ライフサイエンスコーパス: bioavailability

1 inase-1 inhibition (indirectly increasing NO bioavailability).

2 lymer chosen for its ability to improve oral bioavailability.

3 with no toxicities, and good compliance and bioavailability.

4 compound variants with enhanced efficacy and bioavailability.

5 ional compounds, which compromise nutrients' bioavailability.

6 th the highest possibility of achieving oral bioavailability.

7 (SCD), due in part to low nitric oxide (NO) bioavailability.

8 e in part to reductions in nitric oxide (NO) bioavailability.

9 , in turn, shedding light on ways to improve bioavailability.

10 r Se oxidation state and form, impacting its bioavailability.

11 eS were measured as a surrogate for systemic bioavailability.

12 asurement resulted in a 1.9-fold increase in bioavailability.

13 der distribution, higher concentrations, and bioavailability.

14 activating' nuts results in greater nutrient bioavailability.

15 o, because high soil acidity promotes indium bioavailability.

16 n frequently used extractions to estimate Zn bioavailability.

17 sion, endothelial dysfunction and reduced NO bioavailability.

18 cell permeability, and in certain cases oral bioavailability.

19 omes can form G4s in vivo that regulate heme bioavailability.

20 ances binding to alum and prolongs immunogen bioavailability.

21 al food, improving resveratrol stability and bioavailability.

22 nd improve their solubility, dispersion, and bioavailability.

23 derstanding of determinants of house dust Pb bioavailability.

24 bility towards enzymatic degradation and low bioavailability.

25 e and potential strategy to improve the oral bioavailability.

26 al properties of soil-borne Pb can reduce Pb bioavailability.

27 ibitors are limited by their potency or oral bioavailability.

28 est with in vivo solubility and consequently bioavailability.

29 or further research on acylated anthocyanins bioavailability.

30 gastrointestinal tract, leading to poor oral bioavailability.

31 nd the impact they might have on milk folate bioavailability.

32 would not explain the difference in leucine bioavailability.

33 derivatives contribute to increase the iron bioavailability.

34 of achieving both modulator selectivity and bioavailability.

35 vasoreactivity, due to reduced nitric oxide bioavailability.

36 nce of iron speciation on taxa-specific iron bioavailability.

37 tially underappreciated ligands affecting Hg bioavailability.

38 olubility, photosensitivity, reactivity, and bioavailability.

39 yoghurt fermentation had 33% total potential bioavailability.

40 coatings dictate their fate, transport, and bioavailability.

41 n purposes with the aim to provide high iron bioavailability.

42 cellular insulin-like growth factor 1 (IGF1) bioavailability.

43 r controlling phosphorus mobility, fate, and bioavailability.

44 peutic indices, route of administration, and bioavailability.

45 ion in urothelium, suggesting increased 5-HT bioavailability.

46 h measurements of vascular nitric oxide (NO) bioavailability.

47 ine (reuptake inhibitor) increases serotonin bioavailability.

48 tial to encapsulate polyphenols for improved bioavailability.

49 of monogastric animals to improve phosphate bioavailability.

50 rature suggest soaking nuts enhances mineral bioavailability.

51 ibiotic treated animals suggesting decreased bioavailability.

52 enteral replenishment of vitamin B-12 on the bioavailability.

53 igestion, its bioaccessibility and potential bioavailability.

54 to several advantages including greater oral bioavailability.

55 nockdown or antagonism of PAI-1 increases NO bioavailability.

56 xaliplatin-mediated toxicity while improving bioavailability.

57 s to evaluate a possible improvement in oral bioavailability.

58 ly hampered by their low and highly variable bioavailabilities.

59 n in drug delivery for molecules with modest bioavailability(1).

60 FCC showed the highest bioavailability, 5.68 +/- 0.26%, compared to CC, CCT and

61 Conclusion: (18)F-FDG has excellent bioavailability after oral administration, but peak orga

62 Indeed, we showed that increasing serotonin bioavailability alters gene expression of serotonin rece

63 used to produce breads with a higher mineral bioavailability, an important strategy for food industry

64 ability to fit exogenous inputs to specific bioavailability and affinity.

