ライフサイエンスコーパス: biochemical approach

1 used a combined bioinformatics, genetic and biochemical approach.

2 ing a combined immunoelectron microscopy and biochemical approach.

3 potheses that can be tested using genetic or biochemical approaches.

4 s were examined using cell physiological and biochemical approaches.

5 ice was investigated using pharmacologic and biochemical approaches.

6 a combination of genetic, physiological, and biochemical approaches.

7 was further reinforced through cellular and biochemical approaches.

8 cision that heretofore required reductionist biochemical approaches.

9 models and combining genetics, genomics, and biochemical approaches.

10 ing morphological, electrophysiological, and biochemical approaches.

11 asses are still being discovered by targeted biochemical approaches.

12 ice, in combination with pharmacological and biochemical approaches.

13 oited therapeutically using both genetic and biochemical approaches.

14 in situ proximity ligation assay (PLA), and biochemical approaches.

15 studying them challenging using traditional biochemical approaches.

16 .14.99) was studied using genetic, cell, and biochemical approaches.

17 time mobility analyses of the ter locus with biochemical approaches.

18 ogenesis using a variety of cell biology and biochemical approaches.

19 of the human PLC using both biophysical and biochemical approaches.

20 functions using a combination of genetic and biochemical approaches.

21 s for these differences using structural and biochemical approaches.

22 lectron microscopic immunohistochemistry and biochemical approaches.

23 ct analysis of specific genes by genetic and biochemical approaches.

24 ument, and envelope layers using traditional biochemical approaches.

25 hese pathways with complementary genetic and biochemical approaches.

26 EJ by a combination of molecular genetic and biochemical approaches.

27 n of physiological, structural, genomic, and biochemical approaches.

28 ing activity by using different cellular and biochemical approaches.

29 been possible with traditional fixed-cell or biochemical approaches.

30 rized in petunia through reverse genetic and biochemical approaches.

31 important biosynthetic enzymes by classical biochemical approaches.

32 as long been pursued by reverse genetics and biochemical approaches.

33 function has primarily been studied through biochemical approaches.

34 travital imaging, RNA sequence analysis, and biochemical approaches.

35 nactivation of RAP1 confirmed by 2 different biochemical approaches.

36 died using electrophysiological, optical and biochemical approaches.

37 gh-resolution microscopy combined with novel biochemical approaches.

38 cardiomyopathy (DCM) mutants were studied by biochemical approaches.

39 -43(A315T) mice using a battery of tests and biochemical approaches.

40 st a library of CTLA-4 mutants and by direct biochemical approaches.

41 F-1-H3/H4 architecture using biophysical and biochemical approaches.

42 n combination with other cell biological and biochemical approaches, a robust and streamlined strateg

43 Here, using molecular genetics and biochemical approaches, a series of hypotheses was teste

44 Despite numerous attempts, largely involving biochemical approaches, a specific interaction between P

45 A combination of bioinformatic and biochemical approaches allowed identification of phage p

46 In this study, using cell biology and biochemical approaches, along with immunoprecipitation a

47 sociation with Golgi enzymes, as detected by biochemical approaches and 3D Structured Illumination Mi

48 eir impact on the transport cycle of SERT by biochemical approaches and by electrophysiological recor

49 Here, we use a variety of biochemical approaches and compare histone-based substra

50 In this study, we establish, using biochemical approaches and complementation assays in liv

51 Using biochemical approaches and cryo-electron microscopy, we

52 Here we combine biochemical approaches and cryoelectron microscopy (cryo

53 Using biochemical approaches and electron microscopy, we show

54 helial neoplasia (PanIN), along with several biochemical approaches and immunofluorescence microscopy

55 that can overcome limitations of traditional biochemical approaches and improve the potential therape

56 Combining biochemical approaches and in vitro bioassays, we found

57 Here we show using super-resolution imaging, biochemical approaches and in vivo models that the trans

58 Using biochemical approaches and MS analysis, we show that upo

59 Using biochemical approaches and reverse transcriptase-polymer

60 Using a combination of biochemical approaches and various mutant Fis proteins,

61 Through biochemical approaches as well as Atomic Force Microscop

62 We used biochemical approaches as well as fluorescence resonance

63 Using unbiased proteomic and targeted biochemical approaches, as well as two independent metho

64 nging and laborious to map by using standard biochemical approaches because they generally require th

65 Using a combination of genetic and biochemical approaches, both in vivo and in vitro, we id

66 species and cell types by transcriptomic and biochemical approaches, but their antiviral mechanisms r

