ライフサイエンスコーパス: biochemical data

1 fully reflects the available mutagenesis and biochemical data.

2 ents, as well as a large body of genetic and biochemical data.

3 uction, which we curated against the limited biochemical data.

4 ion in the membrane in situ relies mostly on biochemical data.

5 he computational analysis of high-throughput biochemical data.

6 d controversial because of disagreement with biochemical data.

7 lished structure and are consistent with the biochemical data.

8 ystallography, cryo-electron microscopy, and biochemical data.

9 hematical models that can be trained against biochemical data.

10 for these putative roles comes from in vitro biochemical data.

11 bolism and storage was in agreement with the biochemical data.

12 tion for mRNA bound to eIF4E consistent with biochemical data.

13 d hydroxide as a general base as dictated by biochemical data.

14 he trends were generally correlated with the biochemical data.

15 derived from single-molecule experiments and biochemical data.

16 ained by a mathematical model trained on the biochemical data.

17 TsaE binding cavity, confirming our previous biochemical data.

18 r (at 2.65 angstrom resolution) supported by biochemical data.

19 WRC previously identified by mutagenesis and biochemical data.

20 between 1994 and 2015, of whom 699 also had biochemical data.

21 ystal structure that correlate well with our biochemical data.

22 Combining the solution structure and biochemical data, a model of ComAC bound to the ComA rec

23 In the absence of detailed structural and biochemical data about McjB and McjC, these studies allo

24 These biochemical data along with structural modeling suggest

25 Our biochemical data also indicate that the affinity of E2 f

26 Biochemical data and a crystal structure of a ternary co

27 e arrive at a model that supports all of our biochemical data and agrees very well with a cryo-electr

28 In this study, we use extensive biochemical data and algebraic modeling to develop and a

29 the ribozyme that accommodates all available biochemical data and appears competent for catalysis.

30 Similar baseline biochemical data and comparably high success rates of ro

31 Based on biochemical data and confirmed by molecular modeling, we

32 The structural and biochemical data and experiments with cultured cells sho

33 Interestingly, our biochemical data and homology modeling of the CAT domain

34 Utilizing these new biochemical data and intermolecular distance measurement

35 These, together with biochemical data and modeling by molecular dynamics calc

36 Biochemical data and modeling indicate that pY1473 can f

37 correlate well with published structural and biochemical data and provide mechanistic insights.

38 lows rationalization of existing genetic and biochemical data and provides a framework for targeting

39 Parameter values were estimated using biochemical data and reaction time performance on the ps

40 Structural findings agree with biochemical data and support the hypothesis that both no

41 n unbiased, generic model to integrate prior biochemical data and the constructed brain tumor microen

42 This mechanism explains the conflicting biochemical data and the genetic links between Rtt109, V

43 used to investigate disparities between the biochemical data and the X-ray structure of the CR2-C3d

44 inetic model that incorporates both existing biochemical data and the, to our knowledge, novel states

45 Biochemical data and three crystal structures provided i

46 ical with the rapid growth of structural and biochemical data, and the emergence of algorithms that r

47 away from sites catalyzing proteolysis, and biochemical data are consistent with an allosteric mecha

48 Computer modeling and biochemical data are consistent with the encapsulation o

49 We suggest that the biochemical data are consistent with the osmotic gliopat

50 Biochemical data are presented supporting a proposed bio

51 pathogenicity of enteric bacteria, available biochemical data are scarce.

52 picture that emerges from the structural and biochemical data are that GLD-3 activates GLD-2 both ind

53 These genetic and biochemical data argue that ccm2l is a necessary compone

54 Using structural and biochemical data as a guide, we characterized the indivi

55 ed to extract patterns from large volumes of biochemical data at molecular-level resolution while 'de

56 On the basis of the biochemical data, binding of NMM to Tel22 does not rely

57 nd validation due to the wealth of available biochemical data, but the method can be applied to any f

58 Together with supporting biochemical data comparing Suv4-20h1 and Suv4-20h2, we d

59 These biochemical data complement earlier biophysical studies

60 Biochemical data confirm that apoParA forms dimers at ph

61 Biochemical data confirm that irisin is a dimer and that

62 Biochemical data confirm that members of this riboswitch

63 Genetic and biochemical data confirmed a predicted binding site in t

64 However, direct biochemical data correlating FAD redox chemistry with Ch

65 The structures and supporting biochemical data define RNAP and promoter DNA conformati

66 Electrophysiological and biochemical data demonstrate that anti-Ro Abs inhibit IK

67 Biochemical data demonstrate that EM5 and FL772 inhibit

68 These results, in combination with biochemical data, demonstrate that residues 23-31 repres

69 Importantly, our biochemical data demonstrated that PRRSV nsp11 exists ma

70 These are the first biochemical data demonstrating a Ku dependence of Artemi

71 hysiological results with CFTR, there are no biochemical data demonstrating intrinsic adenylate kinas

