ライフサイエンスコーパス: bioanalytical

1 is study in general satisfy the more relaxed bioanalytical acceptance criteria for modern drug discov

2 at can be covalently modified for a range of bioanalytical and acoustophoretic sorting applications.

3 makes HMP very attractive as a component of bioanalytical and bioenergetic devices.

4 Similar bioanalytical and biological results from actual assay s

5 gen lasers are an attractive combination for bioanalytical and biomedical applications.

6 of new functional materials for a number of bioanalytical and biosensor technologies for medical dia

7 trodes represents a promising methodology in bioanalytical and chemical sensing.

8 walker technology is a compelling option for bioanalytical and drug delivery applications.

9 indicates great promise for a wide range of bioanalytical and environmental applications.

10 The use of aldehyde-based materials in bioanalytical and medical settings calls for reliable me

11 les described here cover a broad spectrum of bioanalytical and pharmaceutical applications including

12 o control biomolecular transport systems for bioanalytical and sensing applications, as well as for t

13 Also discussed are the potential bioanalytical and therapeutic applications of mismatch-b

14 on of DNA oligonucleotides onto surfaces for bioanalytical and top-down bio-inspired nanobiofabricati

15 ewater-derived micropollutants via chemical, bioanalytical, and modeling methods in environmental com

16 MS/MS) plays a crucial role in life science, bioanalytical, and pharmaceutical research.

17 The bioanalytical application of the method is demonstrated

18 inexpensive, portable, and accurate tool for bioanalytical applications in laboratory and clinical se

19 vidin for biotin has made it useful for many bioanalytical applications involving the immobilization

20 were used in this report to demonstrate the bioanalytical applications of ambient ion landing.

21 ntensity with CPL activity should enable new bioanalytical applications of macromolecules in chiral e

22 ely young field that explores biomedical and bioanalytical applications of organometallic complexes,

23 Two bioanalytical applications of this micropatterned surfac

24 Finally, we demonstrated potential bioanalytical applications of this SNA-based stochastic

25 ofluidics (DMF) is a technology suitable for bioanalytical applications requiring miniaturized, autom

26 Ps) as background-free luminescent labels in bioanalytical applications strongly depends on the prepa

27 that it is an advantageous configuration for bioanalytical applications such as therapeutic drug moni

28 An example is in bioanalytical applications where microsensing at live pr

29 Bioanalytical applications, however, require a subsequen

30 it an advantageous configuration for several bioanalytical applications, including doping in sports,

31 how it can be tailored to different types of bioanalytical applications, including sample concentrati

32 employing GFP or its mutants in a number of bioanalytical applications, such as clinical analysis an

33 propriate for pesticide residue analysis and bioanalytical applications, was demonstrated.

34 OC diagnostics, immunoassays and diversified bioanalytical applications.

35 , making it beneficial for environmental and bioanalytical applications.

36 ing IM-MS a powerful approach for a range of bioanalytical applications.

37 d protein complexes commonly used in several bioanalytical applications.

38 agging of biomolecules for a wide variety of bioanalytical applications.

39 ns is important to many emerging medical and bioanalytical applications.

40 g (SERS) responses in immunoassays and other bioanalytical applications.

41 nanoliter volume solutions for microfluidic bioanalytical applications.

42 integrated fluorescence detection system for bioanalytical applications.

43 standards, probes, and templates in various bioanalytical applications.

44 le, and provides the requisite stability for bioanalytical applications.

45 t years found a wide range of analytical and bioanalytical applications.

46 of affordable electrodes for a wide range of bioanalytical applications.

47 ioconjugated systems, biosensing and related bioanalytical applications.

48 us offers significant utility in a myriad of bioanalytical applications.

49 A bioanalytical approach was used to identify chemical con

50 hat adversely affects wildlife, we applied a bioanalytical approach.

51 re the ultimate limits of the performance of bioanalytical approaches based on the detection of indiv

52 We highlight analytical and bioanalytical approaches to isolating, characterizing, a

53 he hard drive industry can be applied to the bioanalytical arena where submicrometer to 100 mum separ

54 t of protocols to move GMR concepts into the bioanalytical arena.