67 In some cases, biophysical and biochemical approaches can provide important complementa

68 Using several biochemical approaches combined with functional analysis

69 Using biochemical approaches combined with time-lapse microsco

70 AP complex as well as additional genetic and biochemical approaches confirmed that DksA binds to the

71 Biochemical approaches confirmed that miR-96 directly re

72 mass spectroscopic, molecular modeling, and biochemical approaches confirms that electrophile-protei

73 etwork at the CR and its function, we used a biochemical approach coupled to proteomics to identify a

74 Serendipitously, using a biochemical approach coupled with mass spectrometry, we

75 Genetic and biochemical approaches coupled with functional assays in

76 ble.Significance: Combined computational and biochemical approaches demonstrate that the BAP1-ASXL2 i

77 In this study, several biochemical approaches demonstrated that activated Galph

78 Despite biochemical approaches describing the physiological acti

79 By using electrophysiological and biochemical approaches, diverse mechanisms that dynamica

80 Several biochemical approaches exist to profile DNA methylation,

81 Expression profiling and biochemical approaches exposed the canonical E2F3a activ

82 Using a recently developed biochemical approach for detecting m(6)A, the researcher

83 Here, we review the use of different biochemical approaches for biological synthesis of circu

84 tegy that outperforms existing cell-based or biochemical approaches for identifying CRISPR-Cas9 genom

85 Herein we discuss five biochemical approaches for isolating and characterizing

86 Here, we purified EVs using straightforward biochemical approaches from multiple cancer cell lines a

87 A series of biochemical approaches further established that SycP spe

88 ith pharmacological, immunocytochemical, and biochemical approaches further suggest that, in the adul

89 Genetic or biochemical approaches have been used to generate these

90 Biochemical approaches have been used to pair pathway pr

91 ves LysM domain receptor-like kinases, while biochemical approaches have identified LECTIN NUCLEOTIDE

92 Traditional biochemical approaches have only identified the possible

93 ains unclear, crystal structure analyses and biochemical approaches have revealed critical features o

94 Past studies using biochemical approaches have revealed minor kinetic diffe

95 Traditional genetic and biochemical approaches have shed light on basic principl

96 Using a combination of genetic and biochemical approaches, here we found a conserved N-term

97 bination of functional genomics, genetic and biochemical approaches, here we show that Zbtb11 plays e

98 Using an unbiased biochemical approach, however, we have identified a nove

99 To support histological findings using a biochemical approach, human islets were used for pulse-c

100 In this study, a biochemical approach identified the SH2 domain-containin

101 is in FLVCR1-defient animals via genetic and biochemical approaches improved the anemia, implying tha

102 We utilized flow cytometry and biochemical approaches in combination with lifted whole

103 AT-6 and established the utility of rigorous biochemical approaches in dissecting the virulence of M.

104 Here, using several immunological and biochemical approaches in multiple human cell types, we

105 Here we present a novel biochemical approach, in vivo click selective 2'-hydroxy

106 Here, using various biochemical approaches including peptide sensitivity ELI

107 Using several biochemical approaches, including a novel site-specific

108 Using an array of biochemical approaches, including immunoblotting, kinase

109 Here, using an array of biochemical approaches, including immunoprecipitation an

110 istributions by a variety of biophysical and biochemical approaches, including in-tandem atomic force

111 Here, we undertook biochemical approaches, including MS and posttranslation

112 In our procedures, we used a combination of biochemical approaches, including quantitative PCR and W

113 f VP2 and VP5 and a series of biological and biochemical approaches, including site-directed mutagene

114 Using a panel of biochemical approaches, including size exclusion chromat

115 Furthermore, immunohistochemical and biochemical approaches indicate binding of lumican to be

116 Genetic and biochemical approaches indicate that, upon UV irradiatio

117 P, which was previously identified through a biochemical approach is a bona fide receptor for HBV and

118 Using a biochemical approach, it is here established that ubiqui

119 Biochemical approaches led to the identification of cycl

120 sicle proteins has been estimated using bulk biochemical approaches, no information exists on the int

121 The biochemical approach of Kutik et al. uncovered an unexpe

122 Here we undertake the biochemical approach of substituted cysteine accessibili

123 changes, suppression of MuRF1 by genetic or biochemical approaches prevented muscle fiber atrophy, w

