ライフサイエンスコーパス: biochemically

1 capacitance) and hormone secretion (measured biochemically).

2 and high basal Rac1-GTP levels when measured biochemically.

3 een extensively studied both genetically and biochemically.

4 ne, which we have purified and characterized biochemically.

5 nendothelial cells, an association confirmed biochemically.

6 d efforts to delineate fermentation pathways biochemically.

7 ich we extensively validated genetically and biochemically.

8 iculty of engineering multicellular networks biochemically.

9 ofilms exclusively interact with their hosts biochemically.

10 hen applied it to characterize PLD3 and PLD4 biochemically.

11 r, which we identified as GltT and confirmed biochemically.

12 how the "don't eat me" signal is transduced biochemically.

13 he kinase domain, one of which was validated biochemically.

14 lty, we synthesized solenopsin analogs which biochemically act as ceramides, but cannot be metabolize

15 bronectin-coated plates with cells that have biochemically activated RAP1.

16 an facilitate the assembly and processing of biochemically active complexes, such as ribosomal subuni

17 These biochemically active lamellipodia require cell-substrate

18 We further suggest that potentially biochemically active metabolites were more deterministic

19 are a prolific source of tightly regulated, biochemically active non-coding elements, such as transc

20 :1 (Delta3trans) uniquely labels a small but biochemically active plastid phosphatidylglycerol pool i

21 Yerba mate tea contains various biochemically active substances.

22 Here, we were able to biochemically analyze autophagic intermediate membranes

23 Furthermore, we biochemically analyzed the contribution of RPTPzeta to P

24 We characterized sumoylation of FOXP2 biochemically and analyzed the region-specific function

25 tein synthesis, and made mice resistant both biochemically and behaviorally to the antidepressant eff

26 We analyzed the effects biochemically and behaviorally, using the forced swim, t

27 Notably, the HIPP derivative 4-chloro-HIPP biochemically and biologically phenocopied mutational in

28 to expand on these previous observations, we biochemically and biophysically characterized the intera

29 VIII collagen - are present in BMs, creating biochemically and biophysically distinct structures that

30 and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumo

31 Protein-protein interactions were analyzed biochemically and by means of ab initio calculations.

32 Autophagy was monitored biochemically and cell death was measured using multiple

33 of HDAC proteins are becoming apparent both biochemically and clinically, how this class of proteins

34 We verified the PACSIN1-KCC2 interaction biochemically and demonstrated that shRNA knockdown of P

35 0693 potently inhibited PrkA kinase activity biochemically and exhibited significant selectivity for

36 We find that dynein can be in biochemically and functionally distinct pools: either tr

37 Here we biochemically and functionally interrogate modes of ARF-

38 te that in P. patens the canonical Galpha is biochemically and functionally replaced by an XLG protei

39 ious TTSPs have been characterized in detail biochemically and functionally, the basic properties of

40 IR3DS1 bound to HLA-F, a result we confirmed biochemically and functionally.

41 ysbindin, and subunits of the BLOC-1 complex biochemically and genetically interact, modulating Droso

42 MS-mutagenized red lettuce and characterized biochemically and genetically.

43 planation for many of the complexes detected biochemically and illustrates the ability of Vps75 to in

44 zed Alzheimer-like alterations behaviorally, biochemically and immunohistochemically 6 weeks and 7 mo

45 These conjugates were characterized biochemically and immunologically.

46 nism of Ub E2 activity, which we demonstrate biochemically and in cell-based assays.

47 enesis model in which cells were cultured in biochemically and mechanically defined matrices to exami

48 to the brain involves cell migration through biochemically and physically complex microenvironments a

49 ressure were either histologically scored or biochemically and physically quantified in all animals.