65 Their colorant properties, bioavailability and antioxidant activity, made anthocyan

66 t in part to reductions in nitric oxide (NO) bioavailability and associated vascular dysfunction.

67 -R), secreted by the liver, regulates leptin bioavailability and bioactivity.

68 of small-molecule fluorophore owing to their bioavailability and brightness, variants excited with fa

69 and in this study the cause of variation in bioavailability and content of a vital bioactive phytoch

70 nts in vivo, along with enhancement in their bioavailability and controlled release at the target sit

71 They can also enhance biomolecules bioavailability and controlled release, at the same time

72 he surface of iron minerals may change their bioavailability and determine which minerals will be red

73 ase (AD) but its inherent instability limits bioavailability and effectiveness.

74 Bioavailability and efficacy of selected hits were asses

75 Furthermore, bioavailability and efficacy were verified ex vivo in th

76 displaying higher metabolic stability, good bioavailability and enhanced receptor affinity and selec

77 ies of phytochemicals, despite their limited bioavailability and extremely varied chemical structures

78 In mice, the bioavailability and half-life of IL-2 in vivo can be inc

79 nd astrocytes in the regulation of monoamine bioavailability and homeostatic sleep.

80 t juice (BRJ), has been shown to increase NO bioavailability and improve cardiovascular function in b

81 d nanoemulsions, which may enhance vitamin D bioavailability and improve vitamin deficiency status in

82 t induce in vitro resistance, and shows oral bioavailability and in vivo efficacy.

83 Fentanyl is an anesthetic with a high bioavailability and is the leading cause of drug overdos

84 muM in L6 myoblast cells and excellent oral bioavailability and liver exposure in mice.

85 ad tafenoquine polymer also showed excellent bioavailability and liver-to-blood ratios exceeding the

86 ent pharmacokinetics (PK) profile (high oral bioavailability and low clearance) in multiple preclinic

87 n is compounded by confusion regarding their bioavailability and metabolism, partially because of the

88 lular transforming growth factor beta (TGFB) bioavailability and microfibril integrity.

89 owever, its high hydrophobicity leads to low bioavailability and must be overcome if lutein is to be

90 taining such a salt bridge reached high oral bioavailability and oral exposure.

91 with the extracellular matrix control their bioavailability and spatiotemporal cellular signalling.

92 tive stress, which reduces nitric oxide (NO) bioavailability and stimulates changes in the extracellu

93 ve pharmacological TRPC6 inhibitor with oral bioavailability and suitable pharmacokinetics to amelior

94 d, secondly, through promotion of phosphorus bioavailability and sustainable fertilizer use.

95 ctive hydrophobic molecules to enhance their bioavailability and target affinity.

96 cologically targeted by decreasing glutamate bioavailability and the GLS-dependent glutamine to gluta

97 hanges (e.g., sulfidation) that alter silver bioavailability and toxicity.

98 sm after oral administration results in poor bioavailability and undetectable in vivo pharmacokinetic

99 ils is considered the driver behind chemical bioavailability and, ultimately, toxic effects in benthi

100 cophores while retaining solubility and oral bioavailability, and achieving circulating free plasma l

101 A), a related Fe chelator and enhancer of Fe bioavailability, and increased NA/DMA biosynthesis has p

102 al cell layer, leading to low absorption and bioavailability, and safety concerns owing to tight junc

103 in human polymorphonuclear leukocytes, oral bioavailability, and target engagement in vivo and demon

104 es the encapsulation of fatty acids, in vivo bioavailability, and the use of nanovesicles in behavior

105 xidation states being key to its speciation, bioavailability, and toxicity.

106 ationic liposomes where it retains very good bioavailability, apparently low speciation and enhanced

107 thesized that IGF1 and IGF2 levels, or their bioavailability, are reduced during type 1 diabetes deve

108 tinamide, +33%; P=6.1x10(-67)), nitric oxide bioavailability (arginine/ornithine + citrulline, +29%;

109 omes to bind heme and disrupts cellular heme bioavailability as measured by a genetically encoded flu

110 ived at with no toxicity and acceptable oral bioavailability as potential sweetener candidates.

