ライフサイエンスコーパス: biologically

1 e structures' most energetically favourable, biologically accessible motions which show that within t

2 onomous transendothelial extravasation under biologically accurate circumstances we engineered a thre

3 Further characterization of the biologically active 6C protein demonstrated it was homog

4 amin is subsequently converted to one of two biologically active alkylcobalamins by downstream chaper

5 erol and its precursors and metabolites, are biologically active and important for proper brain funct

6 ence genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways

7 a particularly rich and important source of biologically active bicyclo[3.3.1]nonane-containing mole

8 cular delivery vehicles for the transport of biologically active cargo across the cell membrane.

9 epresents a rare example of the synthesis of biologically active compounds exclusively performed usin

10 e natural products are an important class of biologically active compounds.

11 additional drug-like properties critical for biologically active compounds.

12 ssing synthetically useful intermediates and biologically active compounds.

13 common strategy to improve the properties of biologically active compounds.

14 s, which are among the most common motifs in biologically active compounds.

15 o work for the late-stage C-H methylation of biologically active compounds.

16 Slit-FL and Slit-N are both biologically active cues with distinct axon guidance fun

17 oxidative conditions generating potentially biologically active dihydropyridinone-fused uracils have

18 ties embedded within linear and heterocyclic biologically active entities can be obtained.

19 Retinol, the most biologically active form of vitamin A, might influence c

20 tly overcome the epithelial barrier to focus biologically active IL-10 to the intestinal lamina propr

21 Bisphenol A (BPA) is known to be biologically active in experimental models even at low l

22 binding domain and promoted the synthesis of biologically active interferons.

23 inactive nucleoside analogues into powerful biologically active metabolites.

24 bypass biological barriers and deliver their biologically active molecular cargo to recipient cells.

25 With the trained neuronal networks different biologically active molecules could be regenerated.

26 nantioselective total or formal synthesis of biologically active molecules is underscored.

27 n is a fundamental cellular process in which biologically active molecules stored in long-lasting sec

28 hown to dramatically increase the potency of biologically active molecules(1-3).

29 gnificance in ligands, natural products, and biologically active molecules.

30 hich are key structural motifs found in many biologically active natural products.

31 gment produced from xbp-1 mRNA cleavage is a biologically active non-coding RNA (ncRNA) essential for

32 eyond host defence systems, as several other biologically active oxysterols also mobilize accessible

33 the NC1-peptide is an endogenously produced biologically active peptide which coordinates these cell

34 Testicular cells produce several biologically active peptides that exert their downstream

35 i cells facilitate the generation of several biologically active peptides, which include F5-, noncoll

36 roducts as natural sources for the isolation biologically active peptides.

37 down to the secreted cytolysin ShlA and the biologically active pigment prodigiosin.

38 However, the immobilization of biologically active proteins on a gold carrier technique

39 ves are present in many natural products and biologically active small molecules.

40 ypeptide chains and guides them toward their biologically active structures.

41 Another objective was to analyze the biologically active substances in the obtained mushroom

42 n of C(60) with pregnen-20-carboxaldehyde, a biologically active synthetic steroid, by using a 1,3-di

43 understanding of ENM reactivity in complex, biologically active systems for chronic low-concentratio

44 We show in this article that biologically active vitamin D(3) [1,25(OH)(2)-D(3)] sign

45 In summary, the development of a biologically active, fluorescent Wnt-3a reported here op

46 Plants make many biologically active, specialized metabolites, which vary

47 odified by 14-carbon fatty acyl chains to be biologically active, that HlyA remains active also when

48 to be posttranslationally acylated to become biologically active.

49 antitative and qualitative analysis of their biologically-active compounds, and to the sensory assess

50 ne, a prodrug of 5-FU, was well tolerated at biologically-active doses.

51 nsidering N-substituted 2-pyridone acts as a biologically-active structural unit, this general method

52 ular biophysics, interactions of a series of biologically-active supramolecular cationic metallohelic

53 Identifying one or more biologically-active/native decoys from millions of non-n

54 inoma (PDAC) is a genetically heterogeneous, biologically aggressive malignancy with a uniformly poor

55 e impact coinciding with mass extinction and biologically amplified carbon cycle change.

56 seen the development of PPGs activatable by biologically and chemically benign visible and near-infr

57 s, profoundly advancing our understanding of biologically and clinically heterogeneous disease subgro

58 The exemplified syntheses of several biologically and clinically important radiotracers illus

59 Extensive molecular analyses have identified biologically and clinically relevant intertumoral hetero

60 equencing datasets for the identification of biologically and clinically significant subsets in the d

61 ally validated, are readily interpreted both biologically and clinically, and have the potential to p

62 ted MDR, 23 pyrimidines were synthesized and biologically assessed.

