ライフサイエンスコーパス: biochemical

1 ytochemical sulforaphane affects many of the biochemical abnormalities associated with ASD.

2 Although biochemical abnormalities in common causes of CKD-minera

3 f RNAs that contain a multitude of folds and biochemical activities.

4 ped-flow assays revealed that differences in biochemical activity map to individual modular domains o

5 unlike E. coli where multiple enzymes have a biochemical activity that can generate alanine, the prim

6 rs that reprogram protein output to activate biochemical adaptations.

7 del with unique physical, physiological, and biochemical advantages-by incorporating behavioral data,

8 dietary AM did not change the levels of most biochemical (ALB, AMY, TP and GLOB), antioxidants (SOD,

9 Biochemical analyses determine that these two enzymes ca

10 Genetic and biochemical analyses reveal that the PBL13 receptor-like

11 slinking immunoprecipitation (HITS-CLIP) and biochemical analyses revealed direct binding between end

12 combines in silico, molecular genetics, and biochemical analyses to characterize both the structure

13 Finally, we use a combination of biochemical analyses, mutagenesis, and molecular simulat

14 Based on structural, mutational, and biochemical analyses, the cofactor channel and the subst

15 Using biochemical analyses, we further document a direct inter

16 Using complexome profiling and biochemical analyses, we have explored the structural re

17 ther Na(+)-dependent, which was validated by biochemical analyses.

18 mponents in ETI was confirmed by genetic and biochemical analyses.

19 MS and biochemical analysis demonstrated that TMC6 and TMC8 add

20 ation in clinical settings for point-of-care biochemical analysis is discussed.

21 Here we provide results from a biochemical analysis of the purified Escherichia coli Ye

22 Histology, haematology and biochemical analysis of urine and plasma confirmed no to

23 This biochemical analysis revealed that the DNA-binding activ

24 istration was assessed via histochemical and biochemical analysis using markers of myelin, astrocytes

25 To enable biochemical analysis, protein extraction from FFPE tissu

26 nal trait values (physiological, structural, biochemical, anatomical, phenological, and disturbance-r

27 ates of CO(2) assimilation, (ii) on how leaf biochemical and anatomical factors influence g(m) , (iii

28 ions of 10 Rho-GAP and experimentally tested biochemical and biological consequences for cancer-assoc

29 Combined biochemical and biomechanical degradation is found near

30 Biochemical and biomechanical resistance were significan

31 e data reinforce that mitochondria have both biochemical and biomechanical roles in skeletal muscle a

32 are a widely used experimental platform for biochemical and biophysical analysis of isolated mammali

33 s of cancer are designed to recapitulate the biochemical and biophysical characteristics of the tumou

34 We show through biochemical and biophysical characterization that this c

35 Using biochemical and biophysical methods we identify multiple

36 HD substrates and properties, we carried out biochemical and biophysical studies on PHD homologues fr

37 Biochemical and biophysical studies show that charge-cha

38 two proteins and carried out a comprehensive biochemical and biophysical study of their interaction,

39 und to be potent inhibitors of the enzyme in biochemical and cell-based assays.

40 (50) values in the lower micromolar range in biochemical and cellular assays.

41 gned, fabricated and characterized the first biochemical and cellular microgravity responsive device

42 18), including baseline demographics, donor, biochemical and clinical data at LT, immunosuppression (

43 A cohort study was performed, examining the biochemical and clinical toxicity after PRRT when using

44 Here, we use MD simulations, biochemical and electrophysiological measurements to ide

45 Our biochemical and functional analyses of this vertebrate-s

46 s of the KARS mutation was carried out using biochemical and functional approaches, cell transfection

47 Biochemical and functional details of the Myo1c-14-3-3be

48 y and evaluate the efficacy and stability of biochemical and functional reconstitution in the progeny

49 Using a combination of biochemical and functional studies, we find that human b

50 Biochemical and genetic analyses of the paralogs within

51 Here we demonstrate, by both biochemical and genomic analyses, that MeCP2 directly in

52 Using an integrative omics, biochemical and imaging approach, we dissected the molec

53 Biochemical and imaging experiments support these findin

54 Here, using an array of biochemical and imaging techniques, including a highly r

55 Using biochemical and mass spectrometry approaches, we showed

56 Using comparative biochemical and physiological analyses, we found that mi

57 r-encoded, plastid-targeted proteins for all biochemical and regulatory functions.