55 step in assuring the quality of an LC-MS/MS bioanalytical assay and the integrity of bioanalysis con

56 ough the method development of a uHPLC-MS/MS bioanalytical assay for the quantitation of ketoconazole

57 d sensitive affinity recognition elements in bioanalytical assay formats, thereby opening up the fiel

58 tography-tandem mass spectrometry (LC-MS/MS) bioanalytical assay of dapagliflozin in human plasma.

59 We describe a simple bioanalytical assay platform consisting of a large array

60 d internal standard (SIL-IS) for an LC-MS/MS bioanalytical assay.

61 reated a new method to amplify the signal of bioanalytical assays based on the autocatalytic activati

62 tools, immunogenicity assessments, and other bioanalytical assays can be used to better understand pr

63 l characteristics of MEDI3726, an array of 4 bioanalytical assays detecting 6 different surrogate ana

64 ing whether this approach can lead to robust bioanalytical assays for proteins.

65 In conclusion, a series of bioanalytical assays should be performed to standardize

66 Versatile bioanalytical assays to detect chemically stabilized ham

67 5 assay could be used for the development of bioanalytical assays to provide preclinical and clinical

68 rapid method development of high-throughput bioanalytical assays using ultra high-performance liquid

69 The bioanalytical assays were validated to quantitate both t

70 opment, but necessitates extremely sensitive bioanalytical assays, typically in the pg/mL concentrati

71 undamental importance in many diagnostic and bioanalytical assays, yet current detection techniques t

72 l be a valuable tool for the design of novel bioanalytical assays.

73 lized to reduce the reaction time in various bioanalytical assays.

74 e biomimetic tools for nanobiotechnology and bioanalytical assays.

75 sulting protein chips for the development of bioanalytical assays.

76 cured an important position for their use in bioanalytical assays.

77 t methods used in sample preparation for the bioanalytical assessment of disinfected drinking water r

78 Bioanalytical assessments of anti-drug antibodies (ADAs)

79 cluding drug development, clinical analysis, bioanalytical assessments, food safety, and environmenta

80 ys are hence compatible with a wide range of bioanalytical, biophysical, and cell biological studies

81 ICM realize an important tool in analytical, bioanalytical, biophysical, and materials measurements,

82 s harnessed to create unprecedented wearable bioanalytical capabilities at both the sensor level (dec

83 Besides protein complexity, the greatest bioanalytical challenge facing comprehensive analysis of

84 ce, the system was applied to a contemporary bioanalytical challenge, specifically the analysis of in

85 ass spectrometric analysis is a considerable bioanalytical challenge.

86 ptimization is to improve its analytical and bioanalytical characterization by assessing three main A

87 Herein, we present bioanalytical characterization of the PK and catabolism

88 significant challenges for the comprehensive bioanalytical characterization of their pharmacokinetics

89 ocess that requires extensive analytical and bioanalytical characterization to ensure high and consis

90 quency and dissipation monitoring for use in bioanalytical characterization.

91 l on the four fundamental challenges for the bioanalytical chemist working in living tissue samples a

92 al tissue often presents a challenge for the bioanalytical chemist.

93 enecks in the acoustofluidic applications in bioanalytical chemistry are presented.

94 lation platform represents a new approach in bioanalytical chemistry based on active transport of pro

95 d practicality of nanobody-based reagents in bioanalytical chemistry is demonstrated.

96 Tissues are an exciting frontier for bioanalytical chemistry, one in which spatial distributi

97 applications including materials science and bioanalytical chemistry, where a continuous flow of hype

98 can find many applications in analytical and bioanalytical chemistry.

99 sue engineering, cell implant protection and bioanalytical chemistry.

100 al for many methods in molecular biology and bioanalytical chemistry.

101 he fusion of acoustics and microfluidics) to bioanalytical chemistry.

