ライフサイエンスコーパス: biological action

1 re structurally plastic and can exert unique biological action.

2 ibonucleolytic activity is essential for its biological action.

3 riphosphate metabolites is crucial for their biological action.

4 hat of RNase A but nonetheless essential for biological action.

5 me oxidized over time by UV, mechanical, and biological action.

6 the biophysical properties of GlcCer and its biological action.

7 tochondria represent a significant target of biological action.

8 nt but regular windows of enhanced vitamin D biological action.

9 able structural modifications without losing biological action.

10 d determine its subcellular distribution and biological actions.

11 r signaling pathways, despite their distinct biological actions.

12 l (PI) 3-kinase pathways that mediate leptin biological actions.

13 tiple fragments, many of which have distinct biological actions.

14 e, has been shown to cause multiple systemic biological actions.

15 R), to confer diverse and sometimes opposing biological actions.

16 gues to provide a structural basis for their biological actions.

17 ome marine animals, possess a broad range of biological actions.

18 the peptide and reversibly neutralizing its biological actions.

19 DNA target sequences, events needed for all biological actions.

20 the key phospholipid product mediating these biological actions.

21 ignal the CNS to elicit centrally controlled biological actions.

22 NA sequence CACGTG, yet have quite different biological actions.

23 ions of these lipid mediators and associated biological actions.

24 er cGMP, which in turn leads to a variety of biological actions.

25 TPP likely is a major contributor to these biological actions.

26 vered to the surroundings to exert its known biological actions.

27 itical for mediating signal transduction and biological actions.

28 the therapeutic classification through their biological actions.

29 ized, along with descriptions of their known biological actions.

30 lifies IGF-I-linked downstream signaling and biological actions.

31 created with the idea of investigating their biological actions.

32 d possible distinct temporal and potentially biological actions.

33 d R-(+)equol, both of which have significant biological actions.

34 is a ubiquitous cellular signal with diverse biological actions.

35 nd is likely a critical determinant of their biological actions.

36 for TSHR antibodies, thus influencing their biological action and clinical effects.

37 a challenging task, which requires that the biological actions and bioavailability of the >200 indiv

38 nt protein, have allowed studies on both its biological actions and clinical utility.

39 s of resveratrol broaden the spectrum of its biological actions and may be relevant to the reported c

40 tain, and there is sparse evidence regarding biological actions and pathways implicated in its effect

41 elated agents that nevertheless have diverse biological actions and therapeutic consequences.

42 This study assessed the biological actions and therapeutic utility of a novel (p

43 The present study assessed the biological actions and therapeutic utility of novel GIP/

44 y of drugs and diseases at multiple tiers of biological action, and is therefore a useful approach to

45 has a story-how it folds, what it binds, its biological actions, and how it misbehaves in aging or di

46 However, their cognate receptors, biological actions, and signaling pathways are poorly st

47 ing Set" of 230 compounds, with well-defined biological actions, and the "Diversity Set" of 2000 chem

48 hts into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the hea

49 cellular functions, yet their mechanisms of biological action are still a matter of debate.

50 Its biological actions are demonstrated in various cell type

51 Their biological actions are dependent on the structure of the

52 r, the precise concentrations at which these biological actions are exerted are still poorly defined.

53 sms by which these sphingolipids exert their biological actions are not completely understood.

54 sue raises questions about which of leptin's biological actions arise from direct effects of the horm

55 ts proved to be classifiable by their likely biological action as erythrocytic (also associated with

56 , chronically in 2 normal dogs to assess its biological actions as a blood pressure-lowering agent an

57 not static; they are dynamic and exert their biological actions at different scales of time.

58 GH exerts its biological action by stimulating JAK2, a GH receptor (GH

59 Leptin exerts its biological actions by activating the long-form leptin re

60 ting polypeptide (PACAP) elicits its diverse biological actions by interacting with both PACAP-select

61 id mediator which elicits a diverse array of biological actions by interacting with G protein-coupled

62 icity of IL-2 plays an important role in its biological actions by modulating the strength of recepto

63 clusion, the regulation of PG metabolism and biological actions constitutes a novel pathway of calcit

64 These biological actions depend on adoption of an alpha -helic

65 ings show that BTK has specific pro-tumoural biological actions downstream of surface CD117 activatio

66 chondrial content that vary in their general biological actions, from cell signaling to cell traffick

67 In light of its widespread biological actions, immunohistochemical detection of the

68 Understanding its biological action in mammary development is critical for

69 In contrast to their restricted biological action in vivo, however, most homeodomain fac

70 ssays are necessary to analyse the described biological actions in humans.

