1 ne of most challenging of all substrates for
biochemical study.
2 in this prospective, randomized clinical and
biochemical study.
3 he BamA assisted model, based on genetic and
biochemical studies.
4 tion in neurons emerging from functional and
biochemical studies.
5 venient soluble NUDT9H models for structural/
biochemical studies.
6 family, a character yet to be highlighted in
biochemical studies.
7 n studies, 5 for pharmacogenetics and 21 for
biochemical studies.
8 tructure to 2.15 A and performed genetic and
biochemical studies.
9 al role in Th17 differentiation suggested by
biochemical studies.
10 eractions, which we validated by genetic and
biochemical studies.
11 siological studies of the endplate, and from
biochemical studies.
12 gnal relay through the allosteric network by
biochemical studies.
13 is of streptide was addressed by genetic and
biochemical studies.
14 nous telomerase and is thus a good model for
biochemical studies.
15 ray scattering, electron microscopy (EM) and
biochemical studies.
16 bioinformatics, genetic complementation, and
biochemical studies.
17 hese structures, we conducted mutational and
biochemical studies.
18 of human cytosolic tRNAs, primarily based on
biochemical studies.
19 igated using heterologous reconstitution and
biochemical studies.
20 interactions for future pharmacological and
biochemical studies.
21 ently and directly dephosphorylated Rab8A in
biochemical studies.
22 Yet, despite 2 decades of structural and
biochemical studies,
a comprehensive, accepted model for
23 Structural and
biochemical studies aiming to understand binding of smal
24 Serological and
biochemical studies also supported a diagnosis of subcli
25 rai channels as elucidated by functional and
biochemical studies,
analyze the dOrai crystal structure
26 Subsequent in vitro
biochemical studies and a cell-based genetic screen demo
27 Accordingly, we performed integrated
biochemical studies and adhesion assays to examine the c
28 Biochemical studies and cryo-electron microscopy identif
29 Through
biochemical studies and crystallography, we show that im
30 e findings agree well with those of previous
biochemical studies and extend our understanding of the
31 The structure provides a template for future
biochemical studies and modelling of ICP27 homologs from
32 Results from our
biochemical studies and molecular dynamics simulations s
33 Here we combined complex genetic analyses,
biochemical studies and pharmacological interference to
34 al studies explain decades of biological and
biochemical studies and provides a general strategy to b
35 he results presented here will guide further
biochemical studies and refinement of the model to incre
36 -NPG to provide specificity, as indicated by
biochemical studies and shown directly by X-ray crystall
37 Biochemical studies and the co-crystal structure of CLK1
38 logy used will have broad application across
biochemical study and drug discovery and development.
39 tion of transcription obtained from in vitro
biochemical studies,
and the cellular, phenomenological
40 spare tire concept is proposed based on this
biochemical study,
and this concept opens up a potential
41 for producing such polysaccharides, in vitro
biochemical studies are needed to determine, for example
42 ute conditions in which most biophysical and
biochemical studies are performed.
43 Results from our
biochemical studies are underscored by genome-wide analy
44 Here, by genetic and
biochemical studies as well as deep sequencing analyses,
45 Structural and
biochemical studies by Ferrao et al. (2014) in this issu
46 mulation experiment reported here and recent
biochemical studies by others support this hypothesis.