63 Wilkes station to measure the time-averaged biologically available fraction of metal contaminants.

64 n release from the hemoproteins, it enters a biologically available state (labile heme), in which it

65 er exciting potential for the development of biologically based "smart materials".

66 m) distances through sequential hopping in a biologically based heme network.

67 ations of a multitude of possible scenarios, biologically based mechanistic modeling can be used for

68 ed libraries help accelerate the creation of biologically based networks and their use.

69 the H(4)R in live cells, we synthesized and biologically characterized Py-5-labeled histamine deriva

70 ple with late-onset Alzheimer's disease into biologically coherent subgroups is important for persona

71 These mechanically reinforced and biologically compatible 3D printed PCL-rGO scaffolds are

72 separate them effectively both as viable and biologically competent cells.

73 datasets show that the proposed method finds biologically-connected sets of low-frequency driver gene

74 A biologically constrained model accounts for our findings

75 interferon-stimulated genes (ISGs) against a biologically contained Ebola virus and identify several

76 netic nanocrystals called magnetosomes via a biologically controlled process.

77 r recognition properties of the reactive yet biologically critical hydrochalcogenide anions (HCh(-)).

78 ogical consequences; placing variants within biologically defined functional contexts, reflecting spe

79 Herein, we report a flexible, biologically degradable and wirelessly operated electroc

80 ate absolute quantification is enabled using biologically derived (13)C labeled internal standards el

81 sification protocols allowing one to analyze biologically derived spectrochemical data to obtain accu

82 d computational principles, we present how a biologically detailed neural circuit model of the insect

83 a platform to vastly increase the number of biologically detectable molecules.

84 Our work was done in eight biologically different human BC cell lines and one human

85 m Florida might have led to the emergence of biologically different viral strains.

86 These results establish MET(N375S) as a biologically distinct and clinically actionable molecula

87 are cell subpopulations were associated with biologically distinct behaviors like proliferation in th

88 er (CRC) tumors can be partitioned into four biologically distinct consensus molecular subtypes (CMS1

89 suggesting that the criteria do not identify biologically distinct disease subtypes.

90 However, little is known about these biologically distinct subgroups (endotypes) and their re

91 diagnosed de novo DLBCL patients, yielding 2 biologically distinct subgroups characterized by differe

92 hemical method for the C3-H sulfonylation of biologically diverse 2H-indazoles at room temperature an

93 sleep loss is a normative psychosocially and biologically driven developmental process, it occurs alo

94 e dataset to a new target dataset to perform biologically driven validation by evaluating their use i

95 Together, these findings suggest a more biologically-driven mechanism associated with photosynth

96 TCP) of 99% and, second, a maximal tolerated biologically effective dose (BED(max)) for organs at ris

97 igenetics and the molecular underpinnings of biologically embedded experience; the encoding of experi

98 Zinc is a biologically essential element and involved in a wide ra

99 es, we rationally designed, synthesized, and biologically evaluated a series of novel triazole-based

100 l and enzymatic properties comparable to the biologically expressed proteins.

101 and justifying more extensive resections in biologically favorable disease.

102 oupled plasma mass spectrometry, focusing on biologically functional minerals (Ca, Cu, Fe, K, Mg, Mn,

103 s that are both statistically predictive and biologically functional.

104 oreover, we show how induced polarization of biologically generated mineral deposits can yield a new

105 thus have great potential to contribute to a biologically grounded definition of psychiatric disorder

106 Identification of biologically grounded internalizing subtypes may assist

107 ng and N fertilizer rate trials to show that biologically healthier soils produce greater corn yields

108 al diagnosis of major depression encompasses biologically heterogeneous conditions.

109 Colorectal cancer (CRC) is a biologically heterogeneous disease.

110 ractivity disorder (ADHD) are clinically and biologically heterogeneous neurodevelopmental disorders

111 Alzheimer's disease is biologically heterogeneous, and detailed understanding o

112 WHO guidelines detected biologically implausible data in <1% of records.

113 sure based on the number of fills revealed a biologically implausible inverse dose-effect.

114 mean HAZ by month of birth, 5) proportion of biologically implausible values, and 6) dispersion of HA

115 smission of spikes between neurons, which is biologically implausible.

116 st reflected its utility in the synthesis of biologically important AMP-activated protein kinase depr

117 otype in an individual, are a clinically and biologically important class of genetic variation.

