1 The first example of a
biocatalytic [
2,3]-sigmatropic rearrangement reaction in
2 The glucose probe is based on the
biocatalytic action of glucose oxidase, and the insulin
3 eening of bacterial colonies to identify new
biocatalytic activities is a widely adopted tool in biot
4 , and the potential to significantly improve
biocatalytic activity by populating only the most active
5 It enables regulation of
biocatalytic activity for tyrosine nucleophilic attack o
6 This
biocatalytic activity now addresses previously refractor
7 However, the
biocatalytic activity of anaerobic fungal cellulosomes i
8 Biocatalytic activity of the mobile enzymes is preserved
9 ling circle amplification enables comparable
biocatalytic activity to cell-based workflows in almost
10 This work provides a first example of
biocatalytic aldehyde olefination and extends the spectr
11 H W110A)) in a redox-neutral cascade for the
biocatalytic alkylation of amines using primary and seco
12 Protein endoglycosidases are useful for
biocatalytic alteration of glycans on protein surfaces,
13 g sugar-like compounds such as aminopolyols,
biocatalytic aminations using transaminase enzymes (TAms
14 for the excellent enantiocontrol observed in
biocatalytic amino acid synthesis.
15 ad increased cost and impact, in contrast to
biocatalytic and catalytic technologies.
16 Recent developments of stereoselective
biocatalytic and chemocatalytic methods are discussed.
17 Herein we describe the development of novel
biocatalytic and chemoenzymatic methods for the enantios
18 ical functionalities, having biorecognition,
biocatalytic and drug delivery capabilities are here rep
19 he values obtained were then correlated with
biocatalytic and electrochemical parameters of the prepa
20 Biocatalytic and immunoassays can be used to determine a
21 These include
biocatalytic and organic/inorganic (polymer/iron) nanoco
22 hat is designed to harness the power of both
biocatalytic and radical-based retrosynthetic logic.
23 metalloenzyme primed for future mechanistic,
biocatalytic,
and biosensing applications.
24 and CO(2) emissions across electrocatalytic,
biocatalytic,
and fossil fuel-derived production of chem
25 ases that are emerging as promising tools in
biocatalytic applications and as targets for prodrug act
26 on/reduction processes, developing practical
biocatalytic applications of oxidoreductases has long be
27 dentify or create novel enzymes for specific
biocatalytic applications.
28 facilitates the design of these enzymes for
biocatalytic applications.
29 nd protein robustness, and is attractive for
biocatalytic applications.
30 engineering of STRs and related enzymes for
biocatalytic applications.
31 the development of this class of enzymes for
biocatalytic applications.
32 Here we report the development of a
biocatalytic approach and engineered enzymes to convert
33 A
biocatalytic approach could harness the high affinity of
34 merged: chemoenzymatic glycorandomization, a
biocatalytic approach dependent upon the substrate promi
35 Here, we report the development of a
biocatalytic approach for enantioselective hydrazone red
36 Herein, we describe a general
biocatalytic approach for the enantioselective preparati
37 Finally, the
biocatalytic approach resulted in enantiopure syn-(3 R,4
38 The
biocatalytic approach to combinatorial chemistry uses en
39 Here we establish a
biocatalytic approach to stereoselective S(N)Ar chemistr
40 A potential
biocatalytic approach to the synthesis of this privilege
41 A
biocatalytic approach toward linear aliphatic nitriles b
42 Using a
biocatalytic approach, paclitaxel and a variety of taxan
43 When evaluating complementary
biocatalytic approaches based on the use of a lipase and
44 Finally,
biocatalytic approaches for accessing petroleum-based fe
45 Biocatalytic approaches have yielded efficient total syn
46 Biocatalytic approaches hold particular promise, but rel
47 Biocatalytic approaches to the synthesis of optically pu
48 A
biocatalytic assay for on-site forensic investigations w
49 The
biocatalytic assay was used to determine the age range o
50 ochemical content in the fingerprint using a
biocatalytic assay, coupled with a specially designed ex
51 Cells build fatty acids with
biocatalytic assembly lines in which a subset of enzymes
52 natural enzymes and challenging fundamental
biocatalytic assumptions.