47 lipid-membrane protein particles (SMALP) for
biochemical study,
by destroying the living cellular spe
48 Biochemical studies challenged this model because the pu
49 Here we report detailed
biochemical studies clearly demonstrating that, in purif
50 Biochemical studies confirm the structural observations
51 Final
biochemical studies confirmed dose-dependent, competitiv
52 Biochemical studies corroborate key features of the stru
53 In
biochemical studies,
CS disrupted TCR multimers, apparen
54 Together, our genetic and
biochemical studies define the molecular nature of the D
55 Biochemical studies demonstrate how the removal of ATP p
56 Although genetic and
biochemical studies demonstrate that AGO2 phosphorylatio
57 Biochemical studies demonstrate that the mutant mRNA is
58 Genetic and
biochemical studies demonstrate that the tube is essenti
59 Our molecular and
biochemical studies demonstrate that Zic2 preferentially
60 ined, combined with normal mode analysis and
biochemical studies,
demonstrate that the plasticity of
61 Biochemical studies demonstrated that 17e could induce a
62 action to the APOBEC3B catalytic domain, and
biochemical studies demonstrated that BORF2 stoichiometr
63 g promotes epicardium formation in vivo, and
biochemical studies demonstrated that CDC42 is involved
64 Biochemical studies demonstrated that ChlR1 efficiently
65 Biochemical studies demonstrated that HDAC1 was present
66 Furthermore,
biochemical studies demonstrated that MDV U(S)3 interact
67 Biochemical studies demonstrated that NKG2D(TR) was boun
68 Live-cell microscopy and
biochemical studies demonstrated that p130Cas knockdown
69 Biochemical studies demonstrated that RAC2[E62K] retains
70 Further
biochemical studies demonstrated that the shelterin prot
71 se genetic data are strongly corroborated by
biochemical studies demonstrating physical interactions
72 ecause of their very high sequence identity,
biochemical studies done on H-Ras have been considered r
73 Further
biochemical studies establish that coordination of Ni(II
74 Predictive modeling and
biochemical studies establish why mutations in a positiv
75 These investigations, together with
biochemical studies,
established the nanostructure-activ
76 Most current cell culture and
biochemical studies focus on instant changes in the envi
77 Biochemical studies guided by the co-crystal structures
78 A previous
biochemical study has shown that budding yeast Hop2-Mnd1
79 Structural analysis, in conjunction with
biochemical studies,
has uncovered the molecular basis f
80 Overall, our structural and
biochemical studies have defined the molecular basis for
81 Biochemical studies have demonstrated that as little as
82 Recent
biochemical studies have demonstrated that EsxA is a mem
83 While previous
biochemical studies have demonstrated that GalNAc-T12 se
84 Previous
biochemical studies have demonstrated that in the presen
85 Biochemical studies have established that as an obligate
86 ve revealed the location of these sites, and
biochemical studies have explored the kinetics of ACs, b
87 Biophysical and
biochemical studies have found that OM increases calcium
88 Although recent structural and
biochemical studies have identified conserved sites of p
89 Previous
biochemical studies have identified PriC residues that m
90 Biochemical studies have identified specific sites along
91 Genetic and
biochemical studies have implicated impaired lysosomal a
92 Biochemical studies have led to the identification of ke
93 rlooked as a metabolically active organ, yet
biochemical studies have long demonstrated that glucose
94 Genetic and
biochemical studies have outlined a role for the broadly
95 Several computational and
biochemical studies have proposed an acetate-escape hypo
96 Recent structural and
biochemical studies have provided detailed insights into
97 Although extensive
biochemical studies have provided insight into the NO ac
98 Although multiple physiologic and
biochemical studies have reported defects in mitochondri
99 ical (Golgi-Kopsch, electron microscopy) and
biochemical studies have revealed an increased occurrenc
100 Recent NMR and
biochemical studies have revealed that binding of the pr
101 Previous
biochemical studies have revealed that PLB interacts wit
102 Yeast two-hybrid and
biochemical studies have revealed that the more distantl
103 Structural and
biochemical studies have revealed the basic principles o
104 ls, but in a handful of cases structural and
biochemical studies have revealed the mechanisms and con
105 Bulk
biochemical studies have shown that Bloom helicase (BLM)
106 Genome mining and
biochemical studies have shown that oomycetes, which bel
107 Structural and
biochemical studies have shown that RelE cuts with some
108 While structural and
biochemical studies have shown that the acidic patch con
109 Genetic and
biochemical studies have suggested that GON4L is a trans
110 Biochemical studies have suggested that stimuli predomin
111 Although
biochemical studies have uncovered the mechanisms involv
112 Cellular and
biochemical studies identified distinct molecular defect
113 Structural and
biochemical studies identified key residues that are cru
