ライフサイエンスコーパス: biological clock

1 spe-26: reduced fertility; clk-1: an altered biological clock).

2 the SCN resulting in phase resetting of the biological clock.

3 development, are associated with a circadian biological clock.

4 ronotype, is a manifestation of our internal biological clock.

5 cts, suppress melatonin, and phase-shift the biological clock.

6 eby meeting the three criteria that define a biological clock.

7 hich is important for the functionality of a biological clock.

8 ved through cell-to-cell communication and a biological clock.

9 eir products constitute building blocks of a biological clock.

10 scherichia coli cells expressing a synthetic biological clock.

11 re and reflect the activity of an endogenous biological clock.

12 N) of the hypothalamus function as the major biological clock.

13 iochemical ultradian drivers of the cellular biological clock.

14 and behavior are regulated by an endogenous biological clock.

15 hat constitute the molecular "cogs" of these biological clocks.

16 for the development of DNA-methylation-based biological clocks.

17 been implicated in the function of cellular biological clocks.

18 e metabolic and nutrient status to set their biological clocks?

19 We discuss how disruption of the biological clock, a consequence of modern society, can l

20 gulation and mood disorders, suggesting that biological clock abnormalities may both signal and predi

21 ncovering the physiological circuits whereby biological clocks achieve coherence will inform on both

22 s, leaving a critical gap in understanding a biological clock across the full life cycle, particularl

23 ATP, calcium, and the biological clock affect cell division and have been impl

24 Memory processes are modulated by the biological clock, although the mechanisms are unknown.

25 e that there is more than one way to build a biological clock, although there are parallels in the cy

26 ythms reflect age-related alterations in the biological clock and could be an indicator of disease.

27 e releases of neuropeptides derived from the biological clock and from a metabolic sensory organ as t

28 monstrates the mechanism underlying a robust biological clock and how it can respond to external stim

29 beta as a key factor that links autophagy to biological clock and maintains nutrient homeostasis thro

30 jacket for microECG telemetry unraveled the biological clock and normalization of QT intervals at 26

31 To investigate mechanistic links between the biological clock and pathways underlying inflammatory ar

32 the "circadian" receptors that regulate the biological clock and the pupillary reflex in mammals, is

33 ces that result in disparities between their biological clocks and how they entrain to exogenous cues

34 ights into biological problems as diverse as biological clocks and long-term memory.

35 nergy homeostasis-associated (ENHO) gene, to biological clocks and to glucose and lipid metabolism su

36 o explore this idea, cell cycle checkpoints, biological clocks, and signaling pathways are viewed her

37 hout life, referred to by many as the female biological clock, appears to be driven by a genetic prog

38 Most measurements on the biological clock are made at the macroscopic level of mi

39 Biological clocks are a ubiquitous ancient and adaptive

40 Biological clocks are autonomous anticipatory oscillator

41 Genetically encoded biological clocks are found broadly throughout eukaryote

42 Biological clocks are genetically encoded oscillators th

43 Biological clocks are self-sustained oscillators that ad

44 We propose that CR recruits biological clocks as a natural mechanism of metabolic op

45 Organisms have evolved endogenous biological clocks as internal timekeepers to coordinate

46 m in deciphering the design principle of the biological clock at the system level.

47 Both chronological and biological clocks, but not pace-of-aging clocks, show a

48 Biological clocks capture the imagination because of the

49 rn life involves conditions that disrupt the biological clock, causing metabolic disorders and higher

50 ental to health, deeper knowledge of how our biological clocks change with age may create valuable op

51 first to demonstrate a circadian rhythm of a biological clock component in identified neurons of a ma

52 Circadian biological clocks control many biological events, but th

53 Thus, biological clock-controlled mechanisms promoting glucose

54 An endogenous circadian biological clock controls the temporal aspects of life i

55 e ultradian time keepers (pacemakers) of the biological clock, COS cells were transfected with cDNAs

56 er, we found that strains with a functioning biological clock defeat clock-disrupted strains in rhyth

57 f the resetting of the multitude of internal biological clocks disrupted in a mouse model of jet lag.

58 All biological clocks entrain a set of regulatory genes to t

59 Circadian (daily) biological clocks express characteristics that are diffi

60 accumulated in these proteins to estimate a biological clock for temperate lambdoid phages.The putat

61 rising sun or availability of food, entrain biological clocks for behavioral adaptation.

62 gland and in retinal layers associated with biological clock function provides two candidate opsinli

63 Multiple biological clocks govern a healthy pregnancy.

64 Because disruption of the biological clock has been associated with increased susc

65 Biological clocks have been developed at different molec

66 Although key regulatory factors of biological clocks have been identified and genome-wide a

67 Biological clocks have evolved as an adaptation to life

68 Recently, however, such biological 'clocks' have been discovered in several spec

69 the molecular machinery responsible for the biological clock in cyanobacteria and found that it exer

70 een the environmental lighting cycle and the biological clock in the suprachiasmatic nucleus (SCN) is

71 ction pathways in maintaining a synchronized biological clock in the suprachiasmatic nucleus (SCN).