72 Here, we present structural and biochemical data demonstrating that Sor inhibits the wil

73 Deletion analysis of SPT5 supports our biochemical data, demonstrating the importance of the KO

74 In contrast, and consistent with our biochemical data, EHD2 defines a different domain at the

75 The expression and biochemical data establish an arogenate pathway for Phe

76 Structural and biochemical data establish how a combination of active a

77 Our structural and biochemical data explain how CP12 integrates responses f

78 Furthermore, the extent of biochemical data fails to demonstrate a significant leve

79 ases exist that contain either structural or biochemical data, few integrate these two data sources i

80 for >3000 sequences, in vivo phenotypic and biochemical data for >5750 LacI/GalR mutational variants

81 - to 2.6-A-resolution crystal structures and biochemical data for 12 poliovirus polymerase mutants th

82 ular systems: (i) to integrate heterogeneous biochemical data for data mining, (ii) to combine top-do

83 in the context of available biophysical and biochemical data for ERK2, an archetypal MAPK.

84 The genetic and biochemical data for ime-2 and vib-1 indicate that IME-2

85 N oligomers that support and extend existing biochemical data for IN.LEDGF complexes and lend new ins

86 Biochemical data for mammalian myosin V suggest that a h

87 We present biochemical data for the formation of two distinct oligo

88 udy, we collected clinical, histological and biochemical data from 68 patients carrying the homozygou

89 Q and use it as a framework for interpreting biochemical data from both wild-type and variant protein

90 in is sufficient for DNA unwinding activity, biochemical data from several related enzymes suggest th

91 collection of multiple genetic and detailed biochemical data from small and large patient cohorts ha

92 Biochemical data from the mTau mice demonstrated that mo

93 Biochemical data further demonstrate a reduced catalytic

94 n from a variety of plant species, extensive biochemical data generated over decades, and impressive

95 In vitro biochemical data have been instrumental in deriving some

96 omic resolution structures and complementary biochemical data have defined the mechanisms for respons

97 However, crystal structures and biochemical data have not explained how the second stran

98 Solution structures and biochemical data have provided a wealth of mechanistic i

99 By contrast, biochemical data have shown that two rings are loaded in

100 Together, these structural and biochemical data highlight significant differences betwe

101 containing Gbeta subunits and complementary biochemical data highlight specific sites within Gbetas

102 atoms in purified Yap8, and our genetic and biochemical data identify the cysteine residues that for

103 Previous structural and biochemical data implicate the DNase I binding loop (D-l

104 ytosolic flagellin, consistent with previous biochemical data implicating NAIP6 in flagellin detectio

105 rphological findings, as well as genetic and biochemical data in 14 fused in sarcoma proteinopathy ca

106 d Suc export, are supported by metabolic and biochemical data in C. pepo Additionally, our findings s

107 the utility of combining remote-sensing and biochemical data in examining biological and physiologic

108 Analysis of the biochemical data in the context of the co-crystal struct

109 omic and genetic, biological, functional and biochemical data in yeast and humans establishes GOLPH3

110 Thus, our genetic, in vivo, and biochemical data indicate a role for Coy1 in regulating

111 Our biochemical data indicate that acidic patches on the con

112 Structural and biochemical data indicate that LLG1 (which is geneticall

113 Our crystal and biochemical data indicate that most CDC73 missense mutat

114 Recent biochemical data indicate that NOCT dephosphorylates NAD

115 Biochemical data indicate that SlmA dimer-of-dimers can

116 this enzyme with other type I FPPSs, but the biochemical data indicate that TgFPPS has unique charact

117 Biochemical data indicate that the EGFR complex is seque

118 Genetic and biochemical data indicate that the matrix (MA) domain of

119 Structural and biochemical data indicate the conserved A9 and A10 bases

120 Structure analysis and biochemical data indicate, that AgeI is a monomer in the

121 The structures, together with biochemical data, indicate that NtrC4 binds to DNA in a

122 r modeling of HIV-1 integrase, together with biochemical data, indicate that the conserved residue Q1

