ライフサイエンスコーパス: biology

1 as technology has led to radical advances in biology.

2 fferent scenarios based on known coronavirus biology.

3 insight into basic mechanisms of neutrophil biology.

4 precision tools to interrogate human disease biology.

5 swering diverse and fundamental questions in biology.

6 ether these work together to control exosome biology.

7 as a canonical riboswitch model in synthetic biology.

8 line could be used to decipher prion strain biology.

9 underserved areas of methodology and cancer biology.

10 searcher, mentor, and eminent leader of cell biology.

11 and are indispensable reagents in structural biology.

12 grated reporter faithfully represents target biology.

13 se model organism for studying developmental biology.

14 es and given new insights into developmental biology.

15 strated to play important roles in mammalian biology.

16 Quantification of behaviour is essential for biology.

17 air and reveal a new role for Nedd4 in glial biology.

18 t fundamentally impact gastrointestinal (GI) biology.

19 t exocytic pathways of central importance in biology.

20 networks is ubiquitous across computational biology.

21 applicable across developmental and systems biology.

22 ysis of soft matter in materials science and biology.

23 search directions in parasitophorous vacuole biology.

24 twork morphology as well as endothelial cell biology.

25 s attention on a major new direction in cell biology.

26 bly the best-understood signaling pathway in biology.

27 but valuable model to gain insight into CTL biology.

28 ing environment is a fundamental question in biology.

29 w understanding of Mononegavirales L protein biology.

30 l thus provide a general route to affect RNA biology.

31 hat SDC3 might play an important role in MSC biology.

32 HDX-MS) is now common practice in structural biology.

33 enetics and important drug targets in cancer biology.

34 ions in many areas of chemical and synthetic biology.

35 an ongoing challenge in the field of systems biology.

36 emerged as an important mechanism in cancer biology.

37 ription factor in enhancer and ribosomal RNA biology.

38 cs have functional outputs in terms of their biology.

39 even the simplest of procedures in molecular biology.

40 he rate of aging are set is a key problem in biology.

41 cise functional effects of these variants on biology.

42 chnology that has revolutionised single-cell biology.

43 investigate the dynamic EMT process in tumor biology.

44 he ric1 gene as being essential for skeletal biology.

45 oductivity remains a key objective in global biology.

46 ed our fundamental understanding of pathogen biology.

47 rtfolio as well as uncover novel human sperm biology.

48 egative in another depending on the species' biology.

49 the most abundant regulatory motif known to biology.

50 for retrospective analysis to elucidate new biology.

51 el for the study of comparative reproductive biology.

52 or the emerging field of quantitative R-loop biology.

53 ns for rational protein design and synthetic biology.

54 ed as novel players in the field of leukemia biology.

55 mains of knowledge required in both math and biology.

56 inary pace in developmental and regenerative biology.

57 st criteria to prioritize surgery were tumor biology (80%), time interval from neoadjuvant therapy (6

58 nternational experts from the fields of tick biology, allergy, immunology, infectious disease, and de

59 ing techniques are currently revolutionizing biology, allowing far greater precision than previous mu

60 Systems biology analyses highlight both similarities and differe

61 o study cellular senescence, and our systems biology analyses reveal new insights and gene regulators

62 RNA-seq and systems biology analysis revealed a striking sexual dimorphism i

63 centric model has shaped the field of cancer biology and advanced understanding of cancer pathophysio

64 (COVID-19) outbreak focuses on individuals' biology and behaviors, despite centrality of occupationa

65 however, it does not accurately capture the biology and behaviour of many mosquito vectors that refe

66 ods for synthetic, systems, and evolutionary biology and broadens access to cutting-edge research cap

67 t role of this mechanism in both herpesvirus biology and cancer, our screening assay may be used as a

68 rmational states that are highly abundant in biology and critical in enzymatic reactions.

69 s likely to contribute to its role in cancer biology and demonstrates that different chromatin remode

70 potential in advancing our understanding of biology and disease.

71 ion will promote growth in the field of cell biology and enable scientists to assess and assume their

72 rich source of information for evolutionary biology and engaged considerable public interest.

73 otide mutations is critical for probing cell biology and for precise detection of disease.

