ライフサイエンスコーパス: biological

1 Prediction of 81 biological activities associated with the treatment of H

2 A range of biological activities were proposed for this compound in

3 residues are often found to display diverse biological activities.

4 eptors (FcgammaRs), which confer pleiotropic biological activities.

5 es for the first time that PA influences the biological activity of chitosans, which can now be recog

6 chine-learning methods to predict the likely biological activity of encoded molecules.

7 The biological activity of the prepared bread samples showed

8 To characterize the biological activity of these gold(I) complexes, we used

9 These C-to-C conjugates show biological activity superior to that of the parent fragm

10 natures (i.e., the spectroscopic evidence of biological activity) in exoplanets.

11 in mice, a VHH-PTH peptide conjugate showed biological activity, whereas the corresponding free pept

12 tural trends that contribute to this type of biological activity.

13 marily with the plasma membrane (PM) for its biological activity.

14 ht regimes play in determining the timing of biological activity.

15 le insertions in its backbone and maintained biological activity.

16 fy differences between chronological age and biological age in health and disease including neurodege

17 This study provides comparative data on two biological agents with different mechanisms of action, w

18 uring materials and for sensing chemical and biological analytes.

19 However, despite the biological and biotechnological importance of this macro

20 Although such compounds have an important biological and chemical relevance, the lack of methods f

21 However, the biological and clinical implications of TP53 allelic sta

22 This study reveals the biological and clinical significance of dysplastic hemat

23 pplied with an understanding of the relevant biological and computational theories.

24 larly striking because while the dynamics of biological and cultural evolution may be similar in prin

25 the most comprehensive theory to date of the biological and cultural evolution of music.

26 this difference likely results from distinct biological and disease initiation and progression events

27 eed for a combination of biosystematics with biological and ecological investigations for the develop

28 endence of the effects of solar radiation on biological and ecological processes; the ramifications o

29 vated materials have found widespread use in biological and medical applications and are playing an i

30 gy could be a valuable tool in many areas of biological and medical research.

31 This Perspective reviews the biological and medicinal chemistry advances over the pas

32 utcomes included primary outcome components, biological and pharmacokinetic measures, and adverse eve

33 s play a fundamental role in the dynamics of biological and physical systems, from DNA to turbulent p

34 Research into the biological and societal mechanisms underlying these disp

35 of such an approach, previously unrecognized biological and therapeutic complexity is emerging.

36 sing multidisciplinary epidemiological, cell biological, and gene expression profiling approaches, we

37 Their translation toward biological applications is limited owing to the use of n

38 However, it is crucial for many biological applications such as the design of guide RNA

39 ness of biological entities is vital to many biological applications, such as protein-protein interac

40 engineering the surface of nanoparticles for biological applications.

41 Now, using NMR-based structural and biological approaches, we have characterized the binding

42 d drug delivery system capable of overcoming biological barriers and leveraging on several synergisti

43 literature has focused on understanding the biological barriers that hinder tissue-specific drug del

44 Among all these biological barriers, the blood-brain barrier (BBB) stron

45 ectroscopy that may provide insight into the biological behaviour of various bone tumours is highligh

46 Ri/a-based chemical-genetic screens and cell biological, biochemical, and structural assays to determ

47 The biological carbon pump (BCP) comprises wide-ranging proc

48 tic risk factors in the context of different biological challenges.

49 tion of peri-implant conditions according to biological characteristics is required for further BTMs

50 Accurate biological characterization of exosomes is an important

51 leave open numerous questions regarding the biological characterization of these human groups, espec

52 dox-active proteins because of their role in biological charge transport.

53 n channels and to understand the function of biological circuits.

54 hat constitute the molecular "cogs" of these biological clocks.

55 ting global biogeochemical cycles, yet their biological communities and related carbon dynamics are h

56 line analysis of missense variants by a wide biological community.

57 n spectroscopy (FSRS) to a multichromophoric biological complex, trimers of LHCII.

58 t advances over the last decade, its complex biological component is still oversimplified.

59 understanding of the processes through which biological components interact.

60 e is challenging because of the diversity of biological components regulating stomatal action.

61 rofiling of individual cells under different biological conditions.

62 Understanding common biological consequences of heterogenous mutations in com

63 cogenic potential depending on cell type and biological context.