114 acts downstream of SnRK2.2/2.3 kinases, and
biochemical studies identified phosphorylation sites in
115 Complementary
biochemical studies identified that each of the two bind
116 Transcriptomic, proteomic, and
biochemical studies identified the chaperone BiP/GRP78/H
117 Structural and
biochemical studies identify a conserved region on TREX-
118 sequencer to enable high-throughput protein
biochemical studies,
identifying improved sequence varia
119 Genetic and
biochemical studies implicate alpha-synuclein and leucin
120 Computational and
biochemical studies implicate the blue-light sensor cryp
121 Accumulating evidence from genetic and
biochemical studies implicates dysfunction of the autoph
122 as well as earlier electron microscopic and
biochemical studies implicating a replication origin at
123 Despite many
biochemical studies in diverse MBLs, molecular understan
124 We used electrophysiology, imaging, and
biochemical studies in mice and cells to elucidate the f
125 We performed immunologic, genetic, and
biochemical studies in the patients, family members, and
126 Molecular and
biochemical studies in these mice indicate that FR ameli
127 Biochemical studies in vitro and functional complementat
128 Using genetic and
biochemical studies in vitro and in human MM xenograft m
129 As inferred from
biochemical studies,
in the Poliota/Polkappa pathway, Po
130 l domains combine to create a basic pore and
biochemical studies indicate residues in this region par
131 Biochemical studies indicate that Hook proteins interact
132 Our
biochemical studies indicate that in the Poliota/Polthet
133 Our
biochemical studies indicate that PRORP2 requires Mg(2+)
134 Biochemical studies indicate that R742A as well as D113R
135 Our
biochemical studies indicate that this interaction is re
136 Our
biochemical studies indicate that YTHDC2 is an RNA-induc
137 In vitro
biochemical studies indicated that cortactin binds PI(3,
138 Biochemical studies indicated that PphnRNP-F1 is recruit
139 Moreover, structural comparison and
biochemical studies indicated that Tyr 97 and His 138 ar
140 line but difficult to reconcile with former
biochemical studies indicating that PAG is constitutivel
141 Biochemical studies informed by these structures demonst
142 The aim of this clinico-
biochemical study is to estimate and compare the levels
143 access homogeneously modified chromatin for
biochemical studies,
is well suited to the sensibilities
144 surements as well as sufficient material for
biochemical studies like protein purifications, enzyme a
145 From a series of
biochemical studies,
live imaging, and analyses of mutan
146 were not enough genetic, pharmacogenetic and
biochemical studies of ADHD in adults and that more inve
147 Here, we report the first comparative
biochemical studies of all the A3H variants using highly
148 cribe negative-stain electron microscopy and
biochemical studies of alphaXbeta2 and alphaMbeta2 in co
149 11beta-HSD1
biochemical studies of CA indicated that its functional
150 Biochemical studies of GEN1 revealed that it cleaves syn
151 Biochemical studies of H3 and H4 tails binding to seven
152 This review covers topics from the classic
biochemical studies of human biospecimens to the use of
153 r findings may help guide future genetic and
biochemical studies of MAH pathogenesis and aid in the i
154 Biochemical studies of mutant UBA5 proteins and studies
155 Although many structural and
biochemical studies of NRPSs exist, few studies have foc
156 can precursors, including Lipid II, enabling
biochemical studies of proteins involved in cell wall as
157 tein, Y3, from the mushroom Coprinus comatus
Biochemical studies of recombinant Y3 from a yeast expre
158 tomic sequencing, proteomics, phenotype, and
biochemical studies of relatively unexplored basal fungi
159 Although recent structures and
biochemical studies of RNA bound exosomes from S. cerevi
160 S. cerevisae V-ATPase that explains numerous
biochemical studies of that enzyme.
161 RNA-sequencing and
biochemical studies of the DeltamybA strain suggested th
162 This personal retrospective focuses on how
biochemical studies of the frog egg helped identify the
163 nts in the field, focusing on structural and
biochemical studies of the FZD receptor family and highl
164 Structural and
biochemical studies of the monomeric archaeal XPD homolo
165 n silico modeling, mutagenesis, and in vitro
biochemical studies of the P. falciparum SUMO E1 and E2
166 Biochemical studies of the particular synthetic PrAMP on
167 Crystallographic and
biochemical studies of the PMTs in this pathway provide
168 Here, detailed
biochemical studies of the RxLR effector AVR3a from the
169 Early
biochemical studies of viral replication suggested that
170 Biochemical studies of WT PKM2 (wtPKM2) and the two mime
171 Our comparative structural and
biochemical study of H6 and mH6 shows closely matching c
172 tudy brings a comparative perspective to the
biochemical study of NDMMs through the systematic MS/MS-
173 s process, we have carried out a genetic and
biochemical study of proteins proposed to function in ir
174 Here, we perform structural and