50 During NMP, bile was analyzed biochemically and potential biomarkers were correlated w

51 included osteoblastic responses as measured biochemically and radiologically and changes in quality

52 Abeta aggregations-biochemically and structurally akin to those found in th

53 ase domains in p190RhoGAP, characterize them biochemically and structurally and show that they influe

54 Here, we biochemically and structurally characterize Anf3 from th

55 Here, we biochemically and structurally characterize the naturall

56 Here, we biochemically and structurally characterized diverse inh

57 Here, we biochemically and structurally characterized two evoluti

58 Although BamB has been biochemically and structurally characterized, its mechan

59 oned, over-expressed in Escherichia coli and biochemically and structurally characterized.

60 These were characterized biochemically and structurally, and the one partially sh

61 heir components have been characterized both biochemically and structurally.

62 lower prevalences were more likely to differ biochemically and to be part of an electrophoretic mixtu

63 confirmed the recombinant complex integrity biochemically and with a 2.6 angstrom resolution cryo-EM

64 ellar transport complexes, which we validate biochemically, and by probing structurally predicted, di

65 efine AAV-AAVR interactions, genetically and biochemically, and show that different AAV serotypes hav

66 This genetic specificity is mirrored biochemically as TorA, but not TorA-DeltaE, binds Pom152

67 although CFIm25 was initially identified as biochemically associated with both CFIm59 and CFIm68, we

68 d abstinence for 1 year, which was validated biochemically at the final visit.

69 The third phase is poorly characterized biochemically, because previous in vitro assembly reacti

70 Currently, these interactions are defined biochemically, but a method is needed to evaluate them q

71 cco products since the quit date), confirmed biochemically by a breath carbon monoxide reading of les

72 In this study, we structurally and biochemically characterise the RNase E catalytic domains

73 immunoprecipitation and mass spectrometry to biochemically characterize endogenous signaling complexe

74 Here, we identify and biochemically characterize PCIF1, the methyltransferase

75 Here, we further biochemically characterize the AAV-AAVR interaction and

76 Here, we aimed to biochemically characterize the L protein of Lassa virus,

77 Here we biochemically characterize the substrate preferences of

78 Historically, it has been difficult to biochemically characterize these enzymes that act on pep

79 Here, we biochemically characterize three proteins encoded by a c

80 dynamics simulations of TylHI and MycCI and biochemically characterized a third P450 homolog from th

81 Here, we biochemically characterized agonist-promoted G protein c

82 eterologously expressed and structurally and biochemically characterized an antimicrobial lasso pepti

83 ight that mutant enzymes should be carefully biochemically characterized before making in vivo infere

84 Herein, we cloned and biochemically characterized cDNA encoding CBS from T. go

85 To this end, we recombinantly produced and biochemically characterized CML36 from Arabidopsis thali

86 pecialized motifs on proteins that have been biochemically characterized decades ago.

87 alysis to confirm the over-expression of the biochemically characterized enzymes during growth of the

88 ion, we successfully reannotated >98% of the biochemically characterized enzymes listed on the CAZy d

89 ot belong to the F3'5'H clade, but resembles biochemically characterized F3'Hs (flavonoid 3' hydroxyl

90 Here, we biochemically characterized G-N-7 MTase of PEDV nsp14 an

91 nome contains 32 TPS genes, 17 of which were biochemically characterized in this study.

92 nformatic analysis of both proteins and have biochemically characterized MbnH from Methylosinus (Ms.)

93 Hence, OxsB represents the first biochemically characterized non-methylating Cbl-dependen

94 In the current study, we have identified and biochemically characterized novel ulvan lyases from thre

95 terminants of PDE6 allosteric regulators, we biochemically characterized PDE6 complexes in various al

96 tigate this possibility, we structurally and biochemically characterized recombinant PhiCpeT.

97 oteins selected from subfamilies without any biochemically characterized representatives, from distan

98 E)-beta-caryophyllene synthase (DcTPS01), we biochemically characterized several TPS proteins with di

99 Here, we biochemically characterized the interactions between Ubp

100 We also biochemically characterized the molecular events associa

101 en verified in vitro Herein, we purified and biochemically characterized the radical S-adenosylmethio

102 We purified and biochemically characterized the Sat from both wild-type

103 ent arrangements of the mutated modules, and biochemically characterized their interactions with GroE

104 We also biochemically characterized their relative stabilities a

105 We identified and biochemically characterized three leucoanthocyanidin red

106 TRK1 mutations in the cognitive phenotype we biochemically characterized three TrkA mutations identif

107 Several other ABCFs including biochemically characterized VgaA, LsaA and MsrE confer r

108 ers of clades 1-3 have been structurally and biochemically characterized, but the fourth clade, found

109 the proteins encoded by this locus have been biochemically characterized.

