ライフサイエンスコーパス: biofilm

1 at both bacterial-cell and community levels (biofilms).

2 is faster than the rate of PYO loss from the biofilm.

3 the peak of sporulation to the middle of the biofilm.

4 t method being the formation of a protective biofilm.

5 e compared to desorption and efflux from the biofilm.

6 acteria adhere and form a robust aggregating biofilm.

7 latively quantify periodontopathogens in the biofilm.

8 for horizontal gene transfer of ARGs in the biofilm.

9 largely depends on the presence of a mature biofilm.

10 nd inhibition and eradication of C. albicans biofilms.

11 eliminate resistant pathogens and preformed biofilms.

12 ed from 400 subjects) formed moderate/strong biofilms.

13 yphimurium and Newport also formed floccular biofilms.

14 minates the ability of both microbes to form biofilms.

15 ommunities rather than mono- or dual-species biofilms.

16 composition and pathogenic potential of oral biofilms.

17 potential to prevent or eradicate bacterial biofilms.

18 tem processes and services mediated by algal biofilms.

19 t with electroceutical treatment on the lawn biofilms.

20 ric cell classifications in multi-population biofilms.

21 lms compared to those in tin and groundwater biofilms.

22 vity against gram-positive and gram-negative biofilms.

23 overcome anti-microbial resistance in these biofilms.

24 nt owing to its exceptional capacity to form biofilms.

25 ment for long periods, presumably by forming biofilms.

26 sumption of Streptococcus mutans (S. mutans) biofilms.

27 eir hosts as multicellular structures called biofilms.

28 nic cultures, garlic has no activity against biofilms.

29 cture and function of Pseudomonas aeruginosa biofilms.

30 hallenging persisters as well as established biofilms.

31 increasing biocurrent ~150-fold over control biofilms.

32 mpaired in its ability to form Pel-dependent biofilms.

33 d D-Glu was studied on Staphylococcus aureus biofilms.

34 onjugants persisted much longer in anaerobic biofilms (~1.0 log reduction, after 72 h).

35 t an esthetic concern but also predispose to biofilm accumulation and subsequent initiation and progr

36 We have found the potent anti-biofilm activity of Bald's eyesalve cannot be attributed

37 The anti-biofilm activity of D-Asp and D-Glu was studied on Staph

38 d pH-cycling experiment and a saliva-derived biofilm aging model.

39 transcript levels increased in M. smegmatis biofilms along with that of USP(4207), suggesting that U

40 However, stream biofilms also have the potential to accumulate pesticide

41 ic oxygen gradients, found in many bacterial biofilms, also extends to the fungal kingdom.

42 Biofilm, an aggregation of bacteria, fungi, algae, and p

43 t strain, HS069Deltacap produced more robust biofilm and adhered equivalently to 3D4/31 cells; howeve

44 Samples of subgingival biofilm and gingival crevicular fluid were collected at

45 stress, was inhibited in its ability to form biofilm and had reduced survival in epithelial cells.

46 e water chemistry can disrupt pipe scale and biofilm and negatively impact water quality at the distr

47 tionships were spatially distributed between biofilm and planktonic phases of the reactor.

48 jected to proteolytic cleavage in the colony biofilm and that only the first 57 amino acids of the 25

49 ce of Pseudonocardia (Actinobacteria) in the biofilm and the absence of Limnobacter (Betaproteobacter

50 Quorum sensing (QS) controls biofilm and virulence factors production.

51 vely to the ability of K. pneumoniae to form biofilms and adhere to different host tissues.

52 ylococcus epidermidis are capable of forming biofilms and are important human pathogens.

53 well as the formation of multicellular swarm biofilms and fruiting bodies.

54 re inoculated with human peri-implant plaque biofilms and mechanical antimicrobial interventions were

55 ween primary human neutrophils and S. aureus biofilms and provides insight into how S. aureus evades

56 The ability of A. baumannii to form biofilms and resist oxidative stress in the respiratory

57 , chemical, and biological stresses, support biofilms, and play critical roles in interactions betwee

58 nt that is rapidly bacteriolytic, eradicates biofilms, and synergizes with antibiotics.METHODSIn this

59 ed knowledge in the context of polymicrobial biofilms, and the need for more in-depth analyses of the

60 he polymicrobial community across the intact biofilm architecture remains sparse.

