ライフサイエンスコーパス: biologic

1 59 operations (3 polytetrafluoroethylene; 56 biologic).

2 lar triamcinolone and participants receiving biologics.

3 ficiency for hydrophilic small molecules and biologics.

4 from small molecules and peptidomimetics to biologics.

5 erging as a valuable tool in the analysis of biologics.

6 c arthritis who were naive to treatment with biologics.

7 d thus often offer important advantages over biologics.

8 ation and thus therapeutic efficacy of these biologics.

9 nt differences were found between classes of biologics.

10 to select patients for treatment with type 2 biologics.

11 o COVID-19 in severe asthmatics treated with biologics.

12 Among 9911 patients treated with biologics, 10 923 surgical procedures were identified.

13 ents from 25 countries, 71% were receiving a biologic, 18% were receiving a nonbiologic, and 10% were

14 rugs (1984-2018), generic drugs (1970-2018), biologics (1984-2018), and vaccines (1998-2018); special

15 Chief among them is how to deliver large biologics across the highly restrictive blood-brain barr

16 Small-molecular entities and biologics acting on various stemness signaling pathways,

17 changes to specific gene profiles and likely biologic activities occurring in healthy and diseased gi

18 profile together with signs of clinical and biologic activity as a single agent in patients with R/R

19 ent strategies aimed at interfering with its biologic activity as well as their potential in a precis

20 To explore the biologic activity of EVs in vivo, we used a mouse model

21 us inflammation to determine the payload and biologic activity of EVs released into the microenvironm

22 epertoire of a cell regulates EV payload and biologic activity that affects outcomes in tissue repair

23 (177)Lu and (90)Y offer specific radiologic-biologic advantages in dedicated clinical situations.

24 Biologic agents (also termed biologics or biologicals) a

25 Overall, eyes treated with biologic agents after failure of treatment with corticos

26 ized as a potential limitation to the use of biologic agents at an early stage in their development,

27 Despite the introduction of numerous biologic agents for the treatment of rheumatoid arthriti

28 Biologic agents have become a core component of therapeu

29 rthritis, and it enhances the effect of most biologic agents in RA.

30 However, biologic agents interfering with monoclonal antibodies i

31 numerous, the development of a new class of biologic agents that target airway type 2 inflammation h

32 nophilic esophagitis can now be treated with biologic agents that target specific immune pathways, an

33 line immunosuppression drug and treated with biologic agents who were treated at Moorfields Eye Hospi

34 e specificity and generally high affinity of biologic agents, these therapeutics have been used by rh

35 New, fast-acting T2-targeting biologics (already used for preventing asthma exacerbati

36 Participants treated with biologics also had a 2-point or greater decrease (improv

37 We have developed a new IL-2-based biologic, an IL-2/CD25 fusion protein, with greatly impr

38 Results: Grade 3-4 biologic and clinical toxicities occurred in 24% of pati

39 Commonly used IBD medications, both biologic and nonbiologic, do not significantly impact AC

40 While several biologic and small molecule therapeutics targeting this

41 therapy) vs step-up therapy (acceleration to biologic and/or immunomodulator therapy only after failu

42 e the potential to broaden patient access to biologics and provide cost savings for health care syste

43 ation of different biologics, or mixtures of biologics and small molecule therapeutics.

44 arative efficacy of top-down (upfront use of biologics and/or immunomodulator therapy) vs step-up the

45 for equitable access to medicines (including biologics) and medical devices; 3.

46 nalyses were performed to identify clinical, biologic, and imaging features associated with the MTM-H

47 cant hematologic toxicity, and the clinical, biologic, and ultrasound test results confirmed the succ

48 erstood, and treatment with corticosteroids, biologics, and surgical intervention are the usual thera

49 nation with cytotoxic chemotherapy regimens, biologics, and/or radiotherapy.

50 th antiangiogenic therapy as a promising new biologic approach to combat this lethal disease.

51 Combination drugs are biologics are also discussed.

52 Novel therapies such as type 2 targeting biologics are emerging treatment options for patients wi

53 he drug development pipeline as many branded biologics are reaching the end of their market exclusivi

54 In parallel, biologics are revolutionizing severe asthma management,

55 peptides are establishing their place in the biologics arm of drug discovery.