64 orrelation patterns between genes in various biological contexts (e.g., cancer, mouse genetics, yeast

65 Biological control is a potential alternative for manage

66 uction across 18 countries for the classical biological control of weeds.

67 f hierarchy suggest a possible new model for biological control over crystal growth during amelogenes

68 hypothesis that efferent regulation may be a biological control parameter for tuning the hair bundle'

69 important influences on different stages of biological control programs, including natural enemy sel

70 ns for the development of safe and efficient biological control programs.

71 ose this represents a shift from small-scale biological control to large-scale oceanographic control

72 n the conceptual underpinning or practice of biological control.

73 As large amounts of biological data continue to be rapidly generated, a majo

74 re widely used to interpret high-dimensional biological data.

75 Active matter, both synthetic and biological, demonstrates complex spatiotemporal self-org

76 We identified a novel, biological difference between RV and LV fibroblasts that

77 may occur due to technical variation or true biological differences.

78 lves to becoming model organisms in multiple biological disciplines: one of these is the great pond s

79 geochemical cycling, primary production, and biological diversity by the end of the Ediacaran Period.

80 The Convention on Biological Diversity's (CBD's) post-2020 global biodiver

81 equilibrium thermodynamics for understanding biological dynamics and functions.

82 Results suggest that (a) we can forecast biological dynamics while applying delta-correction and

83 constituents as well as demonstrating their biological effects in order to stimulate the cultivation

84 Most studies on the biological effects of future climatic changes rely on se

85 Our data showing biological effects of non-nitrate components of BRJ have

86 tant mechanism by which nanoparticles induce biological effects, as the function of many embedded mem

87 residue enabled the highest values of yield, biological efficiency, and productivity.

88 The capturing of the semantic relatedness of biological entities is vital to many biological applicat

89 Herein, we report the design, synthesis, and biological evaluation of a series of new epothilone B an

90 Here we report the design, synthesis, and biological evaluation of several close-in analogs of bry

91 Docking study and biological evaluation of synthesized compounds has highl

92 Biological evaluation of these analogues revealed a numb

93 s system lesions in Leigh syndrome and their biological evolution in view of their genetic and clinic

94 s and provide highly credible candidates for biological experiments.

95 xiety symptoms in combination with high-risk biological factors such as APOEepsilon4 and subcortical

96 d suffer from over-correction and alter true biological features (e.g. cell size) due to our limited

97 r-characteristics (primary T4, right colon), biological features (K/N-RAS status), and response to ch

98 e resulting neurogenic progenitors show cell biological features different from multipotent progenito

99 ieved unprecedented results in melanoma, the biological features of the durable responses initiated b

100 eral risk scores combining morphological and biological features were recently proposed for precise s

101 es have revealed that SARS-CoV-2 shares many biological features with SARS-CoV, the zoonotic virus th

102 ts into more homogeneous cohorts with shared biological features, potentially facilitating the identi

103 t for maintaining elevated levels of CD14 in biological fluids and a decrease in its activity results

104 ed good applicability for analysis of SAL in biological fluids and during pharmacokinetic evaluation

105 MD) and disease progression, but the precise biological function of HtrA1 in the eye and its contribu

106 only very limited information regarding the biological function of IL2RA in AML is available.

107 However, the biological function of lncRNAs in HPV16-related CC remai

108 ns the path for future investigations of the biological function of metaphosphates in many organisms.

109 In plants, the biological function of NTA remains enigmatic.

110 Our most predictive features included biological function of proteins, network centrality meas

111 In this study we characterized the biological function of the ACKR2-V41A receptor compared

112 rm, even if assembly per se does not enhance biological function(3-7).

113 oles in UAF complex integrity, assembly, and biological function, and provide roles for previously id

114 vesicles (EVs) are known to influence their biological function, in terms of, e.g., cellular adhesio

115 findings differentiate effector binding from biological function, which has ramifications for riboswi

116 ub-structures is fundamentally important for biological function.

117 llowing for a rapid response demanded by the biological function.

118 equence or causal effect within the scope of biological functionality needs additional research.

119 Biological functionality of isomeric carbohydrates may d

120 These proteins define the biological functions of LDs, and most of them bear amphi

121 tion for future investigation of the diverse biological functions of SA1 and SA2.