111 organisms adapt and navigate at the brink of bioavailability at low concentrations.

112 rs from challenges that include reduced drug bioavailability at the desired site of action.

113 , and the factors that affect nanoparticles' bioavailabilities beyond size-dependent effects.

114 (PK) parameters, including substantial oral bioavailability, brain penetration, and significant inhi

115 esired FXIa inhibitory potency and good oral bioavailability but high in vivo clearance.

116 vided immobilization of BMP-2 with prolonged bioavailability, but also enhanced the attachment and pr

117 Seed phytic acid reduces mineral bioavailability by chelating minerals.

118 ntial of Cu isotopes in bivalves to infer Cu bioavailability changes related to anthropogenic inputs

119 and their enzymatic products can affect the bioavailability, clinical efficacy and toxicity of a wid

120 CGC/CGT and TTT/TTT had 35% higher apparent bioavailability compared to the reference group CGC/CGC,

121 Drug bioavailability decreased by 27% with HIV infection, dec

122 Nicotine bioavailability did not differ between nicotine benzoate

123 red in how we accounted for sorption-related bioavailability differences in soil and activated sludge

124 We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglo

125 having shown previously differences in iron bioavailability during cell culture and animal model fee

126 ar Abeta42 that correlated with decreased NO bioavailability, endothelial dysfunction, and increased

127 ential therapeutic strategy to upregulate NO bioavailability, enhance angiogenesis, and improve wound

128 Rather, bioavailability entails more subtle interactions at part

129 s such as poor protein stability and limited bioavailability, especially for large proteins (molecula

130 However, OE potential bioavailability, evaluated by tangential filtration, was

131 ents-including increase of the relative oral bioavailability F(rel) from 3 to >=100%-led to a highly

132 rmacokinetic properties, including good oral bioavailability for most compounds.

133 n glycopeptide transit in humans, antibiotic bioavailability for target inhibition, in situ generatio

134 inhibitor cedazuridine increases decitabine bioavailability for the treatment of myelodysplastic syn

135 s need to focus on increasing the carotenoid bioavailability from the food matrix.

136 For the first time the mineral bioavailability from the gluten and gluten-free flakes w

137 antages, in some cases it provides increased bioavailability generated by the vegetal cell disruption

138 single double prodrug with very modest oral bioavailability has reached human therapy as a marketed

139 h loading of the active ingredient, (ii) its bioavailability improvement, and (iii) reduced drug syst

140 gonfly larvae are effective indicators of Hg bioavailability in aquatic food webs.

141 im of demonstrating liposomal encapsulation, bioavailability in cultured neuroblastoma cells, and eff

142 Oral bioavailability in dogs indicated that C18-based analogu

143 We thus compared carotene bioavailability in mice after gavage with carotene-rich

144 luding improved Caco-2 permeability and oral bioavailability in mice, and exhibits antiproliferative

145 th favorable pharmacokinetics and 70.8% oral bioavailability in mice.

146 n's patient microbiotas and increases l-dopa bioavailability in mice.

147 ced the viability of TNBC cells and had oral bioavailability in mice.

148 mpound demonstrates significant efficacy and bioavailability in ovarian and colon cancer xenograft mo

149 importance for predicting Zn speciation and bioavailability in soils, especially for low-Zn soils.

150 immunogenic for T lymphocytes, and increased bioavailability in tear fluids.

151 amate P1 linker which provided improved oral bioavailability in the imidazole-based 13-membered macro

152 contributes to drug deposition and ultimate bioavailability in the lung.

153 The % bioavailability in the unfortified parboiled rice was ne

154 s an important role in Fe cycling and Fe(II) bioavailability in the upper ocean.

155 ep quality, redox balance, nitric oxide (NO) bioavailability, inflammation profile, and asymmetric di

156 Oral omadacycline bioavailability is 34.5%; similar exposures are obtained

157 Together, these results indicate that copper bioavailability is a KRAS-selective vulnerability that c

158 rate that targeting glutaminolytic glutamate bioavailability is an effective therapeutic strategy for

159 Vitamin B-12 bioavailability is dose dependent and at a low dose that

160 rom milk decreases with increasing dose, its bioavailability is high.

