ライフサイエンスコーパス: biological function

1 gene expression and provide new insight into biological function.

2 llular chemical signal into an intracellular biological function.

3 brafish, and this result indicates conserved biological function.

4 Protein structure determines biological function.

5 how multiple mutations combine to determine biological function.

6 echanisms that link chromosome structure and biological function.

7 ub-structures is fundamentally important for biological function.

8 llowing for a rapid response demanded by the biological function.

9 ers which enable user-specified control over biological function.

10 ptides are important for their stability and biological function.

11 ional and is frequently linked with specific biological function.

12 biotechnology as well as novel insights into biological function.

13 mechanics of polymeric materials and impart biological function.

14 otein is asked to participate in a different biological function.

15 ers the SDS, linking effector recognition to biological function.

16 ting constructs for structure, dynamics, and biological function.

17 tein complexes are a critical determinant of biological function.

18 e, targeted drug delivery and the probing of biological function.

19 exclusively on annotations for understanding biological function.

20 anoscale structural organization impacts its biological function.

21 ld into specific structures to perform their biological function.

22 onse to environmental changes is critical to biological function.

23 MtLUG, and its transactivation activity and biological function.

24 broad sequence-specificity necessary for its biological function.

25 skeleton but this has never been linked to a biological function.

26 ructures have provided a basis to understand biological function.

27 ystems is regulated to minimize toxicity for biological function.

28 cidation of the genetic basis of disease and biological function.

29 ties to electronically interpret and control biological function.

30 in environmental conditions, is critical to biological function.

31 losteric mechanism that is essential for its biological function.

32 tween fusion and fission in order to sustain biological function.

33 s of parameters that translate directly into biological function.

34 ng plays a regulatory role in various (neuro)biological functions.

35 n essential process for a number of critical biological functions.

36 exes, cellular compartments, or with similar biological functions.

37 l to uncovering the molecular nature of many biological functions.

38 on elaborate transistor circuits to simulate biological functions.

39 associations between physical structure and biological functions.

40 n many proteins that are involved in diverse biological functions.

41 onformational transitions to perform various biological functions.

42 slational control logic over a wide range of biological functions.

43 se an existing protein to participate in new biological functions.

44 d genes that can be related to specific cell biological functions.

45 aining protein 7 (BRD7), which has different biological functions.

46 iced isoforms of a gene actually execute the biological functions.

47 clic dinucleotides to control very different biological functions.

48 nse membrane curvature in support of diverse biological functions.

49 lexes play critical roles in many aspects of biological functions.

50 is thought to play an important role in many biological functions.

51 be used to provide novel insight into their biological functions.

52 uting its catalytic activity to its proposed biological functions.

53 hile enabling exploration of their divergent biological functions.

54 conformational changes, accomplishing their biological functions.

55 f outer arm structure motifs with recognized biological functions.

56 nd morphological changes to fulfill distinct biological functions.

57 od in terms of their chemical structures and biological functions.

58 to our understanding of cholesterol-mediated biological functions.

59 ation of mRNA that affects a wide variety of biological functions.

60 knowledge, providing new insights into their biological functions.

61 chanisms by closely mimicking their original biological functions.

62 ns are ubiquitous proteins that mediate many biological functions.

63 e chemical and physical properties for their biological functions.

64 fication of specific genes and their related biological functions.

65 n be visualized as a heatmap or a network of biological functions.

66 roteins and small molecules are critical for biological functions.

67 es to a spectrum of cells that have distinct biological functions.

68 otor protein and is responsible for numerous biological functions.

69 teins is a critical step to understand their biological functions.

70 airing, creating two integrins with distinct biological functions.

71 DAXX displays complex biological functions.

72 microscopy facilitates the understanding of biological functions.

73 of the AAA+ superfamily achieve specialized biological functions.

74 e to drugs and other anthelmintic-associated biological functions.

75 outs into patterned clusters with associated biological functions.

76 to pharmacologically dissect their distinct biological functions.

77 ergy landscapes that are required for active biological functions.

78 acromolecules that modulates a cornucopia of biological functions.