56 al Psoriasis Foundation guidelines recommend biologics as an option for first-line treatment of moder

57 effects on OCS treatment reduction of three biologic asthma treatments.

58 ata and histologic evidence demonstrate that biologic-based techniques are able to promote periodonta

59 oninvasive methods provide insights into the biologic basis of the global immune response to maximize

60 ditional assistance with understanding tumor biologic behavior after achieving a pCR.

61 , underlying genetic defects, histology, and biologic behavior of human HGSCs have been developed.

62 ge design allows each unit to be loaded with biologic cargo of different compositions, thus enabling

63 tment results in measurable radiographic and biologic changes in estrogen receptor (ER)-positive DCIS

64 differences are likely attributable to true biologic changes in tumor rather than normal physiologic

65 ans of linkage to state cancer registry, and biologic characteristics were grouped by prognostic fact

66 all AEG types, suggesting a rationale for a biologic classification.

67 ce area and a more favorable environment for biologics compared to other delivery routes.

68 Biologic confounders were minimized by measuring the ECV

69 e generation of high-avidity responses, with biologic consequences for airway immunity.

70 Our findings demonstrate that the biologic consequences of a second-site mutation in an on

71 the recognition that race is a social, not a biologic, construct.

72 patient underwent placement of a sutureless biologic corneal badage device.

73 , which is compatible with diverse drugs and biologics, could enable a broad range of non-cutaneous a

74 ) or TLR2(-/-) dams were fed either by their biologic dam or a dam of the alternate genotype.

75 is interaction have stimulated production of biologics designed to disrupt this essential RNA-protein

76 Humanized models enable us to overcome biologic differences that exist between humans and other

77 We would not advise biologic discontinuation in patients on treatment since

78 ents with rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs (DMARDs)

79 nths of apremilast, at least 3 months of non-biologic disease-modifying antirheumatic drugs (DMARDs),

80 ents with rheumatoid arthritis refractory to biologic DMARDs, upadacitinib was superior to abatacept

81 to provide symptomatic control, the current biologics do not prevent the fusion of joints in AS pati

82 d mathematic modeling confirms, that maximal biologic doses were achieved by targeted alpha-therapy a

83 heterogeneity in meningiomas would elucidate biologic drivers and reveal new targets for molecular th

84 Further research is needed into biologic drivers of differences in COVID-19 outcomes by

85 inical and especially clinical studies about biologic drug formats and disease targets.

86 d direct visualization and quantification of biologics drug binding in targeted tissues with cellular

87 Biologic drugs are reshaping clinical practice in variou

88 anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, bu

89 the available literature on cost utility of biologic drugs in atopic disorders.

90 y and development of both small-molecule and biologic drugs that are today benefiting individuals dia

91 The development of biologic drugs that inhibit TNFalpha has led to improved

92 health need unmet by both small-molecule and biologic drugs.

93 the design, development, and application of biologic drugs.

94 he common receptor for IL-13 and IL-4 by the biologic dupilumab prevented the effects of both IL-13 a

95 e in vivo As recently attained for other AAV biologics, e.g., Luxturna and Zolgensma, based on AAV2 a

96 st of the attention has been directed at the biologic effect of proteins and microRNA, the contributi

97 dosimetry helps the field by optimizing the biologic effect of the treatment and trial design in the

98 at 1.85 GBq/m(2)/cycle with a maximal kidney biologic effective dose of 37 Gy.

99 Exposures to mainstream e-cig aerosols have biologic effects but only limited evidence shows adverse

100 e purpose of this review is to highlight the biologic effects of nitric oxide and hydrogen sulfide, t

101 to unequivocally confirm the existence of a biologic efficacy signal; however, it confirmed that rAA

102 umours and lymphoid organs, to alter the way biologics engage with target immune cells and to accumul

103 lty is increasingly recognized as a distinct biologic entity that can adversely affect outcomes befor

104 and were thus selected for extensive further biologic evaluation (apoptosis and cell cycle analysis,

105 hese reagents are supplied by the Center for Biologics Evaluation and Research (CBER) or the National

106 he exact role played by this molecule in the biologic events underlying atherosclerosis has remained

107 tural biology coupled with immunological and biologic evidence.

