ライフサイエンスコーパス: biological macromolecule

1 e of interest (ranging from small ligands to biological macromolecules).

2 ydrogen polarization and solubilization of a biological macromolecule.

3 ch may serve as a mechanical signature for a biological macromolecule.

4 NA is arguably the most functionally diverse biological macromolecule.

5 catalyse the conformational rearrangement of biological macromolecules.

6 ise from the nanoassembly of these important biological macromolecules.

7 harmful to living systems, causing damage to biological macromolecules.

8 ligands directly influence the functions of biological macromolecules.

9 between structure, dynamics, and function in biological macromolecules.

10 ibrium between folded and unfolded states of biological macromolecules.

11 of complex molecular systems, in particular biological macromolecules.

12 for investigating the structural dynamics of biological macromolecules.

13 -assembly behaviors of inorganic species and biological macromolecules.

14 for examining the structure and function of biological macromolecules.

15 indispensable tool for structural studies of biological macromolecules.

16 eveloped as a powerful technique for sensing biological macromolecules.

17 assessment of electrostatic interactions in biological macromolecules.

18 on of molecular materials with DNA and other biological macromolecules.

19 and dynamics is essential to the function of biological macromolecules.

20 tial functions widely used in simulations of biological macromolecules.

21 to be located in smaller crystals of larger biological macromolecules.

22 uired in multidimensional NMR experiments of biological macromolecules.

23 yields a nanostructure capable of detecting biological macromolecules.

24 or to become covalently attached to targeted biological macromolecules.

25 ns of low-frequency deformational motions of biological macromolecules.

26 mitted the application of the PRE to various biological macromolecules.

27 for three-dimensional (3D) structure data of biological macromolecules.

28 e-dimensional structures of many filamentous biological macromolecules.

29 coding synthetic small molecules rather than biological macromolecules.

30 used to probe the conformational dynamics of biological macromolecules.

31 ion structural and thermodynamic modeling of biological macromolecules.

32 trinsic and extrinsic magnetic properties of biological macromolecules.

33 source of information on the 3D structure of biological macromolecules.

34 ues for evaluation of physical properties of biological macromolecules.

35 e and identification of chemical exchange in biological macromolecules.

36 water in the system is interacting with the biological macromolecules.

37 isite complex structures and/or functions of biological macromolecules.

38 ngle worldwide archive of structural data of biological macromolecules.

39 ive structural and functional information of biological macromolecules.

40 ntrifuge and its application to the study of biological macromolecules.

41 epository of files containing coordinates of biological macromolecules.

42 reveal pathways of allosteric transitions in biological macromolecules.

43 ution 3-Dimensional (3D) structures of large biological macromolecules.

44 ms of life, as they regulate the function of biological macromolecules.

45 ows for the high-resolution visualization of biological macromolecules.

46 werful method for resolving the structure of biological macromolecules.

47 ssential tool for structure determination of biological macromolecules.

48 , biophysical, and biochemical properties of biological macromolecules.

49 structures are essential for the function of biological macromolecules.

50 erpin regulation of activity in a variety of biological macromolecules.

51 onment react directly with reactive sites in biological macromolecules.

52 gnetic Resonance (NMR) spectroscopic data of biological macromolecules.

53 heterogeneity, and inter probe distances in biological macromolecules.

54 es, mirrors the sequence variations found in biological macromolecules.

55 d to an increasing number of density maps of biological macromolecules.

56 biomaterials and the controlled delivery of biological macromolecules.

57 -enzymatic covalent modifications (NECMs) on biological macromolecules.

58 structure determination for a wide range of biological macromolecules.

59 nd therefore, function of proteins and other biological macromolecules.

60 120,000 three-dimensional (3D) structures of biological macromolecules.

61 a powerful tool for studying the folding of biological macromolecules.

62 ities for the structural characterization of biological macromolecules.

63 ental resource of the tertiary structures of biological macromolecules.

64 NO), a free radical that can damage numerous biological macromolecules.

65 y influence the architecture and activity of biological macromolecules.

66 ding can alter the structure and function of biological macromolecules.

67 atic for the purpose of fingerprinting large biological macromolecules.

68 allographic characteristics closely resemble biological macromolecules.

69 ve investigation of the dynamics of GNSs and biological macromolecules.

70 n molecular recognition and self-assembly of biological macromolecules.

71 namic, translational friction coefficient of biological macromolecules.

72 es in both the mechanism and architecture of biological macromolecules.

73 d other newcomers to computer simulations of biological macromolecules.

74 ajor properties of soft materials, including biological macromolecules.

75 dely used to study conformational changes of biological macromolecules.

76 nd is essential for molecular recognition by biological macromolecules.