72 Rhythmic behaviors are driven by endogenous biological clocks in pacemakers, which must reliably tra

73 rachiasmatic nuclei (SCN) contain the major 'biological clock' in mammals that controls most circadia

74 s to have potential for the investigation of biological clocks, including the description of internal

75 In this review we consider how sleep and biological clocks influence synaptic plasticity.

76 This biological clock integrates multiple cues to modulate a

77 ion within the cell to a potential role as a biological clock, intracellular Ca is receiving a great

78 frequency, demonstrating that an endogenous biological clock is coupled to the mechanism of neurosec

79 SignificanceThe function of our biological clock is dependent on environmental light.

80 rage intrinsic circadian period of the human biological clock is very close to 24 h.

81 at the Period3 gene, which forms part of the biological clock, is associated with altered sleep-wake

82 We first assessed if the biological clock located in suprachiasmatic nuclei (SCN)

83 An endogenous biological clock located in the hypothalamic suprachiasm

84 the endogenous human circadian pacemaker, a biological clock located in the hypothalamus.

85 Our biological clock, located in the suprachiasmatic nucleus

86 How the suprachiasmatic nucleus, the biological clock, maintains these day-night variations w

87 es show that the molecular components of the biological clocks mediating tidal rhythms are likely dif

88 Here we introduce LifeClock, a biological clock model that predicts biological age acro

89 ring the machinery that underlies individual biological clocks, much less is known about how multiple

90 an visual system and indirect input from the biological clock nuclei.

91 zed for decades that mitochondria act as the biological clock of ageing, but the evidence is incomple

92 es a chronobiological mechanism by which the biological clock of morning types may be set to an earli

93 The biological clock of Neurospora crassa includes interconn

94 Thus, the biological clock of sinoatrial nodal pacemaker cells, li

95 CN) can be reset by light to synchronize the biological clock of the brain with the external environm

96 These data provide direct evidence that the biological clock of very premature primate infants is re

97 retina, absorbs blue light and triggers the "biological clock" of mammals by activating the suprachia

98 Endogenous biological clocks, orchestrated by the suprachiasmatic n

99 This biological clock orchestrates cellular events to occur i

100 Their "biological clock" orchestrates cellular events to occur

101 Our findings reveal distinct biological clock patterns across different life stages.

102 human homolog of the Caenorhabditis elegans biological clock protein CLK-2 (HCLK2), associated with

103 However, it is unclear whether different biological clocks reflect similar aging processes and de

104 te an unexpected mechanism through which the biological clock regulates cholesterol homeostasis throu

105 nts strongly support the conclusion that the biological clock regulates the transcriptional activity

106 These biological clocks rely on neural networks to orchestrate

107 oughout torpor the suprachiasmatic nucleus ('biological clock') showed increasing activity, likely pa

108 ting the light sensitivity of the Neurospora biological clock, specifically the rapid induction by li

109 for E. gracilis, serving as an indicator of biological clock status, photosynthetic and respiratory

110 ough SCN neural networks, particularly since biological clocks such as the SCN are assumed to be temp

111 nct phases and suggests a mechanism by which biological clocks sustain high-amplitude feedback oscill

112 The biological clock synchronizes the organism with the envi

113 In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcri

114 African-American women may have a different "biological clock" than white women, especially when unde

115 2 is a component of an output pathway of the biological clock that affects the circadian expression o

116 ctors play a crucial role in controlling the biological clock that controls circadian rhythm.

117 y homeostasis is controlled by an endogenous biological clock that is synchronized by light informati

118 Like most organisms, plants have endogenous biological clocks that coordinate internal events with t

119 Circadian rhythms are driven by endogenous biological clocks that regulate many biochemical, physio

120 d into multitissue systems which function as biological clocks that regulate the activities of the or

121 Living organisms possess biological clocks that resonate with environmental cycle

122 inant mutations in rodents with fast or slow biological clocks (that is, short or long endogenous per

123 circadian rhythms generated by the mammalian biological clock, the suprachiasmatic nucleus (SCN) of t

124 ganglion cells project predominately to our biological clock, the suprachiasmatic nucleus (SCN).

125 For biological clocks, timing, or phase, characteristics mus

126 ated profile of sensitivity of the mammalian biological clock to a melatonin signal.

127 lectric lighting has caused the near-24-hour biological clock to be set to a later time and that huma

128 sor systems that are not part of any natural biological clock to build an oscillating network, termed

129 behavior, and sets the responsiveness of the biological clock to subsequent changes in photoperiod.

130 vioral and physiological adaptability, using biological clocks to anticipate specific environmental c

131 Synchronization or entrainment of biological clocks to environmental time is adaptive and

132 warm/cold), synchronize (entrain) endogenous biological clocks to local time.

133 Most organisms use internal biological clocks to match behavioural and physiological

134 AM regulation can be a general mechanism for biological clocks to robustly modulate pulsatile downstr

135 It has been proposed that the biological clock underlying the limited division potenti

136 he cellular responses of the elements of the biological clock which are induced by lighting cues to p

137 tia are associated with dysregulation of the biological clock, which contributes to disrupted circadi

138 Biological clocks with a period of approximately 24 h (c

139 inal ganglion cells (ipRGCs) synchronize our biological clocks with the external light/dark cycle [1]

140 c chromosomes and are often thought of as a 'biological clock,' with their average length shortening