53 nthesis of cyclopropanol derivatives via the
biocatalytic asymmetric cyclopropanation of vinyl esters
54 Artificial cells were synthesized using
biocatalytic atom transfer radical polymerization-induce
55 , comprehensive, strain-level information on
biocatalytic/
biodegradative microbes is not readily avai
56 design is general and broadly applicable to
biocatalytic,
biosensing, and tissue-engineering applica
57 te of enzymes available for highly selective
biocatalytic C-C bond formation.
58 Biocatalytic C-H activation has the potential to merge e
59 s review highlights key advances in scalable
biocatalytic C-H oxyfunctionalization reactions develope
60 sed on an inventory of the large spectrum of
biocatalytic C-O functional group chemistry, this review
61 Biocatalytic carbene transfer from diazo compounds is a
62 /or hard-to-handle carbene donor reagents in
biocatalytic carbene transfer reactions.
63 Herein we report a new type of
biocatalytic cascade by localizing two different enzymes
64 ring, biocatalyst (formulation) engineering,
biocatalytic cascade engineering and reactor engineering
65 ated operation of the GOx/HRP and LDH/NAD(+)
biocatalytic cascade in the conjugate mixture of auxilia
66 Herein, we present novel
biocatalytic cascade reactions for synthesising various
67 We report an in vitro
biocatalytic cascade synthesis of the investigational HI
68 The applicability of this tandem
biocatalytic cascade was demonstrated to produce the cor
69 Biocatalytic cascade with these amide bond-forming enzym
70 from simple building blocks in a three-step
biocatalytic cascade.
71 generating enzymes, we established versatile
biocatalytic cascades and demonstrated a general, concis
72 uided upregulation/downregulation of the two
biocatalytic cascades are demonstrated.
73 Biocatalytic cascades are uniquely powerful for the effi
74 Combining enzymatic reactions into multistep
biocatalytic cascades brings additional benefits.
75 35(1-61) fibrils as a molecular scaffold for
biocatalytic cascades consisting of reusable enzymes tha
76 Biocatalytic cascades consisting of the glucose oxidase
77 As
biocatalytic cascades get more complex, reactions become
78 ive sequential/concurrent chemoenzymatic and
biocatalytic cascades have been developed to access a br
79 Developing
biocatalytic cascades in abiological conditions is of ut
80 accessible tool for computer-aided design of
biocatalytic cascades, freely available at retrobiocat.c
81 the spatially confined GOx/HRP or LDH/NAD(+)
biocatalytic cascades.
82 ncompatibility, thus allowing for successful
biocatalytic cascades.
83 Finding new mechanistic solutions for
biocatalytic challenges is key in the evolutionary adapt
84 This coupled
biocatalytic condensation/assembly approach is thermodyn
85 ino acid reductase pair could be evolved for
biocatalytic conversion of l-amino acids to d-amino acid
86 Here we report the
biocatalytic conversion/transformation of AA to 6-ACA an
87 Biocatalytic copper centers are generally involved in th
88 transformations in organic synthesis have no
biocatalytic counterpart.
89 Here we disclose a strategy for
biocatalytic cross-coupling through oxidative C-C bond f
90 us electron transfer rate (kS) and a maximum
biocatalytic current density.
91 oanode of a microbial battery, showing rapid
biocatalytic current development (~10 times higher than
92 The
biocatalytic current was substantially impacted by the a
93 ng the growth of gold nanoparticles with the
biocatalytic cycle of the enzyme label.
94 to regenerate the cofactors needed by their
biocatalytic cycles.
95 Further, the selective
biocatalytic deacylation methodology has been utilized f
96 d catalytic mechanisms provide insights into
biocatalytic defluorination, which may inspire drug desi
97 Biocatalytic degradation of non-hydrolyzable plastics is
98 Finally, this dynamic enantioconvergent
biocatalytic desaturation was applied to the preparation
99 is of forskolin, showcasing the potential of
biocatalytic desaturations as a greener and more stereos
100 The development of
biocatalytic desulfurization of petroleum fractions may
101 biodesulfurization and the development of a
biocatalytic desulfurization process.