102 QDs have found their niche in the bioanalytical community due to their remarkable brightne

103 In response to the needs of the bioanalytical community, here we report the creation of

104 Our studies revealed key bioanalytical conditions to guide future chemical proteo

105 This strategy significantly improves bioanalytical data quality and saves time, costs, and re

106 gest promise for these devices in label-free bioanalytical detection systems.

107 g carboxylic functional films for label-free bioanalytical detection techniques.

108 -ray crystallography and revises the earlier bioanalytical determinations.

109 s substantial improvements as a substrate in bioanalytical devices and is likely to find widespread u

110 TRAP has application in lab-on-a-chip bioanalytical devices as well as in the fabrication of p

111 nces in the application of AuNPs as label in bioanalytical devices, especially electrochemical immuno

112 nd cooling in electronic, optoelectronic and bioanalytical devices, where cooling is currently achiev

113 d, sensitive, reproducible, and miniaturized bioanalytical devices, which exploit the high binding av

114 -8 properties limit its application in these bioanalytical devices.

115 f protein molecules in integrated, nanoscale bioanalytical devices.

116 rokinetic systems applicable to microfluidic bioanalytical devices.

117 ther lipid rich species and a wider range of bioanalytical end points.

118 sents the first reporting of a comprehensive bioanalytical GLP methodology detailing the mass spectro

119 antitative Western blotting is a long-sought bioanalytical goal in the life sciences.

120 s validated in accordance with international bioanalytical guidelines over the clinically relevant ra

121 A quantitative bioanalytical high-pressure liquid chromatography-tandem

122 A quantitative bioanalytical HPLC-MS/MS assay requiring small blood vol

123 Bioanalytical imaging techniques have been employed to i

124 y display exquisite sensitivities, but their bioanalytical implementation is limited due to the need

125 ed and near-native states, while MS provides bioanalytical information for proteins and protein compl

126 natomical evaluation is a powerful source of bioanalytical information which reveals the chemical cha

127 sease have increased the demand for portable bioanalytical instrumentation and point-of-care.

128 In most bioanalytical laboratories, high-resolution mass spectro

129 struments that are increasingly available to bioanalytical laboratories.

130 s with least-squares regression algorithm in bioanalytical LC-MS/MS assays is reported.

131 ways be used as the weighting factor for all bioanalytical LC-MS/MS assays.

132 New high-resolution bioanalytical mass spectrometers are now not only offeri

133 ration methods and established protocols for bioanalytical mass spectrometry, a high-throughput, smal

134 Quantitative bioanalytical measurements are commonly performed in a k

135 ctrometric determination in applications for bioanalytical measurements for these important compounds

136 e of these particles, making them useful for bioanalytical measurements, is also demonstrated.

137 ce architectures with potential relevance to bioanalytical, medical, or "BioMEMS" applications.

138 A bioanalytical method based on nanoflow liquid chromatogr

139 Despite the need for a sensitive and rapid bioanalytical method for accurate quantification of PPIX

140 pectrometry (TOF-SIMS) is a well-established bioanalytical method for directly imaging the chemical d

141 he origins of the discipline and is a staple bioanalytical method for efforts ranging from research t

142 hroughput selected reaction monitoring LC-MS bioanalytical method for the determination of idoxifene,

143 The aim of this study was to validate a bioanalytical method for the quantification of the chlor

144 The applied bioanalytical method is based on the determination of p-

145 wing work describes a combined enzymatic and bioanalytical method that permits absolute quantitation

146 e within the generally accepted criteria for bioanalytical method validation (<15%).

147 for idoxifene and tamoxifen satisfy current bioanalytical method validation criteria on two separate

148 the U.S. Food and Drug Administration (FDA) Bioanalytical Method Validation Guidance for Industry to

149 osed method was fully validated according to bioanalytical method validation guidelines.

150 ctrometry (LC-MS/MS) methods, an alternative bioanalytical method was developed by combining oligonuc

151 y, a highly selective and sensitive LC-MS/MS bioanalytical method was developed for the simultaneous

152 Therefore, a reliable bioanalytical method which can differentiate recovery lo

153 The complete bioanalytical method, based on the automated LLE and fas

154 generally adopted acceptance criteria for a bioanalytical method.