79 vities suggest that they also have different biological functions.

80 by stochastic responses to the cessation of biological functions.

81 ct cell populations specialized in divergent biological functions.

82 rder structures (HOS) to enable their unique biological functions.

83 ar local network structure also have similar biological functions.

84 ist of molecular modules which perform vital biological functions.

85 detection of AKI and has multiple potential biological functions.

86 with varying sizes, cellular abundance, and biological functions.

87 leads to distinct metabolic requirements and biological functions.

88 uggability features with indication specific biological functions.

89 ubfamilies of HeRs, suggesting their diverse biological functions.

90 lly adjusted to carry out a diverse array of biological functions.

91 structure, and could affect membrane-hosted biological functions.

92 rm, even if assembly per se does not enhance biological function(3-7).

93 on Earth, with a plethora of structural and biological functions(5)-has not been possible so far(6).

94 genes were grouped into modules relating to biological functions, all were found to be conserved bet

95 targets like short interfering RNAs or lack biological function altogether.

96 al framework, including data integration and biological function analysis.

97 tors that are diverse in their structure and biological function and are divided into different class

98 d to connect non-coding genomic variation to biological function and disease pathology.

99 n aggregation process in driving deleterious biological function and establish a direct causative con

100 primary stem cells is essential for studying biological function and for clinical applications.

101 eins onto mineral surfaces may alter protein biological function and other environmental interactions

102 is fundamentally important for understanding biological function and rational drug design.

103 SNPs in OPRM1 expression, and to assess the biological function and relevance of OPRM1 expression in

104 l-defined 3D structures yet perform numerous biological functions and are associated with a broad ran

105 ls in Gene-Set Test (GST) that describe gene biological functions and associated pathways.

106 oteoforms, play an important role in diverse biological functions and diseases.

107 tudy of RiPPs may lead to discoveries of new biological functions and highlight that a better knowled

108 ological processes, studies to elucidate its biological functions and how it integrates into, or func

109 s datasets that enable the identification of biological functions and mechanisms via multiple facets.

110 ory EVs, delineated the potentially targeted biological functions and pathways during hematopoietic c

111 cs, and other modalities to infer or predict biological functions and phenotypes associated with prot

112 Many metals have biological functions and play important roles in human h

113 E2 and TMPRSS2, and to further explore their biological functions and potential as druggable targets.

114 They regulate a wide range of important biological functions and processes, including embryogene

115 hways implicated in cancer, describing their biological functions and their connections to the diseas

116 mbryo development and contribute to distinct biological functions and tissue morphology.

117 d in transgenic GFP reporter mice, and their biological functions and transitions during the postnata

118 oles in UAF complex integrity, assembly, and biological function, and provide roles for previously id

119 y cAMP (EPAC) play a central role in various biological functions, and activation of the EPAC1 protei

120 larified the domain architectures, potential biological functions, and evolutionary relationships of

121 cell-surface proteins implicated in diverse biological functions, and identify many potential surfac

122 rix adhesion in the skin; however, its other biological functions are largely unclear.

123 cteria and microbial eukaryotes, where their biological functions are largely unknown.

124 e lipids in the formation of pores and their biological functions are largely unknown.

125 rtant regulators of tumorigenesis, but their biological functions are often context dependent with un

126 tate chromatin compaction(1), although their biological functions are poorly understood.

127 o salt stress and pathogenesis; however, its biological functions are still unknown.

128 of tau protein has been implicated in normal biological function as well as neurodegenerative disease

129 Molecular pathways and biological functions associated with innate immune and I

130 enes in specific cell types to examine their biological functions at defined developmental stages.

131 latory behavior and advance understanding of biological functions at the genomic level with spatiotem

132 amines the multiple antiviral mechanisms and biological functions attributed to viperin.

