ライフサイエンスコーパス: biological role

1 s some potential unifying hypotheses for its biological role.

2 on wherever heterogeneity plays an important biological role.

3 the Caliciviridae, it suggests an important biological role.

4 factor (TF), can help to elucidate the TF's biological role.

5 stimuli is crucial for the fulfilment of its biological role.

6 ts have generally not been thought to have a biological role.

7 eripheral nerves, suggests a potential wider biological role.

8 tes amboinensis (TaOr8) suggests a different biological role.

9 which is an obstacle for understanding their biological roles.

10 y popular due to their potentially important biological roles.

11 lymeric protein nanofibers that have diverse biological roles.

12 uctural isomers and further understand their biological roles.

13 nding properties, resulting in their diverse biological roles.

14 icrobial species is needed to decipher their biological roles.

15 log, CAMKK1, are thought to have overlapping biological roles.

16 ER signaling pathway and to understand their biological roles.

17 hways or channels and fulfil quite different biological roles.

18 ments is highly relevant in predicting their biological roles.

19 d by different genes that play non-redundant biological roles.

20 ecules, recent findings point to its broader biological roles.

21 ential and stationary growth phases play key biological roles.

22 1 interaction is conserved and has important biological roles.

23 teins with undefined molecular functions and biological roles.

24 ing determined in relation to their putative biological roles.

25 nriched with important genes and likely play biological roles.

26 tep in studying their expression pattern and biological roles.

27 opment and tumourigenesis, questioning their biological roles.

28 of general importance in understanding their biological roles.

29 at early-evolving ARABIDILLOs had additional biological roles.

30 cations on proteins to determine their exact biological roles.

31 n which motor proteins move to perform their biological roles.

32 series of mutants to examine Abl's many cell biological roles.

33 d structures form in vivo and play essential biological roles.

34 rse oxidative transformations with important biological roles.

35 ere short, raising questions regarding their biological roles.

36 , coexist in biological systems with diverse biological roles.

37 oxylcytosine-each of which may have distinct biological roles.

38 ucleic acid structures form in vivo and play biological roles.

39 mechanotransduction mechanisms to fit their biological roles.

40 in vivo with either proscribed or postulated biological roles.

41 easome system, yet little is known about its biological roles.

42 further study of its chemical structure and biological roles.

43 Notwithstanding its central biological role, 5'-dAdo. has eluded characterization de

44 Among its other biological roles, acetylcholinesterase (AChE, EC 3.1.1.7

45 e context of understanding their fundamental biological role and of potentially using them as disease

46 biology, and isomers usually differ in their biological role and pharmacological effects.

47 on has been a challenge due to their diverse biological roles and because lncRNA loci can contain mul

48 ly conserved throughout all organisms, their biological roles and biochemical redundancies remain lar

49 and their reference spectra as well as their biological roles and locations.

50 Understanding their biological roles and mechanisms remains analytically cha

51 ls provided valuable tools for exploring the biological roles and molecular mechanisms of PRMT overex

52 es in their isolation and cultivation, their biological roles and potential for stem cell-based tissu

53 ophages, it is important to understand their biological roles and requirements for efficient targetin

54 a more comprehensive understanding of their biological roles and significance.

55 ave yielded only limited insights into their biological roles and substrates.

56 he microbiota is essential to decipher their biological roles and to gain new mechanistic insights.

57 In this study, we aim to investigate the biological roles and use of sarcKATP and mitoKATP in hES

58 However, the biological roles and/or clinical applications of such pa

59 Silver has no biological role, and it is particularly toxic to lower o

60 RALF isoforms play many biological roles, and their specific functions are defin

61 bundant class of small non-coding RNAs whose biological roles are not well understood.

62 stitute the largest enzyme family, yet their biological roles are obscured by our rudimentary underst

63 emical properties, and it plays an important biological role as a chaperone of phosphodiesterase 6 (P

64 ed to fluctuating light, demonstrating FLV's biological role as a safety valve from excess electrons

65 ar body and serves a fundamentally important biological role as a site of ribonucleoprotein particle

66 production of EFVs has been reported, their biological role as a vector for the transmission of path

67 otein sequence and structure, play important biological roles as macromolecular binding and scaffoldi

68 remain regarding its molecular functions and biological roles, as well as the activity of the ADP-rib

69 increases our resolution of the cellular and biological roles associated with this poorly characteriz

70 o enriched in these transcripts, most with a biological role based on GO analysis.