58 Combining biochemical and single molecule fluorescence approaches,

59 Using biochemical and single-molecule Forster resonance energy

60 The action mechanisms revealed by the biochemical and structural analyses of replicative and t

61 ts the location of the protein as we show in biochemical and structural analyses.

62 Here we report biochemical and structural characterization of TnmH from

63 amples are of sufficient quality for further biochemical and structural characterization, as well as

64 recent advances in our understanding of the biochemical and structural consequences of DNMT3A mutati

65 f APE2, APE1, and TDP1 deficiency coupled to biochemical and structural dissection of APE2.

66 lathrin assembly on the plasma membrane, and biochemical and structural studies have revealed the nat

67 recent years, many have sought to expand our biochemical and structural understanding of the clock pr

68 ducted morphological test and physiological, biochemical and transcriptional analyses to reveal the d

69 wever, single-layered helical oligomers with biochemical and ultrastructural similarity to those foun

70 tically reduced FANCD2 monoubiquitination in biochemical and/or cell-based assays tended to show earl

71 ys a full court press of genetics, genomics, biochemical, and advanced analytical techniques to disse

72 Recent structural, biochemical, and biologic work has shown that binding of

73 We report structural, biochemical, and chemical evidence that benzoxazole bios

74 We therefore used molecular, biochemical, and electrophysiological approaches to exam

75 hemical-genetic screens and cell biological, biochemical, and structural assays to determine that rig

76 s, neurotransmitters, as-yet-uncharacterized biochemicals, and derivatives of neuromodulatory drugs a

77 Using biochemical approaches and cryo-electron microscopy, we

78 helial neoplasia (PanIN), along with several biochemical approaches and immunofluorescence microscopy

79 Using an array of biochemical approaches, including immunoblotting, kinase

80 In this work, using genetic and biochemical approaches, we identified the initial scaffo

81 Biochemical assays and structural remodeling demonstrate

82 Here, using purified proteins and several biochemical assays and surface plasmon resonance, we rep

83 Biochemical assays confirmed that PNP disrupts the GCV s

84 Biochemical assays demonstrated that acetylation of Pif1

85 ount of biological knowledge grows, targeted biochemical assays enabling high-throughput screening ha

86 downregulated PI3K, which were confirmed by biochemical assays in mammalian adipocytes.

87 However, analyses of HK phosphorylation in biochemical assays in vitro suggest negative cooperativi

88 Quantitative biochemical assays reveal that RALF4 binds LLGs and LRX

89 Biochemical assays revealed PG activity of recombinant P

90 In-vitro biochemical assays show that albopeptide originates from

91 is still heavily dependent upon conventional biochemical assays that retain the challenges of being t

92 es virus-derived, immunostimulatory dsRNA in biochemical assays to eliminate the danger signal and in

93 We also performed biochemical assays to monitor template DNA translocation

94 pplying ancestral protein reconstruction and biochemical assays to the evolution of steroid hormone r

95 tigen (PSA) that is detected by conventional biochemical assays which require expensive reagents, is

96 single-quantum coherence spectra, kinetics, biochemical assays, and MS analyses, we show that the co

97 re, by performing chemical genetic analyses, biochemical assays, structural modeling, and molecular d

98 show using patients' primary fibroblasts and biochemical assays, that these mutations either impair U

99 Here, through the use of in vitro biochemical assays, we demonstrate that the amide backbo

100 Using CRISPR-generated mouse models and biochemical assays, we demonstrate the pathogenicity of

101 circadian rhythm in U2OS cells, and various biochemical assays, we tested these compounds experiment

102 ade virus-derived immunostimulatory dsRNA in biochemical assays.