155 the feasibility and utility of the proposed bioanalytical method.

156 h, primarily owing to limitations in current bioanalytical methodologies.

157 Our bioanalytical methods and the Decision Tree are applied

158 Our bioanalytical methods are based upon a mass spectrometry

159 Bioanalytical methods based on automated solid-phase ext

160 ering the complex structure of ADCs, various bioanalytical methods by liquid chromatography coupled w

161 ng technology that could replace many of the bioanalytical methods currently used in drug discovery,

162 ighly desirable, development of ADA-tolerant bioanalytical methods enabling unbiased measurement of b

163 Bioanalytical methods have been developed to solve this

164 ed to address the limitations of the current bioanalytical methods in terms of sensitivity, throughpu

165 rands is fundamental to nearly all molecular bioanalytical methods ranging from polymerase chain reac

166 nance spectroscopy (and, in principle, other bioanalytical methods that use derivatized SAMs on gold,

167 ctionalization, particles are widely used in bioanalytical methods to capture molecular targets.

168 nzyme conjugate is commonly employed in many bioanalytical methods to increase assay sensitivity.

169 rapeutic antibody are sensitive and specific bioanalytical methods to measure levels of therapeutic a

170 it is increasingly important to have robust bioanalytical methods to measure the pharmacokinetics (P

171 the most critical issues associated with the bioanalytical methods used for dried blood spot (DBS) sa

172 dicines Agency in Guideline on Validation of Bioanalytical Methods was performed.

173 accuracy and precision with common limits in bioanalytical methods, and applicability to a natural li

174 and elimination of the matrix effect in the bioanalytical methods, but the experimental procedures n

175 n data usually provided for the conventional bioanalytical methods, need to be conducted to confirm H

176 Despite recent advances in ADC bioanalytical methods, the DAR-sensitive quantification

177 Using both radiolabeling and sensitive bioanalytical methods, we demonstrate that the formyl mo

178 genetic engineering techniques coupled with bioanalytical methods, we have employed site-directed mu

179 n each microchannel, achieved via optical or bioanalytical methods, yields quantitative data on the s

180 5% set in the criteria for the acceptance of bioanalytical methods.

181 Single-cell bioanalytical microanalysis has also become increasingly

182 applied to capture and transport analytes in bioanalytical microdevices.

183 the detectability of single fluorophores for bioanalytical monitoring.

184 ensional electrophoresis is demonstrated for bioanalytical objectives where replicate experiments are

185 anoparticle tags thus show great promise for bioanalytical or product-tracking/identification/protect

186 nds within the body, represents an important bioanalytical parameter.

187 best-scoring reference control based on the bioanalytical parameters of linearity, accuracy, and sel

188 a case study, we investigate and compare the bioanalytical performance of flow-through surface plasmo

189 The bioanalytical performance of these photonic crystals was

190 e advanced multiplexed sensing with enhanced bioanalytical performance.

191 routine clinical analysis and now provides a bioanalytical platform for the development of similar as

192 Here, we present a bioanalytical platform for the quantification of positio

193 the goal to develop a simple, rapid, and new bioanalytical platform of HLM useful for drug metabolism

194 chemical interface, delivering an integrated bioanalytical platform.

195 Microfluidic bioanalytical platforms are driving discoveries from syn

196 nt is central to the realization of wearable bioanalytical platforms that are poised to autonomously

197 materials offers new working perspectives as bioanalytical platforms.

198 of palladium(II) reagents in biochemical and bioanalytical practice.

199 on, such as the type of transducer platform, bioanalytical principles (affinity or kinetic), and bior

200 of their function are difficult for any one bioanalytical probe to measure.

201 roscopy, in a wide variety of analytical and bioanalytical problems.