71 DNA haplotypes in a cell, plays an important biological role, but its features are not well understoo

72 chromatin remodeling enzymes play essential biological roles by mobilizing nucleosomal DNA.

73 Protein kinases play essential biological roles by phosphorylating a diverse range of s

74 probe suitable for further understanding the biological role CARM1 plays in cancer and other diseases

75 While lipids diverse biological roles contribute to their clinical utility, t

76 s is an appealing field due to the important biological role copper plays as a trace metal.

77 ata indicate that BD1 and BD2 have different biological roles depending upon their cellular context,

78 of transcription factors play non-redundant biological roles despite recognizing the same DNA sequen

79 fy p40 as an anti-autoimmune cytokine with a biological role different from IL-12, IL-23, and p40(2)

80 on RNA nucleosides has been focused on their biological roles, discovery of new modifications remains

81 ubject of decades of studies; however, their biological roles during in vivo infection remain unknown

82 These studies identify a key biological role for a lncRNA: by regulating protein stab

83 This work reveals a novel biological role for a rhomboid protease and highlights n

84 evidence in additional datasets to support a biological role for AMH in complex traits and diseases i

85 tuberculosis infection, representing a novel biological role for CFP-10 in the ESAT-6:CFP-10 complex,

86 s for m3C modification and suggest a crucial biological role for DALRD3-dependent tRNA modification i

87 f IP3R1 represents a previously undiscovered biological role for epsin proteins and may provide new t

88 While there is no currently known biological role for high electronic conductance, its dep

89 on and tumour suppression, a clearly defined biological role for LXN is still lacking.

90 This work presents the expansion of the biological role for PepN in antibiotic maturation and th

91 for its canonical dsDNA ligand, suggesting a biological role for RNA binding by SMAD3.

92 in bacteria has never been reported, and no biological role for such a modification has ever been pr

93 M in cellular RNA metabolism and establish a biological role for the first 5' to 3' RNA exonuclease i

94 ese results provide the first evidence for a biological role for the NSC in vivo and pave the way for

95 matically at pH <7, suggesting a significant biological role for the protonated KP1212 molecules.

96 er developmental stages suggesting a similar biological role for this gene family in this species.

97 Our results uncover a biological role for TRMT1-catalyzed tRNA modification in

98 xpress AQP-1 mRNA and protein, implicating a biological role for water channel protein function durin

99 modifications, recent evidence has suggested biological roles for 5-formylcytosine and 5-carboxylcyto

100 mily of cysteine-rich proteins that play key biological roles for a wide range of metal ions, but unl

101 Biological roles for most long non-coding RNAs (lncRNAs)

102 ond to cytokine activation, we can delineate biological roles for myeloid cells in different cytokine

103 died extensively, few examples of definitive biological roles for site-specific PARylation have been

104 ver the properties, molecular mechanisms and biological roles for TEI.

105 lar studies, here we demonstrate independent biological roles for the DDR kinases DNA-PKcs, ATM, and

106 stigations aimed at deconvoluting the myriad biological roles for Ub.

107 for Uba1 and Uba6 that reflect non-redundant biological roles for Uba6.

108 nge of ascribing function to ncRNAs, diverse biological roles for virally expressed ncRNAs have been

109 MNT's biological role has been linked to its function as a MYC

110 ions that opsin apoproteins alone might have biological roles have come from archaebacteria and platy

111 re ranked according to knowledge about their biological role in body weight regulation and classified

112 bored key genes that might play an important biological role in controlling hormone signaling and met

113 nd metabolite accumulation did not support a biological role in flavonoid metabolism but correlated w

114 e and AMP salvage pathways suggests a strong biological role in high-CO2 subsurface carbon cycling.

115 eins has been sufficiently demonstrated, its biological role in higher eukaryotes remains poorly unde

116 factors, with the aims of (i) studying their biological role in human neural progenitors and (ii) inc

117 As SOX9 biological role in mammalian gonads is to determine Sert

118 5 is highly expressed in MCC tumors, but its biological role in MCC remains unknown.

119 is implicated in tumorigenesis; however, its biological role in multiple myeloma (MM) has not been el

120 mmunoprecipitation, as was NEDD9's potential biological role in prostate cancer cell growth regulatio

121 cooperative recruitment to chromatin and its biological role in target gene expression.

122 early response transcripts play an important biological role in the acclimation of plants to light st

123 e GP processing and membrane fusion, but its biological role in the context of an infectious virus ha

124 However, its biological role in the disease is unclear.

125 arget-specific translation repression to its biological role in the maternally controlled stages of v

126 t EVs released from adult F. hepatica have a biological role in the sequestration of TCBZ and additio

127 -dependent capsid dynamics play an important biological role in the viral life cycle.