103 pounds actually show activity when tested in biochemical assays.

104 y of most other Ctf19c factors, disobeys the biochemical assembly hierarchy when observed in dividing

105 o understand the genetic, physiological, and biochemical bases of salt-tolerance mechanisms.

106 Here, we identify a genetic and biochemical basis for activation of glucosinolates to is

107 ity of PRL2 to down-regulate PTEN provides a biochemical basis for its oncogenic propensity.

108 consensus binding sequence, both in in vitro biochemical binding assays and in vivo studies of differ

109 Here, we compared the biochemical, biophysical, and cell biological properties

110 Moreover, the data highlight biochemical, biophysical, and functional properties of E

111 Characterizations by biochemical, biophysical, and reverse genetics approache

112 However, exact biochemical boundaries between these different metabolit

113 n-trap mass spectrometry in combination with biochemical, cellular, and computational approaches, we

114 Using an array of biochemical, cellular, and computational techniques, we

115 Previous studies documented multiple biochemical changes in recipient cells shortly after mtD

116 sistant and infectious form perpetuating the biochemical characteristics of Delta(Spont) prion.

117 Herein we report the biochemical characterization and crystal structures of t

118 This structural and biochemical characterization helps to rationalize the pr

119 optimized chemical synthesis and preliminary biochemical characterization of a new oligonucleotide an

120 rray-mediated primer-exchange-reaction-based biochemical circuit cascade, which probes a specific bio

121 This upstream biochemical circuit is further wired with a downstream e

122 llenges associated with building timers from biochemical components.

123 mones, fecundity, sperm and egg quality, egg biochemical composition and fads2 expression were studie

124 well-established technique for assessing the biochemical composition of intact tissue samples.

125 The effect of UVB dose on the growth and biochemical composition of the cells (vitamin D(3), PUFA

126 the distinct histopathological morphologies, biochemical composition, and affected cell types seen ac

127 nd to and adapt to their changing tissue and biochemical contexts.

128 elative rates of vesicle budding, fusion and biochemical conversion.

129 to affect the kinetics and thermodynamics of biochemical conversions because CO(2) is an intermediate

130 sslinks are in close agreement with previous biochemical data on DNA binding and mostly fit known com

131 Our structural and biochemical data showed that the BAH domain protein AIPP

132 In addition, genetic and biochemical data suggest that the examined domain suppor

133 thesis in Legionella pneumophila and provide biochemical data to extend knowledge of the Thi5 enzyme,

134 structures in the context of functional and biochemical data, we attempt to summarize new insights i

135 These structures-together with biochemical data-indicate that the monoubiquitinated ID

136 he computational analysis of high-throughput biochemical data.

137 hile all patients share the primary gene and biochemical defect, there is considerable patient-patien

138 TFs) and genome-wide targets typically elude biochemical detection.

139 although relating this to physiological and biochemical differences has only been performed on small

140 o mammalian SAR1 paralogs lead to pronounced biochemical differences that significantly affect COPII

141 ordinated effort to quantify the genetic and biochemical diversity of this species.

142 using purified components reveals additional biochemical diversity, including both narrow and broad r

143 se correspondences with experimentally-known biochemical domains.

144 ents and provides powerful means to quantify biochemical dynamics in living cells.

145 s to evaluate the structural, functional and biochemical effects of eliminating one allele of Rom1 (R

146 We demonstrate the biophysical and biochemical effects of preconditioning human MSCs (hMSCs

147 s require several weeks before reaching full biochemical efficacy and remission is not achieved in ma

148 ular, physiologic, genetic, immunologic, and biochemical events at microscopic to macroscopic levels,

149 Here we report the biochemical evidence for the ability of photosystems to

150 old Aip+/- mice demonstrated phenotypic and biochemical evidence of GH excess including significantl