110 ditional lethal mutants were genetically and biochemically characterized.

111 study, Cape gooseberry PPO was isolated and biochemically characterized.

112 deciphering LD TAG composition in different biochemically complex samples with submicrometer spatial

113 thors use reverse immunology to predict, and biochemically confirm, NPM1-derived neoepitopes (DeltaNP

114 The primary outcome was biochemically confirmed 7-day point prevalence tobacco a

115 Adults with biochemically confirmed PHPT who received primary care w

116 Six-month biochemically confirmed quit rates were 34.5% (n = 51 in

117 medication advice resulted in higher 6-month biochemically confirmed quit rates.

118 d topology of Mfn1 and Mfn2 was demonstrated biochemically, confirming that the C-terminal, redox-sen

119 k of common hub metabolites and how they are biochemically connected and only offloaded searches to a

120 y influencing systemic lipid homeostasis and biochemically contributing many metabolites.

121 to occur in mechanically active media can be biochemically controlled to robustly drive morphogenetic

122 ne kinase inhibitory potential in silico and biochemically; cyanidin-3-O-glucoside had one of the hig

123 propose this two-site binding can be used to biochemically define a sigma-1 receptor antagonist.

124 ), contains a compaction region that has the biochemically defined activity of bridging adjacent nucl

125 well documented, but without assays that use biochemically defined components and measure single-pore

126 n of autophagy induces a morphologically and biochemically defined form of cell death termed autosis.

127 (ACAT) triggered rapid internalization of a biochemically defined fraction of cholesterol, termed 'a

128 ifunctionality, but each SMOC has a singular biochemically defined function.

129 titatively explored for the first time using biochemically defined kinetic assays examining rates of

130 STRIP1 is a core component of the biochemically defined mammalian striatin-interacting pho

131 h B-cell SHM, our in vitro data suggest that biochemically defined reconstituted Pol II transcription

132 but pore properties are poorly known because biochemically defined single-pore assays are lacking.

133 ticle classes, some of which are assigned to biochemically defined states.

134 all six human KMT2 complexes, we employed a biochemically defined system reconstituted with recombin

135 pagate and spread is not known, nor are they biochemically defined.

136 ation and Hedgehog signaling are driven by a biochemically-defined, small fraction of membrane choles

137 ntermediate formed before lipidation, and we biochemically demonstrate that ATG4B can cleave LC3B-ATG

138 Here, we biochemically demonstrate that the HA antigenic site B o

139 ad PhoX and PhoD implies the potential for a biochemically dependant interplay between oceanic zinc,

140 We built a biochemically detailed model of post-synaptic plasticity

141 tially attributed to technical challenges in biochemically determining polysaccharide cargo in specif

142 in cytoskeleton consists of structurally and biochemically different actin filament arrays.

143 ininae), O.fultoni has a morphologically and biochemically distinct bioluminescent system which evolv

144 In support, we reveal the existence of two biochemically distinct DAXX-containing complexes: the AT

145 in which individual faces are established as biochemically distinct domains by endomembrane trafficki

146 ow sequence encodes these differences, since biochemically distinct motors often have nearly indistin

147 ty-based probe-labelled enzymes isolated was biochemically distinct, with different enzyme kinetic pr

148 ack of cis, medial, trans cisternae that are biochemically distinct.

149 t with the ancestral hosts in ways which are biochemically distinct.

