ライフサイエンスコーパス: biological effect

1 ve cytoplasm where they normally exert their biological effect.

2 hotolytically released to create the desired biological effect.

3 he contribution of detected chemicals to the biological effect.

4 uptake between cells resulted in influenced biological effect.

5 ronmental concentration that has significant biological effect.

6 synergize to give a significantly heightened biological effect.

7 hat influence signaling pathways to profound biological effect.

8 echanism of action, subtype selectivity, and biological effect.

9 igodeoxynucleotide in the specificity of its biological effect.

10 d the investigation of the potential related biological effects.

11 tral profile, highlighting the occurrence of biological effects.

12 perties of amphiphiles, thus affecting their biological effects.

13 ar affinity, resulting in a diverse range of biological effects.

14 ructures and related physical, chemical, and biological effects.

15 he JAK/STAT signaling pathway to exert their biological effects.

16 sment and the straightforward elucidation of biological effects.

17 thfully replicate in vivo and cause specific biological effects.

18 rrecting for batch effects and retaining the biological effects.

19 y focused on socio-environmental rather than biological effects.

20 non-SMAD pathways to elicit a wide array of biological effects.

21 NPs to enable the separation of physical and biological effects.

22 her understanding of their stereoselectivity biological effects.

23 ors that could contribute to their differing biological effects.

24 o their molecular functions and higher level biological effects.

25 DBPs) and hence likely tend to underestimate biological effects.

26 nalysis and to evaluate potentially relevant biological effects.

27 ppropriate performance indicators, including biological effects.

28 of drug development and understanding their biological effects.

29 ablish a structural logic that governs these biological effects.

30 e exposure may result in potentially adverse biological effects.

31 s functionally important for miR-31-mediated biological effects.

32 nanoparticles, suggesting the involvement of biological effects.

33 termines the availability of metals to exert biological effects.

34 displays an exceedingly diverse spectrum of biological effects.

35 ion mechanism by which 3OC12 can mediate its biological effects.

36 lethersatrienoic acids (DHETs) with lessened biological effects.

37 lators of EPO and EPOR expression, and EPO's biological effects.

38 ones and should be evaluated for undesirable biological effects.

39 demonstrate that the interaction has several biological effects.

40 decreased cardiac output, and various other biological effects.

41 hese models may be unable to reliably detect biological effects.

42 changes in DNA sequence can often have major biological effects.

43 r than the scientific understanding of their biological effects.

44 rs Pb and explains the absence of measurable biological effects.

45 ranberry matrix may be responsible for these biological effects.

46 stewater treatment plant (WWTP) effluents to biological effects.

47 ar organisms, in which they display profound biological effects.

48 ural abundance has hampered mapping of their biological effects.

49 ed by bacterial toxins to exert their myriad biological effects.

50 g compounded over time to augment downstream biological effects.

51 ixture constituents that interact to achieve biological effects.

52 nied with enhanced regulation of pleiotropic biological effects.

53 extra- or intracellularly to produce desired biological effects.

54 ms increasingly are used in the detection of biological effects.

55 contaminant sources, exposure pathways, and biological effects.

56 mechanistic understanding of the underlying biological effect(3).

57 ceive high doses (>20 Gy or 100 Sv [relative biological effect = 5]).

58 y that the oligomers could elicit a systemic biological effect after dietary intake.

59 s with high confidence of eliciting relevant biological effects, along with their source foods and as

60 These biological effects also required both PLD activity and m

61 ening large chemical libraries for a desired biological effect and, conversely, ensuring biological e

62 oride metabolism is critical to identify its biological effects and avoid fluoride toxicity in humans

63 P-Ti substantially enhanced the physical and biological effects and integration with bone.

64 des no mechanistic relationship to potential biological effects and is inadequate as a comprehensive

65 e should facilitate the investigation of its biological effects and its therapeutic potential.

66 of some phenolic compounds, addressing their biological effects and potential for applications in var

67 s in the hormones can result in differential biological effects and that these effects can be recepto

68 f soluble agonists to understand further the biological effects and therapeutic opportunities for ADG

69 rent chain lengths have unique metabolic and biological effects, and a small number of recent studies

70 As many biological effects are concentration dependent, it is cr

71 s of Vpr target proteins through which these biological effects are exerted are unknown.

72 is driven by multiple common variants whose biological effects are not immediately clear.