128 Although GSH may still play a biological role in trypanosomatid parasites beyond being

129 nthetically challenging molecules with vital biological roles in all living systems.

130 show for the first time that IL2RA plays key biological roles in AML and underscore its value as a po

131 Some novel smORFs have crucial biological roles in cells and organisms, which motivates

132 nvolved in flagellar glycosylation and their biological roles in emerging hypervirulent C. difficile

133 ng dynamics are required to understand their biological roles in greater detail.

134 al challenge in the differentiation of their biological roles in healthy and disease states.

135 e composition of VLVs and demonstrated their biological roles in manipulating host cell responses and

136 elengths, has been suggested to play several biological roles in metazoans.

137 es that accumulate secretions with important biological roles in plant-environment interactions.

138 gnaling components have been attributed many biological roles in plants, but the extent of involvemen

139 their high complexity, glycans play crucial biological roles in protein quality control and recognit

140 Vertebrate Bicaudal-C (Bicc1) has important biological roles in the formation and homeostasis of mul

141 igmatic mechanism, and recently emergent new biological roles including "translocon unclogger" and (n

142 synthase kinase-3beta (GSK3beta) has diverse biological roles including effects on cellular different

143 Their most widespread biological role is providing a rigid hydrophobic contact

144 yl, HNO) is a highly reactive compound whose biological role is still a matter of debate.

145 uses increased postnatal growth, its precise biological role is still unknown.

146 While its biological role is unclear, CarD functions by interactin

147 However, we show that the CRIB motif's biological role is unexpectedly complex.

148 in understanding how ceramides execute their biological roles is hampered by a lack of methods to man

149 spite of a considerable understanding of its biological role, little information is known about Arabi

150 composition of the penile microbiota and its biological role might lead to new cancer prevention and

151 parison with other Th effector cells, as the biological role of a GC Tfh cell is to provide help to i

152 We now delineate the biological role of a novel SENP7 isoform SENP7S in mamma

153 lso raises new questions about the potential biological role of acylated carbohydrates in nature.

154 These tools were used to investigate the biological role of AlyA1, the only Z. galactanivorans al

155 This paper focuses on elucidating the innate biological role of an orphan transporter in vivo, which

156 enzymes and BCKA content and highlights the biological role of BCKAs in regulating muscle insulin si

157 However, the biological role of BRD4 in normal hematopoiesis and infl

158 selective tool compounds to interrogate the biological role of BRD9 in diverse cellular systems.

159 Therefore, the biological role of CCRL2 in immunity is still unclear.

160 Thus, we aimed to elucidate the biological role of CDC7 in promoting Vemurafenib resista

161 to the roots of a host plant, resembling the biological role of cellulose in other bacteria.

162 trary to the existing paradigm regarding the biological role of computationally predicted EBOV ncRNAs

163 additional loci are needed to determine the biological role of CTCF sites associated with enhancers.

164 assays for substrate specificity supported a biological role of CYP750B1 in alpha- and beta-thujone b

165 unpairing, which are fundamental to both the biological role of DNA and its technological application

166 the identified proteins correlated with the biological role of each organ.

167 study gives novel insights into the complex biological role of EVs in osteolineage cell-HSPC crossta

168 Thus, the biological role of FAN1 remains unclear.

169 To examine the biological role of il7 in teleosts, we generated an il7

170 These results reveal an unexpected biological role of IN binding to the viral RNA genome du

171 obular region (residues 245 to 586), but the biological role of increasing cardiolipins on the surfac

172 The expression pattern and biological role of ITGAV expression in esophageal adenoc

173 The biological role of its oligomerization is unclear.

174 he first time, to our knowledge, the in vivo biological role of m(6)A modification in T-cell-mediated

175 ine species for m3C formation as well as the biological role of m3C in mammals is unknown.

176 To study the biological role of m6Am, we developed a robust methodolo

177 This work confirms a new biological role of MAP1B in the regulation of sodium cha

178 However, the biological role of MatR remains unclear.

179 imetaphosphates, supporting the presence and biological role of metaphosphates in cells.