71 lels in their physicochemical properties and biological actions in in vitro models.

72 ish neuropeptide, exerts a broad spectrum of biological actions in mammals: responses that influence

73 ebo), which were then linked to demonstrated biological actions in the heart and kidneys.

74 igations into their production and potential biological actions in vivo.

75 However, there are differences in the biological actions, in binding affinities to E-cadherin

76 ssociation with ageing at multiple levels of biological action including pathways, functions and prot

77 e cytokinin family, has shown in humans many biological actions, including antitumoral effects throug

78 The putative mechanism for cannabinoid biological action involves binding to cannabinoid recept

79 Antagonism of glucagon's biological action is a proven strategy for decreasing gl

80 de convincing evidence that the mechanism of biological action is mediated by the inhibiting of mitoc

81 depend on better understanding its range of biological actions, its mechanism of action, and the mol

82 e for mediation of a wide range of essential biological actions, most of which are mediated by specif

83 Studies in knock-out mice confirmed the biological action of [dA(2)]GLP-1/GcG via multiple targe

84 ministration of antibodies that mitigate the biological action of anthrax toxin.

85 The most common biological action of differentially expressed proteins a

86 may play an important role in mediating the biological action of hormone and the receptor protein.

87 thways are linked and how they relate to the biological action of IL-2 is incompletely understood.

88 These results shed new light on the biological action of miRNAs in breast cancer and may con

89 The biological action of neurotrophins is thus regulated by

90 These observations suggest that the biological action of NF-kappaB in different cell types c

91 Despite growing reports on the biological action of nitric oxide (NO) as a function of

92 rroneous and does not accurately reflect the biological action of oxytocin across different contexts.

93 Furthermore, the biological action of R-Ras3 in PC12 cells was dependent

94 s in Elapidae snakes also interfere with the biological action of short-chain alpha-neurotoxins.

95 eventing zymogen activation, or impeding the biological action of the active form), including antisen

96 Since these effects may be related to the biological action of the drugs, it was of interest to de

97 Nuclear expression and consequent biological action of the eukaryotic NF-kappa B transcrip

98 The in vitro biological action of the gold complexes and the phosphon

99 d its role in the intracellular behavior and biological action of the hormone, a single chain CG vari

100 traits are required to better determine the biological action of the unclassified variants.

101 randial window were sufficient to elicit the biological action of these peptides (ie, opioid and anti

102 The biological action of this peptide includes inhibition of

103 In this study, we investigated the biological action of three alpha1-adrenoceptor antagonis

104 The biological actions of 1, 25-dihydroxyvitamin D, are medi

105 The biological actions of 1,25-dihydroxyvitamin D3 (1,25(OH)

106 Investigations into the potential biological actions of 15-HETE-G indicate that this lipid

107 ch investigators have clearly documented new biological actions of 1alpha,25(OH)(2)D(3) through the V

108 These insights into the biological actions of 7,3',4'-THIF provide a molecular b

109 anscription factor that mediates many of the biological actions of a large class of environmental com

110 Here we have studied the biological actions of a ligand-receptor fusion of growth

111 -mRNA splicing, important in determining the biological actions of agrin, is not well understood.

112 systematic empirical investigations into the biological actions of alcohols and unearthed a surprisin

113 Interest in the biological actions of alcohols, ethanol in particular, d

114 rotein tyrosine kinases, is critical for the biological actions of alpha/beta interferon (IFN-alpha/b

115 The biological actions of anandamide (arachidonylethanolamid

116 AR manifests the biological actions of androgens and its transcriptional

117 (AR), the nuclear receptor that mediates the biological actions of androgens.

118 ry ANP and cGMP excretion, markers for renal biological actions of ANP, were greatest in mild CHF.

119 An essential component of the biological actions of Arfs is their ability to reversibl

120 This observation explains how the biological actions of B-cell lymphoma 6 can be physiolog

121 In this review, we examined the biological actions of bFGF and FGF-18 in articular and I

122 the molecular basis underlying these diverse biological actions of BHA is thus of great importance.

123 Taken together, the biological actions of Clld7 are consistent with those of

124 of HCs could help to understand some of the biological actions of CO in physiological and pathologic

125 ide expression monitoring to investigate the biological actions of complex extracts.