161 ce of esterification on bioaccessibility and bioavailability is not well established.

162 nding decrease in vascular nitric oxide (NO) bioavailability, is associated with impaired cerebrovasc

163 peutic use is often limited by stability and bioavailability issues.

164 which can cause variability due to changing bioavailability, it can be used for quantitative longitu

165 s focusing on potency, selectivity, and oral bioavailability led to the discovery of the potent, high

166 rict biodegradation of organic contaminants, bioavailability limitations are challenging to observe d

167 ycles in the networks benefits them improved bioavailability, making them serve as reagents for bacte

168 nefits, but questions remain regarding their bioavailability, molecular targets, and mechanism of act

169 and delivery strategies that ensure durable bioavailability need to be developed to translate this c

170 Specifically, we discussed (i) the high bioavailabilities of nanoparticles due to increased spec

171 e oral insulin formulation shows a high oral bioavailability of >40%, offers the possibility to fine

172 r weight > 50 kDa), which exhibit an average bioavailability of 1% to 5% when delivered via the pulmo

173 les obtained in this work showed an improved bioavailability of 151% for vitamin B(12) and 109% for v

174 200 mug/kg) of EL-CSG showed a relative oral bioavailability of 19.5%, compared with subcutaneous adm

175 inhibits HA synthesis and that the effective bioavailability of 4-MU is higher than previously though

176 um, thereby greatly increasing the effective bioavailability of 4-MU.

177 PS was glucuronidated, leading to a systemic bioavailability of 57.4%.

178 The aim of this study was to measure the bioavailability of [13C]-cyanocobalamin in humans and to

179 o prolong the residence time, absorption and bioavailability of a broad spectrum of active compounds

180 ffect on the solubility and consequently the bioavailability of a drug.

181 The bioaccessibility and bioavailability of a functionalized Calcium (Ca) salt as

182 B permeability has been shown to enhance the bioavailability of administered intravenous therapeutics

183 ng, the aim of this study was to compare the bioavailability of amino acids, in particular the leucin

184 nd anti-inflammatory effects, as well as the bioavailability of bioactive compounds of edible members

185 (53%), thus accounting for the low systemic bioavailability of BPA (0.50%).

186 In order to study the bioavailability of calcium and vitamin D(3), the W/O/W d

187 ed soil is a key driver for mobilization and bioavailability of contaminants under nonflooded irrigat

188 linity curcumin nanoparticles to enhance the bioavailability of curcumin.

189 PyCs may reduce bioavailability of dietary toxic metals such as cadmium.

190 Tanichthys albonubes was used to assess the bioavailability of divalent mercury (Hg(II)) complexed i

191 bolic activity of biofilms may be limited by bioavailability of DOM in WWTP effluent; and leaf-litter

192 her improves the nasal absorption as well as bioavailability of drugs in the brain.

193 This results in low bioavailability of drugs to the infection site, as well

194 e as it affects pharmacokinetic behavior and bioavailability of drugs.

195 and S species, affecting the solubility and bioavailability of each other.

196 ning the similar bioaccessibility but higher bioavailability of FCC compared to CCT, tri-CP and CC.

197 o control bread consumption, indicating good bioavailability of flavonols.

198 storage, washing and cooking stability, and bioavailability of fortified rice.

199 vity by acting as gatekeepers that limit the bioavailability of GLP-1.

200 chondrial respiration but also decreased the bioavailability of glucose by increasing its uptake.

201 Postulated mechanisms include reduced bioavailability of intestinal cholesterol and alteration

202 values represented a remarkable increase in bioavailability of intranasal insulin, causing a signifi

203 nd warrant further investigations to enhance bioavailability of intrathecally administered ASOs.FUNDI

204 study investigated the bioaccessibility and bioavailability of iron from some plant products.