180 However, the biological role of miR-15b/16-2 is still controversial.

181 However, the biological role of mutation of PPP2R1A in ovarian and en

182 The biological role of mvT* miR was verified by overexpressi

183 However, the biological role of N(6)-mA and the molecular pathways th

184 al model where both the clinical utility and biological role of neutralizing MAbs against B cell or e

185 universal genetic code establishes that the biological role of peptides predates life's last univers

186 ha1 and -alpha4 have been described, but the biological role of PGC-1alpha2 and -alpha3 remains elusi

187 present study we addressed the function and biological role of PntAB in oxygenic photosynthetic cyan

188 However, the biological role of PSMA has not been explored, and its r

189 was to determine the expression pattern and biological role of PTCH1 in the lungs of patients with C

190 l be useful in efficiently interrogating the biological role of RA in larger study populations.

191 used ribosome profiling to characterize the biological role of ribosome recycling factor (RRF) in Es

192 A better understanding of the biological role of serum chloride is warranted.

193 ult to draw definitive conclusions about the biological role of tau in these models.

194 Notwithstanding the central biological role of the (6-4) photoadduct in the inductio

195 ciated TRMT1 mutations is unknown, since the biological role of the encoded TRMT1 protein remains to

196 ween GNC and GNL, nothing is known about the biological role of the four other LLM-domain B-GATAs, GA

197 ummary, our results demonstrate an essential biological role of the GP2 CT in arenavirus replication

198 for new research aimed at investigating the biological role of the gut virome in human physiology, a

199 despite its importance for understanding the biological role of the interaction.

200 erized function of the secreted isoform, the biological role of the intracellular isoforms remains la

201 open new avenues of research to explore the biological role of the LE in the biosynthetic pathway an

202 for known proteins and hypothesize about the biological role of the localization of some viral ORFan

203 We elucidated a major biological role of the nematode mir-35 family of materna

204 Little is known about the biological role of the phospholipase A2 receptor (PLA2R1

205 aining granules when activated; however, the biological role of the released Zn is currently unclear.

206 luence on the structure stability and on the biological role of the whole promoter.

207 However, the biological role of the WRN exonuclease is poorly defined

208 ely used both as chemical tools to study the biological role of their targets in living organisms and

209 However, the dynamics, determinants, and biological role of these conformations are unknown; furt

210 To determine the biological role of these DGs, null animal models have be

211 However, the biological role of these dual genetic alterations in pro

212 rt on recent insights into the mechanism and biological role of these intricate cotransport processes

213 To corroborate the biological role of these molecules and investigate the e

214 To investigate the biological role of these RSV G gene mutations, recombina

215 ides a new chemical tool to study the unique biological role of this abundantly expressed molecular c

216 for asymmetric cell elongation, however the biological role of this interaction remained unknown.

217 vital to improving our understanding of the biological role of this process and harnessing it as a s

218 ibitors can aid in further investigating the biological role of this specific methyltransferase in tr

219 wn photoreceptor families and unveiled a new biological role of this vitamin.

220 e observations raise questions regarding the biological role of tooth-innervating fibers.

221 We here investigated the biological role of tripartite motif-containing 28 (TRIM2

222 irus-free lines enabling studies probing the biological role of trypanosomatid viruses.

223 To determine the biological role of visual arrestin-1 oligomerization in

224 These results expand the biological role of vitamin B12 and provide fundamental i

225 chemical probe suitable to help dissect the biological role of WDR5.

226 DPO4 to bypass DNA lesions, which is a known biological role of Y-family polymerases.

227 Despite three decades of investigation, the biological roles of AMPK and its potential as a drug tar

228 Our study revealed biological roles of ANT1 in several developmental proces

229 Here we analyzed the biological roles of approximately 600 genes - we previou

230 work provides insight into the molecular and biological roles of biased signaling downstream RTK and

231 her researchers to investigate functions and biological roles of both known coding genes and novel ln

232 This study provides insights into the biological roles of cancer cell-derived matrisome protei

233 in eukaryotes and have defined the different biological roles of circRNAs to illuminate this previous

234 .521 will be useful toward understanding the biological roles of cyclic GMP-AMP synthase and can serv

235 FGFR heterodimers form, suggesting that the biological roles of FGFR heterodimers may be as signific

236 bioorthogonal ligation have enabled study of biological roles of glycans in vivo; however, direct inv

237 microRNA can be used as a proxy to identify biological roles of glycosylation enzymes (glycogenes).

238 r study provides important insights into the biological roles of GPC SSP and implicates it as a good

239 ing new chemical tools for understanding the biological roles of H2 S include developing platforms th

240 The biological roles of IL2RA were confirmed in two genetica

241 While our understanding of the biological roles of inositol heptaphosphates (PP-InsP(5)

242 Inference of the biological roles of lncRNAs in breast cancer development

243 In particular, the biological roles of long non-coding RNAs (lncRNAs) have

244 Despite recent progress in understanding the biological roles of m(6)A, the inability to install m(6)

245 will summarize the current knowledge of the biological roles of mRNA caps in eukaryotic cells.