102 The strategy represents a new
biocatalytic disconnection, which relies on an omega-TA-
103 withstanding extraordinary architectural and
biocatalytic diversity, all PKSs are evolutionarily rela
104 ineering toolbox with previously unavailable
biocatalytic diversity.
105 pplies a library of nucleic acids coupled to
biocatalytic DNA machineries as functional modules for t
106 rase represents an operational prototype for
biocatalytic DNA synthesis at a commercial scale.
107 obscures the underlying principles governing
biocatalytic efficiency.
108 Implantation of
biocatalytic electrodes and extraction of electrical pow
109 , was able to regenerate glucose consumed by
biocatalytic electrodes, upon appropriate feeding and re
110 on of supramolecular nanostructures based on
biocatalytic formation and hydrolysis of self-assembling
111 oligase and transaminase enzymes enabled the
biocatalytic formation of (1R,2S)-metaraminol.
112 orial biosynthesis in total biosynthetic and
biocatalytic formats in Saccharomyces cerevisiae and in
113 Here, we describe a stereospecific,
biocatalytic Friedel-Crafts alkylation of the 2-position
114 s should aid in the optimization of this new
biocatalytic function.
115 ivated ketones, thus facilitating the facile
biocatalytic generation of 1,1'-disubstituted THIQs.
116 ortunity for the utilisation of Pac13 in the
biocatalytic generation of antiviral compounds.
117 plexes), chemical (pH-doped polyaniline), or
biocatalytic (
glucose oxidase/urease) triggers.
118 Halogenated l- or d-tryptophan obtained by
biocatalytic halogenation was incorporated into RGD pept
119 We present a
biocatalytic hydrogen-borrowing amination of primary and
120 her extended by combining with a dual-enzyme
biocatalytic hydrogen-borrowing cascade in one pot to al
121 In this transformation,
biocatalytic hydroxylation of a benzylic C-H bond afford
122 ry effort is the incorporation of additional
biocatalytic hydroxylations in modular analogue synthesi
123 alts as additives that result in significant
biocatalytic improvements.
124 rees C, based on melting temperature and the
biocatalytic inactivation rate at 115 degrees C.
125 Here we report a
biocatalytic,
intermolecular benzylic C-H amidation reac
126 This work introduces a first example of
biocatalytic intramolecular cyclopropanation and provide
127 ein, large-scale synthetic routes containing
biocatalytic key steps toward >130 APIs of approved drug
128 The
biocatalytic layer demonstrated to be highly reproducibl
129 Immobilized
biocatalytic lithography is presented as an application
130 eover, 1541 nanofibrils function as a unique
biocatalytic material that activates procaspase-3 via in
131 ished through the synergistic combination of
biocatalytic mechanism and photoredox catalysis.
132 ompared with those of organic synthesis, the
biocatalytic mechanism for controlling the 3R or 3S-spir
133 We start by tracing
biocatalytic mechanisms operating in metabolic enzymes a
134 acterization of ionomers and proteins within
biocatalytic membranes to aid in the development of ener
135 This reveals a simple, flexible
biocatalytic method for glycoconjugate synthesis using P
136 Here we report a
biocatalytic method for the creation of quaternary carbo
137 nd the use of combinatorial biosynthesis and
biocatalytic methodologies for new compound development.
138 These new
biocatalytic methods address issues facing alternative t
139 Although both synthetic and
biocatalytic methods are available for constructing thes
140 molecules, chiral ligands and catalysts, but
biocatalytic methods for their asymmetric synthesis are
141 mework for organic molecules, development of
biocatalytic methods for their formation has been largel
142 The review provides a guide to the use of
biocatalytic methods in the area of chemical synthesis w
143 Here we summarise
biocatalytic methods that have been applied to the produ
144 Broad-based adoption of
biocatalytic methods will require widely available datab
145 has led to a surge in the development of new
biocatalytic methods.
146 ond-forming transformations possible through
biocatalytic methods.
