used successfully to predict TF binding specificities, we found that including DNA shape

291 A-binding proteins with different degrees of binding specificity, we found that highly specific DNA-b

292 To investigate EBNA3 binding specificity, we identified sequences and transcr

293 t determined the receptors' response element-binding specificity were far from the proteins' DNA-bind

294 ture: a variable Fab domain mediates antigen-binding specificity, whereas the constant Fc domain enga

295 form to systematically elucidate MUC1-lectin binding specificities, which in the long term may provid

296 G12V directly affects binding specificity while leaving the energy landscape l

297 l method, named mCross, to jointly model RBP binding specificity while precisely registering the cros

298 ng RNAs reveals that each display degenerate binding specificity, while still displaying different de

299 s from apoE4 with respect to different lipid-binding specificities, why lipid increases the binding o

300 this system that allows rapid modulation of binding specificity within a high affinity background.