77 o model nano-size objects together with real biological macromolecules.

78 king replacement of phosphorus by arsenic in biological macromolecules.

79 uld substitute arsenic for phosphorus in its biological macromolecules.

80 atomic structures and working mechanisms of biological macromolecules.

81 ated our interpretation of ligand binding in biological macromolecules.

82 cterization of the structure and dynamics of biological macromolecules.

83 its ability to act as a molecular sensor of biological macromolecules.

84 ing increased use in exploring properties of biological macromolecules, alone and in association.

85 Determining high-resolution structures of biological macromolecules amassing less than 100 kilodal

86 l resonances and determine the structures of biological macromolecules and (iv) a database of one- an

87 l changes as occur during the functioning of biological macromolecules and assemblies can be elucidat

88 rarchical structure (tertiary/quaternary) of biological macromolecules and assemblies.

89 Over the past decades, therapeutics based on biological macromolecules and cells have successfully en

90 lity for dose-efficient imaging of unstained biological macromolecules and cells.

91 s for the study of structure and dynamics of biological macromolecules and complexes.

92 Hydration water is the natural matrix of biological macromolecules and is essential for their act

93 CSB PDB) provides access to 3D structures of biological macromolecules and is one of the leading reso

94 can inflict oxidative damage on all types of biological macromolecules and lead to cell death.

95 a vital tool for the structural analysis of biological macromolecules and materials.

96 ins, enabling precise covalent linkages with biological macromolecules and paving the way for new app

97 analysis of a variety of materials including biological macromolecules and polymers.

98 tive, noncovalent interaction often found in biological macromolecules and synthetic supramolecular c

99 alizes the advantages of naturally occurring biological macromolecules and their building-block natur

100 perimentally determined atomic structures of biological macromolecules and their complexes with one a

101 measurements for Na(+) ions in solutions of biological macromolecules and their complexes.

102 Our results demonstrate that the dynamics of biological macromolecules and their hydration water depe

103 static potentials for various regions around biological macromolecules and thereby may facilitate imp

104 logy developed here is broadly applicable to biological macromolecules and will provide useful inform

105 ffectively and rapidly pattern living cells, biological macromolecules, and biomaterials.

106 icity of the interactions within and between biological macromolecules, and hence accurate modeling o

107 biological antibody analogues that recognize biological macromolecules, and hold great promise for me

108 impact of supercooling for future studies of biological macromolecules, and shows that our approach e

109 Many proteins or other biological macromolecules are localized to more than one

110 Biological macromolecules are often studied in mixed sol

111 nt for the atropselective binding of PCBs to biological macromolecules are, therefore, needed to pred

112 Therefore, using biological macromolecules as a model system, we have stu

113 till largely ignoring the flexible nature of biological macromolecules as the number of degrees of fr

114 MS) groups present outstanding NMR probes of biological macromolecules as they produce intense single

115 Such algorithms represent biological macromolecules as vectors in d-dimensional sp

116 ations of these long-distance NMR methods to biological macromolecules as well as small molecules are

117 The method is suitable for biological macromolecules, as relaxation not resulting f

118 ated with the degradation and utilization of biological macromolecules, as well as plastics, other pe

119 , general tool for computing the behavior of biological macromolecules at equilibrium because it esta

120 iction of the structures and interactions of biological macromolecules at the atomic level and the de

121 image nonperiodic nanostructures, including biological macromolecules, at diffraction intensity-limi

122 nation has been widely used to detect single biological macromolecules because it can notably enhance

123 -resolved crystallographic investigations on biological macromolecules belong to an important class o

124 n types of commercial SWCNTs, representative biological macromolecules (bovine serum albumin and meth

125 scovery relies on the selective targeting of biological macromolecules by low-molecular weight compou

126 ermined three-dimensional (3D) structures of biological macromolecules by the Worldwide Protein Data

127 Determining the structure of biological macromolecules by X-ray crystallography invol

128 Biological macromolecules can be encapsulated into prefo

129 ny cases, the properties and applications of biological macromolecules can be further expanded by att

130 onstrate that the dynamics of cations around biological macromolecules can be revealed by (23)Na diff

131 Biological macromolecules can condense into liquid domai

132 Crystallization of biological macromolecules can represent a significant ob

133 ation under mild conditions that DNA and RNA biological macromolecules can tolerate.