biochemical studies on a recently isolated antibody, CR9
175 Recent
biochemical studies on bovine papillomavirus 1 (BPV1) E1
176 review, we discuss the recent structural and
biochemical studies on four major components of the HH p
177 results highlight the importance of detailed
biochemical studies on GLUT protein expression levels in
178 nctional assay will facilitate molecular and
biochemical studies on how gene regulatory proteins and
179 Despite
biochemical studies on individual gene products, the com
180 Here we present
biochemical studies on novel mouse cationic trypsinogen
181 Biochemical studies on purified rhodopsin from mice indi
182 Here, in coupled immunolocalization/
biochemical studies on SAG1, we show that, within minute
183 ll allow for further detailed structural and
biochemical studies on the interaction of PAR with its m
184 Biochemical studies on the kinesins confirmed KIFC1, KIF
185 Crystallographic and
biochemical studies on the Pseudomonas syringae ethylene
186 Prior
biochemical studies on the Sen1 homolog from Schizosacch
187 However, in vitro
biochemical studies on the thermal stability of Rho show
188 Structural and
biochemical studies on this enzyme elucidate the mechani
189 Biochemical studies over the past 10 years have allowed
190 Genetic and
biochemical studies,
primarily in Salmonella enterica, h
191 Biochemical studies proved the importance of the C-termi
192 EF-G) bound to the ribosome, as well as many
biochemical studies,
provide evidence that the direct in
193 vely, the structure along with corroborating
biochemical studies provided insights into the novel mod
194 A
biochemical study provided evidence that Cav1.233L chann
195 Many of these
biochemical studies require access to a structurally wel
196 Our structural and
biochemical studies reveal an unusually tight interactio
197 Our structural and
biochemical studies reveal catalytically essential resid
198 Furthermore,
biochemical studies reveal that L. pneumophila uses two
199 Genome-wide analyses and
biochemical studies reveal that methylated Pontin functi
200 Our structural and
biochemical studies reveal that SAV1 and MST2 heterodime
201 beta-tryptase/antibody complex coupled with
biochemical studies reveal the molecular basis for allos
202 These
biochemical studies reveal two features of reentrant pha
203 RNA sequencing and
biochemical studies revealed an association with impaire
204 Biochemical studies revealed NEUROG3 variants have disti
205 Additional
biochemical studies revealed that Arg-65 is critical for
206 Biochemical studies revealed that csd1, csd2 and sodx di
207 Our
biochemical studies revealed that FraB Glu214Ala, Glu214
208 Our recent molecular and
biochemical studies revealed that impaired mitochondrial
209 Biochemical studies revealed that MltG is an inner membr
210 Recent
biochemical studies revealed that NisB glutamylates Ser/
211 Biochemical studies revealed that platelet DREAM positiv
212 Biochemical studies revealed that scFvG9 impairs the mat
213 Previous
biochemical studies revealed that the CP-AMPARs accumula
214 Biochemical studies revealed that the enhanced anoikis r
215 Structural and
biochemical studies revealed that the helix domain is re
216 Genetic and
biochemical studies revealed that the incompatibility is
217 Biochemical studies revealed unexpected findings that re
218 tural modeling, coupled with mutagenesis and
biochemical studies,
revealed dual binding sites for fed
219 Based on our
biochemical studies,
sarecycline appears to be a more po
220 chromatin presents a formidable obstacle to
biochemical studies seeking to understand the role of co
221 While
biochemical studies show that DNMT3L is capable of inter
222 In vitro
biochemical studies show that G-CSF programs MPO-EL expr
223 Biochemical studies show that most analogues consistentl
224 ns the pH dependence of this transition, and
biochemical studies show that pH regulates calcium influ
225 Crystallographic and
biochemical studies show that quinolone binding involves
226 Our structural and
biochemical studies show that SagA is a NlpC/p60-endopep
227 Biochemical studies show that the glutamate rich C-termi
228 Our genetic and
biochemical studies show that UBCH7 (UBC-18) and the RBR
229 Biochemical studies showed markedly decreased activities
230 Finally, immunocytochemical and
biochemical studies showed preferential enrichment of th
231 Second,
biochemical studies showed that aldolase indeed catalyze
232 Our
biochemical studies showed that auranofin inhibits the b
233 Biochemical studies showed that NCU08746 requires copper
234 Recent
biochemical studies showed that one pool of cholesterol
235 Biochemical studies showed that sIL-27Ralpha is released
236 Biochemical studies showed that the affinities of ACm1A
237 Biochemical studies showed that the C-6 benzyl and biary
238 Combined genetic and
biochemical studies showed that the cytoplasmic tail of
239 for in vivo delivery applications. In vitro
biochemical studies showed that the HpSGN system require
240 Biochemical studies showed the two subtypes with an N-1
241 cation of Orai, a plethora of functional and
biochemical studies sought to compare Orai homologs, det