73 tant mechanism by which nanoparticles induce biological effects, as the function of many embedded mem

74 ore the importance of considering downstream biological effects, as tumor suppression cannot be infer

75 ratio approach identified the potential for biological effects associated with detected OMPs that wa

76 wever, little attention has been paid to the biological effects associated with RNA content of FBS on

77 benzodiazepenes, are tapered to reduce their biological effect at receptors by fixed amounts to minim

78 evidence that the t(1;11) translocation has biological effects at both the systems and cellular leve

79 de () is a free radical with a wide range of biological effects, but practically impossible to visual

80 g, however, in which small molecules exert a biological effect by interacting with RNA, both to study

81 ss of chemical probes and drugs that produce biological effects by irreversibly modifying proteins.

82 Part of their biological effects can be attributed to the transfer of

83 The biological effects caused by alteration of those identif

84 ssible to quantitatively predict macroscopic biological effects caused by ion radiation on the basis

85 n bioactives, including polyphenols, however biological effects compared with non-germinated grains a

86 es, i.e., the "exposome", and their specific biological effects constitutes a new paradigm for enviro

87 ty, total proteins, drug concentrations, and biological effects (cytotoxicity and anti-migration) on

88 ter protein structure and function and exert biological effects directly by binding to free thiol gro

89 This explains the increasing number of biological effects discovered during the past few decade

90 this silver ion release and their subsequent biological effects distinct from delivered particulate m

91 l foods with improved sensory properties and biological effects, due to enhanced color and anthocyani

92 A new way to increase selectivity of biological effects entails the identification of biased

93 entification of food compounds with specific biological effects, especially when accompanied by relev

94 nt ligands are capable of inducing different biological effects, even in the same cell.

95 rtunities to prioritize chemicals, sites, or biological effects for further investigation based on co

96 y between beta-arrestin isoforms governs the biological effects for most GPCRs, as yet unexplored for

97 To assess the potential risk of harmful biological effects from exposure to ionizing radiation,

98 -1), yet a ligand that would account for its biological effects has remained unknown.

99 ution, considering how their composition and biological effects have detrimental effects on cardiovas

100 ecular parameters of how CDA-KLF1 exerts its biological effects have not been addressed.

101 ures derived from indel sequence context and biological effect in a machine-learning framework.

102 elicitation of these cells in vivo and their biological effect in cell to cell communication during t

103 ther analysis revealed that NDRG1 exerts its biological effect in Merkel cell lines by regulating the

104 ed chemicals explained less than 0.2% of the biological effect in the PXR activation, adaptive stress

105 ether different IgLONs could elicit the same biological effect in vivo.

106 to be achieved when considering their known biological effects in dogs.

107 ocused primarily on the link between adverse biological effects in exposed test organisms on the leng

108 Sunlight has important biological effects in human skin.

109 ntestinal and oral permeability; 7) proof of biological effects in mice after oral administration.

110 constituents as well as demonstrating their biological effects in order to stimulate the cultivation

111 course of 3 weeks to link Pb distribution to biological effects in periphyton.

112 ng and cytokine secretion that elicit unique biological effects in progenitors.

113 c acid sensors are activated and exert their biological effects in the context of various disease set

114 wever, if uric acid generated by XO also had biological effects in the gastrointestinal tract.

115 d polyphenolic molecules that have potential biological effects including anti-oxidative, anti-inflam

116 COSAN elicits a range of cell biological effects, including altered cell morphology, i

117 thetic drugs leads to central and peripheral biological effects, including analgesia and respiratory

118 ptors to mediate both unique and overlapping biological effects, including cell migration, proliferat

119 in many cancers, where it mediates important biological effects, including cell proliferation, differ

120 metabolite of vitamin A, exerts pleiotropic biological effects, including the activation of both inn

121 ggesting that psychological treatments exert biological effects independent of symptom reduction.

122 ronmental factors, and quantification of the biological effects induced.

123 yperthermia and radiation, quantification of biological effects is key for dose prescription and resp

124 sformations to enzymes and elucidating their biological effects is undoubtedly challenging.

125 ls of neointimal proliferation and sustained biological effect </=90 days compared with a polymer-fre

126 d fluoroalkyl substitution and its prominent biological effects makes this new photochemical approach

127 t associations (P < 0.01) between pH and the biological effects measured in R philippinarum, except f

128 Here we report the biological effects measured in the pig heart tissue of t

129 hat oxidative transformation is required for biological effects mediated by covalent adduction to pro

130 perimposition of processes involving natural biological effects (no larval phase and thus limited lar

131 workflow to predict key contributors to the biological effect of a complex mixture.