124 Here, we combine biochemical approaches, quantitative imaging and mathema

125 Molecular genetics and biochemical approaches reveal that the processing of the

126 Biochemical approaches reveal the impact of specific sub

127 Biochemical approaches revealed a cell wall fraction con

128 However, neither immunolocalization nor biochemical approaches revealed significant accumulation

129 Genetic and biochemical approaches revealed that the initial two tra

130 Biochemical approaches show that both SH-SY5Y and SK-N-A

131 Photoactivation and biochemical approaches show that lysosomally targeted in

132 They also demonstrate that widely used biochemical approaches such as detergent-resistant membr

133 tein-protein interactions, while traditional biochemical approaches such as sub-cellular fractionatio

134 A combined genetic, cellular, and biochemical approach supports that some of the tested ba

135 ctation, we found by electron microscopy and biochemical approaches that endogenous Bcl-x(L) also loc

136 In this review, we describe the chemical and biochemical approaches that have enabled nucleic-acid ba

137 riments employing physiological, genetic and biochemical approaches that support a model in which the

138 ution offered by the traditional genetic and biochemical approaches that were used to create it.

139 using a combination of mass spectrometry and biochemical approaches, that native TRPP2 is glycosylate

140 we endeavored to dissect, using genetic and biochemical approaches, the domains of this protein that

141 Using immunofluorescence assays and biochemical approaches, the HG methylesterification stat

142 on of bioinformatic, genetic, structural and biochemical approaches, the universal protein family Yrd

143 We have also developed a biochemical approach to define candidate transcripts tha

144 Chemical genetics is a biochemical approach to develop small peptide-mimetic li

145 We took a biochemical approach to directly isolate and characteriz

146 Here, we use a combined structural and biochemical approach to explore the role of Sec71-Sec72

147 To address this situation, we employed a biochemical approach to identify and characterize a cons

148 Here, we use a biochemical approach to identify Dynamin-associated prot

149 his issue of Neuron, Jeworutzki et al. use a biochemical approach to identify GlialCAM, a protein wit

150 In a biochemical approach to identify non-histone substrates

151 Here, we have used a biochemical approach to identify Rumpelstiltskin, a Dros

152 of a combined genetic, genomic and in vitro biochemical approach to identify the evolutionary mechan

153 Here, we used an unbiased biochemical approach to identify this enzyme.

154 In this work, we used a molecular biochemical approach to investigate how the efficiency o

155 Here, we present a biochemical approach to investigate the internal subunit

156 We take an evolutionary biochemical approach to show that S100A9 evolved both fu

157 We also used a biochemical approach to test whether the intergenotypic

158 We used a combination of RNA sequencing and biochemical approaches to assess caterpillars fed honeyc

159 ployed behavioral, electrophysiological, and biochemical approaches to assess cognitive and synaptic

160 Here, we used genetic and biochemical approaches to clarify the contribution of th

161 ation of directed evolution and chemical and biochemical approaches to demonstrate that tellurite inh

162 study, we employed electrophysiological and biochemical approaches to demonstrate that Trp(136), loc

163 , electrophysiological, cell biological, and biochemical approaches to describe a novel mechanism in

164 We used genomics and biochemical approaches to determine if lambda-exo digest

165 echanism of translation control, we employed biochemical approaches to determine the regulatory featu

166 Here, we combine genetic and biochemical approaches to discern the interplay between

167 Here, we combine genomic and biochemical approaches to dissect a role of ZFP-1, the C

168 Comparative genomics complements genetic and biochemical approaches to dissect metabolism, continues

169 Therefore, we used biochemical approaches to elucidate how proteins contain

170 n and mouse genetics and cell biological and biochemical approaches to elucidate mechanisms by which

171 Here we used integrated structural and biochemical approaches to elucidate the molecular mechan

172 In this study we have combined genetic and biochemical approaches to examine the molecular mechanis

173 In this study, we used genetic and biochemical approaches to examine the PHD1-PHD2 region o

174 CRISPR/Cas9-based genetic manipulations and biochemical approaches to examine the role of YB-1 in ti

175 Here, we use a combination of genetic and biochemical approaches to examine these sites individual

176 We used crystallographic and biochemical approaches to gain insight into activating m

177 In this issue, Malhotra and colleagues use biochemical approaches to identify a new class of secret

178 hobic nature complicates the use of standard biochemical approaches to identify interacting proteins.

179 We used biochemical approaches to identify seven constituents of

180 The development of molecular and biochemical approaches to identify start sites of DNA re

181 This study implemented biochemical approaches to infer changes in ACD6 complexe

182 talytic cycle, we used multiple independent, biochemical approaches to interrogate the catalytic cycl

183 zebrafish in concert with bioinformatics and biochemical approaches to investigate CISH function.