147 As a
biocatalytic model system, we analyzed few Corynebacteri
148 Biocatalytic N-acyl transfer of novel acyl groups to the
149 potentially provides a tool for alternative
biocatalytic N-aroylation/alkanoylation to construct nex
150 Biocatalytic nicking of the L(1)/L(1)' duplex fragments
151 Finally, a
biocatalytic nitration process was developed to nitrate
152 have previously described the development of
biocatalytic nitration processes driven by an engineered
153 present a synergistic platform enabling both
biocatalytic nucleobase diversification from 4'-thiourid
154 ents of artificial biosynthetic pathways and
biocatalytic or chemoenzymatic cascades, and therapeutic
155 An improvement of
biocatalytic oxidation current was observed by 6.2% due
156 we present the development of an asymmetric
biocatalytic oxidation of 2-arylindole substrates aided
157 An increasing number of
biocatalytic oxidation reactions rely on H(2) O(2) as a
158 Biocatalytic oxidations are an emerging technology for s
159 Biocatalytic oxidative cross-coupling reactions have the
160 Finally, the developed
biocatalytic oxidative dimerization is applied to a prep
161 Here we demonstrated a
biocatalytic pathway, termed the methanol condensation c
162 tool to be capable of identifying promising
biocatalytic pathways to target molecules, validated usi
163 the proximity effects, leading to a boost in
biocatalytic performance.
164 ith better starting sequences for increasing
biocatalytic performance.
165 VirX1 is interesting from a
biocatalytic perspective as it shows strikingly broad su
166 ach enables discovery and mass-production of
biocatalytic phages.
167 Biocatalytic phosphorylation has attracted attention fro
168 These
biocatalytic plastics, containing alpha-chymotrypsin and
169 Here, we report a
biocatalytic platform for constructing CF(3)-substituted
170 II)/aKG)-dependent enzymes offer a promising
biocatalytic platform for halogenation chemistry owing t
171 alphaKG)-dependent enzymes offer a promising
biocatalytic platform for halogenation chemistry owing t
172 by PagF, demonstrating utility as a general
biocatalytic platform for modifications on any peptide s
173 Herein, we advance a dual
biocatalytic platform for the efficient asymmetric alkyl
174 Herein, we present a green and sustainable
biocatalytic platform for the enantioselective synthesis
175 We report a
biocatalytic platform of engineered cytochrome P450 enzy
176 lectivity profiles and substrate scope, this
biocatalytic platform should be readily tunable for any
177 A
biocatalytic platform that employs the final two monomod
178 te methane monooxygenase (pMMO), we create a
biocatalytic polymer material that converts methane to m
179 rately thermophilic bacterium and holds high
biocatalytic potential as a source for several highly th
180 CglAlcOx, respectively, to explore the wider
biocatalytic potential in AA5.
181 The
biocatalytic potential of AgcA was demonstrated by the a
182 of sLac on woody biomass and highlights the
biocatalytic potential of bacterial enzymes.
183 and deploy it to systematically explore the
biocatalytic potential of refactored MIA pathways for th
184 h amide bond-forming enzymes display notable
biocatalytic potential, including scalability, stereosel
185 olism and are of great interest due to their
biocatalytic potentials.
186 ith the antibody-antigen binding reaction by
biocatalytic precipitation of 5-bromo-4-chloro-3-indolyl
187 recent volumes and reviews for more detailed
biocatalytic procedures.
188 ws the fuel to immediately separate from the
biocatalytic process after synthesis, yet does not precl
189 Here we report a concise
biocatalytic process for Molnupiravir, a nucleoside anal
190 design criteria for a commercially relevant
biocatalytic process involved in the synthesis of a chol
191 This
biocatalytic process is efficient and selective (up to 3
192 the biosynthesis of melanin pigments, a key
biocatalytic process that is regulated by compartmentali
193 Herein, we report a
biocatalytic process to access a specific diastereomer o
194 Here, we describe a
biocatalytic process to produce nonhydrolyzable NAD+ ana
195 Here, we report an efficient
biocatalytic process to replace a recently implemented r
196 emical chlorination protocol paralleling the
biocatalytic process was developed.
197 s and hence increase the productivity of the
biocatalytic process.