202 t time and cost savings and greatly simplify bioanalytical procedures compared to current manual prac

203 This novel approach simplifies current bioanalytical procedures providing time and cost savings

204 rein originally introduce different reliable bioanalytical procedures using filter paper as well as n

205 Each water type had a characteristic bioanalytical profile with particular groups of toxicity

206 alf-life; therefore, (198)Au can be used for bioanalytical purposes.

207 High-throughput bioanalytical quantitation using pcSFC-MS/MS for pharmac

208 lly too low to be practical as diagnostic or bioanalytical reagents.

209 eriophage particles with aptamers for use as bioanalytical reporters, and demonstrate the use of thes

210 es based on gas-phase HDX more applicable in bioanalytical research.

211 f the significant challenges in contemporary bioanalytical research.

212 tions in the biomedical field, especially in bioanalytical research.

213 practice is sometimes inadequate to confirm bioanalytical results that are unexpected.

214 evaluated, and proposed solutions to control bioanalytical risks from nonuniform matrix ion suppressi

215 ution of study samples are critical steps in bioanalytical sample processing for quantitative liquid

216 od spots (DBS) as a widely used quantitative bioanalytical sampling technique for regulatory studies.

217 join these photonic crystals with dedicated bioanalytical scanners based on compact disk drives.

218 d present risk level-based 'fit-for-purpose' bioanalytical schemes for the investigations of treatmen

219 analyses and hence for wider applications in bioanalytical science.

220 Abundant opportunities exist for the bioanalytical sciences to help extend this revolutionary

221 ore, they represent the first application of bioanalytical SCMS to the study of mammalian-infectious

222 tu biological/enzymatic assays is a powerful bioanalytical screening tool for the nontargeted detecti

223 Fc using biophysical (DSC, CD, and NMR) and bioanalytical (SEC and RP-HPLC-MS) methods.

224 anopores has found widespread application in bioanalytical sensing as a result of the inherent signal

225 ophysics and the production of surface-based bioanalytical sensor platforms.

226 tegies and challenges for the development of bioanalytical sensors with sub-picomolar detection limit

227 also important embodiments of many types of bioanalytical sensors, pointing to an intriguing opportu

228 g a practical add-on unit in a wide range of bioanalytical setups, in particular as a first-dimension

229 d the resulting lipid distributions serve as bioanalytical signatures to reveal cell- or tissue-speci

230 f SFC for separation and purification in the bioanalytical space, especially at the preparative scale

231 steine and PTH-S-carbamidomethyl cysteine as bioanalytical standards for cysteine detection and quant

232 A typical bioanalytical strategy for ADCs involves quantification

233 Thus, the bioanalytical strategy for ADCs must be designed to addr

234 Collectively, this study provides a bioanalytical strategy to validate the AR-interactome an

235 ated LLE techniques allowing high-throughput bioanalytical studies on small-volume samples using dire

236 ion of multiple datasets can greatly enhance bioanalytical studies, for example, by increasing power

237 standardized analytical approach to provide bioanalytical support for both preclinical and clinical

238 This assay can be widely used for bioanalytical support of future clinical studies for the

239 ing on measurements conditions the developed bioanalytical system allows determination of beta-galact

240 This new fluorogenic bioanalytical system is based on the GSH-mediated stabil

241 Given that the bioanalytical system is capable of processing promoter,

242 The developed bioanalytical system was applied for evaluation of optim

243 This bioanalytical system, furthermore, sophisticates in arra

244 el approach to extending the linear range of bioanalytical systems and biosensors by utilizing two en

245 reagent generation and to develop integrated bioanalytical systems for clinical diagnostics.