108 l, epoetin alfa); (3) drugs with alternative biologic explanations for the association (e.g., sevelam

109 progress in computational reconstitution and biologic exploration of CRCs across various human malign

110 early-stage CD (validation cohort 1) and 195 biologic-exposed patients with chronic CD (validation co

111 Both anatomic and biologic factors yielded reliable and reproducible progn

112 ables (SVs) (capturing unknown technical and biologic factors).

113 for breast cancer now includes anatomic and biologic factors, although the guidelines for stage IV d

114 atic cohort, incorporating both anatomic and biologic factors.

115 tivity in relapsed AML/MDS without reversing biologic features of T-cell exhaustion.

116 Despite growing awareness of the biologic features underlying MLL-rearranged leukemia, ta

117 ifies treatment on the basis of clinical and biologic features, has improved 5-year overall survival

118 evidence for micelle stability within human biologic fluids and offers evidence of polymer micelle i

119 f understanding of micelle interactions with biologic fluids following injection.

120 to identify the properties and components of biologic fluids that influence micelle stability.

121 s evidence of polymer micelle instability in biologic fluids that is not explained by either total pr

122 y of amphiphilic block copolymer micelles in biologic fluids to identify the properties and component

123 ate of the dye cargo after exposure to human biologic fluids.

124 rmine the level of evidence for the use of a biologic for a given disorder.

125 the safety and efficacy of B cell-targeting biologics for the treatment of immune-mediated diseases.

126 ral and spatial expression of THSD7A and its biologic function for podocytes are unknown, information

127 However, its biologic function in human adult lung-resident mesenchym

128 e inhibitor for execution of proteolytically biologic function; however, TMPRSS2's cognate inhibitor

129 ohypophyseal hormone oxytocin (OT) regulates biologic functions in both peripheral tissues and the ce

130 The biologic half-life of (131)I-GMIB-anti-HER2-VHH1 in heal

131 (LTC(4)), LTD(4), and LTE(4), have different biologic half-lives, cellular targets, and receptor spec

132 rrow averaged 23% +/- 11% and cleared with a biologic half-time of 215 +/- 107 h (43 patients) or lon

133 ey averaged 2.4% +/- 2.0% and cleared with a biologic half-time of 243 +/- 144 h (27 patients) or lon

134 leen averaged 22% +/- 12% and cleared with a biologic half-time of 271 +/- 185 h (36 patients) or lon

135 nts), which cleared monoexponentially with a biologic half-time of 293 +/- 157 h (33 patients) or did

136 ment (including pharmacotherapy, surgery and biologics) has experienced enormous progress based on th

137 Biologics have limited permeability across the intestine

138 Systemically delivered targeted biologics have revolutionized the treatment of moderate-

139 atopic eczema, as well as purpose-developed biologics, have been studied in phase II trials in patie

140 Biologic heterogeneity is a feature of diffuse large B-c

141 To determine the biologic impact of this second-site mutation in vivo, we

142 ro and in vivo models were used to determine biologic impacts of MPC-1 and KDM5A on PDA and mitochond

143 user fee funding expanded from new drugs and biologics in 1992 to generic and biosimilar drugs in 201

144 st-utility analyses conducted for the use of biologics in asthma and other atopic diseases, their con

145 hanism of action and the rationale for using biologics in periodontal plastic surgery, as well as the

146 Relative efficacy of biologics in reducing OCS treatment for severe, uncontro

147 a state-of-the-art review on the efficacy of biologics in root coverage procedures, including enamel

148 sts can substitute biosimilars for reference biologics in some EU countries, but not in the USA or Ja

149 s eligible for extended surgery and possibly biologics in the future.

150 h superior adverse event profiles, including biologics (in particular, anti-tumour necrosis factor (T

151 Most newly developed biologics, including monoclonal antibodies, are structur

152 Other biologics inhibit cytokines such as the p40 subunit of t

153 ere we describe the development of a pan-RAS biologic inhibitor composed of the RAS-RAP1-specific end

154 ts is through the development of long-acting biologic inhibitors.