198 s a prerequisite for their implementation in
biocatalytic processes and in the evolution of new funct
199 the gap between fundamental understanding of
biocatalytic processes and their potential for bioenergy
200 Biocatalytic processes for the manufacture of small, hig
201 Biocatalytic processes have also been described for the
202 Biocatalytic processes have been described for the synth
203 The search for affordable, green
biocatalytic processes is a challenge for chemicals manu
204 particle wrapping, intracellular uptake and
biocatalytic processes that could have biocompatible or
205 itrant compounds, and for the development of
biocatalytic processes to produce useful compounds.
206 ed biocatalysis and in the design of related
biocatalytic processes to recycle or upcycle commodity p
207 since the 1960s and although many industrial
biocatalytic processes use the technology to improve enz
208 pective implications for the optimization of
biocatalytic processes via solvent tuning.
209 inson's disease, is also being developed for
biocatalytic processes, including vanillin production, a
210 ss the possibility of combining electro- and
biocatalytic processes, using sequential upgrading of CO
211 one oxidoreductases and their application in
biocatalytic processes.
212 es with potential application to a wealth of
biocatalytic processes.
213 o create a urea biosensor with an innovative
biocatalytic product-to-dopant relay mechanism for the d
214 -guided engineering of mouse MAT2A to enable
biocatalytic production of an extended AdoMet analogue,
215 Significant progress has been made in the
biocatalytic production of both synthetic and natural po
216 nucleophile substrate range has enabled the
biocatalytic production of diverse non-canonical amino a
217 mediated extraction" (COME), which relies on
biocatalytic production of oxygen occurring directly in
218 nverted to (-)-ibogaine by heating, enabling
biocatalytic production of these compounds.
219 g the photophysical features of PSI with the
biocatalytic properties of hSOX for advanced light-contr
220 lays a thermostabilizing role and influences
biocatalytic properties, suggesting that beta subunit co
221 The development of
biocatalytic protocols will be facilitated by the increa
222 compile relevant information on enzymes for
biocatalytic purposes.
223 The inclusion of a
biocatalytic racemization along with the PAM-catalyzed r
224 , a shear-stress induced permeabilisation of
biocatalytic reaction compartments, is transferred to po
225 We then optimized the FGE
biocatalytic reaction conditions for conversion of cyste
226 lysts are discussed, including how 'green' a
biocatalytic reaction may be, and trends in biocatalyst
227 A simple model involving the
biocatalytic reaction network coupled with burst nucleat
228 t the structure of and flux distributions in
biocatalytic reaction networks.
229 the depletion of silver ions induced by the
biocatalytic reaction of the alkaline-phosphatase enzyme
230 s transportation to promote efficient tandem
biocatalytic reaction.
231 ymes has thus furnished a previously unknown
biocatalytic reaction.
232 strategies, but is challenging to achieve in
biocatalytic reactions given enzymes' innate preferences
233 the polymersomes on demand, and to activate
biocatalytic reactions in the interior of the polymersom
234 chip" protocol integrating on-line precolumn
biocatalytic reactions of multiple (oxidase and dehydrog
235 in 1995 to provide information on microbial
biocatalytic reactions of, and biodegradation pathways f
236 zyme catalyzes the rate-limiting step of two
biocatalytic reactions producing Neu5Ac in industry.
237 ng enzymes and the invention of entirely new
biocatalytic reactions that were previously unknown in N
238 lly general activation mode to advance novel
biocatalytic reactions with synthetic utility.
239 , nature has developed complexity-generating
biocatalytic reactions within natural product pathways.
240 ectiveness and, hence, the sustainability of
biocatalytic reactions.
241 l devices include targeted drug delivery and
biocatalytic reactors.
242 Biocatalytic recycling is gaining momentum, with enginee
243 (Saccharomyces cerevisiae) are a convenient
biocatalytic reducing agent for a wide variety of carbon
244 A
biocatalytic reduction of 2 H-1,4-benzoxazines using imi
245 e-mediated enzyme-linked assay involving the
biocatalytic reduction of H2O2 was investigated.
246 enzymes and developing a more comprehensive
biocatalytic repertoire.