61 , and the result of, A. fumigatus late-stage biofilm architecture.

62 3-amino acid protein are required for colony biofilm architecture.

63 anisms associated with Staphylococcus aureus biofilms are becoming better understood.

64 Biofilms are dense bacterial colonies that may adhere to

65 es on which a variety of clinically-relevant biofilms are grown.

66 Vibrio cholerae biofilms are hyperinfectious, and biofilm formation and

67 Biofilms are structured microbial communities adhered to

68 faces, which is particularly true for mature biofilm assemblages.

69 A mutant lacking endocarditis- and biofilm-associated pili (Ebp) exhibited a decreased abil

70 We also show that the persistence of biofilm bacteria trapped in NETs is facilitated by S. au

71 sms of EPS matrix formation, and its role in biofilm biology, function, and microenvironment are bein

72 ared with that of DeltasarA infection, wound biofilm burden was significantly higher in response to D

73 inhibited S. epidermidis but did not inhibit biofilms by Pseudomonas aeruginosa or Bacillus subtilis,

74 ruginosa or Bacillus subtilis, and inhibited biofilms by S. aureus to a lesser extent.

75 n abundance of T. forsythia in the bacterial biofilm can cause local inhibition of fibrinolysis, whic

76 Pathogenic bacterial biofilms can be life-threatening, greatly decrease patie

77 In addition, the detached biofilm cells are found sensitized to bactericidal antib

78 ells revealed two distinct fates: one set of biofilm cells expanded ballistically outward, while the

79 ressors on OMV contents and composition from biofilm cells of the plant health-promoting bacterium Ps

80 0 nm diameter OMVs from control and stressed biofilm cells.

81 Biofouling was tested using biofilms collected from the influent and effluent of a t

82 mental filtering is elevated in sediment and biofilm communities compared with free-living and partic

83 shifting towards investigating multispecies biofilm communities rather than mono- or dual-species bi

84 tly less diverse than the fixed sediment and biofilm communities, the latter two communities displaye

85 ions of metabolites were generated by tongue biofilm compared to planktonic salivary bacteria.

86 s and connections were found in the silicate biofilms compared to those in tin and groundwater biofil

87 ith lead tetroxide (minium) was covered by a biofilm consisting of a network of filaments and other s

88 firmed that extracellular fibrils from these biofilms contain Aap.

89 ventional oral hygiene have shown to improve biofilm control during PMT leading to a better periodont

90 curvature reduced microcolony formation and biofilm density.

91 ecies, and Pel may therefore be a widespread biofilm determinant.

92 Biofilms develop from bacteria bound on surfaces that gr

93 ion in different concentrations against oral biofilms developed on titanium surface.

94 and control motility, fimbriae, hyphae, and biofilm development as well as virulence characteristics

95 lteration in sugar metabolism that restricts biofilm development by S. mutans.

96 r understanding of community composition and biofilm development in marine ecosystems, we critically

97 (7) tetradecamer that is required for proper biofilm development.

98 eptidase active site uniquely contributes to biofilm development.

99 play a key role in pattern formation during biofilm development.

100 zed data set derived from DNA extracted from biofilms dislodged from the surfaces of resected arthrop

101 c PNAG oligosaccharide analogs, and in vitro biofilm dispersal assays.

102 factors and provide important insights into biofilm dispersal by V. fischeri.

103 nterventions aimed at modulating V. cholerae biofilm dispersal to ameliorate disease.

104 es: cell attachment, biofilm maturation, and biofilm dispersal.

105 ted with EAEC strains exposed a differential biofilm distribution, greater penetration of the mucus l

106 In vivo, biofilm eDNA can also support rapid electron transfer be

107 dy disrupts the biofilm structure, enhancing biofilm eradication by antibiotics and immune cells.

108 quired for different applications, including biofilm eradication.