134 Collagen is a biological macromolecule capable of second harmonic gene

135 ations such as understanding the dynamics of biological macromolecules, cell-cell interactions and th

136 e tool for the manipulation of cells, single biological macromolecules, colloidal microparticles and

137 own, cannot lead to unique 3-D structures of biological macromolecules comparable to all-atom models

138 ich isolates the core from interactions with biological macromolecules, controls diffusion of oxygen

139 thermodynamic hypothesis', the sequence of a biological macromolecule defines its folded, active (or

140 Crystals of many important biological macromolecules diffract to limited resolution

141 n microscopy, poses extreme risk of damaging biological macromolecules due to interactions with the a

142 ent of the cell and affect the corresponding biological macromolecules either via direct binding or a

143 gh primary sequence is a defining feature of biological macromolecules, enabling precise control over

144 Biological macromolecules, especially proteins, provide

145 is a major limitation in crystallography of biological macromolecules, even for cryocooled samples,

146 In biological macromolecules, fluorophores often exhibit mu

147 ctive medium to test the mechanisms by which biological macromolecules fold into complex three-dimens

148 terplay between the topology and activity of biological macromolecules from a mechanochemical perspec

149 olloidal systems, from synthetic nanogels to biological macromolecules, from viruses to star polymers

150 R(1 rho) measurements for heteronuclei in biological macromolecules generally require decoupling o

151 couplings (RDCs) in solution NMR studies of biological macromolecules has become well established ov

152 Single-molecule imaging of biological macromolecules has dramatically impacted our

153 though cryo-electron microscopy (cryo-EM) of biological macromolecules has made important advances in

154 he functionality and structural diversity of biological macromolecules has motivated efforts to explo

155 le of characterizing binding interactions of biological macromolecules have become commercially avail

156 An increasing number of density maps of biological macromolecules have been determined by cryo-e

157 majority of three-dimensional structures of biological macromolecules have been determined by X-ray

158 rtiary structures of an increasing number of biological macromolecules have been determined using cry

159 Biological macromolecules have evolved to fold and opera

160 molecules that mimic the activity of native biological macromolecules have therapeutic potential, ut

161 Allosteric regulation of biological macromolecules, however, is affected by both

162 rometry (IM-MS) allows structural studies on biological macromolecules in a solvent-free environment.

163 goal of structural biology is to understand biological macromolecules in as much detail as possible.

164 gnized as important organizing mechanisms of biological macromolecules in cellular environments.

165 Where possible, the roles of key biological macromolecules in controlling production of t

166 dynamics simulations capture the behavior of biological macromolecules in full atomic detail, but the

167 dy dynamic phenomena such as slow folding of biological macromolecules in greater detail.

168 The interaction between water and biological macromolecules in living organisms is of fund

169 arbohydrates form one of the major groups of biological macromolecules in living organisms.

170 is a technology for the mass measurement of biological macromolecules in solution.

171 analyze the size, shape, and interactions of biological macromolecules in solution.

172 e applied to the structural determination of biological macromolecules in solution.

173 weaker than those of the strongest bands of biological macromolecules in the same spectral regions.

174 zing different aspects of interactions among biological macromolecules in their native environments.

175 ography allow determination of structures of biological macromolecules in their native state in solut

176 structure and dynamics of proteins and other biological macromolecules in various environments is amo

177 sses that drive function and pathogenesis in biological macromolecules, including (mis)folding, compl

178 The nuclear environment is highly crowded by biological macromolecules, including chromatin and mobil

179 artemisinins form adducts with a variety of biological macromolecules, including haem, translational

180 y is applicable to detection of a variety of biological macromolecules, including proteins and proteo

181 haracterize the conformation and dynamics of biological macromolecules inside living cells.

182 a wavelength of 1042 nm was used to vaporize biological macromolecules intact from the condensed phas

183 l approach for refining structural models of biological macromolecules into cryo-EM density maps by c

184 or femtosecond laser vaporization to deliver biological macromolecules into the gas phase for mass an

185 or determining high-resolution structures of biological macromolecules invites the questions, how muc

186 Activities of many biological macromolecules involve large conformational t

187 Molecular recognition by biological macromolecules involves many elementary steps

188 Selective C-H activation on complex biological macromolecules is a key goal in the field of

189 es onto three-dimensional (3D) structures of biological macromolecules is a powerful tool to show geo

190 The automated functional annotation of biological macromolecules is a problem of computational

191 mputers to simulate the functions of complex biological macromolecules is essential to achieve a micr

192 cadmium(II), mercury(II), and lead(II) with biological macromolecules is metal ion exchange dynamics

193 e xi0 of filamentous networks assembled from biological macromolecules is one of the most important p

194 the computed electrostatic potentials around biological macromolecules is rare and methodologically l

195 ence that water structure in the vicinity of biological macromolecules is unusual and that the proxim

196 Cellulose, the most abundant biological macromolecule, is an extracellular, linear po

197 dynamics, which assumes that the dynamics of biological macromolecules just follows the dynamics of h

198 changes on a nanometer scale, within single biological macromolecules, may be possible with single p

199 Allostery is the process by which biological macromolecules (mostly proteins) transmit the

200 All structured biological macromolecules must overcome the thermodynami

201 arge N) systems, up to molecules as large as biological macromolecules (N > 1000 atoms).