155 up to 10 half-lives with (18)F-FDG, revealed biologic insight and supported the ability to track biol

156 polymeric self-assembly and maintains their biologic integrity throughout release up to 8-12 weeks.

157 diment to the translation of small bioactive biologics into drugs.

158 mic stability, prediction of poorly-behaving biologics is difficult, and searching for sequences with

159 h in extending half-lives of a wide range of biologics, it is unclear whether the existing constructs

160 ody-induced arthritis model, where it showed biologic-like in vivo efficacy, will be discussed.

161 actor VIII, safety, expression kinetics, and biologic markers of AAV transduction for up to 3 years.

162 to targeting eosinophils, IL-5 and anti-IL-5 biologics may have a direct role on AEC.

163 ood-derived whole genomes may also provide a biologic measure of age-related functional deterioration

164 The need to understand the biologic mechanisms at the tumor-immune interface has gi

165 ts in pathologic lesions offers insight into biologic mechanisms that control their function; fibrobl

166 However, little is known about the biologic mechanisms that regulate TG2 function.

167 to further expand knowledge regarding risk, biologic mechanisms, clinical and radiologic presentatio

168 used to evaluate stunting and its underlying biologic mechanisms.

169 Program (CAMP) could serve as biomarkers and biologic mediators of ICS clinical response over the 4-y

170 levant to other members of the CYP family of biologic, medical, and pharmacological importance.

171 on after arthroplasty, yet risks of specific biologic medications are unknown.

172 ecause this may predict clinical response to biologic medications that target type 2 inflammation.

173 to assess fundamental determinants of use of biologic medicines in sub-Saharan Africa.

174 Most recipients were high-acuity with median biologic MELD 35 for dCLKT and 34 for eCLKT (p=ns).

175 The movement of ammonium across biologic membranes is a fundamental process in all livin

176 s recurrent hernia repair (2.69, 1.14-6.35), biologic mesh (3.1, 1.67-5.75), and wound complications

177 ssessing the long-term outcomes of VHR using biologic mesh are scarce.

178 omy (2.6, 1.8-3.9), and operations requiring biologic mesh were predictors of wound complications, wh

179 ge cohort of patients who underwent AWR with biologic mesh.

180 Clinical trials assessing how biologics might improve ICU outcomes are direly needed.

181 Most recipients were high-acuity with median biologic model of end-stage liver disease (MELD) score o

182 ists, (2) comparative efficacy and safety of biologic monotherapy vs combination therapy with immunom

183 Exposure was to thiopurines (n = 242), biologics (n = 642), or both (n = 227) vs unexposed (n =

184 Consecutive biologic naive psoriasis patients (n=209) underwent coro

185 lient only among black participants who were biologic naive.

186 Guselkumab in biologic-naive patients with active psoriatic arthritis

187 We enrolled biologic-naive patients with active psoriatic arthritis

188 rug antibodies in a discovery cohort of 1240 biologic-naive patients with Crohn's disease starting in

189 independent cohorts of patients with CD: 116 biologic-naive patients with early-stage CD (validation

190 was a phase 3 trial to assess guselkumab in biologic-naive patients with psoriatic arthritis.

191 patients who were biologic-treatment naive (biologic-naive) or had received no more than one prior a

192 donor dipropylenetriamine NONOate (DPTA) and biologic NO in HeLa and HuH7 cell lines.

193 Our data did not show any adverse impact of biologics on COVID-19 outcome in patients with psoriasis

194 However, the difference in effects of biologics on ECRS has not been elucidated and warrants f

195 inflammatory bowel disease (IBD) may require biologic or thiopurine therapy to control disease activi

196 Biologic agents (also termed biologics or biologicals) are becoming increasingly impo

197 ed, such as the use of virus-like particles, biologics or novel adjuvants.

198 gic systemic therapy than in those receiving biologics (OR = 0.68; 95% CI = 0.50-0.94).

199 iologic systemic therapy than in those using biologics (OR = 2.84; 95% CI = 1.31-6.18).