133 lysis identified cell differentiation as one biological function being specifically associated with A

134 interactions in human ARSs, revealing hidden biological functions beyond their catalytic roles in pro

135 ular relocalization is known to impart novel biological functions but has not been described before o

136 the conventional counterparts that modulate biological function by reversibly binding to proteins, i

137 omains perform an extraordinary diversity of biological functions despite sharing a common mechanoche

138 ults indicate that stress may affect certain biological functions differently in wild, domesticated a

139 The main biological functions disrupted in these mutants, includi

140 otein modifications without perturbing their biological function, enabling the selective installation

141 chemically-detailed conformational movies of biological function, extracted data-analytically from ex

142 We propose a novel biological function for MSCI: the initiation of MSCI seq

143 recently, evidence has emerged to support a biological function for TET-mediated m(5)C oxidation in

144 in understanding not only revealed a second biological function for the p7 viroporin from hepatitis

145 inae larvae indicate an additional important biological function for the substrate, and therefore the

146 DEK1 during spermatogenesis suggests another biological function for this protein in plants.

147 RNA molecules perform a variety of biological functions for which the correct three-dimensi

148 ng properties directly translate to distinct biological functions: free IgE initiated allergic inflam

149 pathway protein mutants are male sterile, no biological function has been identified for any mammalia

150 must be regulated to coordinate G4-mediated biological functions; however, how cells regulate the sp

151 e bacterial kingdom, suggesting an important biological function in bacteria.

152 However, its biological function in cancer remains largely unknown.

153 splicing (AS) is involved in virtually every biological function in eukaryotes, including cellular di

154 erties that also appear to be central to its biological function in heterochromatin compaction and re

155 th new, phase-separation-mediated control of biological function in living cells.

156 ig-G and the underlying mechanism(s) for its biological function in lung cancer remain largely unexpl

157 ification in albumin might have an important biological function in mice that is not affected by the

158 ulating exosomal miR-221-3p levels also have biological function in promoting HLECs sprouting in vitr

159 Here, we explore implementation of such biological functions in artificial membranes and demonst

160 ture and function of OXPHOS complexes, their biological functions in cancer, relevant research tools

161 omplexes is paramount to understanding their biological functions in cellular processes.

162 osed two-stage DE approach display potential biological functions in Gene Ontology and circRNA-miRNA-

163 I1-FFL to control a large number of distinct biological functions in human cell lines, such as four d

164 s on expression of diverse genes with shared biological functions in neuronal signaling.

165 Nuclear receptors have a broad spectrum of biological functions in normal physiology and in the pat

166 amma-aminobutyric acid (GABA) serves diverse biological functions in prokaryotes and eukaryotes, incl

167 as a biomarker for reactive gliosis, but its biological functions in retinal diseases remain elusive.

168 vesicles (EVs) are known to influence their biological function, in terms of, e.g., cellular adhesio

169 The system's main biological functions include lysis, opsonization, and re

170 most eukaryotes and are involved in numerous biological functions including ATP production, cofactor

171 smotic stresses, and it also guides multiple biological functions including cardiovascular control an

172 ly diverse class of molecules with important biological functions including cellular signaling and en

173 effects of beta-endorphin and modulate many biological functions including reward processing and add

174 esistance included 453 SNPs involved in wide biological functions, including genes associated with di

175 d APC signaling, an enrichment of associated biological functions, including key modulators of endoth

176 intracellular condensates control essential biological functions, including messenger RNA processing

177 istinct classes of genes assigned to several biological functions, including metabolic processes, sug

178 DRs) serve an increasingly expansive list of biological functions, including regulation of transcript

179 TSG-6 has several known biological functions, including the enzymatic transfer o

180 etylase sirtuin 6 (SIRT6) regulates numerous biological functions, including transcriptional repressi

181 The systemic impairment of several key biological functions, including vision, reported here wo

182 pled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging

183 n consistent trajectory groups with coherent biological functions-including extracellular matrix regu

184 concept that a structure can guide desirable biological function is applied to physically engineer th

185 lycosylation sites over time, although their biological function is poorly defined.

186 lly conserved archaeal proteins with unknown biological function is the Factor that terminates transc

187 ps associated with mRNA processing and whose biological function is tightly regulated through multi-s

188 structural dependency of microRNAs for their biological functions is essential for designing syntheti

189 dification is regulated to modulate specific biological functions is poorly understood.