184 Here we combine clinical specimens with biochemical approaches to investigate secretory immunogl

185 Here we used various biochemical approaches to investigate Set-beta isoforms

186 We used primary patient cells and biochemical approaches to investigate the effects of pat

187 modeling, induced fit docking, genetic, and biochemical approaches to investigate the molecular basi

188 ntify genes involved in mitosis and deployed biochemical approaches to isolate and identify proteins

189 ta are complementing traditional genetic and biochemical approaches to more fully address the complex

190 ITPs, we used structural, computational, and biochemical approaches to probe the diversities of the l

191 Here, we utilize structural and biochemical approaches to probe the DNA sculpting mechan

192 We used cytological and biochemical approaches to show that Baf200 plays an impo

193 We use combined structural, biophysical, and biochemical approaches to show that loss of a receptor-l

194 We used x-ray crystallography and biochemical approaches to show that the S1 CendR motif d

195 We combined transcriptomic and biochemical approaches to study rhizobial and plant sulf

196 e many advantages of Caenorhabditis elegans, biochemical approaches to study tissue-specific gene exp

197 We have used biochemical approaches to test structural models for how

198 e the need to apply multiple biophysical and biochemical approaches to the elucidation of the physica

199 stmortem studies, discuss the application of biochemical approaches to this substrate, and present ex

200 conjunction of structural, biophysical, and biochemical approaches to this system has brought our un

201 conjunction of structural, biophysical, and biochemical approaches to this system reveals molecular

202 analyses, and classic molecular biology and biochemical approaches to understand the mechanism by wh

203 he channel, in particular the structural and biochemical approaches to understanding channel gating.

204 review progress in the use of structural and biochemical approaches to understanding how each FANC pr

205 er the years, a common theme emerges: simple biochemical approaches to understanding molecular messen

206 Both computational and biochemical approaches underscore the relevance of exoni

207 e yeast two-hybrid assay as well as in vitro biochemical approaches using purified recombinant protei

208 A biochemical approach was developed to analyze portal fun

209 Here, a biochemical approach was used to identify host factors i

210 A combination of cellular imaging and biochemical approaches was used to refine the cellular l

211 Through structural biology and biochemical approaches we demonstrate that these copper-

212 Using biochemical approaches we identify a nucleosome interact

213 Using genetic and biochemical approaches we identify Ankyrin2 as a key pre

214 Combining genomic and biochemical approaches we show that CTCF and cohesin co-

215 Using bioinformatics and biochemical approaches we show that interaction of PTBP1

216 Using live imaging and biochemical approaches we show that TTC26/DYF13 is an IF

217 Using a biochemical approach, we aimed to assess the hepatic bio

218 Using an unbiased biochemical approach, we discovered that the transcripti

219 ecific antibody and a combined morphological/biochemical approach, we establish that Id1 is a nuclear

220 Using a biochemical approach, we establish that the Ia.2 epitope

221 Using a biochemical approach, we find that the helicase is essen

222 Using a biochemical approach, we found that the K63-specific DUB

223 Using a biochemical approach, we found that the onset of VSVG en

224 First, using a biochemical approach, we found that the total isoasparty

225 Using a comprehensive genetic and biochemical approach, we have delineated the physiologic

226 Using a biochemical approach, we have studied the role of the nu

227 Using a biochemical approach, we identified lipoproteins LprG an

228 Using a combined genetic and biochemical approach, we identified PA1343 as the PA gen

229 Using a biochemical approach, we now report that dimerization of

230 Using an activity-based biochemical approach, we recently uncovered the JmjC dom

231 Using an activity-guided biochemical approach, we report the molecular identifica

232 Using a biochemical approach, we show that all four C1ql protein

233 Using a biochemical approach, we show that the A673T substitutio

234 Using genetic and biochemical approaches, we characterized the intragenic

235 Using various biochemical approaches, we clearly demonstrate that both

236 On the basis of microscopic and biochemical approaches, we conclude that death results f

237 ing a citrate-insensitive AtALMT9 mutant and biochemical approaches, we could demonstrate that AtALMT

238 Combining genetic and biochemical approaches, we delineated the SA biosyntheti

239 Using convergent genetic and biochemical approaches, we demonstrate LRP130 complexes

240 Using a combination of imaging and biochemical approaches, we demonstrate that inside cells

241 Using combined genetic, molecular, and biochemical approaches, we demonstrate that MepS is rapi

242 Using complementary cellular and biochemical approaches, we demonstrate that RGS14 forms

243 microscopy (cryo-EM) structure analysis and biochemical approaches, we demonstrate that there is a c