200 ctive sites using a combination of different biologics, or mixtures of biologics and small molecule t

201 ncluding a precision medicine approach using biologics, oral desensitization, targeted gut microbiome

202 d safety study in the development of a novel biologic originator product.

203 The FDA approved 355 new drugs and biologics over the study period.

204 A novel biologic pathway identified in this study highlighted a

205 methylation, and their effects on different biologic pathways are still limited.

206 ty, or circadian patterns to identify common biologic pathways that influence their interrelations.

207 oteins has revolutionized the development of biologic pharmaceuticals; however, they are not free of

208 ndon the use of racial categories to explain biologic phenomena but instead rely on a more comprehens

209 However, these studies are unable to prove biologic plausibility and causality as randomized contro

210 of these findings and investigations of the biologic plausibility and potential mechanisms underlyin

211 ese genes were enriched in the gene ontology biologic process 'receptor-mediated endocytosis', and 52

212 onitor the clearance of these lipases during biologics process development.

213 c insight and supported the ability to track biologic processes over time.

214 ther understanding of protein abundances and biologic processes present in CRS and its endotypes comp

215 Ultimately, the differing proteome and biologic processes provide further insight into CRS path

216 Pathway analysis revealed different biologic processes regulated by genes with FOXA2 binding

217 dard imaging methods, being able to quantify biologic processes related to the bone microenvironment

218 of cellular protein localization are the top biologic processes responsible for cisplatin resistance.

219 ne, and mRNA catabolic processes are the top biologic processes responsible for cisplatin sensitivity

220 ay contribute to altered gene expression and biologic processes that enhance inflammatory tissue dest

221 They are important in a wide range of biologic processes, including development, synaptic plas

222 This regulates further biologic processes, including fibroblast and myofibrobla

223 ortant roles as second messengers regulating biologic processes, such as cell growth, differentiation

224 s therapies has led to an increased focus on biologics produced in mammalian cells.

225 New biologic product approvals increased from a median of 2.

226 nitors two high risk lipases known to impact biologics product quality, Phospholipase B-like 2 protei

227 ns that were harmonic, suggesting purposeful biologic regulation to create this subtype of circadian

228 ed anticancer therapies have illuminated the biologic relevance of B cells, plasma cells (PCs), and p

229 ted therapies eventually in association with biologic response modifiers in the early phases, whereas

230 ediated inflammation is an explicitly robust biologic response that plays a critical role in maintain

231 trategy for modifying EVs mediating specific biologic responses.

232 efficacy, long-term safety, and clinical and biologic results in 15 adults with severe hemophilia A (

233 ty to track patterns of emotions, behaviors, biologic rhythms, and their contextual influences in rea

234 rate system, we separate the majority of the biologic role of LIN28 from its known activity of blocki

235 rinary clinical setting that supports serial biologic sample collections and exploration of dose, sch

236 apabilities make CDPs an attractive mid-size biologic scaffold to complement conventional antibody-ba

237 mmune modulation through the transmission of biologic signals to host cells.

238 lded by molecular imaging (MI) into relevant biologic signatures at an organ-specific and systemic le

239 ared with standard methods, along with their biologic significance in predicting survival.

240 ility of these methods is constrained by the biologic, spatial, and temporal heterogeneity of the pro

241 In vitro and in vivo biologic specificity was assessed in a MCF-7 cell line a

242 review covers the recent small molecule and biologics strategies to target the small GTPases through

243 Type 2-targeting biologics such as anti-IgE, anti-IL4Ralpha, anti-IL5, an

244 In all three examples, biologics such as dupilumab or omalizumab become reliabl

245 G protein-coupled receptors (GPCRs) are biologic switches that transduce extracellular stimuli i

246 ationale: MicroRNAs are potent regulators of biologic systems that are critical to tissue homeostasis

247 ts (58.5 +/- 5 years, 46.0% female, 72.5% on biologic, targeted, or immune-based therapies) with 148,

248 The observation that therapeutic biologics, targeting type 2 immune responses, can revers

249 represents a prototype for structure-guided biologics that can efficiently repair or remodel neurona

250 Biologics that inhibit TNF-alpha, p40IL-12/23, and IL-17

251 moderate to severe plaque psoriasis include biologics that inhibit TNF-alpha, p40IL-12/23, IL-17, an

252 Biologic therapeutics are the medicines of the future an

253 dvancements in co-formulation strategies for biologic therapeutics must be established.