150 Biochemically, Dok3 recruited protein phosphatase 1 (PP1

151 Spores are usually regarded as biochemically dormant, but our findings demonstrate that

152 FA synthetic capacity with their capacity to biochemically downregulate it.

153 Biochemically, E4 cells exhibited increased tau phosphor

154 Here, we describe the first application of biochemically engineered TET mutants that unlink 5mC oxi

155 To prove their circularity as well as biochemically enrich these transcripts, it has become st

156 vascular networks that are biophysically and biochemically entangled, creating complex three-dimensio

157 These observations suggest that biochemically equivalent organic matter has accumulated

158 lved that the three related RAS isoforms are biochemically equivalent.

159 or M2-15' mutations abutting an anesthetic's biochemically established binding sites were consistentl

160 tors, modulating channel activation via four biochemically established intersubunit transmembrane poc

161 in non-template DNA, corroborating with all biochemically established properties of R-loops.

162 unusual case of a middle-aged clinically and biochemically euthyroid woman with a stable HT, who deve

163 /+), Nnt(+/-), and Nnt(-/-) mouse liver were biochemically evaluated and challenged with exogenous pe

164 These results further biochemically explain how phosphate availability determi

165 Importantly, biochemically extracted pTDP-43 assemblies showed differ

166 used most often by mutations in K-Ras, which biochemically favours the stabilization of active RAF si

167 titative prediction of physicochemically and biochemically feasible phenotypic states.

168 incorporation efficiency is readily measured biochemically from released particles, very little is kn

169 Biochemically, human RAD51 polymerises faster on single-

170 Rnf and Ech activity was also biochemically identified and investigated in membranes o

171 ime-resolved serial crystallography to study biochemically important interactions between biomacromol

172 ation, which plays a role in a wide range of biochemically important processes.

173 es that physically interact in networks near biochemically important regions.

174 /MS was used to identify these neuropeptides biochemically in Cataglyphis fortis.

175 he final step of the urea cycle, and results biochemically in hyperargininemia and the presence of gu

176 to deactivate Galpha, as overexpression of a biochemically inactive variant protein resulted in plant

177 ology of human mesenchymal stem cells during biochemically-induced adipogenic differentiation.

178 RFOs, the individual pathway components are biochemically inefficient.

179 isolated SC-associated muscle fibers within biochemically inert agarose gels tuned to mimic native t

180 This technique is applicable to an array of biochemically inert polymers, and it delivers hundreds o

181 LCA mutants of CCTbeta, T400P and R516H, are biochemically instable and the affinity for the adjacent

182 nt of the nucleolin-14-3-3zeta axis, despite biochemically interacting with both proteins.

183 CBX8 biochemically interacts with TRIM33, and its recruitment

184 The mechanism found was not only biochemically interesting but also points to possible ne

185 Ligand chemotaxis has been biochemically investigated using mammalian and model sys

186 We used cdN-conjugated beads to biochemically isolate host receptors for bacterial cdNs,

187 Cellular compartments that cannot be biochemically isolated are challenging to characterize.

188 itatory synaptic input onto neurons, and are biochemically isolated from the parent dendritic shaft b

189 achieve near-atomic-resolution structures of biochemically isolated macromolecular complexes.

190 ar mechanism underlying this observation, we biochemically isolated reporter-tagged Mbp mRNA granules

191 To address this question, we biochemically isolated skeletal muscle proteins that ass

192 To test this hypothesis, we biochemically isolated skeletal muscle proteins that ass

193 By biochemically isolating postinitiation complexes stalled

194 Biochemically, K50Q- and K61Q-actin, when bound to CAP2,

195 syltransferase-mediated tagging platform, to biochemically label and capture antigen-specific T cells

196 ncy virus (HIV) proteins, are informative of biochemically linked networks of interacting sites that

197 hough pathogenic LCs have been characterized biochemically, little is known about the biology of amyl

198 Biochemically, Lmods differ from Tmods, acting as powerf

199 tative mass spectrometry-based proteomics to biochemically map the long-term effects of Meth within t

200 Biochemically, marked accumulation of CYP7B1 substrates

201 on model postulates that transient cisternae biochemically mature to ensure anterograde transport.