151 Genetic and biochemical evidence points to an association between mi

152 Here, we provide biochemical evidence that the GGDEF-EAL domain protein R

153 on suspicion derived from clinical history, biochemical exams and eventually on histological examina

154 The network exhibits hallmarks of biochemical excitability: the annihilation of oppositely

155 Our biochemical experiments also showed that deletion of the

156 Biochemical experiments indicated that cytoplasmic Cx43

157 Biochemical experiments provide evidence that NaTrxh spe

158 Biochemical experiments with model nucleosomes demonstra

159 Biochemical experiments with synaptosomes from Slc38a1 k

160 Current clinical devices based on biochemical extraction and microfluidic solutions typica

161 ividuals with 'typical' AD may have distinct biochemical features of tau.

162 capitulate the several of the phenotypic and biochemical features of the human disorder, including oc

163 Microtubule cytoskeleton exists in various biochemical forms in different cells due to tubulin post

164 single CaM sufficed for Ca(2+) feedback, yet biochemical, FRET, and structural studies showed that mu

165 NA degradosome mRNA decay machinery, but the biochemical function of such organization remains poorly

166 suppressing transmembrane protein of unknown biochemical function, TMEM127, are required for SteD-dep

167 L13B (V358A) and showed it retains all known biochemical function.

168 gene families still await discovery of their biochemical functions.

169 are versatile enzymes that serve a range of biochemical functions.

170 In this review, we focus on how biochemical, genomic, and single-cell data describe the

171 No signs of toxicity on biochemical, hematological parameters.

172 solicited and serious adverse events (SAEs), biochemical/hematological parameters, cell-mediated immu

173 Using a series of molecular, biochemical, imaging, electrophysiological, and behavior

174 ynapses which facilitate exchange of crucial biochemical information and are critical for T-cell immu

175 g explored in endoscopy as a tool to extract biochemical information that may improve contrast for ea

176 Transcriptome analysis after biochemical inhibition of biosynthesis of branched-chain

177 ational model that combines polarity protein biochemical interactions with vesicle trafficking to pro

178 Presentation was commonly clinical or biochemical jaundice, n = 30 (28%) each.

179 Here, we use a general model based on biochemical kinetics to quantify the combined effects of

180 le have been investigated extensively at the biochemical level, analyzing the subcellular redox dynam

181 Our work highlights, at a biochemical level, how tumor-initiating ETS translocatio

182 quantified physiological, histological, and biochemical lung injury markers.

183 immunohistochemical, and on the left kidney biochemical (malonyl-aldehyde [MDA], glutathione, oxidat

184 y relevant differences in anthropometric and biochemical markers depending on sex and age were found.

185 an noninvasively and continuously screen for biochemical markers in body fluids for the prognosis, di

186 r machine illustrate the limits of inferring biochemical mechanism from protein structure.

187 Thus, genetic interactions can arise from biochemical mechanisms that calibrate morphogen signalin

188 Yet the physical and biochemical mechanisms that govern this spatial heteroge

189 Further, the biochemical methane potential (BMP) test was done for IO

190 several experimental findings obtained using biochemical methods, electrophysiological measurements i

191 Using biochemical methods, we demonstrate that a 5' T- or C-ri

192 iparum asexual blood stages using a suite of biochemical methods.

193 rapyrrole biogenesis represents a remarkable biochemical milestone that is summarized in this review.

194 p maintain functionality amid changes in the biochemical milieu, including those relating to energy-t

195 nephropathic cystinosis is associated with a biochemical mineral pattern distinct from that typically

196 Although biochemical models of adaptation have been previously pr

197 tified site was validated by mutagenesis and biochemical modification.

198 ed through a combination of gene expression, biochemical, morphological and functional analysis in Ri

199 which a single receptor can exhibit a binary biochemical nature.

200 toskeleton network and feedback loops in the biochemical network of activators and repressors of cyto

201 iginally developed by Savageau for analysing biochemical networks.