74 available for further understanding of ACE2 biology and for the investigation of ACE2 in the pathoge

75 a more detailed understanding of neutrophil biology and function.

76 hile CSF-1 has been extensively studied, the biology and functions of IL-34 are only now beginning to

77 Specifically, our cell biology and gene expression studies have revealed that D

78 tanding the latest discoveries in neutrophil biology and how these novel functions affect the care of

79 aim to integrate our understanding of HNSCC biology and immunobiology to identify predictive biomark

80 versatile tool for studies of interfaces in biology and materials science with notable utility in bi

81 reactions and their applications in chemical biology and materials science.

82 scopy has enabled important breakthroughs in biology and materials science.

83 rofit organization that promotes intelligent biology and medical science.

84 This Review provides a timeline of PARP biology and medicinal chemistry, summarizes the pathophy

85 he International Association for Intelligent Biology and Medicine (IAIBM) is a nonprofit organization

86 The importance of complex traits in biology and medicine has motivated diverse approaches to

87 ts to study the developmental genetics, cell biology and morphogenesis that underlie the incredible v

88 mplex models in fields such as computational biology and neuroscience is often intractable to compute

89 ribed spatial metabolic heterogeneity in GBM biology and opportunities for MSI investigations.See rel

90 enhance our fundamental understanding of the biology and pathogenesis of these viruses.

91 tion becomes a central issue regarding viral biology and pathogenesis.

92 mathematical model that integrates data from biology and pathology on the microenvironmental regulati

93 ues for future investigations into collectin biology and pathology.

94 eat importance in stereochemistry, molecular biology and pharmacology(2).

95 processes for shared resources (Klein 2018, Biology and Philosophy33:36).

96 olecular connections between extra-telomeric biology and pluripotency.

97 cing can provide information about leukaemia biology and prognosis, it cannot distinguish which mutat

98 er with important advances in genetics, cell biology and spectroscopy.

99 g the HIV genome profoundly alters astrocyte biology and that strategies that keep the virus latent (

100 th the understanding of molecular-scale cell biology and the design of synthetic machines.

101 lecular level is a major goal of fundamental biology and therapeutic drug development.

102 which recaps current concepts underlying the biology and therapeutic rationale behind B-cell-directed

103 Emerging phenomena in developmental biology and tissue engineering are the result of feedbac

104 ladida, are experimental models of stem cell biology and tissue regeneration.

105 n ideal tool to study cytotoxic T lymphocyte biology and to optimize personalized immunotherapy in ca

106 s such as genome stability and developmental biology and to test concepts such as phase separation of

107 motility will aid in dissecting spatial cell biology and transport-related diseases.

108 ow the study of the epigenetic basis of tick biology and vectorial capacity will enrich our knowledge

109 focused empirical studies of SARS-CoV-2 RNA biology, and a preliminary guide for exploring potential

110 h numerous different histological, molecular biology, and analytical techniques.

111 bination of immunological assays, structural biology, and cheminformatics to construct a recombinant

112 has been one of the core subjects in systems biology, and is the focus of this study.

113 microalgae in the context of evolution, cell biology, and metabolic adaptations.

114 Metabolomics plays a pivotal role in systems biology, and NMR is a central tool with high precision a

115 tissues facilitate research in reproductive biology, and overview strategies for making engineered r

116 opic result, consideration for applied phage biology, and the importance of ecology in evolution of p

117 scinating and challenging problems in modern biology, and tracing the evolution of complex traits is

118 ntroduced into circuit designs for synthetic biology applications.

119 engineer cell functions for future synthetic biology applications.

120 findings illustrate the power of a synthetic biology approach in which bottom-up construction of phot

121 Here, we applied a systems biology approach to gain deeper insights into the PCSK6

122 n integrative analytical strategies, systems biology approaches for the study of infectious disease a

123 Combining integrative genomics and systems biology approaches has revealed new and conserved featur

124 types, and organ systems, rendering systems biology approaches particularly amenable to their interr

125 tocytes, we applied state-of-the-art systems biology approaches to models of liver regeneration, phar

126 omarkers of BBB integrity along with systems biology approaches, should enable new personalized treat

127 sm that has resisted conventional structural-biology approaches, to obtain atomic models of multiple