118 rge-coronated complexes are analogues of the biologically important Compound I (Cpd I) and synthetic

119 portant insights into the mechanism of these biologically important enzymatic reactions.

120 synthesis of 4H-1,3-benzoxazines and related biologically important heterocycles in high yields under

121 nd studied a tele-substitution reaction in a biologically important heterocyclic ring system.

122 ng expression levels, they contain much more biologically important information such as copy number v

123 , and delineating which targets are the most biologically important is even more difficult.

124 versatility of this approach for addressing biologically important molecules.

125 es to investigate the conformations of these biologically important motifs and provide quantitative m

126 and convenient approach for the synthesis of biologically important organophosphorus compounds known

127 n transfer in a wide range of chemically and biologically important processes.

128 Biologically important pyroquilon (tetrahydropyroquinoli

129 The discovery and design of biologically important RNA molecules is outpacing three-

130 thus making it suitable for studies of many biologically important structures.

131 plasmanyl species, a too little studied but biologically important substance class.

132 giotensin I and II - initially thought to be biologically inactive - have key roles in cardiovascular

133 a, which is secreted after processing of its biologically inactive precursor pro-IL-1beta in the cyto

134 or adrenal androgen precursors, but they are biologically inactive.

135 echanisms underlying this instruction remain biologically indeterminate.

136 played by proteins in the transformation and biologically induced biomineralization of metals by micr

137 eneficial for 3D bioprinting while retaining biologically inductive properties supporting tissue matu

138 le confounders from true signals to generate biologically informative embeddings.

139 Although biologically informative transcriptional pathways can be

140 contribute with disjoint information toward biologically informed and interpretable machine learning

141 Biologically informed stratification of periodontal dise

142 Biologically-informed neural networks (BINNs), an extens

143 Although there are several efficient biologically inspired algorithms in artificial intellige

144 This work shows that hierarchical RL, a biologically inspired and computationally simple algorit

145 We further consider the many new biologically inspired approaches that have emerged in re

146 Recently in Nature, using biologically inspired design principles to recapitulate

147 way for potentially expanding biomimetic and biologically inspired designs to incorporate lessons fro

148 Biologically inspired machine-learning systems approach

149 r, we review MTT studies in neuroscience and biologically inspired MTT methods in computer vision and

150 bjects received tactile feedback using three biologically inspired stimulation paradigms while perfor

151 just 5000 cells, and several other small but biologically interesting immune cell populations invisib

152 uster assignment probabilities from DESC are biologically interpretable and can reveal both discrete

153 side effects that are both reproducible and biologically interpretable.

154 iopsied for diagnosis and thus are not often biologically interrogated.

155 uman activities have increased the supply of biologically limiting nutrients, and changed the density

156 human activities have increased supplies of biologically limiting nutrients, such as nitrogen (N) an

157 approaches have been proposed to recover the biologically meaningful expression by borrowing informat

158 protein interactions allows identifying the biologically meaningful gene and sample subsets and impr

159 lly executing data analysis required to test biologically meaningful hypotheses.

160 sed with machine learning methods to predict biologically meaningful interactions.

161 mploy brain annotation information to enable biologically meaningful interpretation and (iii) make fu

162 ional regions of interest (ROIs) given their biologically meaningful interpretation and modest dimens

163 tural and functional change will reveal more biologically meaningful markers of brain aging in health

164 ement, but its efficacy for assigning P into biologically meaningful pools remains unknown.

165 d accurate deconvolution (RAD) to deconvolve biologically meaningful tumor populations from multiple

166 can be dense and difficult to interpret in a biologically meaningful way.

167 ial rate of arrestin recruitment (k(tau)), a biologically-meaningful kinetic drug efficacy parameter,

168 It broadens our understanding of biologically-mediated iron precipitation during the Arch

169 lycerophospholipids (GPLs) for many types of biologically motivated applications has led to the devel

170 and transfer learning, as well as the use of biologically motivated, structure-agnostic features to c

171 In a simulated dataset based on the biologically-motivated impulse model, LPWC is the only m

172 Biologically-motivated modeling revealed that phase sepa

173 Bioaerosols consisting of biologically originated airborne particles such as micro

174 Biologically plausible architectures for this task are w

175 of ectopic cardiovascular calcification and biologically plausible candidate drugs that could be rep

176 Biologically plausible factors related to sepsis-associa

177 ausal genes for IR, we screened regional and biologically plausible genes (16 in total) near the top

178 ), P(discovery) = 2.6 x 10(-9)) as well as a biologically plausible interaction between functional va

179 n the intensive care unit, discuss potential biologically plausible mechanisms for a causal associati

180 ell datasets and show that they provide more biologically plausible results.