246 The numerous biological roles of NAD(+) are organized and coordinated

247 The biological roles of oxylipins have been extensively stud

248 lins will play a seminal role in identifying biological roles of phyllobilins.

249 virescin A and DKxanthene-560 to their known biological roles of predation and phase variation, respe

250 been extensively studied, but the nature and biological roles of protein-linked glycans remain overlo

251 and our results may relate to the different biological roles of RecA, Rad51, and Dmc1.

252 Our results open avenues to investigate the biological roles of RNA modifications in their native RN

253 The biological roles of RNAPII pause release and the mechani

254 ractive strategy for determining the diverse biological roles of senescent cells and developing speci

255 to elucidate the structural arrangement and biological roles of Spc42 elements.

256 sis and to increase our understanding of the biological roles of specific enzyme targets.

257 nces are not only providing insight into the biological roles of specific receptor populations, but h

258 Other biological roles of surface acidity may be found, now th

259 Here, we investigated the biosynthesis and biological roles of the 8-O-methylated benzoxazinoids, D

260 es crucial questions regarding the potential biological roles of the enhancer transcription process a

261 sed phosphorylation reaction and investigate biological roles of the observed directional phosphoryla

262 e results provide molecular insight into the biological roles of the plant ALDH12 family.

263 decipher how such effects contribute to the biological roles of the proteins.

264 ecific mATG8-LIR interactions to dissect the biological roles of the six mATG8 homologs for potential

265 This manuscript reviews the phylogeny and biological roles of the T6SS in plant-associated bacteri

266 Here we investigate the biological roles of the transcription factor Foxp1 in br

267 Findings from this study unveil novel biological roles of the UDP-sugar receptor P2Y14 in hCPC

268 However, the biological roles of the vast majority of these molecules

269 immunity and cancer, yet elucidation of the biological roles of their glycodomains has been complica

270 understanding of both unique and overlapping biological roles of these critical enzymes.

271 Given the key biological roles of these enzymes, these findings have i

272 ly facilitate future analysis of the various biological roles of this important class of proteins.

273 ompound will be critical for elucidating the biological roles of this isozyme and may ultimately be u

274 However, the biological roles of viral RNA m(6)A remain elusive.

275 rtant and robust tools for investigating the biological roles of vitamin B12 .

276 Considering the biological roles of WNT4 and WNT5A involved in adipogene

277 ecificity among McrB homologs and expand the biological roles of YTH domains.

278 rstanding of their signalling, synthesis and biological roles - or so it seems.

279 tr1 and Ctr2 that discriminate between their biological roles, providing mechanistic insights into th

280 alysis of the gene panel identified multiple biological roles ranging from extracellular matrix reorg

281 se findings suggest that circRNAs might play biological roles relevant to the aging nervous system.

282 r, stilbene epoxidation biosynthesis and its biological roles remain unknown.

283 Although the WE is ubiquitous, its biological role remains controversial, and whether gluco

284 While its biological role remains unclear, crystal structure analy

285 ins many types of small RNAs (sRNAs) but the biological role(s) of bona fide microRNAs (miRNAs) remai

286 tal lipid class, fatty acids (FA) play vital biological roles serving as energy sources, cellular sig

287 hin the body, extending its function to cell biological roles such as mediating cellular receptors an

288 ncreatitis, and carcinogenesis, although the biological role that these isoforms serve in the systemi

289 nding specificities signifying their various biological roles that dictate further structural study.

290 Our results can help elucidate the biological roles that TE play in the genetic architectur

291 Despite such critical biological roles, the structures and patterns of their o

292 tic cell-specific transcripts with predicted biological roles; the most abundant transcripts encode f

293 Despite the critical biological roles these interactions play, the GSL ligand

294 animal PABPs are well-studied proteins, the biological role, three-dimensional structure and RNA-bin

295 tional RNA modification that plays important biological roles through mechanisms that are not entirel

296 to cell-fate programs and assigned putative biological roles to uncharacterized genes.

297 expands the repertoire of R-loops' potential biological roles under both normal and aberrant conditio

298 Despite its significant biological role, variants in SMARCC2 have not been direc

299 s numerous volatile compounds with undefined biological roles, were detected.

300 l growth and development, DCs have important biological roles with respect to pathogenicity in some f