202 these enzymes also modulate the effect that biochemical noise and environmental fluctuations produce

203 We sought to evaluate the rate of biochemical nonadherence to adjuvant tamoxifen using ser

204 Consistent with these biochemical observations, knocking down EB1 increases F-

205 ized plasma GC levels and all behavioral and biochemical parameters analyzed.

206 n between degree of elevation in cardiac and biochemical parameters and the need for intensive care s

207 OAc for last 6 weeks, and body weight, blood biochemical parameters as well as hepatic inflammation r

208 ir correlation with baseline virological and biochemical parameters as well as interferon and nucleos

209 present study assessed the dynamics of serum biochemical parameters in a model of experimental peri-i

210 d not affect chick survival but altered some biochemical parameters posthatching.

211 alysis revealed significant reduction in key biochemical parameters reflecting decreased tissue damag

212 ) PID affects inflammatory and hepatic serum biochemical parameters, and (b) following open flap debr

213 In such cases, clinical, biochemical, pathological and functional imaging assessm

214 CRISPR interference screen that reveals the biochemical pathway for CI-M6PR-mediated cargo internali

215 tionary time scales, to elucidate changes in biochemical pathways of energy metabolism in flight musc

216 ptured human plaques, we aimed to illuminate biochemical pathways through which proteolysis causes pl

217 ergetics and metabolism and is implicated in biochemical pathways underlying angiogenesis, fertilizat

218 used" proteins are often involved in similar biochemical pathways, here we examined the putative func

219 bly inducing transient NPC-like cellular and biochemical phenotypes, constitute plausible mechanisms

220 s unravelled the complex network of genetic, biochemical, physical and metabolic interactions among t

221 vitro protein reconstitution and associated biochemical/physical studies have provided significant i

222 h in brain and liver tissues, similar to the biochemical picture in ALDH7A1-deficient patients.

223 ific for ions, nucleotides, amino acids, and biochemical potentials.

224 sential metabolite participating in cellular biochemical processes and signaling.

225 s regulate themselves via dizzyingly complex biochemical processes called signaling pathways.

226 and CoA, which are fundamental for numerous biochemical processes in every organism.

227 (pTyr), are ubiquitous and important to many biochemical processes of the cell.

228 teraction between nitrogen additions and the biochemical processes that control N(2)O emissions.

229 Compartmentalization of biochemical processes underlies all biological systems,

230 ies have provided detailed insights into the biochemical processes underpinning this unusual enzyme's

231 ul abstraction to formally represent complex biochemical processes.

232 We report on biochemical progression-free survival, freedom from non-

233 damage attributable to multiple myeloma and biochemical progression.

234 amyloid fibrils that exhibit structural and biochemical properties closely similar to those of natur

235 In this study, we explored the biochemical properties of a chloroplastic ClpB disaggreg

236 and determined if these were correlated with biochemical properties of ANG variants.

237 excellent model system for understanding the biochemical properties of DNA2-like helicase-nucleases a

238 Here, we study the biochemical properties of FtsZ from Pseudomonas aerugino

239 Several studies have investigated the biochemical properties of purified FCP complexes, but li

240 thaliana) and validated the biophysical and biochemical properties of the sensor that are critical f

241 is based on the 16S rRNA gene sequencing and biochemical properties.

242 The results of biochemical, rapid-quench, and stopped-flow assays revea

243 revalent in nature, spanning all scales from biochemical reaction networks in single cells to food we

244 nd self-assembling spatial organization with biochemical reaction systems.

245 Also, since formaldehyde is the byproduct of biochemical reactions for detecting creatinine and creat

246 ession levels of key enzymatic regulators of biochemical reactions linked to transmethylation and pol

247 To promote the biochemical reactions of life, cells can compartmentaliz

248 Mechanistic understanding of biochemical reactions requires structural and kinetic ch

249 ribution to shear stress stimuli and diverse biochemical reactions with NO.