109 Bacterial biofilms, especially those associated with implanted med

110 A common assumption is that biofilms exclusively interact with their hosts biochemic

111 agreement with experimental measurements of biofilm expansion dynamics, and it accurately predicts t

112 However, the ultrastructure of biofilms exposed to these species has not been studied.

113 in appearance to those reported in S. mutans biofilm extracellular matrices, are reconstituted by co-

114 o generate a thermal gradient in relation to biofilm for active thermography (AT).

115 l interventions were applied on the Ti-bound biofilms for 30 seconds each: (1) rotary nylon brush; (2

116 Specifically, how biofilms form on soft, tissue-like materials remains unk

117 t stains of S. aureus with varying degree of biofilm formation ability was studied in an established

118 ovides detailed insights into S. epidermidis biofilm formation and architecture that improve our unde

119 wn to be necessary and sufficient for mature biofilm formation and catheter infection.

120 o cholerae biofilms are hyperinfectious, and biofilm formation and dispersal are considered central t

121 The decision between biofilm formation and dispersal is mediated by LapD, a c

122 TapA is a secreted protein also needed for biofilm formation and helps in vivo TasA-fibre formation

123 ing dentifrices are effective in controlling biofilm formation and maintaining gingival health; howev

124 ialdehyde (MDA) production and a decrease in biofilm formation and metabolic activity of the bacteria

125 roles ranging from plasmid stabilization to biofilm formation and persistence.

126 The deletion of mpaR increased biofilm formation and reduced pyocyanin production.

127 pographies with the optimized design prevent biofilm formation and remove established biofilms of uro

128 Overproduction of LapG inhibited biofilm formation and, unlike the wild-type parent, a De

129 rived from LBG supported better Lactobacilli biofilm formation as compared to KG hydrolysate containi

130 Biofilm formation by bacterial pathogens is associated w

131 ecent rise in antibiotic drug resistance and biofilm formation by microorganisms has driven scientist

132 ed that recombinant SPLUNC1 protein inhibits biofilm formation by Nm, and impedes Nm adhesion and inv

133 s the current understanding of LapA-mediated biofilm formation by P. fluorescens and discusses severa

134 Biofilm formation by P. fluorescens occurs through the l

135 Biofilm formation by Vibrio cholerae facilitates environ

136 m sensing inhibitors (QSIs) interfering with biofilm formation can thus complement antibiotics.

137 between isolates and observed that increased biofilm formation correlated with mutations in the putat

138 The effect of both IATs on biofilm formation correlated with the presence of differ

139 bacteria use AHL to coordinate virulence and biofilm formation in a cell density-dependent manner; th

140 s, leading to efficient cell aggregation and biofilm formation in homogenous populations.

141 Biofilm formation is regulated by 3',5'-cyclic diguanyla

142 ily, but its potential role in Pel-dependent biofilm formation is unknown.

143 sing from acquired resistance and/or through biofilm formation necessitate the development of innovat

144 assays revealed that YrInv and YrIlm promote biofilm formation on different abiotic substrates.

145 oids, but the role of individual PSMs during biofilm formation remains poorly understood and the mole

146 Our results indicate that Pel-dependent biofilm formation requires a UDP-GlcNAc C4-epimerase tha

147 Ms have evolved to ensure fast and efficient biofilm formation through cooperation between individual

148 e expression of pelX under these conditions, biofilm formation was unaffected in a DeltapelX strain.

149 A damage, and control of central metabolism, biofilm formation, acid stress resistance, and other fun

150 s virulence, host colonization, sporulation, biofilm formation, among others.

151 ion in SPLUNC1 affecting mucosal attachment, biofilm formation, and invasion of mucosal epithelial ce

152 peptides inhibits bacterial growth, prevents biofilm formation, and leads to the recruitment of neutr

153 significantly enhanced intestinal adherence, biofilm formation, and pro-inflammatory interleukin-8 se

154 cteria have roles in cell-to-cell signaling, biofilm formation, and stress responses.

155 ntion of bacterial attachment and subsequent biofilm formation, and thus are promising in circumventi

156 lR deletion strain is defective in motility, biofilm formation, and tumorigenesis of potato discs.