132 N platform now allows for the readout of the biological effect of a toxicant through metabolomic-deri

133 In previous studies, the biological effect of CAP on cancer cells and other mamma

134 endogenous receptor assembly, mimicking the biological effect of decoy receptors that lack the death

135 consistent feature of glioblastoma, yet the biological effect of each single gene is generally modes

136 An enhanced understanding of the biological effect of exposure to violence is critical.

137 To rationalize the biological effect of GK-15, molecular docking of GK-15 i

138 The biological effect of halogens seems to be linked to the

139 This study tested the negative biological effect of hydrocarbon deposition onto titaniu

140 25 mAb treatment sensitizes Treg cell to the biological effect of IL-7, possibly rendering more commo

141 model enables more accurate estimates of the biological effect of interest, while better accounting f

142 We sought to compare the biological effect of paclitaxel delivered by 2 different

143 be a sensitive biomarker for assessing early biological effect of PM2.5 exposure on the developing fe

144 ted disorder, relapse mostly occurs when the biological effect of RTX decreases, which argues for tre

145 ndividualized dosing schedule adapted to the biological effect of RTX monitored by memory B-cell meas

146 The biological effect of RTX was considered significant with

147 patients showed relapse despite an effective biological effect of RTX.

148 But the biological effect of SDT on oral squamous cell carcinoma

149 residual unmeasured confounding, although a biological effect of smoking cannot be excluded.

150 s underscore the enhanced sensitivity to the biological effect of smoking exposure in the developing

151 ions and variants can enhance or repress the biological effect of specific mtDNA mutations.

152 rovide more accurate insights in to the true biological effect of specific mutations.

153 We demonstrate the biological effect of sphingosine-1-phosphate contained i

154 In order to understand the biological effect of such modification, we report here a

155 We looked for a biological effect of the tau variant by performing real-

156 he result of reverse causality rather than a biological effect of these drugs on the risk of PD.

157 ediated 8-oxoguanine (8-oxoG) formation, the biological effect of this common lesion at telomeres is

158 The biological effects of 3 identify it as a novel, potent m

159 l biosensors allows the investigation of the biological effects of a tested sample, as well as the bi

160 in tissue and delineates the physical versus biological effects of a tumor.

161 We assessed the clinical and biological effects of ACY-1215, an HDAC6-specific inhibi

162 omoted growth arrest, demonstrating that the biological effects of agents relied on the expression an

163 s sensitive in the detection of clinical and biological effects of allergen immunotherapy and may be

164 ine the plasticity of amino acid 226 and the biological effects of alternative amino acids on variant

165 s musculus whole-genome probes to assess the biological effects of an industrial settlement on inhabi

166 ession; however, the expression profiles and biological effects of Angpts on ovarian cancer remain la

167 However, data on the biological effects of anionophores are scarce, and it re

168 This study investigated the biological effects of ARNi with neprilysin inhibitor sac

169 -of-concept study evaluated the clinical and biological effects of BI 655066 in patients with moderat

170 ng this biomimetic system, we discovered new biological effects of blink-induced mechanical forces.

171 Biological effects of BMPs are mediated through binding

172 The biological effects of both serum samples were also compa

173 Here, in vitro and in vivo biological effects of BPs with and without titanium sulf

174 To evaluate biological effects of carbon-ion radiation through entra

175 The mechanism and biological effects of CAT-tailing-like activity in metaz

176 ibitory effect of Cetn3, suggesting that the biological effects of Cetn3 are due to the inhibition of

177 In particular, the biological effects of changing sea ice conditions are po

178 The beneficial biological effects of cinnamic acid derivatives and the

179 The biological effects of circularly polarized light on livi

180 Therefore, we interrogated the biological effects of class I HDAC inhibitors with varyi

181 Biological effects of climate change are expected to var

182 for developing and testing hypotheses about biological effects of climate change.

183 To understand potential biological effects of degradation intermediates, we test

184 analysis of our current understanding of the biological effects of different elements of the storage

185 Yet the biological effects of different RAS mutations and the ti

186 was used to generate images identifying the biological effects of different treatments using ultraso

187 and sensitive screening assays to assess the biological effects of emerging contaminants.