123 These structures-together with biochemical data-indicate that the monoubiquitinated ID

124 Biochemical data indicated that a majority of MLK4 mutat

125 Biochemical data indicated that ETR1RD is involved in ph

126 Biochemical data indicated that this mutation impairs la

127 These structures, in conjunction with biochemical data, indicated that AA3 mediates substrate

128 ng pockets in the hub and present supporting biochemical data indicating sugar moiety binding is impo

129 Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor,

130 al model is in good agreement with published biochemical data indicating that procapsid expansion exp

131 We provide structural and biochemical data indicating that the autoinhibitory inte

132 erichia coli cell by gathering the available biochemical data into a ribosome kinetics description.

133 Stepping towards this goal of incorporating biochemical data into ASD diagnosis, this paper analyzes

134 nt limited structural data, the inclusion of biochemical data is critical for achieving the accuracy

135 An important question in the analysis of biochemical data is that of identifying subsets of molec

136 cted, and on the basis of our data and other biochemical data, lithium binds to site II, coupled to a

137 low-resolution structural, biophysical, and biochemical data obtained by many teams over decades.

138 rature-based prior knowledge network against biochemical data obtained from primary human hepatocytes

139 Structural and biochemical data of archaellum subunits are missing.

140 e metal cofactors have to be considered when biochemical data of ferric proteins are rationalized by

141 ations for existing electrophysiological and biochemical data, offering an explicit mechanism for vol

142 idues in the APE1 active site and to explain biochemical data on APE1-catalyzed 3' repair activities.

143 sslinks are in close agreement with previous biochemical data on DNA binding and mostly fit known com

144 imization given the wealth of structural and biochemical data on HIV-1 reverse transcriptase (RT) and

145 Biochemical data on one of the orphan pathways suggest a

146 f the holoenzyme is consistent with previous biochemical data on RNP assembly and provides a simple s

147 Structural and biochemical data on the bacterial transcription-repair c

148 Here we provide structural and biochemical data on UBA5 N-terminal extension to underst

149 Biophysical and biochemical data on WRC mutants confirm that Rac1 binds

150 By synthesizing genomic, structural and biochemical data, our framework represents a new approac

151 first step in lysine biosynthesis, and early biochemical data placed it in the cytoplasm or mitochond

152 workflow allowed us to collect thousands of biochemical data points revealing the binding preference

153 Taken together, the structural and biochemical data presented here have implications for th

154 The structural and biochemical data presented here provide insights into th

155 The structural, biophysical, and biochemical data presented here provide the framework ne

156 OXs, LTC(4) synthase, and FLAP combined with biochemical data provide a framework for understanding h

157 Our structural and biochemical data provide a mechanistic basis to explain

158 The model and biochemical data provide a rationale for Atg7 dimerizati

159 These biochemical data provide direct evidence for TREX1 resid

160 Structural and biochemical data provide evidence that CYP46A1 activity

161 The combined structural and biochemical data provide insight into dNTP promiscuity a

162 These functional and biochemical data provide novel insights into the mechani

163 Biochemical data provide support for a model of the targ

164 ndings, discussed in relation to genetic and biochemical data, provide a critical foundation for futu

165 microfluidics that, in combination with bulk biochemical data, provides direct visual evidence for ou

166 his novel structure, in combination with new biochemical data, provides important insights into the m

167 Despite the vast biochemical data regarding the importance of metal ions

168 The structures and additional biochemical data reported here are consistent with a new

169 The structural and biochemical data reported here expand our knowledge on t

170 The structure and biochemical data reveal a dimeric arrangement of Dok7 PH

171 This structure and supporting biochemical data reveal a mechanism for accurate anneali

172 Current structural and biochemical data reveal a wide range of different helica

173 Biochemical data reveal that conserved aspartate residue

174 Our combined genetic and biochemical data reveal that D53 acts as a repressor of

175 n this work, FAN1-DNA crystal structures and biochemical data reveal that human FAN1 cleaves DNA succ

176 Together, our genetic and biochemical data reveal that it is possible to modulate

177 Structural and biochemical data reveal the molecular basis of polyspeci

178 Our structural and biochemical data reveal the molecular basis underying on

179 Crystal structures and biochemical data revealed a diverse protein superfamily

180 Structural and biochemical data revealed that binding of phosphorylated

181 of the CLK family as a model, structural and biochemical data revealed that the DFG-1 valine controll

182 Here, we present structural and biochemical data revealing the organization of Hsp104 fr

183 n of PARP2 that, in combination with NMR and biochemical data, reveals a composite active site formed

184 The structure, in combination with biochemical data, reveals molecular mechanisms for coord

185 re, which is consistent with our kinetic and biochemical data, reveals the molecular interactions tha

186 Guided by biochemical data, rigid body modeling of subunits into t

187 xtracting important information from complex biochemical data sets.