157 Agd3, leads to defects in GAG deacetylation, biofilm formation, and virulence.

158 both early and late stages of S. epidermidis biofilm formation, and we confirmed that extracellular f

159 ple sugars, fungal cell wall deconstruction, biofilm formation, antimicrobials biosynthesis, and meta

160 ts application to studies of cell growth and biofilm formation, automated in silico control of optoge

161 This reduced acute virulence and enhanced biofilm formation, both of which are phenotypic changes

162 processes in S. aureus, including autolysis, biofilm formation, capsule synthesis and virulence.

163 e K treatment uncoupled electron uptake from biofilm formation, likely through proteolytic degradatio

164 , second-messenger turnover, quorum sensing, biofilm formation, motility, host-pathogen and beneficia

165 tion of virulence-related genes that control biofilm formation, streptolysin S (SLS)-mediated hemolys

166 -regulated by acylation but are required for biofilm formation, thus providing a defined role for thi

167 er important for major phenotypes, including biofilm formation, virulence, and antibiotic tolerance.

168 trical signals, which represent the onset of biofilm formation, were dynamically detected by the DGTF

169 Pseudomonas aeruginosa are characterized by biofilm formation, which effectively enhances resistance

170 virulence, interbacterial interactions, and biofilm formation.

171 phenotypes including virulence, motility and biofilm formation.

172 a would promote C difficile colonization and biofilm formation.

173 hromosome I), only the latter contributed to biofilm formation.

174 lack of serine results in the initiation of biofilm formation.

175 lity, antagonism against other microbes, and biofilm formation.

176 system with spacers during the first 4 h of biofilm formation.

177 We also found differences in biofilm-formation capability between isolates and observ

178 yloid-binding activity (mAb 3H3) can disrupt biofilms formed by Salmonella enterica serovar Typhimuri

179 yloid fibers are important components of the biofilms formed by the Enterobacteriaceae family.

180 Microscopic analysis of biofilms formed in vitro revealed that S. maltophilia fo

181 s and interkingdom communities within intact biofilms formed on teeth of toddlers with caries.

182 nazole combination significantly reduced the biofilm-forming abilities of the tested Candida species

183 g degree (DeltarexB > USA300 > DeltasarA) of biofilm-forming ability were used to infect full-thickne

184 antibiotic resistance genes characterized by biofilm-forming and human-microbiome-influenced environm

185 f S. epidermidis to antibiotic killing under biofilm-forming conditions.

186 we report a reference genome for the marine biofilm-forming diatom Seminavis robusta, showing that g

187 r contribute to LasR- strain fitness even in biofilms grown in normoxic conditions.

188 resent a study of developing Vibrio cholerae biofilms grown on agar substrates in which the spatiotem

189 In vitro biofilm-grown cells activate expression of the virulence

190 h the abundance and localization patterns of biofilm-grown cells differ from that of planktonic-grown

191 on is also higher in vivo when infected with biofilm-grown cells, and modulation of their regulation

192 Here we show that biofilm-grown cells, irrespective of the surfaces on whi

193 higher bacterial burdens when infected with biofilm-grown rather than planktonic PAO1; Scnn1b-Tg mic

194 ntitatively captured by a continuum model of biofilm growth against substrate friction.

195 light on the mechanisms of G. sulfurreducens biofilm growth and suggests the possible existence of a

196 Therefore, inhibiting biofilm growth is the key to completely addressing the c

197 fumigatus forms biofilms in vivo, and during biofilm growth it has reduced susceptibility to all thre

198 This platform enables biofilm growth, quantification, and treatment as in a co

199 strains with Cd(II) led to the production of biofilm, H(2)S, and succinic acid (SA), and Cd(II) was a

200 The importance of microbial biofilms has been well-recognized for several decades, a

201 The study of oral biofilms has revealed complex composition, spatial organ

202 V. cholerae biofilms have been shown to be hyperinfective, but the m

203 found that P. protegens forms Pel-dependent biofilms; however, despite expression of pelX under thes

204 their regulation is sufficient to cause the biofilm hyperinfectivity phenotype.