128 Rapid advances in synthetic biology are enabling us to exploit the information-proce

129 ging tools in big data analytics and systems biology are facilitating novel insights on glycans and t

130 he fields of bat virus ecology and molecular biology are still nascent, with many questions largely u

131 lighting a new fundamental question in plant biology: are plants capable of integrating two different

132 these structures for elucidating fundamental biology as well as developing improved diagnostic and th

133 ) contributed to our understanding of cancer biology as well as to the development of early diagnosti

134 netic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on

135 rning framework to approximate in vitro cell biology assay experiments while respecting a generalized

136 y investigated RBPs in the context of cancer biology based on published literatures, PPI-network and

137 sults have important implications for cancer biology because oxidized purines in the nucleoside pool

138 ur understanding of basic mechanisms of iron biology but also for the development of new pharmacologi

139 that have a close connection to the disease biology but are limited in screening capacity.

140 e not only valuable for understanding B cell biology, but also have important implications for unders

141 f EpiSCs after MI to better understand their biology, but also may permit the cell-specific delivery

142 eatly advanced molecular insights into prion biology, but translation of in vitro to in vivo findings

143 ortunities to profoundly transform synthetic biology by enabling new approaches to the model-driven d

144 lerate the development of dynamic structural biology by identifying transient conformational states t

145 TRIM37 drives aggressive TNBC biology by promoting resistance to chemotherapy and indu

146 tor (NGF) regulates many aspects of neuronal biology by retrogradely propagating signals along axons

147 ls in a variety of fields such as structural biology, cell imaging, and drug discovery.

148 Mechanical signals in biology change quickly over time and are often embedded

149 In structural biology, collision cross sections (CCSs) from ion mobili

150 Here, we use integrative structural biology combined with yeast genetics and biochemistry to

151 road applications in the yeast and synthetic biology communities that contains only the four CRISPR-a

152 IBSM) model of P. malariae to study parasite biology, diagnostic assays, and treatment.

153 t aspects of the disease, including parasite biology, disease ecology, human/animal infection, and ad

154 provides a powerful tool to study hepatocyte biology, disease mechanisms, genetic variation, and drug

155 cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including tumor

156 er (TNBC) is characterized by its aggressive biology, early metastatic spread, and poor survival outc

157 complex data in areas such as computational biology, ecology and econometrics.

158 As biochemistry and molecular biology educators, we have an obligation to provide stud

159 A recent wave of synthetic biology efforts has focused on the establishment of mole

160 of useful promoters and facilitate synthetic biology efforts in this model organism.

161 of the fascinating phenomena studied in cell biology emerge from interactions among highly organized

162 tional mechanisms of the structures, and the biology enabled by these structures, to be addressed for

163 We thus demonstrate that structural systems biology enables a proteome-wide, computational assessmen

164 rts in the fields of material sciences, cell biology, engineering, and many other disciplines will gr

165 ctrometry and Related Methods for Structural Biology (EU COST Action BM1403), which involved particip

166 imensional structure/function analyses, cell biology experiments, and reported early effects.

167 tic engineering, gene editing, and synthetic biology exponentially expand opportunities to enhance th

168 s also contributing to dialogue in the islet biology field focused on how to correct the defects in i

169 ank orders have been studied in evolutionary biology for almost a hundred years.

170 ars, it has been used especially in chemical biology for peptide/protein synthesis, posttranslational

171 w of (a) current understanding of complement biology for the clinician, (b) novel insights into compl

172 al enzymatic components, is to use a systems biology framework, such as a Genome-Scale Metabolic Netw

173 PS matrix formation, and its role in biofilm biology, function, and microenvironment are being reveal

174 Using structural biology, functional assays, and molecular dynamics simul

175 Similar to germline mutations in telomere biology genes leading to bone-marrow failure, these data

176 In the first wave of synthetic biology, genetic elements, combined into simple circuits

177 Tryptophan oxidation in biology has been recently implicated in a vast array of

178 However, how Bcl-6 controls T(FH) biology has largely remained unclear, at least in part d

179 ll, the role of IL-4 and IL-13 in neutrophil biology has not been well studied.