126 in target tissues, possibly by antagonizing biological actions of diurnally fluctuating circulating

127 These observations suggested that biological actions of E2 are derived from expression of

128 c peptide (ANP; vasodilatory) antagonize the biological actions of each other.

129 Recent work has revealed the presence and biological actions of eicosanoids in insects and many ot

130 The biological actions of estrogens are mediated via two dis

131 elective pharmacological probes to study the biological actions of estrogens mediated through ERbeta,

132 The biological actions of extracellular nucleotides are exer

133 5 as an important signaling component in the biological actions of G-CSF.

134 ism of GAG biosynthesis, and to decipher the biological actions of GAG chains in model organisms.

135 Because many biological actions of heparin including the antiallergic

136 ption, or protein nitration may modulate the biological actions of IDO expressed in inflammatory tiss

137 the role of STAT2 as it relates to not only biological actions of IFN but also resistance to chemoth

138 us, there is a close concordance between the biological actions of IFN-alpha and the appearance of th

139 establish the role of STAT1 in mediating the biological actions of IFN-alpha in the CNS, transgenic m

140 IGF-I receptor (IGF-IR), which mediates the biological actions of IGF-I and IGF-II, has emerged in r

141 Despite its clinical potential, the biological actions of IL-21 are not yet fully understood

142 Such biological actions of IL-6 are characterised by both the

143 ical processes, but the understanding of the biological actions of individual PKDs (based upon studie

144 eact with numerous cysteine-active proteins, biological actions of individual signal inducers have em

145 We focus on the biological actions of InsPs in mammals, with an emphasis

146 The biological actions of insulin are associated with a rapi

147 Biological actions of insulin are initiated by activatio

148 strates for PKC-zeta that participate in the biological actions of insulin have not been reported.

149 Biological actions of insulin regulate glucose metabolis

150 Insulin receptor substrates (IRS) mediate biological actions of insulin, growth factors, and cytok

151 The sheer amplitude of biological actions of insulin-like growth factor I (IGF-

152 lose proximity to it is a key target for the biological actions of leptin.

153 he biology of OSM but, rather, reflected the biological actions of LIF.

154 cerning the importance of pleiotropy for the biological actions of miRNAs and provide mechanistic ins

155 s about the importance of pleiotropy for the biological actions of miRNAs.

156 ever-increasing substrates and diversity of biological actions of MMPs, it is likely that continued

157 Our data support the view that the opposing biological actions of Myc and Mxi1 extend beyond recipro

158 unknown role for telomerase in mediating the biological actions of neurotrophic factors during brain

159 Many of the biological actions of nitric oxide are mediated by the g

160 fate has generated confusion, separating the biological actions of NO on the basis of its physiologic

161 emoglobin which binds to and inactivates the biological actions of NO, but not by methylene blue (Mel

162 Different biological actions of NPY are assigned to NPY receptor s

163 The biological actions of P4 in target cells are mediated by

164 an influence in vivo signaling responses and biological actions of pharmacological agents used to man

165 Functionally, CID755673 inhibited the known biological actions of PKD1 including phorbol ester-induc

166 Here, to help evaluate the biological actions of PP5, a Cre/loxP-conditional mouse

167 advances in our understanding of the diverse biological actions of PPARgamma with an eye toward the e

168 atase (PPP) are essential to investigate the biological actions of PPPs and to guide drug development

169 aled that PPARgamma is a key mediator of the biological actions of PR in the granulosa cells and acti

170 PR signaling pathways that contribute to the biological actions of progesterone in the normal breast

171 Thus, the biological actions of R-Ras are mediated by multiple eff

172 hts into similarities and differences in the biological actions of related drugs or toxic agents, the

173 The diverse biological actions of retinoic acid (RA) are mediated by

174 The diverse biological actions of retinoic acid (RA) are mediated by

175 The diverse biological actions of retinoic acid (RA) are mediated by

176 interrelationships may have relevance to the biological actions of retinol, including its role in car

177 These diverse biological actions of RSK1 involve regulation of both cy

178 Because several of the biological actions of S1P are assumed to proceed through

179 ether with the ALX/FPR2 receptor, transduces biological actions of several proresolving mediators tha

180 The biological actions of SNC may also involve the transnitr

181 opmental functions of ERK/MAPK signaling and biological actions of specific RTK-activating factors.

182 ivatives will be valuable in determining the biological actions of specific tocopherols and tocotrien

183 However, the biological actions of SST/CORT are conditioned by the me

184 molecular weight (MW) play a key role in the biological actions of sulfated glycans.