181 advances in machine learning have revealed a biologically plausible set of algorithms for reconstruct

182 However, it is still unclear whether biologically plausible synaptic plasticity rules can org

183 combinations that alter CRP levels and more biologically plausible than other clustering approaches.

184 circuits may implement pattern separation of biologically plausible, temporally structured input in m

185 ot fully understood, however transmission is biologically plausible.

186 tional models do not typically use realistic biologically-plausible learning.

187 cular endothelium is constantly perturbed by biologically potent molecules, including the complement

188 stions that certain races/ethnicities may be biologically predisposed to poorer COVID-19 outcomes.

189 orks, but historically it has been viewed as biologically problematic.

190 Methane is biologically produced and oxidized until sediments reach

191 is known about the physiological effects of biologically produced volatiles.

192 ues, as well as a concomitant development of biologically realistic computational models.

193 tability in multiple connected networks with biologically realistic dynamics, including synaptic plas

194 l populations or cannot be implemented using biologically realistic mechanisms.

195 and provides useful model specifications for biologically realistic neural network simulations, until

196 ously demonstrate zero inflation in multiple biologically realistic scRNA-seq datasets.

197 This may or may not be biologically realistic.

198 Among biologically related donors aged <35, 35-49, and >=50 ye

199 Relative to biologically related non-carriers, preclinical MAPT carr

200 red between activator and target to generate biologically relevant affinity and in vivo function.

201 trategy to rapidly prepare and functionalize biologically relevant amines.

202 hesis of cross-linked PG fragments, carrying biologically relevant amino acid modifications and pepti

203 ds, is common in ruminants and may provide a biologically relevant and practical way to test individu

204 c classes in the peach extract, in these two biologically relevant assays.

205 Our results suggest that these subtypes are biologically relevant because they appear to have distin

206 tion as building blocks for the synthesis of biologically relevant beta-amidosulfones is described as

207 Herein, we used the biologically relevant calcium ion to investigate the con

208 However, many biologically relevant cell states involve cellular and s

209 lar similarity networks that may represent a biologically relevant chemical space known to date.

210 es from fragmentation spectra, including all biologically relevant classes.

211 een demonstrated to be capable of preserving biologically relevant complexes into the gas phase as mu

212 enzylic gem-diboronates, building blocks for biologically relevant compounds, are unknown.

213 termine the complete functional landscape of biologically relevant compounds.

214 l in the context of peptidomimetic design of biologically relevant compounds.

215 epidermidis biofilms and demonstrated that a biologically relevant construct containing five and a ha

216 ies akin to wild-type (WT) Wnt-3a in several biologically relevant contexts.

217 variety of (hetero)aryl chlorides including biologically relevant derivatives.

218 The applicability in biologically relevant detection was further demonstrated

219 ling performed the best in term of detecting biologically relevant differentially expressed genes.

220 eptibility to exonucleases revealed that the biologically relevant ecDNA element is large and complex

221 but residual pRBCs within the organ may have biologically relevant effects following implantation as

222 sal relationships between proteins and other biologically relevant entities: chemicals, phenotypes, c

223 These three biologically relevant examples emphasize the diversity i

224 yne complex (P(6)ArC)Fe(2)(mu-H) featuring a biologically relevant Fe(mu-carbyne)(mu-H)Fe motif.

225 nge to the discovery and characterization of biologically relevant GBP-GSL interactions.

226 a human glioblastoma dataset, the ranking of biologically relevant genes and pathways showed clear im

227 differential expression of a small number of biologically relevant genes.

228 hat selective recruitment applies to GRK2, a biologically relevant GPCR regulator, through discrete i

229 el additions of aldehydes to challenging but biologically relevant heterocycle-containing nitroalkene

230 The isotopic niche of consumers represents biologically relevant information on resource and habita

231 This device works by taking up biologically relevant ions from solution and injecting m

232 ic modeling, we quantify cavitation rates on biologically relevant length scales and timescales.

233 litatively investigated with HRdm, including biologically relevant lipids and carbohydrates, which we

234 The sequestration of biologically relevant macromolecules can be programmed b

235 availability may regulate AspH activity in a biologically relevant manner.

236 that NK cell phenotyping may be a useful and biologically relevant marker to predict COPD exacerbatio

237 ntitate tumor fraction and identify distinct biologically relevant mCRPC phenotypes.

238 availability by mitochondrial activity as a biologically relevant mechanism and demonstrate its cont

239 and real-time monitoring of biomolecules in biologically relevant media such as blood, urine, and sa

240 asize the need to use cellularly derived and biologically relevant membranes for biophysical characte

241 ) forms a block copolymer that binds several biologically relevant metal ions.