247 Applying these rules for automated
biocatalytic retrosynthesis, we show our tool to be capa
248 Biocatalytic retrosynthetic analysis of dibenz[c,e]azepi
249 Here, we report a versatile
biocatalytic route to access chiral 2,3-dihydroxy-1,4-di
250 Herein, we describe a single-step
biocatalytic route to high-value, complex indolizidine,
251 ctases was studied with the aim to provide a
biocatalytic route to precursors for GABA analogues, suc
252 reactions provide a convenient and effective
biocatalytic route to the stereoselective synthesis of k
253 Here, we present a
biocatalytic route towards MEGAs and analogues using a t
254 If
biocatalytic routes for lignin breakdown could be develo
255 e electrocatalytic properties of MWCNTs, the
biocatalytic specificity of GOx, and the permselective p
256 Developing a
biocatalytic step involves identifying an initial enzyme
257 Their biosynthesis incorporates many unusual
biocatalytic steps, including regio- and stereo-specific
258 Using IvoA, we demonstrate a
biocatalytic stereoinversion/deracemization route to acc
259 k extends the toolbox of currently available
biocatalytic strategies for the asymmetric formation of
260 Biocatalytic strategies for the synthesis of chiral amin
261 These
biocatalytic strategies outperform currently available m
262 Additionally, by discussing
biocatalytic strategies towards potential anti-viral age
263 Here, we report the development of a
biocatalytic strategy for the stereoselective constructi
264 Herein a
biocatalytic strategy for the stereoselective synthesis
265 A
biocatalytic strategy is reported here for the highly di
266 n structural type using a recently developed
biocatalytic strategy, which involves laminarinase enzym
267 ngineering strategies currently employed for
biocatalytic sugar upgrading to "green" chemicals and fu
268 mes on MPS have been described, their use as
biocatalytic supports is limited.
269 s that assemble these NPs for application in
biocatalytic syntheses.
270 m biological sensing to the industrial-scale
biocatalytic synthesis of chiral products.
271 Finally, the
biocatalytic synthesis of methyl dihydrosterculate 1 and
272 econstruction (ASR) to resurrect enzymes for
biocatalytic synthesis.
273 further expands the reactivity repertoire of
biocatalytic,
synthetically useful asymmetric transforma
274 Here we report a pure
biocatalytic system by successfully repurposing an ene-r
275 nfluence on the performance of inorganic and
biocatalytic systems alike.
276 eneral approach for metabolic engineering of
biocatalytic systems comprising the uses of a chemostat
277 With this concept, enzymatic, photo-
biocatalytic systems for solar energy conversion can be
278 e core along with syntheses applying various
biocatalytic techniques have also been reviewed.
279 sents a departure from existing light-driven
biocatalytic techniques, which are typically explored in
280 In its current undeveloped state, the
biocatalytic technology was approximately 1 order of mag
281 Therefore, it represents a valuable new
biocatalytic tool.
282 treptomyces maritimus, thereby expanding the
biocatalytic toolbox and enabling the production of the
283 This work expands the
biocatalytic toolbox for asymmetric C-C bond transformat
284 ent one of the most important enzymes of the
biocatalytic toolbox for chiral amine synthesis as they
285 ymes studied here may represent valuable new
biocatalytic tools for investigating the structures of r
286 The application of these
biocatalytic tools in organic synthesis, however, remain
287 enzymes and provides potential TE domains as
biocatalytic tools to diversify HRPKS structures.
288 oach was utilized to monitor stereoselective
biocatalytic transamination and assign the absolute conf
289 ort a highly diastereo- and enantioselective
biocatalytic transamination method to prepare a broad ra
290 The
biocatalytic transfer of an acyl group to the tertiary h
291 Biocatalytic transformation has attracted increasing att
292 In the absence of
biocatalytic transformation, such structural control wou
293 The investigation of stereoselective
biocatalytic transformations at a single-cell level is t
294 Biocatalytic transformations in living organisms, such a
295 Exploring the scope of
biocatalytic transformations in the absence of enzyme st
296 The
biocatalytic transformations used by chemists are often
297 l for photoenzymatic catalysis to enable new
biocatalytic transformations via previously unknown elec
298 ore natural sequence diversity for desirable
biocatalytic transformations.
299 enzymes could create opportunities for their
biocatalytic use in preparing complex synthetic scaffold
300 The
biocatalytic versatility of wildtype and engineered carb