246 However, the need emerges for alternative bioanalytical systems that combine their favorable featu

247 important in the development of miniaturized bioanalytical systems with enzymes, since it can provide

248 high-throughput organic synthesis products, bioanalytical target analysis for preclinical and clinic

249 linked glycans is among the most challenging bioanalytical tasks because of their complexity and vari

250 r these systems, which enable a range of new bioanalytical tasks with different samples and models in

251 ometry (MALDI-IMS) is an emerging label-free bioanalytical technique capturing the spatial distributi

252 l-free, spatially resolved, and multipurpose bioanalytical technique for direct analysis of biologica

253 ry by time-of-flight detection [CyTOF]) is a bioanalytical technique that enables the identification

254 Mass cytometry (MC) is a bioanalytical technique that uses metal-tagged antibodie

255 continues to gain strength as an influential bioanalytical technique, showing intriguing potential in

256 salts on bacterial membrane was assessed by bioanalytical techniques including assays in model membr

257 Nevertheless, the integration of label-free bioanalytical techniques like mass spectrometry is still

258 There is a strong demand for bioanalytical techniques to rapidly detect protease acti

259 Conventional bioanalytical techniques used to characterize glutamate

260 ging versus those that could be utilized for bioanalytical techniques.

261 flow cytometry, and Western blot are common bioanalytical techniques.

262 Various bioanalytical technologies are employed in flexible elec

263 A plethora of bioanalytical technologies exist to determine such chara

264 s and opens new avenues for developing novel bioanalytical technologies for protein analysis.

265 sonance (NMR) spectroscopy is an established bioanalytical technology for metabolic profiling of biof

266 try are considered as an efficient nontarget bioanalytical tool for fast evaluation of complex sample

267 tiple glycobiomarkers or as a rapid low-cost bioanalytical tool for glycoproteome analyses.

268 Effect-directed detection as bioanalytical tool for risk assessment showed coumarin t

269 that this approach could become an important bioanalytical tool to investigate the effect of treatmen

270 s (CE) has become increasingly valuable as a bioanalytical tool to quantify analytes from single cell

271 etry imaging (MSI) has emerged as a powerful bioanalytical tool to visualize PL distributions, inferr

272 elucidation techniques is a straightforward bioanalytical tool, especially if microbiological assays

273 ens the door to greater utility of SIMS as a bioanalytical tool, such as lipid mapping of single cell

274 de surface has been shown to be an effective bioanalytical tool.

275 ls when the micropallet arrays are used as a bioanalytical tool.

276 ple acoustic based mass sensor to a powerful bioanalytical tool.

277 HRMS expands the bioanalytical toolbox of cell and developmental biology,

278 Consequently, bioanalytical tools can be applied complementary to chem

279 Conventional bioanalytical tools cannot efficiently examine ASV and P

280 n made in the development and application of bioanalytical tools for single cell metabolomics based o

281 crofluidic technologies are rapidly emerging bioanalytical tools that can miniaturize and revolutioni

282 highly sensitive, selective, and inexpensive bioanalytical tools that can provide alternative methodo

283 this study demonstrates the applicability of bioanalytical tools to investigate DBP formation in a dr

284 To alleviate these problems, new bioanalytical tools to investigate influenza antigenicit

285 recently developed RCA-based diagnostics and bioanalytical tools, and summarize the use of RCA to con

286 rea in Australia was assessed using in vitro bioanalytical tools, as well as through quantification o

287 ribed forms the basis for a diverse suite of bioanalytical tools, including DNA/RNA blotting and mult

288 door to new applications for these important bioanalytical tools.

289 rticles is very important for affinity-based bioanalytical tools.

290 tform for integrating SPR sensors with other bioanalytical tools.

291 compatibility of cascaded FF-IEF with common bioanalytical tools.

292 st in the development of inorganic drugs and bioanalytical tools.

293 the discrete dispensing of biosamples into a bioanalytical unit.

294 For bioanalytical use, accurate quantitation of water conten

295 e of the hemaPEN devices, using an extensive bioanalytical validation and application on authentic pa

296 L using 20 muL of plasma and met the regular bioanalytical validation requirements, both in the absen

297 linearity, accuracy, and precision data for bioanalytical validations with and without the inclusion

298 Bioanalytical verification requires both plasma generati

299 toring biochip, and iv) the development of a bioanalytical Wien-bridge oscillator for the fused measu

300 A bioanalytical workflow involving streptavidin chromatogr