202 via vesicles and another one where cisternae biochemically mature to ensure anterograde transport.

203 Our study found discordant associations of biochemically measured and genetically predicted differe

204 We examined the associations of biochemically measured lipids with stroke in a nested ca

205 l-Th biochemically modulates various anti-neoplastic agents b

206 Biochemically mutant mice showed impaired electron trans

207 amoxifen serum assessment, patients who were biochemically nonadherent had significantly shorter DDFS

208 ucturally characterized 101 Mass2Motifs with biochemically or chemically relevant substructures.

209 Biochemically overt primary aldosteronism was diagnosed

210 responding adjusted prevalence estimates for biochemically overt primary aldosteronism were 11.3% (CI

211 and negative predictive value for detecting biochemically overt primary aldosteronism.

212 These cluster phenotypes were biochemically perturbed by using drugs, biasing toward t

213 se leads were optimized to identify a highly biochemically potent, PKMT-selective, and cell-active ch

214 To biochemically probe the function of metal ion interactio

215 Livers from each animal were biochemically profiled using UHPLC-QTof-MS in ESI+ mode

216 fferentially glycosylated CD4 receptors were biochemically purified and used in neutralization assays

217 Biochemically, R-loops act as intrinsic Pol II promoters

218 As RONS are biochemically reactive, the difficulty lies in finding e

219 Using purified Xenopus laevis proteins we biochemically reconstitute branching microtubule nucleat

220 ng that it is possible in principle to fully biochemically reconstitute the sequential processes of H

221 We biochemically reconstituted a 12-component signaling pat

222 Here we have biochemically reconstituted key elements of this pro-cro

223 To understand this movement, we biochemically reconstituted LAT condensates with actomyo

224 We biochemically reconstituted NPC core protomers and eluci

225 Using biochemically reconstituted systems, we show that two tr

226 e the binding properties of the receptor, we biochemically reconstituted the GLR3.3 ligand-binding do

227 ay for [2Fe-2S] cluster biosynthesis that we biochemically reconstituted using purified mitosomal ISC

228 Biochemically, RECQ5 alleviates the inhibitory effect of

229 ethods: The study included 102 patients with biochemically recurrent PC after radical prostatectomy u

230 promising diagnostic tool in the work-up of biochemically recurrent PC, given the high positivity ra

231 ho underwent (68)Ga-PSMA11 PET/CT because of biochemically recurrent PC.

232 tection of prostate cancer (PCa) in men with biochemically recurrent PCa.

233 Biochemically recurrent prostate cancer (BCR) is the mai

234 1)C-choline PET/CT detection performance for biochemically recurrent prostate cancer (PCa) in a large

235 ormance of (11)C-choline PET/CT in detecting biochemically recurrent prostate cancer (PCa) in a large

236 herapy (IADT) is an attractive treatment for biochemically recurrent prostate cancer (PCa), whereby c

237 ecific membrane antigen ((68)Ga-PSMA-11) for biochemically recurrent prostate cancer at a tertiary me

238 Imaging of biochemically recurrent prostate cancer has been establi

239 ET/CT imaging offers high detection rates in biochemically recurrent prostate cancer patients and is

240 ET/CT imaging offers high detection rates in biochemically recurrent prostate cancer patients; and is

241 Conclusion Patient-level detection rates for biochemically recurrent prostate cancer were greater for

242 (18)F-fluciclovine images from subjects with biochemically recurrent prostate cancer with acceptable

243 on the intended management of patients with biochemically recurrent prostate cancer.

244 with pelvic multiparametric MRI in men with biochemically recurrent prostate cancer.

245 utions in this small cohort of patients with biochemically recurrent prostate cancer.

246 o-controlled study enrolled 10 patients with biochemically recurrent prostate cancer.

247 y is how cells respond to stress signals and biochemically regulate apoptosis.