250 oach assigns to each core an equal number of biochemical reactions without consideration of their sol

251 ar bioenergetics and is consumed by numerous biochemical reactions, making it essential for most spec

252 Biochemical reconstitution shows that Bre1 binds the sca

253 s with CSLD-CESA chimeric proteins, in vitro biochemical reconstitution, and supporting computational

254 toes for primary staging (n = 93/388, 24%), biochemical recurrence (BCR) localization (n = 225/388,

255 rate of (18)F-DCFPyL PET/CT in patients with biochemical recurrence (BCR) of prostate cancer (PC).

256 ction rate (CDR) of (18)F-rhPSMA-7 PET/CT in biochemical recurrence (BCR) of prostate cancer (PCa) af

257 nducted on 135 prostate cancer patients with biochemical recurrence and a PSA level of less than 1 ng

258 nts were scanned for primary staging, 67 for biochemical recurrence, and 23 for metastatic castration

259 hanges in fatty acids, antioxidant capacity, biochemicals related to methylation, protein glycosylati

260 mal degradation, with broad implications for biochemical research and for therapeutics.

261 Here, by combining in silico and biochemical screening strategy, we have identified a sma

262 We apply cell-free biochemical screens to assess the protospacer adjacent m

263 a logical step toward improving chemical and biochemical sensing, separations and amplification, amon

264 These results uncover the biochemical sequence of intermediates in a bacterial pat

265 anosensing, in which the interaction between biochemical signaling and cell tension facilitates adapt

266 SynGAP is a potent regulator of biochemical signaling in neurons and plays critical role

267 Many critical biological events, including biochemical signaling, membrane traffic, and cell motili

268 umbers of GluR1s and GluR2s predicted by the biochemical signalling model.

269 ls sense and convert mechanical stimuli into biochemical signals and physiological responses is still

270 inatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been d

271 etics of HIV-1 nuclear import and define the biochemical staging of these steps of infection.

272 to delve more deeply and precisely into the biochemical state of cells and its perturbations by smal

273 Biochemical, structural and integrated chromatin immunop

274 In this review, we summarize and discuss biochemical, structural, and biological functions of the

275 enesis of the LBs at the genetic, molecular, biochemical, structural, and cellular levels.

276 We performed multistep biochemical, structural, and computational experiments t

277 ibe the synthesis of this series, as well as biochemical structure-activity relationships driving sel

278 al studies explain decades of biological and biochemical studies and provides a general strategy to b

279 Biochemical studies and the co-crystal structure of CLK1

280 ls, but in a handful of cases structural and biochemical studies have revealed the mechanisms and con

281 Although biochemical studies have uncovered the mechanisms involv

282 This personal retrospective focuses on how biochemical studies of the frog egg helped identify the

283 Biochemical studies of the particular synthetic PrAMP on

284 Biochemical studies on purified rhodopsin from mice indi

285 for in vivo delivery applications. In vitro biochemical studies showed that the HpSGN system require

286 ether, our cell-based findings together with biochemical studies suggest a critical function of FANCJ

287 Biochemical studies suggested that the antimicrobial pep

288 w access to these substrates has now enabled biochemical studies that deepen our understanding of how

289 wild type and isogenic mutants together with biochemical studies with purified phospholipases, we inv

290 Here, we present a combined biophysical and biochemical study to explore the structure-dynamics-func

291 "lawn" despite being nucleated by repeating biochemical subunits.

292 t on the role of elevated pCO(2) in delicate biochemical syntrophic conversions by connecting kinetic

293 sion providing better access to cutting edge biochemical techniques, including diagnostics, by making

294 Here, using biochemical techniques, terminal deoxynucleotidyl transf

295 Biochemical, toxicological and biophysical methods enabl

296 drivers of higher decomposition rates, while biochemical transformation of plant remains was negative

297 o- and micro-nutrients) on decomposition and biochemical transformation of standard plant materials b

298 interact with their environment, undergoing biochemical transformations and moving through the soil

299 Overall, our findings underscore the biochemical versatility of RNA as a mediator molecule in

300 Both may contribute to biochemical weathering in addition to enzymatic function