205 The bioavailability of iron from vegetables is low and varia

206 Such findings suggest that the bioavailability of iron may have an influence on the pro

207 In this Review, we describe how the bioavailability of lactate differs in the microenvironme

208 Furthermore, the bioavailability of LPV was also substantially increased

209 Results demonstrate increased bioavailability of lutein from LNCs with no toxicity sug

210 amental changes in biodistribution and brain bioavailability of macrophage-based formulations upon di

211 own to limit both brain penetration and oral bioavailability of many chemotherapy drugs.

212 rapeutic intervention aimed at resetting the bioavailability of metabolites and correcting the dysreg

213 The low bioavailability of nitric oxide (NO) and its precursor,

214 Decreased bioavailability of NO in the arterial vessel wall facili

215 Higher bioavailability of nutrients from small watersheds sugge

216 decade offers great promise in improving the bioavailability of oral insulin.

217 onic poly(carboxybetaine) (pCB) polymer, the bioavailability of organophosphate hydrolase (OPH) was s

218 resulted in a 11.3-fold increase in the oral bioavailability of oxytocin in pigs in the absence of ce

219 The bioavailability of persistent organic pollutants can be

220 , a characterization of the gastrointestinal bioavailability of PFSP anthocyanins was assayed and com

221 obiota composition significantly affects the bioavailability of phenolic acids that drive the dietary

222 Bioavailability of phenolics, flavonoids and FRAP activi

223 hat contributes to determine bioactivity and bioavailability of plant natural products, including tha

224 In clean gut systems, the bioavailability of plastic-associated PCBs for lugworms

225 ed at triggering apoptosis or increasing the bioavailability of platinum.

226 ng of emulsion-based delivery vehicle on the bioavailability of polyunsaturated fatty acids rich fish

227 rphous solid dispersions increasing the oral bioavailability of poorly soluble drugs.

228 ic of formulations that may enhance the oral bioavailability of poorly soluble drugs.

229 thocyanins was assayed and compared with the bioavailability of Red Wine anthocyanins.

230 on in sediments, and accordingly reduces the bioavailability of seawater P.

231 gands of SHBG maybe designed to modulate the bioavailability of sex steroids.

232 etalloregulators-that are tuned to sense the bioavailability of specific metals in the cell in order

233 t as an additional phase that can reduce the bioavailability of the chemicals and the apparent sensit

234 The oral bioavailability of the encapsulated molecules and the se

235 The bioavailability of the formulated fish oil and its inhib

236 e zone, coinciding with the lowest potential bioavailability of the leached OM.

237 n mice is limited by the poor solubility and bioavailability of the NanoLuc substrate furimazine.

238 and organ-distribution, the AUC and relative bioavailability of the three drugs in rat plasma was als

239 dietary polyphenols greatly depend upon the bioavailability of their phenolic metabolites derivative

240 Although, the bioavailability of these anthocyanins remains unknown.

241 Nevertheless, low ocular bioavailability of topically applied drug molecules can

242 flecting the fact that the reported absolute bioavailability of trastuzumab (in the absence of rHuPH2

243 The measurement of bioavailability of vitamin B-12 is etiologically importa

244 monstrated a significantly higher (P < 0.05) bioavailability of Zn chelated by SR4 followed by LGG i.

245 tal antioxidant capacity while increasing NO bioavailability, offsetting constrictor hyper-reactivity

246 have been developed in order to improve drug bioavailability on the ocular surfaces.

247 atient compliance, adverse side effects, low bioavailability, or undesirable pharmacokinetics.

248 turated with oxygen (P50), nitric oxide (NO) bioavailability, oxidative stress, and antioxidant capac

249 ds, concentrations, stoichiometry (N:P), and bioavailability (percentage dissolved inorganic nutrient

250 . cerevisiae AYI7 had the best effect on the bioavailability phenolic compounds as resulted by the LC

251 are anyway challenged by its very poor oral bioavailability profile and any attempt to overcome this

252 We hypothesized that increased serotonin bioavailability promotes serotonergic signaling and modu

253 etics results have demonstrated an increased bioavailability rate by about 20-fold for total querceti

254 S) fingerprinting and in vivo mouse relative bioavailability (RBA) measurements for a subset of house

255 LJ and used a mouse assay to assess relative bioavailability (RBA) of Pb in untreated (U) and remedia

256 rye is of interest due to their known higher bioavailability relative to typical cereal grain C-glyco

257 cluded reduced oxidative stress, enhanced NO bioavailability, restored antioxidant defenses and norma

258 ential and good safety profile, but the poor bioavailability restricts its application as a functiona

259 mization to improve BD2 selectivity and oral bioavailability resulted in the clinical development com

260 ampered by very low and highly variable oral bioavailabilities resulting from their poor absorption,

261 ulses of compounds that affect micronutrient bioavailability should be further explored.