185 mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly r

186 naling, it appears to be dispensable for the biological actions of the Axl kinase.

187 Although the biological actions of the cell membrane and serum lipid

188 We review the biological actions of the chemokine superfamily, focusin

189 The biological actions of the hormonal form of vitamin D, 1,

190 The widespread biological actions of the neurotransmitter dopamine (DA)

191 ignaling partners, suggest that the numerous biological actions of the neurotrophins via p75(NTR) may

192 (7OH) are the major alkaloids mediating the biological actions of the psychoactive plant kratom.

193 r level the diversity and its effects on the biological actions of the toxin, including receptor bind

194 rovides a useful means by which to probe the biological actions of these and other related enzymes.

195 e often keenly invested in understanding the biological actions of these drugs.

196 Indeed, many of the biological actions of these gases can be accounted for b

197 ons of steroid hormones, responsible for the biological actions of these molecules.

198 on with functional studies to illuminate the biological actions of these pathways in humans as well a

199 by which the cGMP-dependent and -independent biological actions of this agent are amplified.

200 (R) alpha1 is primarily responsible for the biological actions of this cytokine, while Ralpha2 posse

201 e concentrations, and drugs that augment the biological actions of this system, show the potential fo

202 hese results support the conclusion that the biological actions of TrkC activation affect medulloblas

203 ith prolonged in vivo survival and sustained biological action on the target cells, which may account

204 inds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, sur

205 nous and exogenous IGFBP-5 exhibits opposing biological actions on cell survival and underscore the n

206 r that exerts a number of well characterized biological actions on fibroblasts and other cells.

207 the first time that FSH may exert different biological actions on OVCA cells than on HOSE cells, by

208 cation for ischemic stroke, exerts important biological actions on the CNS besides its well-known thr

209 t from these memristors not only function at biological action potentials (e.g., 100 mV, 1 ms) but al

210 nd the mechanisms via which DAPK elicits its biological action remain largely unknown.

211 To determine if E-peptide biological actions required the IGF-IR, we took advantag

212 This raises the question: Do alcohol's biological actions result predominantly from direct prot

213 NO is known to exert numerous biological actions resulting in rapid but transient phys

214 of mechanisms by which DHEA and DHEAS exert biological actions, show that they have specific functio

215 suggests that these ligands can have a broad biological action, stimulating the transcriptional activ

216 s are markers of oxidative stress that exert biological actions such as vasoconstriction.

217 ns of nitrogen have a much richer profile of biological actions than hitherto assumed, and several ef

218 Several members utilize a unique mode of biological action that involves the sequestration of lip

219 NO-generating component of NCX-2216 confers biological actions that go beyond those of typical NSAID

220 These lipid mediators exhibit wide-ranging biological actions that include regulating both vasomoto

221 ncingly that both VEGF and FGF mediate their biological action through a common intermediate, EGR 1,

222 rs unique opportunities to probe its mode of biological action through the preparation of otherwise u

223 NO, which exerts its biological actions through cGMP and heme, has recently b

224 Evaluation of their biological action to inhibit human acetylcholinesterase

225 ion illustrate the challenges of attributing biological actions to specific sulfation patterns, and s

226 aises the possibility that MIF may exert its biological action via an enzymatic reaction.

227 Estrogens exert their biological action via both genomic and non-genomic mecha

228 ulfur compounds (H(2)S(n)), that exert their biological actions via cysteine S-sulfhydration of targe

229 ulfur compounds (H(2)S(n)), that exert their biological actions via cysteine S-sulfhydration of targe

230 potent bioactive lipid, elicits many of its biological actions via the specific G-protein-coupled re

231 2Cp2 (Cp = eta-C5H5)2, to assume its mode of biological action was closely aligned with cisplatin [ci

232 use protein molecules to carry out very fast biological actions, we quantified single-molecule reacti

233 IGF-I-stimulated downstream signaling and biological actions were also significantly impaired in N

234 OPN biological actions were studied in human hepatic stellat

235 l stress response have a range of additional biological actions which are involved in bacterial virul

236 administrated systemically, exert peripheral biological actions which may be mediated by brain pathwa

237 Artichoke has several biological actions, which are related to the synergistic

238 ntal translocation, have distinct endogenous biological actions within each compartment, and are regu

239 cule was implicated as possessing many other biological actions within the cardiovascular system, inc