205 ) better physical characterization of marine biofilms, (II) inclusion of relevant controls, (III) stu

206 The ultrastructure changes in the lawn biofilms imaged using transmission electron microscopy d

207 d by colony forming units (CFU mL(-1) ), and biofilm images were acquired by confocal laser scanning

208 networks (CNNs) are trained using simulated biofilm images with experimentally realistic SBRs, cell

209 ution in the presence of mature phototrophic biofilm in a rotating annular bioreactor.

210 ion of SarA and a reduced capacity to form a biofilm in both strains.

211 . coli host (EcoFJ1) in the liquid phase and biofilms in bioreactors.

212 Our data also highlight the role of biofilms in creating spatially distinct geochemical nich

213 the first step in the formation of microbial biofilms in environmental technology, and there is high

214 wild-type parent, a DeltalapG mutant formed biofilms in vitro.

215 fungal pathogen Aspergillus fumigatus forms biofilms in vivo, and during biofilm growth it has reduc

216 neity when analysing synthetic multi-species biofilms, in vitro, and the importance of multi-scale ap

217 the human biofilm model supported a diverse biofilm including known peri-implant pathogens.

218 xygen levels toward the base of A. fumigatus biofilms increases antifungal drug resistance.

219 Tensile strength of the biofilm infected skin was compromised supporting the not

220 notion that healed wounds with a history of biofilm infection are likely to recur.

221 Biofilm infection caused degradation of cutaneous collag

222 vides maiden evidence that chronic S. aureus biofilm infection in wounds results in impaired granulat

223 tablished preclinical porcine model of wound biofilm infection.

224 oviding rapid readout in minutes for chronic biofilm infections.

225 esistance.New generation antibiotics such as biofilm inhibitors and quorum sensing inhibitors are bei

226 Dental plaque biofilm is considered to be the underlying cause of peri

227 Here we show that EPS of Salmonella biofilms is a cooperative trait whose benefit is shared

228 ides, the influence of water shear forces on biofilms is dual.

229 rug-resistant niches in bacterial and fungal biofilms is thus a promising target for improving antimi

230 This work defines the starting point for new biofilm/lectin-targeted drugs to modulate antibiotic pro

231 The biofilm lifecycle occurs in three stages: cell attachmen

232 hanism to increase fitness in planktonic and biofilm lifestyles.

233 observed that viable F. nucleatum assembles biofilm-like structures in the tumor spheroid microenvir

234 ichia coli and Salmonella enterica produce a biofilm matrix composed primarily of the exopolysacchari

235 yanin (PYO) and phenazine carboxamide in the biofilm matrix is facilitated by eDNA binding.

236 s up the expression of genes associated with biofilm matrix production (CsgD pathway), epithelial inv

237 the presence of different biopolymers in the biofilm matrix, including extracellular DNA, RNA and pro

238 ecessary for cells to escape from the porous biofilm matrix.

239 adients inevitably arise during A. fumigatus biofilm maturation and are both critical for, and the re

240 ts not only contribute to filamentous fungal biofilm maturation but also drive resistance to antifung

241 r aggregation, while groEL1 was required for biofilm maturation in M. smegmatis.

242 cle occurs in three stages: cell attachment, biofilm maturation, and biofilm dispersal.

243 Furthermore, the biofilm microbiomes at electrodes were studied using the

244 lained by microbes adopting a drug-resistant biofilm mode of growth during infection.

245 Sequencing revealed that the human biofilm model supported a diverse biofilm including know

246 In this study, we utilized a three species biofilm model to understand the impact of S. parasanguin

247 e packing media (polyurethane foam without a biofilm) obtained using microtomography with computation

248 Single and multi-species biofilms of Porphyromonas gingivalis, Fusobacterium nucl

249 ent biofilm formation and remove established biofilms of uropathogenic Escherichia coli (UPEC), Pseud

250 ibrin (L-PRF), on a mature oral multispecies biofilm on a rough titanium surface.

251 tat types (free-living, particle-associated, biofilm on benthic stones and rocks, and sediment).

252 ke is dependent on direct cell contact via a biofilm on the cathode surface rather than through secre

253 ed for the imaging of Pseudomonas aeruginosa biofilms on metallic surfaces using an infrared camera.