122 ide a framework for connecting enzymatic and biological functions of specific HDAC complexes.

123 However, the biological functions of these ancient primary DR sequenc

124 antly hampered progress in understanding the biological functions of this scaffold protein.

125 redundancies in functional descriptions and biological functions shared among genes.

126 l to uncovering the molecular nature of many biological functions.

127 f outer arm structure motifs with recognized biological functions.

128 leads to distinct metabolic requirements and biological functions.

129 ubfamilies of HeRs, suggesting their diverse biological functions.

130 ng properties directly translate to distinct biological functions: free IgE initiated allergic inflam

131 hich is the most commonly employed model for biological growth processes.

132 terogeneity in defining phenotype, obscuring biological heterogeneity in research concerning allergy,

133 ive loss-averse decisions and highlights the biological heterogeneity of loss aversion across individ

134 egy by which the rich information present in biological images is reduced to a multidimensional profi

135 ally noninvasive, high-resolution, and rapid biological imaging materials.

136 ce approaches, can be used to generate novel biological insights.

137 g the prognostic and therapeutic modalities, biological interaction of nanomaterials with various bod

138 r represents an "undruggable" target of high biological interest due to its central role in various c

139 ype by comparing prediction performances and biological interpretation across 8 machine learning meth

140 ted due to limited personnel and funding for biological invasion prevention.

141 These results from one of the greatest biological invasions highlight how biogeographic process

142 rol efforts is critical to the management of biological invasions in a changing world, such as sea la

143 te change may exacerbate negative impacts of biological invasions.

144 s based on their meta-patterns for intuitive biological investigations.

145 sequently, some crucial aspects of available biological knowledge may get ignored, which could furthe

146 nd deciphering, reconstruction and design of biological machine assembly lines.

147 Reporting the sex of biological material is critical for transparency and rep

148 These discoveries illustrate how a biological materials strategy of interplay between stren

149 cterize the surface and interface regions of biological materials.

150 s constitute a versatile platform for making biological measurements due to their ability to recogniz

151 and a series of computational models of the biological mechanism of the RNA interference (RNAi) path

152 eta-based hippocampal encoding and provide a biological mechanism to support the expression of revers

153 he noncoding genome, which makes deciphering biological mechanisms difficult.

154 (IL-4), IL-5, and IL-13, are now established biological mechanisms in asthma.

155 The biological mechanisms involved in fear transmission with

156 t formation are well characterized, the cell-biological mechanisms of platelet recruitment to inflamm

157 one step closer to understanding the complex biological mechanisms responsible for fibrotic diseases

158 ery, unveiling plausible candidate genes and biological mechanisms underlying ventricular excitabilit

159 highlighting heterogeneity in the underlying biological mechanisms.

160 etween the two phenotypes and, hence, shared biological mechanisms.

161 ce (EPR) due to their unmatched stability in biological media and long relaxation times.

162 pectively, toward detection of SARS-CoV-2 in biological media, while blind clinical evaluations of 10

163 ssion and plasticity may serve as a possible biological mediator of this association.

164 ve the ability to rapidly internalize across biological membranes.

165 fication of NCys-bearing proteins in complex biological milieu.

166 wledge on the relationship between different biological modalities (RNA, chromatin, etc.) can help fu

167 bolite detectable by LC-MS/MS and in various biological models (such as mice).

168 designs for better pragmatic and explanatory biological models of psychiatric disorders.

169 Using patient samples and orthotopic PDAC biological models, we showed that radiotherapy increased

170 A synthetic biological module, however, can be designed to reprogram

171 Biological molecular motors (or biomolecular motors for

172 s by determining the spatial distribution of biological molecules.

173 Nitrogenase is the enzyme that catalyzes biological N(2) reduction to NH(3).

174 Biological networks across scales exhibit hierarchical o

175 ers controlling the electrical properties of biological neurons is essential to determine their compl

176 ) represents an energy-efficient process for biological nitrogen removal, particularly from wastewate

177 e a manifold that is robust to technical and biological noise found in normalized scRNA-seq data.

178 ar expression profiles may be the product of biological noise, while the LCI variants may be under ti

179 e these choices based on different scales of biological organization and available data.