242 ll-derived brain organoids have emerged as a biologically relevant model system to study normal human

243 ides, proteins, lipids, and other classes of biologically relevant molecules are emphasized in this R

244 um-assisted measurements on a large class of biologically relevant molecules.

245 uable building blocks for the preparation of biologically relevant molecules.

246 the potential for novelty detection to yield biologically relevant niches that are missed by current

247 nity, it increases with mRNA size, and, with biologically relevant parameters, is substantially large

248 trieve both previously established and novel biologically relevant patterns, demonstrating the potent

249 This reagent was then used to assemble two biologically relevant peptides and characterize their ph

250 ex to exhibit pH-sensitive relaxivity in the biologically relevant pH range.

251 ton, the frequency of which changed over the biologically relevant pH range.

252 ification and ribosome profiling to identify biologically relevant prion-induced changes during disea

253 The method is validated on biologically relevant proteins.

254 We choose here the biologically relevant protoporphyrin molecule as the ele

255 With biologically relevant rates, we find that the genetic ci

256 ut potential of protein microarrays with the biologically relevant readout provided by IgE reporter c

257 our data clarify that IL-6Ralpha is the only biologically relevant receptor for IL-6 in mice.

258 Archetypal biologically relevant secondary structures investigated

259 ble late-stage structural diversification of biologically relevant small molecules, and site-selectiv

260 uss a design approach for the preparation of biologically relevant small-molecule libraries, harnessi

261 bis-ligand complex being detected even under biologically relevant solution conditions.

262 mimics with conformationally constrained and biologically relevant structure.

263 sion, and genome annotations for discovering biologically relevant SVs altering coding and non-coding

264 package, SpectralTAD, detects hierarchical, biologically relevant TADs, has automatic parameter sele

265 s approach -100 bar does cavitation occur on biologically relevant timescales.

266 ights for flexible regions of p53 along with biologically relevant ubiquitination sites.

267 However, a biologically relevant, functional role of RB phosphoryla

268 This was achieved at biologically relevant, nanomolar concentrations, allowin

269 that the interactions observed in vitro are biologically relevant, we use a recently developed compl

270 dent inhibition of SARS-CoV-2 RdRp by RDV is biologically relevant.

271 amines; useful building blocks on the way to biologically-relevant compounds.

272 cation, to annotate, prioritize, and explore biologically-relevant expressed gene fusions, downstream

273 tro to deliver disease-related gene cargo to biologically-relevant NHP brain circuits by packaging a

274 Here, we have used a highly biologically replicated whole transcriptome sequencing a

275 eptors (SR) are insufficient to generate the biologically required specificity for protein targeting

276 em are principally designed to keep the body biologically safe, which they do by continually monitori

277 Our results show that, under a wide range of biologically sensible parameter values, a noisy dynamic

278 However, identifying biologically significant and reproducible sets of genes

279 rs' DNA binding and precise determination of biologically significant binding sites.

280 vised approach for finding statistically and biologically significant cells using cytometry data from

281 mes, allele-specific measurements can reveal biologically significant differences in DNA methylation

282 Biologically significant differences were usually tissue

283 of adipocyte, depot-specific differences, a biologically significant extracellular matrix and import

284 consequences, and can be used to help reduce biologically significant fishing impacts on small cetace

285 predicted non-classical function of CBX7 is biologically significant for the maintenance of pluripot

286 d biology together with the visualization of biologically significant interactions.

287 As biologically significant organismal activities often occ

288 CD44 plays a biologically significant role in mediating phagocytosis

289 ned novel avenues to experimentally identify biologically significant variants en masse.

290 r are more functionally specific, robust and biologically significant.

291 d categories of patients into clinically and biologically similar groups.

292 modeling, and 3) caries scores in groups of biologically similar tooth surfaces derived from hierarc

293 nt GWAS can be limited in that it is usually biologically simple to elucidate a comprehensive genetic

294 riod of major brain reorganization shaped by biologically timed and by environmental factors.

295 H(2) formation is catalyzed by a biologically unique hexanuclear iron cofactor denoted th

296 per associated region which is recognized as biologically unrealistic.

297 ort vector machines are then trained on each biologically valid image phenotype, and used to classify

298 Second, the model is biologically validated using multiple electrophysiologic

299 y heterogeneous disease, both clinically and biologically, whereas patients are still being treated a

300 ciated DLC1 mutants evaluated were deficient biologically, with various mechanisms contributing to th