254 The use of methotrexate and subsequently biologic therapies (such as TNF inhibitors, among others

255 of patients with plaque psoriasis receiving biologic therapies compared with the general population.

256 Whether biologic therapies enhance the risk of coronavirus 2019

257 The advent of biologic therapies has transformed care for severe atopi

258 Since the 1990s, most biologic therapies have been developed for one or severa

259 Biologic therapies have shown high efficacy in psoriasis

260 In addition, targeted biologic therapies have shown promise, including teprotu

261 hus, earlier, more aggressive treatment with biologic therapies or novel small molecules could profou

262 We used biologic therapies to avert potentially fatal acute resp

263 Despite the advent of more specific biologic therapies, a notable proportion of individuals

264 The two biologic therapies, anti-IgE (omalizumab) and anti-IL-5

265 Before the advent of biologic therapies, conventional synthetic DMARDs (csDMA

266 n requires the use of immunomodulator and/or biologic therapies, including thiopurines, methotrexate,

267 ytokines is responsive to corticosteroid and biologic therapies, many severe asthmatics exhibit corti

268 aque psoriasis (n = 6501) being treated with biologic therapy and regularly followed up at the divisi

269 ts being treated with immunomodulator and/or biologic therapy for moderate to severe UC.

270 At 1-year, participants receiving biologic therapy had a reduction in LRNC (mm(2); 3.12 [1

271 e financial burden of the highly efficacious biologic therapy in retinal pathologies.

272 ]; P=0.028), while those who did not receive biologic therapy over 1 year demonstrated no significant

273 cid Bioimaging, Boston, MA) before and after biologic therapy over 1 year.

274 s favorable modification of LRNC in those on biologic therapy.

275 riasis and how LRNC modulates in response to biologic therapy.

276 ospitalization, and reimbursement of another biologic therapy.

277 No definite CD cases occurred during biologic therapy.

278 steroids; and, eventually, pathway-specific biologic therapy.

279 proval process and market launches for these biologics, therefore expanding patient access to these p

280 Biologic, thiopurine, or combination therapy exposure du

281 pregnancies exposed vs unexposed in utero to biologics, thiopurines, or a combination.

282 Intracellular delivery of a potent anti-RAS biologic through a receptor-mediated mechanism represent

283 be found and (2) predictions as to the best biologic to be used in an individual patient are not yet

284 However, delivering large biologics to primary T lymphocytes directly in vivo is t

285 Despite the introduction of biologics, topical dithranol (anthralin) has remained on

286 Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC)

287 es) investigated UC and CD patients who were biologic-treatment naive (biologic-naive) or had receive

288 s pathogenesis, genetics, comorbidities, and biologic treatments.

289 ore precise diagnostic tests that can assess biologic tumor features decisive for treatment outcome a

290 model the human disease and inform improved biologic understanding and design of novel therapeutics.

291 patients with moderate-to-severe psoriasis, biologic use was associated with lower risk of COVID-19-

292 Framingham risk, body mass index, and active biologic use.

293 wel disease (IBD) patients since the rise of biologic use.

294 udesonide effervescent tablet in Europe; (2) biologics used for other T(H)2-mediated diseases, such a

295 ve imaging across different MRI systems, and biologic validation of quantitative imaging.

296 The purpose of this study was to gather biologic validity evidence for correlates of different t

297 patients will implicitly teach it about the biologic variation between them.

298 For each avid osseous lesion, we measured biologic volume; size; PSMA Reporting and Data System (R

299 nual number of new drug approvals, including biologics, was 34 from 1990-1999, 25 from 2000-2009, and

300 okine-receptor targeting small molecules and biologics with novel pharmacology.

301 Recent structural, biochemical, and biologic work has shown that binding of PIP(3) to the pl