244 Using computational and biochemical approaches, we demonstrate that this transla

245 Using molecular and biochemical approaches, we demonstrated that the C-termi

246 Here, through genetic and biochemical approaches, we describe a previously unident

247 Using bioinformatic and biochemical approaches, we determined that ORF57 contain

248 oscopy and molecular modelling combined with biochemical approaches, we determined the I-layer struct

249 Using biophysical and biochemical approaches, we discovered that CB(2) recepto

250 Herein, using cell biology and various biochemical approaches, we established that variant BRAF

251 In this study, using biochemical approaches, we examined BER enzymatic activi

252 combination of pharmacological, genetic, and biochemical approaches, we examined the possible relatio

253 Using genetic and biochemical approaches, we find that MEF2 is phosphoryla

254 Using biophysical and biochemical approaches, we found that CXCR4 can form an

255 e in longitudinal axon guidance, and through biochemical approaches, we found that Dscam1 and Robo1 f

256 of recombinant human Hsp70 and quantitative biochemical approaches, we found that high-affinity RNA

257 d epithelial permeability assays and several biochemical approaches, we found that IGF2BP1 ablation i

258 ation-mass spectrometry, bioinformatics, and biochemical approaches, we found that XRN2 associates wi

259 Using a number of biochemical approaches, we found these interactions to b

260 By using several biochemical approaches, we have analyzed the influence o

261 Using bioinformatics, genetics, and biochemical approaches, we have identified three residue

262 By integrating computational and biochemical approaches, we identified TARBP2, a double-s

263 Using reverse-genetic and biochemical approaches, we identified that the AN8677 ge

264 h a variety of pharmacological, genetic, and biochemical approaches, we identified the DNA damage res

265 In this work, using genetic and biochemical approaches, we identified the initial scaffo

266 Using in silico and biochemical approaches, we identified two heme binding s

267 g metabolic genetics, mass spectrometry, and biochemical approaches, we identify new activities in DA

268 Here, using bioinformatic and biochemical approaches, we identify the AMPA receptor Gl

269 Using genetic and biochemical approaches, we investigated interaction of t

270 a combination of bioinformatic, genetic, and biochemical approaches, we investigated the mechanism by

271 Using genetic, cellular, and biochemical approaches, we now demonstrate that the CD45

272 Using imaging and quantitative biochemical approaches, we now report that APP selective

273 Using biophysical and biochemical approaches, we observe that RAM increases th

274 By utilizing a variety of computational and biochemical approaches, we present evidence for a class

275 ing a combination of genetic, proteomic, and biochemical approaches, we report a divergent RDE-10/RDE

276 Here, using several molecular and biochemical approaches, we report that Vgl1, a member of

277 Using pharmacological and biochemical approaches, we show that both the convention

278 Using genetic and biochemical approaches, we show that charged residues in

279 Using structural biology and biochemical approaches, we show that GR binds directly t

280 Using cryo-electron microscopy (cryo-EM) and biochemical approaches, we show that PF846 inhibits tran

281 Using immunochemical and biochemical approaches, we show that PRX9 and PRX40 like

282 Using proteomic and biochemical approaches, we show that RPGR interacts with

283 Using genetic and biochemical approaches, we show that this increased requ

284 Combining metabolomics, plant genetics and biochemical approaches, we show that transgenic BAR inde

285 Using molecular and biochemical approaches, we show the presence of several

286 Using biochemical approaches, we show this arises due to both

287 lectron microscopy and other biophysical and biochemical approaches, we unveil the underlying mechani

288 To this aim, a plethora of biochemical approaches were adopted for the purification

289 Molecular and biochemical approaches were employed to evaluate the mec

290 Arabidopsis organelles, reverse genetic and biochemical approaches were employed.

291 In this work, molecular genetic and biochemical approaches were taken to establish that FHL-

292 Bioinformatic, genetic, and biochemical approaches were used to document and analyze

293 In this study, biochemical approaches were used to identify the consequ

294 Using a biochemical approach with purified proteins, as well as

295 teractions combining traditional genetic and biochemical approaches with 'omics' based approaches in

296 By combining biochemical approaches with a genetic complementation as

297 Flux measurement and proteomic, genetic, and biochemical approaches with a metabolomics bent are all

298 Coupling traditional genetic and biochemical approaches with advanced technologies, such

299 In this report, we combined biochemical approaches with in vivo mRNA reporter assays

300 scale precision, here we combine traditional biochemical approaches with superresolution microscopy m