248 (PSMA)-targeted PET agent, in patients with biochemically relapsed prostate cancer after primary loc

249 ific sex pheromone, consisting of a blend of biochemically related components, to which males are att

250 Although biochemically related, C(4) and crassulacean acid metabo

251 and starch in plants are evolutionarily and biochemically related.

252 tion data from a given experiment to extract biochemically relevant features in an unsupervised manne

253 cluding membrane structure and function, and biochemically relevant for their exquisite enzymatic cyc

254 viously, we presented MS2LDA, which extracts biochemically relevant molecular substructures ("Mass2Mo

255 ndwork for animating crystal structures with biochemically relevant motions.

256 By biochemically replicating conditions necessary for antib

257 We introduce a new biochemically responsive Mn-based MRI contrast agent tha

258 a redox-active iron complex, Fe-PyC3A, as a biochemically responsive MRI contrast agent.

259 omplexes represent a new design paradigm for biochemically responsive MRI contrast agents.

260 Biochemically, Rrh(-/-) mice had approximately 2-fold hi

261 PET requires biochemically selective radiotracers to realize full pot

262 e farnesyltransferase Fntb, which mediates a biochemically similar process of protein farnesylation,

263 ity-changing switch for two structurally and biochemically similar signaling molecules.

264 the same sites and physically interact as a biochemically stable complex.

265 nserved C-terminal portion of the peptide is biochemically stable in human serum, and most serum-stab

266 biomarker to identify, among clinically and biochemically stable liver transplant recipients, a subs

267 Here we have designed and biochemically tested a range of chimeric enzymes, substi

268 We then synthesized, purified, and biochemically tested the carboxylation rates of 143 repr

269 We demonstrate biochemically that irreversible DSBs are generated by su

270 We then show biochemically that MOAG-2/LIR-3 can also catalyze the ag

271 We demonstrated biochemically that PotriKCS1 elongates monounsaturated f

272 Biochemically, the cells of individuals with SRS accumul

273 hough MMB has been extensively characterized biochemically, the requirement for MMB in tumorigenesis

274 such mutants and validated structurally and biochemically their binding to 8-nt RNA elements.

275 unicate with each other, both physically and biochemically, thereby facilitating the functions of thi

276 Biochemically, these two mutations (N64I and S67 deletio

277 Biochemically, this lincRNA fine-tunes cellular sterol/s

278 s a V-1 homolog that we show is very similar biochemically to mouse V-1.

279 s, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength of Hedgehog signa

280 ous gene, up-regulated ~15-fold, coded for a biochemically uncharacterized starch binding domain-cont

281 tance to mycobacterial disease, has remained biochemically uncharacterized.

282 iallelic mutations in LYRM7 in patients with biochemically unclassified leukoencephalopathy.

283 nal effector functions of T helper cells are biochemically uncoupled.

284 nctions of mouse T helper 1 (T(H)1) cells by biochemically uncoupling these two processes.

285 rbon preservation: selective preservation of biochemically unreactive compounds(4,5) and protection r

286 any are highly conserved across species, are biochemically unstable upon purification, and possess de

287 Here, we demonstrate biochemically using Xenopus laevis egg extracts that the

288 se chemoproteomic platforms, we identify and biochemically validate important transcriptional factors

289 These binding sites were biochemically validated by EMSA-FRET analysis and valida

290 We biochemically validated doublecortin (DCX), also an X-li

291 We biochemically validated the screen by demonstrating that

292 s point prevalence abstinence (7-day recall, biochemically validated using expired carbon monoxide) a

293 Computational predictions, which were biochemically validated, show an extensive overlap of re

294 Smoking status was biochemically verified (exhaled air CO and serum cotinin

295 We also assessed biochemically verified 7-day abstinence at 3, 6, and 18

296 tances of cross-pathway regulation, which we biochemically verified.

297 ich fungi acquire, utilize, and control this biochemically versatile trace element.

298 the preQ(1)-II riboswitch-a structurally and biochemically well-characterized HL(out) pseudoknot that

299 on approaches revealed that SERK1 interacted biochemically with EMS1.

300 en that they were established and delineated biochemically with only a few model organisms.