202 Structural information about biological macromolecules near the atomic scale provides

203 cant attention recently for the synthesis of biological macromolecules of defined homogeneous composi

204 es a unique window into the dynamic world of biological macromolecules, offering the capacity to dire

205 dimensional structures of proteins and other biological macromolecules often aids understanding of ho

206 el three-dimensional (3D) structure data for biological macromolecules often prove critical to dissec

207 The adsorption or covalent attachment of biological macromolecules onto polymer materials to impr

208 d data analysis approaches for investigating biological macromolecules, organic materials, and inorga

209 ters entering the long range interactions of biological macromolecules, providing accurate data for t

210 ominant source of structural information for biological macromolecules, providing fundamental insight

211 cosolutes whose spatial distributions around biological macromolecules reflect electrostatic potentia

212 The ability to activate biological macromolecules remotely, at specific location

213 utine high-resolution structural analyses of biological macromolecules, resulting in a flood of new m

214 e-dimensional structures and compositions of biological macromolecules sheds light on their functions

215 To this aim, biological macromolecules should ideally be characterize

216 The most common recognition motifs involve biological macromolecules such as antibodies and aptamer

217 ctions play an import role in the folding of biological macromolecules such as DNA and proteins.

218 hereby prevent oxidative damage to important biological macromolecules such as DNA, lipids, and prote

219 atform that can be used for the detection of biological macromolecules such as mismatch repair protei

220 ty of pH-coupled conformational phenomena in biological macromolecules such as protein folding or mis

221 Biological macromolecules such as proteins and nucleic a

222 Biological macromolecules such as proteins often interac

223 l rings for the minimal motif for binding to biological macromolecules such as RNA and proteins.

224 When the target is a biological macromolecule, such as a protein, the process

225 The exploitation of biological macromolecules, such as nucleic acids, for th

226 RNA is a versatile biological macromolecule that is crucial in mobilizing a

227 all classes of biologically active drugs or biological macromolecules that affect cellular attachmen

228 signaling systems often rely on complexes of biological macromolecules that can undergo several funct

229 est a route to improved energy functions for biological macromolecules that combines the generality o

230 nvestigating rapid conformational changes in biological macromolecules that have previously been inac

231 40-150-nm extracellular vesicles, transport biological macromolecules that mediate intercellular com

232 hniques allow high-resolution experiments on biological macromolecules that were mere pipe dreams onl

233 cts the polymeric primary structure of these biological macromolecules, their intrinsic flexibility,

234 ts, ranging from inorganic nanostructures to biological macromolecules.Three-dimensional ptychographi

235 ophores, which bind directly to receptors or biological macromolecules to produce biological effects,

236 is a powerful tool for the investigation of biological macromolecules under a wide range of solution

237 cidation of the detailed mechanisms by which biological macromolecules undergo major structural conve

238 The structural features and dynamics of biological macromolecules underlie the molecular biology

239 Biological macromolecules use binding forces to access u

240 ears the primary source of information about biological macromolecules was the Protein Data Bank, whi

241 olar couplings (RDCs), commonly measured for biological macromolecules weakly aligned by liquid-cryst

242 ool in structural and mechanistic studies of biological macromolecules where large conformational cha

243 ies for the binding of a small molecule to a biological macromolecule, which has immense implications

244 of facile structure determination of complex biological macromolecules, which cannot be coaxed to for

245 ty to control the aggregation of organic and biological macromolecules, which typically poses signifi

246 In particular, samples of biological macromolecules, which usually contain salts t

247 ts aim to expand our structural knowledge of biological macromolecules while lowering the average cos

248 examine and characterize the interaction of biological macromolecules with a binding surface.

249 s enable molecular detection of chemical and biological macromolecules with a high degree of specific

250 rophilic amino acids, and (c) DNA fragments, biological macromolecules with double-stranded polymeric

251 more general LAFM algorithm that can handle biological macromolecules with multiple distinct conform

252 used to study the evolution of robustness in biological macromolecules, with similar results.

253 Crystal structure analyses for biological macromolecules without known structural relat

254 decrease the proton T(1) relaxation time of biological macromolecules without the significant line-b

255 groups, such as amines and carboxylates, on biological macromolecules without using ultraviolet irra

256 A fundamental appreciation for how biological macromolecules work requires knowledge of str

257 latter reflects possible oxidative stress to biological macromolecules, yielding supporting data to t