188 Unfortunately, whereas biological effects of EV-mediated RNA transfer are abund

189 However, the biogenesis and downstream biological effects of EVs released from gram-positive ba

190 rait-based approaches to quantify uptake and biological effects of fluoxetine, a selective serotonin

191 Most studies on the biological effects of future climatic changes rely on se

192 Biological effects of GLI mutations were tested in lucif

193 Here, we investigated the biological effects of graphene and carbon nanotubes (CNT

194 both an H2S source and sink, and many of the biological effects of H2S relate to its interactions wit

195 ve experience importantly regulates the cell biological effects of HDACi administration, however, has

196 vide a greater understanding of the vascular biological effects of HDL, with potential therapeutic im

197 The difference in the biological effects of high-energy charged particles comp

198 The biological effects of histamine are mediated by four his

199 The biological effects of human missense variants have been

200 g, these findings begin to explain the broad biological effects of HYAL2.

201 In the current study, we investigate the biological effects of ID331 Triticum monococcum gliadin-

202 The biological effects of IL-1beta are mediated through IL-1

203 The biological effects of IL-35 were assessed on group 2 inn

204 lytic processing that may provide a range of biological effects of importance in wound healing.

205 sease pathogenesis, we investigated the cell biological effects of increased TMEM106B expression.

206 stration and provides a means to examine the biological effects of inhibiting these two important enz

207 screens and provide initial insight into the biological effects of insertions on candidate cancer gen

208 Careful specification of biological effects of interest is very important to fact

209 garding their bioavailability, the potential biological effects of isoflavones and soyasaponins in in

210 This is the first study of the biological effects of LCs on pulmonary epithelia and our

211 To study the biological effects of low GSH levels, we disrupted its s

212 To determine the biological effects of low-dose radiation from SPECT MPI,

213 G-protein-coupled receptors mediate the biological effects of many hormones and neurotransmitter

214 studies are relevant for tissue engineering, biological effects of materials, tissue and organ regene

215 thylcytosine conversion, indicating opposite biological effects of Mbd1 isoforms.

216 ation of p73 rescued the transcriptional and biological effects of Mdm2 loss, indicating that p73 med

217 a, and anaphylaxis, are an expression of the biological effects of mediators on endothelial cells.

218 vide further information into the safety and biological effects of mesenchymal stem/stromal cell trea

219 Biological effects of microplastics on the health of biv

220 is apparently responsible for the different biological effects of MkMPs versus PMPs on HSPCs.

221 Several groups studied the biological effects of MPs generated ex vivo.

222 We previously found that the biological effects of MSC EV were through the transfer o

223 and help provide a rationale for the diverse biological effects of NGF and proNGF at the molecular le

224 The biological effects of nitric oxide are mediated via prot

225 Our data showing biological effects of non-nitrate components of BRJ have

226 igorously proven.Objectives: To evaluate the biological effects of normalizing AAT trough levels with

227 terfacial interaction and help to understand biological effects of NPs.

228 Despite the variety of studies on the biological effects of OA with marine commercial species,

229 butyric acidergic forebrain neurons to major biological effects of opiates, and also challenge the ca

230 When the biological effects of POC oil intake (20-40 uL.die(-1))

231 in women's CD risk after a birth may reflect biological effects of pregnancy.

232 allow full STAT5 recruitment and promote the biological effects of PRL signaling.

233 However, the long-term biological effects of proton irradiation in cancer initi

234 intermediates is relevant to understand the biological effects of radiation and to explain formation

235 Here we compare the biological effects of reading an electronic book on a li

236 hematopoiesis and focus particularly on the biological effects of Runx1 in the generation of hematop

237 y, beta-catenin/TCF-LEF pathway mediated the biological effects of SATB2 in CSCs.

238 in future studies aiming to investigate the biological effects of SHBG or develop targets for therap

239 However, research into the biological effects of small molecule anionophores is sti

240 lated genes were novel genes with respect to biological effects of smoking and might represent therap

241 In this Review we discuss the known biological effects of smoking on cancer cell biology and

242 Our findings provide insight into the direct biological effects of social inequality on immune functi

243 um Trial to further our understanding of the biological effects of sodium intake beyond blood pressur

244 r's disease (AD) is subject to debate as the biological effects of soluble and aggregated Amyloid-bet

245 s so far not yielded therapies targeting the biological effects of specific mutations.