180 y mathematically fitting the data, important biological parameters can then be estimated, including t

181 Defining high risk as having at least one biological parent with major depression, the authors ide

182 ies, respectively, affecting many associated biological pathways.

183 molecular endotypes exist in AP and reflect biological patterns that are also present in ARDS, sugge

184 ed to a wide range of materials for improved biological performance.

185 Furthermore, we image biological phenomena that would be otherwise challenging

186 multifunctional proteins regulating diverse biological phenomena, such as aging, immunity, proteosta

187 ing the TOFT offer new perspectives on basic biological phenomena.

188 genotyping data, and more recently from the biological point of view with the characterization of do

189 ined HDAC8 inhibitors present an alternative biological probe for further determining the clinical ut

190 ernative electrophilic warheads for chemical biological probes and drug molecules is demonstrated thr

191 Tooth eruption is a unique biological process by which highly mineralized tissues e

192 The fundamental biological process of electron transfer (ET) takes place

193 o Stress" as the top significantly different biological process, respectively.

194 represents a hypothesis about the underlying biological process.

195 h between the nature of the generating (i.e. biological) process and the form of the statistical anal

196 Many biological processes are based on interfacial protein ac

197 increasingly used to capture the dynamics of biological processes at the molecular level in convenien

198 Multivalent binding is essential to many biological processes because it builds high-affinity bon

199 markable birds can help us uncover the basic biological processes driving technological progress.

200 Essentially all biological processes fluctuate over the course of the da

201 The Hippo pathway regulates myriad biological processes in diverse species and is a key can

202 Mechanical patterns control a variety of biological processes in plants.

203 in critical roles covering a broad range of biological processes in the Apicomplexa.

204 ptors (aGPCRs) have key functions in diverse biological processes including neurodevelopment, embryog

205 Our data analysis revealed that multiple biological processes including trehalose metabolism and

206 Sulfur is essential for biological processes such as amino acid biogenesis, iron

207 are also important for orchestrating complex biological processes such as immunity.

208 importance of mitonuclear coevolution in key biological processes such as speciation and mitochondria

209 entified by re-organizing KEGG pathways into biological processes that are more relevant to ecotoxico

210 solidated memories require not only positive biological processes that facilitate long-term memories

211 ssical pathways to crystallization, based on biological processes, about the fabrication of damage-to

212 ar chemists use to emulate the efficiency of biological processes, and elucidating how chemical react

213 ater and lipids are key participants in many biological processes, but there are few non-invasive met

214 ariable and can relate to defects in diverse biological processes, including DNA damage repair (Fanco

215 cting with RNAs, and contributes to numerous biological processes.

216 lation of gene expression is central to many biological processes.

217 nderstanding metabolic mechanisms of various biological processes.

218 alian circRNAs is proposed to influence many biological processes.

219 ins and participate in a myriad of different biological processes.

220 of carbohydrates is a key step in essential biological processes.

221 important contribution of PE in these major biological processes.IMPORTANCE Phosphatidylserine (PS)

222 The biological properties observed in these extracts could h

223 arding brain organisation and its underlying biological properties.

224 acid-ligand conjugates in the context of the biological protein receptors they interrogate.

225 Biological proton channels are sub-1-nm protein pores wi

226 is latest research and consider the possible biological purposes of these enigmatic inflammasomes.

227 Lack of overlap likely stems from biological rather than technical limitations as most syn

228 Ru360, we show that Ru360 is deactivated by biological reductants.

229 results in a complex range of isoforms whose biological relevance largely remains to be determined.

230 llmarks of the disease, which highlights the biological relevance of the partitions found.

231 NORS, further strengthening the case for its biological relevance.

232 nsights into chromatin organization of great biological relevance.

233 ies could compromise downstream analyses and biological reproducibility, we built a more comprehensiv

234 tures, interactions and protein functions in biological research.

235 towards considering only one out of multiple biological resources.

236 aratumumab) was proposed with a clinical and biological response.

237 salts, and in turn whether this affected the biological responses in cells, and in vivo.

238 These insights into the biological responses of tumors to ICI provide a strategy

239 enzymes and BCKA content and highlights the biological role of BCKAs in regulating muscle insulin si

240 trary to the existing paradigm regarding the biological role of computationally predicted EBOV ncRNAs

241 e observations raise questions regarding the biological role of tooth-innervating fibers.