242 ether, our cell-based findings together with
biochemical studies suggest a critical function of FANCJ
243 Further
biochemical studies suggest that EcEndoV is able to bind
244 Genetic and
biochemical studies suggest that enzyme action depends o
245 Biochemical studies suggest that excitatory neurons are
246 Recent structural and
biochemical studies suggest that multiple steps of filam
247 Previous
biochemical studies suggest the membrane interaction can
248 Biochemical studies suggested that spontaneous migration
249 Biochemical studies suggested that the antimicrobial pep
250 Our genetic and
biochemical studies support a model whereby Top1p recrui
251 on coordinate, combined with mutagenesis and
biochemical studies support a single Mg(2+)-ion mechanis
252 Our
biochemical studies support a uniquely nuanced pathway o
253 Biochemical studies support that promotion of spine form
254 It was shown by several
biochemical studies that activation and regulation depen
255 w access to these substrates has now enabled
biochemical studies that deepen our understanding of how
256 We review recent structural and
biochemical studies that have advanced our understanding
257 Remarkably, this is consistent with recent
biochemical studies that identified a defective interact
258 Here, we report through crystallographic and
biochemical studies that K-80003 binds to and stabilizes
259 orical perspective, I highlight foundational
biochemical studies that led to the discovery of an expa
260 This review will highlight structural and
biochemical studies that provide important insight into
261 In this study, we conducted structural and
biochemical studies that revealed that HdeB indeed works
262 dels of Cas9 function and the structural and
biochemical studies that support it.
263 oluble collagen fibrils poses challenges for
biochemical studies that the single-molecule tracking ca
264 Here, we report an in vitro
biochemical study that shows that Sco1 is a metallochape
265 Finally, for
biochemical studies,
the designed sequences can suggest
266 Despite extensive structural and
biochemical studies,
the molecular mechanisms whereby th
267 t two crystal structures of Sda1, as well as
biochemical studies to address key structural features a
268 Using
biochemical studies to characterize the wild-type (WT) a
269 e combine multi-"omic" analyses and detailed
biochemical studies to comprehensively characterize loci
270 Here, we combine structural and
biochemical studies to define the function of three auxi
271 rystal structure of GS-5745.MMP9 complex and
biochemical studies to elucidate the mechanism of inhibi
272 membrane anchor has allowed for physical and
biochemical studies to identify the role of substrate in
273 We relate these
biochemical studies to potential cellular examples and d
274 We combine genetic, epigenomic, and
biochemical studies to show that HNF1A recruits KDM6A to
275 Here, we present a combined biophysical and
biochemical study to explore the structure-dynamics-func
276 Biochemical studies using muscle extracts from transgeni
277 Our previous
biochemical studies using synaptoneurosomes demonstrate
278 Our
biochemical studies,
using recombinant Delta22 (a versio
279 Using mutational, genetic and
biochemical studies we demonstrate that cellular concent
280 Using
biochemical studies,
we demonstrate that both GTP and dG
281 By mutagenesis and
biochemical studies,
we demonstrated that the phylogenet
282 isms in a milieu amenable for structural and
biochemical studies,
we identified, cloned, and partiall
283 Based on structural and
biochemical studies,
we now provide insight into an unpr
284 Using structural and
biochemical studies,
we report the effect of substrate a
285 In
biochemical studies,
we show that CB1R and 5-HT2AR form
286 Through an E3 ligase screen and
biochemical studies,
we unexpectedly identified that RNF
287 f these, 15 genetic, 2 pharmacogenetic and 6
biochemical studies were included in the meta-analyses.
288 ibroblasts (MEFs) are convenient sources for
biochemical studies when cell number in mouse embryos is
289 This included not only
biochemical studies which revealed the expected presence
290 lly heme-loaded MamP from AMB-1 for in vitro
biochemical studies,
which show that its Fe(III)-Fe(II)
291 Biochemical studies with human ATM and genetic studies i
292 roposed to anchor Tim44 to the membrane, but
biochemical studies with MB-10 show that this region is
293 Biochemical studies with myofilaments showed that RLC ph
294 wild type and isogenic mutants together with
biochemical studies with purified phospholipases, we inv
295 Mutant phenotypic analyses and
biochemical studies with purified proteins revealed that
296 h alternative forks may be utilized, and new
biochemical studies with purified proteins that are aime
297 Biochemical studies with recombinant human DHODH led us
298 Biophysical, mutational, and
biochemical studies with the hyperthermostable two-domai
299 phate, this study sets the stage for further
biochemical studies with this material.
300 oaches has complemented previous genetic and
biochemical studies,
yielding new information about how