188 Recent structural and biochemical data show how the channel opens during trans

189 Indeed, biochemical data show that CcpA-(HPr-Ser46-P) binds the

190 Biochemical data show that Cdc13N weakly binds long, sin

191 Genetic and biochemical data show that dEGFR is tightly regulated by

192 Correlating structural and biochemical data show that DNA sequence modulates DNA bi

193 Biochemical data show that hOAS3.DI is essential for act

194 However, recent biochemical data show that small metaphosphates, cyclic

195 Combined cryo-electron microscopy and biochemical data show that the monomeric rhesus TRIM5alp

196 Biochemical data show that the mutations associated with

197 Our genetic and biochemical data show that the two ER-resident proteins

198 type III-A Csm complex targets DNA, whereas biochemical data show that the type III-B Cmr complex cl

199 Genetic and biochemical data show that this CR3 motif affects both e

200 In both enzymes, crystallographic and biochemical data show their respective C-terminal transm

201 These structures, accompanied by biochemical data, show that the translocation pathway is

202 Biochemical data showed that Rad26 uses its C-terminal d

203 Our structural and biochemical data showed that the BAH domain protein AIPP

204 nly in the absence of CNGC20, supporting the biochemical data showing homo- and heteromeric assembly

205 In addition, we provide biochemical data showing that although CIPK23 is intrins

206 We present structural and biochemical data showing that CARs are peripheral membra

207 t the crystal structure of S14 to 2.65 A and biochemical data showing that S14 can form heterodimers

208 Biochemical data shows that several of the cancer-associ

209 Here, we report biochemical data, small-angle X-ray scattering results,

210 Our structural and biochemical data suggest a mechanism where reversible bi

211 together, these structural, biophysical and biochemical data suggest a model where transition from t

212 The combination of genetic and biochemical data suggest a modified 'bacterial switch' h

213 The structures and existing biochemical data suggest a nucleic acid conformation-ind

214 These structural and biochemical data suggest a previously undescribed mechan

215 The genetic and biochemical data suggest a similar substrate role for he

216 Biochemical data suggest large parts of NS5A are unfolde

217 Biochemical data suggest that ADR-1, a deaminase-deficie

218 Biochemical data suggest that alpha-catenin adopts an au

219 Genetic and biochemical data suggest that ATH1 anchors STM to activa

220 The structural and biochemical data suggest that ATP binding is functionall

221 Most important, our biochemical data suggest that cocaine induces CD4(+) T-c

222 Genetic and biochemical data suggest that CypA protects HIV-1 from a

223 Importantly, the structural and biochemical data suggest that domain alternation and rem

224 Our genetic and biochemical data suggest that dRASSF8 acts in concert wi

225 c RecQ4 subfamily helicases, and genetic and biochemical data suggest that Hrq1 likely interacts with

226 Recent biochemical data suggest that human prostate cancer cell

227 M proteins have been shown to dimerize, and biochemical data suggest that RSV M also dimerizes.

228 These biochemical data suggest that the dipeptide insertion el

229 In addition, genetic and biochemical data suggest that the examined domain suppor

230 Biochemical data suggest that the Hoc protein has two fu

231 Biochemical data suggest that the magnesium ions provide

232 The structural and biochemical data suggest that the protein undergoes conf

233 Finally, in vitro biochemical data suggest that the stem-loop sequence is

234 Combined structural and biochemical data suggest that this DNA-activated SlmA ol

235 Biochemical data suggest that this genetic interaction i

236 Biochemical data suggest that unlike the enzymes in the

237 Emerging structural and in vitro biochemical data suggest that XRCC4 and XLF together gen

238 Structural and biochemical data suggest the aaRS efficiency improvement

239 are known to bind ubiquitin, but genetic and biochemical data suggest the existence of at least one o

240 The current results, together with earlier biochemical data, suggest that the proton pumping in com

241 In addition, we report biochemical data suggesting that Hoc can bind to Escheri

242 nucleotide binding domain supporting earlier biochemical data suggesting that the inactive form exist