190 anti-inflammatory state, suggesting that the biological functions it represents serve a protective ro

191 nd indicate that different genes with shared biological functions may have driven the formation of th

192 The biological function of alpha-syn remains elusive; howeve

193 Understanding the biological function of amyloid beta (Abeta) precursor pr

194 However, the biological function of APP is poorly understood.

195 a novel mechanism by which Gfi1 augments the biological function of c-Myc and may have implications f

196 To reveal the biological function of group 21 allergens and to underst

197 evolutionarily conserved in eukaryotes, the biological function of Hbs1 in multicellular organisms i

198 The biological function of high-density lipoprotein (HDL) na

199 MD) and disease progression, but the precise biological function of HtrA1 in the eye and its contribu

200 only very limited information regarding the biological function of IL2RA in AML is available.

201 However, the biological function of lncRNAs in HPV16-related CC remai

202 triction factor of coronaviruses expands the biological function of LY6E and sheds new light on the i

203 ns the path for future investigations of the biological function of metaphosphates in many organisms.

204 In plants, the biological function of NTA remains enigmatic.

205 Our most predictive features included biological function of proteins, network centrality meas

206 erally applicable method for elucidating the biological function of single lipid species on subcellul

207 ns, and benefits further study regarding the biological function of SP_0782, probably in DNA protecti

208 However, the biological function of SULT4A1 is unclear.

209 In this study we characterized the biological function of the ACKR2-V41A receptor compared

210 atistics and extensive information about the biological function of the analyzed biomolecules.

211 Given our growing understanding for the biological function of this and other functional amyloid

212 However, the biological function of this well-conserved gene in filam

213 To elucidate the biological function of TMEM106B and determine whether lo

214 he present study was designed to explore the biological function of TSPAN5 with a focus on 5-HT and k

215 ranscription that in turn contributes to the biological function of YAP/TAZ.

216 The biological function of Z-DNA and Z-RNA, nucleic acid str

217 However, the biological functions of 6mA in mammals have yet to be ad

218 tial to a comprehensive understanding of the biological functions of CAZymes and exploiting these enz

219 However, the biological functions of CDK8 in plant abiotic stress res

220 INtegrative Annotations (Cerina), to predict biological functions of circRNAs based on the competing

221 T, are important drug targets; however, the biological functions of each bromodomain remain ill-defi

222 , we first discuss the distinct features and biological functions of each oxidative species.

223 ditions is a promising way to understand the biological functions of epigenetic modifications.

224 h organisms is crucial for understanding the biological functions of genes and their evolution.

225 Biological functions of hyaluronic acid (HA) depend on i

226 These proteins define the biological functions of LDs, and most of them bear amphi

227 oci associated with MDD that are involved in biological functions of likely importance to MDD etiolog

228 lysis proves to be critical for studying the biological functions of lipids, current mainstream metho

229 Biological functions of many proteins are governed by po

230 ed in other alphaherpesviruses; however, the biological functions of MDV U(S)3 and its substrates hav

231 timal physiology are well-known, the overall biological functions of Mn are rather poorly understood.

232 the biochemistry, molecular mechanisms, and biological functions of mRNA modifications in plants.

233 Studies on biological functions of N6-methyladenosine (m6A) modific

234 arify our understanding of the mechanism and biological functions of NAIP/NLRC4 activation.

235 omedicine that targets both the chemical and biological functions of neutrophils in tumor is designed

236 To understand the biological functions of PARP14, we catalogued the geneti

237 Biochemical and biological functions of proteins are the product of both

238 tion for future investigation of the diverse biological functions of SA1 and SA2.

239 Potential biological functions of SNPs were analyzed by HaploReg v

240 t genotype-phenotype relationships, into the biological functions of specific enzymes of the Kennedy

241 ide a framework for connecting enzymatic and biological functions of specific HDAC complexes.

242 ramming, as well as for dissecting the other biological functions of TET enzymatic activities without

243 er brings new insights into the cellular and biological functions of the cell types in gastrointestin

244 fferentiation and provides new insights into biological functions of the cellular tubulin PTM "code."

245 f structural tissues and some of the complex biological functions of the human brain.