262 n BDNF Met carriers due to insufficient BDNF bioavailability, specifically during a peri-adolescent t

263 iver substantial micronutrient content, high bioavailability, stability during storage, and retention

264 olves drug discovery studies (addressing the bioavailability, stability, tumour penetration, toxicity

265 demonstrate proteolytic stability and better bioavailability than corresponding peptides while in man

266 rotonation) e-liquid yielded higher nicotine bioavailability than unprotonated nicotine (18 mg/mL) e-

267 stein) for further examination of their oral bioavailability through molecular properties, drug liken

268 in part, on the chemical form of Hg and its bioavailability to anaerobic microorganisms that can met

269 We show that shape affects microplastic bioavailability to different species of zooplankton, wit

270 es in soil content and factors affecting its bioavailability to plants.

271 ary nitrate administration would increase NO bioavailability to reduce systolic blood pressure (SBP),

272 d to design leads that have either high oral bioavailability to treat systemic infections or low inte

273 in aquatic food webs; and (3) Se inhibits Hg bioavailability to, and/or methylmercury production by,

274 f arsenic speciation, which directly affects bioavailability, toxicity and bioaccumulation.

275 @siRNA-PLGA NCs were characterized for size, bioavailability, toxicity and biocompatibility.

276 s with variable concentrations that track Cu bioavailability trends at the sampling site.

277 o the micellar fraction (and also carotenoid bioavailability) using a human Caco-2 cell model system.

278 The relative bioavailability value of the iron-casein complex to ferr

279 CE), an oil-in-water emulsion with increased bioavailability versus conventional CsA formulations.

280 However, drug bioavailability via the oral route remains poor due to t

281 e delta(65)Cu values with the increase of Cu bioavailabilities was associated with anthropogenic Cu i

282 At a low dose of 2.3 ug, the mean bioavailability was 46.2 +/- 12.8 (%, mean +/- SD, n = 1

283 At a higher dose of 18.3 ug, the mean bioavailability was 7.6 +/- 1.7 (%, mean +/- SD, n = 4).

284 f 6.1 mo; Q1-Q3, 1.8-20 mo) the mean enteral bioavailability was 72% (range, 11-91%).

285 Iron bioavailability was determined using an in vitro simulat

286 - 0.01 mg/100 g), but the highest percentage bioavailability was from baobab fruit pulp (99.7% +/- 0.

287 Results show that nicotine bioavailability was greater for Vype ePen3 with greater

288 MA bioavailability was greater than that of OA, and consump

289 n compared to trastuzumab where interstitial bioavailability was high.

290 e ability of rHuPH20 to enhance interstitial bioavailability was higher for cetuximab where intrinsic

291 r for cetuximab where intrinsic interstitial bioavailability was low, when compared to trastuzumab wh

292 pectrometry-based characterization, its oral bioavailability was measured in the fasted state with hi

293 ated to increase inhibitory potency and drug bioavailability were tested.

294 anging ocean chemistries will alter the iron bioavailability when a decrease in pH shifts elemental s

295 rice flour, might not provide adequate zinc bioavailability when the effect of calcium and phytate o

296 at achieved the objectives of oral and brain bioavailability, while maintaining high affinity binding

297 6a and 6d demonstrated impressive mouse oral bioavailability with 6a, providing effective in vivo pro

298 ed in vitro digestion showed increased rutin bioavailability with significantly higher (p < 0.05) in

299 ion of endothelial function via increased NO bioavailability, with advancing age.

300 d considerable exposure levels and good oral bioavailability, with detectable distribution to the lun