246 Identification of the biological effects of specific somatic variants on allos

247 current understanding of the mechanistic and biological effects of spliceosomal gene mutations in MDS

248 Here, signals, mediators, and biological effects of terrein production were studied in

249 In this study, the biological effects of the ABO Expresser phenotype were i

250 develop appropriate models to elucidate the biological effects of the contributing variants.

251 and can additionally potentially enhance the biological effects of the delivered protein.

252 identifies derivative 27c, which mimics the biological effects of the irreversible inhibitors at com

253 Biological effects of the RAS are mediated by the vasoac

254 LktC-mediated acylation is necessary for the biological effects of the toxin.

255 conditions, miRNA families can fine tune the biological effects of their regulation by having individ

256 This work has also revealed that the biological effects of these enzymes often involve regula

257 Analysis of the biological effects of these mutations has revealed the t

258 mark for biophysical models that predict the biological effects of these particles.

259 hese other roles defines the richness of the biological effects of these systems and affects their sp

260 Biological effects of Ti particles and surfaces changes

261 -4 function, raising new questions about the biological effects of using checkpoint inhibitors alone

262 Many of the biological effects of XO were due to the hydrogen peroxi

263 s, the genes and loci with the most critical biological effects often differ from those with the stro

264 ave become the mainstay for studying diverse biological effects on a genome wide scale.

265 often adversely affect vector titres due to biological effects on cell metabolism and/or on the vect

266 ns and the biliary epithelium and exerts its biological effects on cholangiocytes by interaction with

267 er, its involvement in advanced CTCL and its biological effects on CTCL pathogenesis have not been ex

268 PbT (330 nM Pb(2+)) did not have observable biological effects on photosynthesis, respiration, extra

269 nflammatory cytokine with well-characterized biological effects on stromal cell activation, angiogene

270 ein folding can have profound and unexpected biological effects on such diverse processes as cancer,

271 , but relatively little is known about their biological effects on the endothelial cells lining the v

272 issues, the GLMM effectively quantified true biological effects on zebrafish locomotor response.

273 he link between the sensor responses and the biological effect onto the ecosystem into which the wast

274 ing chemical properties, toxicokinetics, and biological effects other than KCs.

275 Ten pMHCII-based nanomedicines show similar biological effects, regardless of genetic background, pr

276 haracterize the transcriptional networks and biological effects regulated by TEAD transcription facto

277 A set of 4 metabolites with known biological effects relevant to stroke pathophysiology sh

278 ompounds, being directly responsible for the biological effects some of them present.

279 cant amounts of organic compounds exhibiting biological effects such as lovastatin.

280 This model accurately accounts for biological effects such as nutrient uptake, respiration,

281 chieve a more comprehensive understanding of biological effects surrounding of carbon-ions Bragg peak

282 -1) may have utility as biomarkers, or cause biological effects that are unaffected by endothelin rec

283 ring of environmental mixtures for detecting biological effects that could not be ascertained solely

284 d have impacts on the food chain and further biologicals effects that are dependent on the size of th

285 ct by multimodal MoA resulting in the global biological effects, that is, they damage nuclear DNA, re

286 MET mediates its specific biological effects through different intracellular signa

287 The free radical nitric oxide (NO(*)) exerts biological effects through the direct and reversible int

288 such as tetrahydrocannabinol, produce their biological effects through their interactions with canna

289 via extracellular vesicles, extending their biological effect throughout the whole tumor.

290 cal analysis methods along with a variety of biological effects tools.

291 e and is particularly important for studying biological effects under low-dose ionizing radiation, sa

292 cles directly influences their transport and biological effects under physiological conditions, but t

293 is small, soluble protein triggers a host of biological effects upon binding and activating CXCR1, a

294 was to experimentally validate the enhanced biological effects using a novel beam delivery strategy

295 We spatially mapped the biological effects using high-content automated assays b

296 Lactate exerts its biological effects via G-protein-coupled receptor 81 (GP

297 AT2, and IRF9, IFN-I can mediate significant biological effects via ISGF3-independent pathways.

298 Polyphenols and biological effects were compared between malted-wheat (M

299 s of genes and loci have similarly important biological effects when mutated.

300 RTKs and to explain many of the complicated biological effects which have been described in the lite