246 We have a limited understanding of the biological functions of the risk alleles that have been

247 responsible for binding to RANKL, the exact biological functions of the three C-terminal domains of

248 However, the biological functions of these ancient primary DR sequenc

249 While the biological functions of these deceptively simple molecul

250 y facilitate the exploration of the specific biological functions of these pheromones in the worm.

251 ize and discuss biochemical, structural, and biological functions of these proteins including their r

252 antly hampered progress in understanding the biological functions of this scaffold protein.

253 The biological functions of this unique hook complex-centrin

254 the past decades for their ability to mimic biological functions of traditional functional groups wh

255 ional modifications on ubiquitin itself, the biological functions of which are not well understood.

256 lecular and genetic studies to elucidate the biological functions of XVP.

257 harming the survival rate, development, and biological functions of zebrafish embryos.

258 icantly associated with angiogenesis-related biological functions (p < 0.025) and angiogenic factors

259 However, most de novo proteins lack biological function, presenting a major methodological c

260 They serve a wide variety of biological functions, ranging from energy storage to str

261 Candidate genes with biological function related to transpiration, root devel

262 set enrichment analyses identified important biological functions related to growth, hormone levels a

263 ss-species phenomenon whose evolutionary and biological function remain poorly understood.

264 Their biological functions remain largely unknown.

265 s (lncRNA) in breast cancer cells, but their biological functions remain largely unknown.

266 exes, but which mode is more relevant to its biological function remains controversial.

267 nts locating downstream of xrRNAs, but their biological function remains unknown.

268 ng these modifications, their substrates and biological functions, remains vague.

269 t of 136 VUSs interrogating a range of PALB2 biological functions resulted in the identification of 1

270 ased on oncology targets and cancer relevant biological functions, resulting in significantly higher

271 redundancies in functional descriptions and biological functions shared among genes.

272 Thyroid hormones regulate essential biological functions such as growth and development, reg

273 These molecules may have biological functions such as signaling, cell communicati

274 s leukemia though influencing cancer-related biological functions, such as cell proliferation, telome

275 Arteries serve diverse mechanical and biological functions, such as conducting blood to tissue

276 soscopic length and time scales of important biological functions, such as viral budding and lipid-pr

277 ow NCoR1 and SMRT may contribute to distinct biological functions, suggesting an exclusive role of NC

278 Biological functions supporting replication of viruses a

279 modified residues, it is probable that their biological functions take place in the context of an ord

280 Here, we summarize the known biological functions, target substrates, and expression

281 Circadian rhythms are daily cycles in biological function that are ubiquitous in nature.

282 versatile biomolecule with a broad range of biological functions that go far beyond its initially de

283 hPXR and hCAR have distinct and overlapping biological functions, these results highlight the value

284 olution couples differences in ambient pH to biological function through protonatable groups, in part

285 Most proteins perform their biological functions through interactions with other pro

286 We conclude that SynGAP protein retains biological functions throughout adulthood and that non-d

287 genes can then be tested for convergence in biological function, tissue, cell type, or developmental

288 B. microti antigens, and assigned potential biological function to these antigens, which can be eval

289 To identify pathways and biological functions uniquely induced by combination tre

290 quantitative trait loci (eQTL) analyses for biological function using the BRAINEAC database.

291 of heterogeneous tumour subclones and their biological functions using radiogenomic signatures.

292 eptin/orphanin FQ (N/OFQ) controls different biological functions via selective stimulation of the N/

293 uch smaller subspace that optimally realizes biological function, we deliver a rich class of models t

294 o understand how motif divergence relates to biological function, we first determined a crystal struc

295 findings differentiate effector binding from biological function, which has ramifications for riboswi

296 condary metabolites of plants have important biological functions, which often depend on their locali

297 relationships between DC subtypes and their biological functions will rationalize oral vaccine desig

298 O) has been reported to exhibit two distinct biological functions with a nonheme iron center.

299 Is) are involved in many of life's essential biological functions yet are also an underlying cause of

300 Protein dynamics are integral to biological function, yet few techniques are sensitive to