243 The combination of analytical and biochemical data suggests that the higher 18:2n-6 conten

244 Genetic and biochemical data support a model in which direct binding

245 Genetic and biochemical data support a model in which the pupylation

246 The structures, along with biochemical data, support a model where the recognition

247 in combination with previous structural and biochemical data, support an asymmetric inchworm mechani

248 posed pK(a) shift mechanism accounts for the biochemical data supporting the essential role for the B

249 rms a helical conformation, no structural or biochemical data supporting this hypothesis have been pu

250 The biochemical data taken in conjunction with the biologica

251 the allotetraploids are consistent with the biochemical data that AaCHE showed preferential binding

252 Here, I present genetic and biochemical data that confirm the requirement of MurJ fo

253 This study provides biochemical data that show that SAX-7 associates with DY

254 Notably, we present sequence and biochemical data that suggest that deamidation has been

255 Here we present structural and biochemical data that suggest that two conserved tyrosin

256 ve conceptualized based on morphological and biochemical data that this degeneration is better classi

257 Here we present new biochemical data that underscore the validity of our pre

258 pose, based on phylogenetic, structural, and biochemical data, that the GUAAY pentaloop-receptor inte

259 In agreement with the biochemical data, the crystal structure of Pfk-2 obtaine

260 In accordance with previous biochemical data, the majority of the heterotypic H3K27M

261 By incorporating independently available biochemical data, the model can reproduce a large number

262 In combination with biochemical data, the structure suggests that the antibo

263 Together with biochemical data, the structure supports a mechanistic m

264 Together with the biochemical data, the structures define the molecular de

265 Together with biochemical data, the structures point to a step size fo

266 In accord with the biochemical data, these growth defects were exacerbated

267 Together with our biochemical data, these physiological results indicate t

268 ke structures is not yet known, based on our biochemical data they are expected to be comprised of un

269 l genomes, with refined protein families and biochemical data to assign fully consistent functional a

270 Here, we combine genomic, proteomic, and biochemical data to demonstrate that many common nonsens

271 thesis in Legionella pneumophila and provide biochemical data to extend knowledge of the Thi5 enzyme,

272 Here, the authors provide transcriptomic and biochemical data to identify two enzymes that, in tandem

273 We used in vivo biochemical data to infer that a conformational intermed

274 However, biochemical data to support these observations and concl

275 The structural and biochemical data together offer insights into PDGF-PDGFR

276 Our structural and biochemical data together with phylogenetic analyses of

277 panding body of microbial, physiological and biochemical data, together with new technologies for man

278 This is consistent with biochemical data, using full-length MDM2, showing that t

279 Consistent with biochemical data, vibrational sum frequency spectroscopy

280 structures in the context of functional and biochemical data, we attempt to summarize new insights i

281 ologous Type II/IV secretion ATPases and our biochemical data, we believe that EpsE is active as an o

282 On the basis of biochemical data, we herein discussed structure-affinity

283 Informed by mammalian crystallographic and biochemical data, we introduced amino acid substitutions

284 spectrometry with cryo-EM, computational and biochemical data, we investigate the oligomeric formatio

285 Together with previous structural and biochemical data, we now propose a molecular mechanism o

286 Incorporating genetic, immunologic, and biochemical data, we present a multistep pathogenesis mo

287 Based upon genetic, cell biological, and biochemical data, we propose that Opy1 functions as a co

288 On the basis of structural and biochemical data, we propose that pi-pi' is a dynamic in

289 Based on our structural and biochemical data, we proposed a model for the complete c

290 gand-bound crystal structures and supporting biochemical data, we show that this protein, which we re

291 vely the resulting findings on the available biochemical data, we successfully revise the concept of

292 Biochemical data were analyzed by linear regression and

293 Histologic and biochemical data were collected from 315 kidney transpla

294 lected within 30 days of blood sampling, and biochemical data were collected within 7 days of blood s

295 Demographic, haemodynamic and biochemical data were drawn from participants in the Ang

296 of diabetes, and demographic, clinical, and biochemical data were retrieved from standardized databa

297 Clinical and biochemical data were reviewed.

298 Clinical and biochemical data were systematically recorded perioperat

299 mplex structures of the enzyme combined with biochemical data, which reveal that the enzyme utilizes

300 Electron micrographs and biochemical data with a PFKL/PFKP chimera indicate that