254 C difficile was found to colonize and form biofilms on MUC2-coated coverslips, and 16S rRNA sequenc

255 copy verified the presence of staphylococcal biofilms on the skin of MPAACH children.

256 materials give them the capability to target biofilms, overcoming recalcitrant infections.

257 findings may suggest a trophic link between biofilm PFASs and aquatic insect PFASs.

258 mechanistic link between filamentous fungal biofilm physiology and contemporary antifungal drug resi

259 e algae (CCA) and their associated microbial biofilms play important roles in determining the settlem

260 The phototrophic biofilm presents a non-negligible highly labile metal po

261 equired for the assembly and architecture of biofilms produced by a wide variety of microorganisms.

262 of RNA-Seq, we monitored the early steps of biofilm production in M. bovis BCG, to distinguish inter

263 In support of a stepwise process regulating biofilm production in mycobacteria, it was shown elsewhe

264 ndent expression of genes that contribute to biofilm production in slow-growing mycobacteria.

265 ips, and 16S rRNA sequencing showed a unique biofilm profile with substantial cocolonization with Fus

266 ssion of the c-di-GMP and calcium-regulated, biofilm-promoting brp exopolysaccharide was IamA-depende

267 S aureus and S epidermidis colonization and biofilm propensity and determine their associations with

268 balance between these two species, and their biofilm propensity, has important implications for AD.

269 ike what has been observed for amyloidogenic biofilm proteins from other bacteria, which typically us

270 was achieved in a lab-scale upflow membrane biofilm reactor (MBfR) by coupling anammox with nitrite/

271 f reduction in both single and multi-species biofilms, respectively, when compared to the control (sa

272 a major structural determinant of bacterial biofilms responsible for persistent and nosocomial infec

273 ) counts were higher in p-trap and tail pipe biofilm samples from HCP compared to PR sinks (2.77 +/-

274 pollutant levels both in stream water and in biofilm samples, and to shifts in the community structur

275 Insect and spider Se increased with biofilm Se (p = 0.004, p = 0.003), reaching 95 and 26 mu

276 Biofilm Se concentration increased (p = 0.006) with mini

277 showed downregulation of genes underpinning biofilm signaling (luxS) and regulation (bssR) by up to

278 Biofilm-specific antibiotic delivery could locally incre

279 We emphasize that targeting biofilm-specific conditions such as the matrixome could

280 the planktonic growth, colony morphology and biofilm structuration, as well as on low temperature tol

281 The antibody disrupts the biofilm structure, enhancing biofilm eradication by anti

282 ans is largely due to its propensity to form biofilms, surface-adherent bacterial accumulations that

283 sanguinis disrupts S. mutans and C. albicans biofilm synergy in a contact and H(2)O(2)-independent ma

284 etected, 20 were detected more frequently in biofilm than in sediment and 10 with equal frequency.

285 oids detected, 7 occurred more frequently in biofilm than sediment.

286 ining cyanobacteria within natural beachrock biofilms that are widespread on (sub)tropical coastlines

287 its metabolic diversity and ability to form biofilms, this Gram-negative nonfermenting bacterium can

288 rculosis and M. smegmatis form drug-tolerant biofilms through dedicated genetic programs.

289 omprise the structural scaffold of S. aureus biofilms through self-assembly into functional amyloids,

290 ced susceptibility of bacteria embedded in a biofilm to existing antimicrobial agents.

291 converge to promote the ability of S. aureus biofilms to evade killing by neutrophils.

292 Subsequently, the bacteria disperse from the biofilm via an unknown mechanism and enter through pores

293 l infection resulting from dysbiosis of oral biofilms, we hypothesized that sucrose can introduce a m

294 These biofilms were grown from groundwater (a drinking water s

295 The dominant populations in the cathode biofilms were shaped by the cathode materials.

296 Biofilms were treated with ozonized saline solution at d

297 increase the diversity of the saliva-derived biofilms, which implied that the novel materials could h

298 d that S. maltophilia formed well-integrated biofilms with P. aeruginosa, and these organisms colocal

299 dida albicans is known to form polymicrobial biofilms with various Streptococcus spp., including miti

300 actor fluid promoted the growth of a surface biofilm within the artificial slope, which naturally agg