242 s some potential unifying hypotheses for its biological role.

243 ng dynamics are required to understand their biological roles in greater detail.

244 primarily dependent on the type of collected biological sample, with highest sensitivity observed in

245 metry can detect thousands of molecules in a biological sample.

246 hnique will be applicable to a wide range of biological samples and will help to improve the sensitiv

247 Target ASOs were extracted from biological samples by hybridization with biotinylated se

248 m complex analysis on real three-dimensional biological samples that would otherwise be impossible by

249 Clinical data and biological samples were obtained at admission, days 3 to

250 ecisely capture the mechanical properties of biological samples with force sensitivity and spatial re

251 quantifying ribose concentration in complex biological samples.

252 Mapping this biological setting into the 'Ant-in-a-Labyrinth' framewo

253 ur understanding of gene function in complex biological settings, including T cell immunology.

254 signal processing that can be used in other biological settings, such as being introduced into circu

255 Biological sex differences may manifest themselves in su

256 ncer prognosis and theragnosis by harnessing biological signals imperceptible to the human eye.

257 rain region that integrates feeding-relevant biological signals with learning and memory processes to

258 population compartmental mask, corroborating biological significance of our annotation of the chromat

259 -specific m(6)A patterns, and we discuss the biological significance of such regulation.

260 The biological significance of the DHTKD1-encoded 2-oxoadipa

261 ar FHL1 protein in CHIKV HVD and defined the biological significance of this interaction.

262 stably inherited methylation variants are of biological significance.

263 e learned factors reflect tissues with known biological similarity and identify transcription factors

264 a multifaceted approach to address genetic, biological, socioeconomic, and lifestyle contributors to

265 At the crossroads of interacting biological, socioeconomic, behavioral, and institutional

266 teriosis, the geographical origin of diverse biological species including humans and proteomic data t

267 from a wide range of physical, chemical, and biological stresses, support biofilms, and play critical

268 ural studies by cryo-EM into the cell, where biological structures and processes may be imaged in con

269 rming future utility of ETPs in chemical and biological studies.

270 nctive specificity of intrinsic Xase for its biological substrate.

271 Many biological surfaces of animals and plants (e.g., bird fe

272 We start with a brief primer on the biological synthesis of nucleotides, followed by an exte

273 of representing the internalstructure of the biological system by the mathematical structure of the D

274 illustrate the utility of network theory in biological systems and investigate modern techniques whi

275 level insights into conformationally dynamic biological systems at experimentally relevant time resol

276 ill tend to mix until they reach equilibrium-biological systems frequently exhibit organization that

277 The complexity of biological systems is encoded in gene regulatory network

278 balance between plasticity and robustness in biological systems is important to allow adaptation whil

279 talyst design, the trafficking of TM ions in biological systems, and drug design in metalloprotein pl

280 Across biological systems, cooperativity between proteins enabl

281 ation of biochemical processes underlies all biological systems, from the organelle to the tissue sca

282 bes and the immune system takes place in all biological systems, including the human body, but this i

283 l modelling is well established in informing biological systems, many models are often informed by da

284 g treatment and the performance of synthetic biological systems.

285 en thousands of molecules across hundreds of biological targets or pathways.

286 scoveries, and experimental variations among biological/technical replicates.

287 s of these proteins are harmonized by common biological themes including up-regulation of nutrient tr

288 ulfonylpyridines that selectively react with biological thiols via nucleophilic aromatic substitution

289 mic response of 3D printed phantoms, ex vivo biological tissue, and in vivo mouse and rat models of c

290 monitor changes in the water content within biological tissues.

291 udies, and we discuss current challenges for biological understanding and future requirements to over

292 at benefit from expert knowledge and allow a biological understanding of their output.

293 between the aspiration of considering sex as biological variable and the execution of such studies, p

294 tment, (c) separately analyzing physical and biological variables fails to identify the significant a

295 les and conditions by actively incorporating biological variation into study design through diversify

296 to treatment options that address individual biological variations and precision therapies for oral h

297 t that recurrent connectivity, a hallmark of biological visual systems, may be essential for understa

298 y in oleaginous microbial populations from a biological wastewater treatment plant.

299 ic the structural and functional features of biological water channels (aquaporins).

300 instrumental for developing a model for the biological water oxidation cycle.