180 Advances in developmental and stem cell biology have allowed the development of cell-replacement

181 ifferent but overlapping roles in osteoclast biology, highlighting the importance of the HIF pathway

182 researchers in understanding the B. microti biology, host modulation and diverse parasite developmen

183 provided fundamental understanding of plant biology, however not all of this knowledge is directly t

184 A paper published in Global Change Biology in 2006 revealed that phenological responses in

185 e of great value for the study of macrophage biology in different organs and various models of injury

186 These findings shed new light on GM-CSF biology in sterile tissue inflammation and identify seve

187 e that the apicoplast has a key role in heme biology in T. gondii and is important for both mitochond

188 Membraneless organelles are sites for RNA biology including small non-coding RNA (ncRNA) mediated

189 e revealed hierarchical changes in skin cell biology, including activation of an immune response, a s

190 light the developments in understanding TIM3 biology, including novel ligand identification and the d

191 elp to explain otherwise puzzling aspects of biology, including the complexity and stability of livin

192 ajor holes in our understanding of T. gondii biology, including the genes controlling parasite develo

193 We have developed a new systems-biology-informed deep learning algorithm that incorporat

194 is is a major posttranslational regulator of biology inside and outside of cells.

195 n using standard pathology as proxy for poor biology is associated with survival and response to ther

196 Structural biology is entering an exciting time where many new high

197 Thus, stress biology is one of the best understood systems in affecti

198 However, current theory on rank orders in biology is somewhat fragmented.

199 A major challenge in cell and developmental biology is the automated identification and quantitation

200 n important unanswered question in chromatin biology is the extent to which long-range looping intera

201 A challenge in biology is to associate molecular differences among prog

202 .IMPORTANCE The current trend in CNS disease biology is to attempt to understand the neural-cell-immu

203 One of the great ambitions of structural biology is to describe structure-function relationships

204 One primary objective of synthetic biology is to improve the sustainability of chemical man

205 A central task in developmental biology is to learn the sequence of fate decisions that

206 A major challenge in biology is to understand how complex gene expression pat

207 A key goal of cancer systems biology is to use big data to elucidate the molecular ne

208 honored to be awarded the 2020 Women in Cell Biology Junior Award for Excellence in Research and am t

209 ed by 6 years in Germany (European Molecular Biology Laboratory), 16 years in the United States (Yale

210 mework that consists of model-, feature- and biology-level assessments to provide complementary resul

211 e gene mapping to identify modulators of HSC biology linked to MPN risk, and show through targeted va

212 nergy physics, cosmology and astrophysics to biology, magneto- and hydrodynamics and condensed matter

213 proximately 6 h and requires basic molecular biology, mammalian cell culture and fluorescence microsc

214 ng across materials science, nanotechnology, biology, medicine, geology, optics, catalysis, art conse

215 Here, we apply synthetic biology methods to reverse-engineer gene expression cont

216 eters will be a valuable service for systems biology modellers.

217 which has quickly impacted neuroscience and biology more broadly.

218 Key features of GM-CSF biology need to be defined better, such as the respondin

219 sponses to stress and other aspects of their biology, numerous genomic and transcriptomic studies hav

220 ted applications in areas, such as medicine, biology, oceanography, bioprocess monitoring, corrosion

221 results provide new insights into the basic biology of adjuvant-elicited cellular immunity and have

222 ispensable tool for better understanding the biology of any species.

223 el systems offer a window into the molecular biology of cell fate and tissue shape, mechanistic studi

224 isms may help to explain some of the complex biology of genetic associations with SCZ.

225 The biology of harlequin ichthyosis (HI), a devastating skin

226 the amino acid sequence of gO influences the biology of HCMV.

227 Here, we review the discovery and biology of HRP2, as well as the strengths and weaknesses

228 presents a new frontier in understanding the biology of human health.

229 provides opportunities to study the systems biology of innate immunity and to determine how sustaine

230 Consideration of the biology of invasive species and adaptation of the timing

231 in vitro tool with which to interrogate the biology of IRAK3.

232 owerful approach to examine the personalized biology of liver cancers and the influence of host tissu

233 study will improve our understanding of the biology of Lso acquisition and transmission as well as i

234 and outline a research agenda that takes the biology of masting from a largely observational field of

235 nexin hemichannels are key regulators of the biology of neural progenitors during development and in

236 Little is known about the biology of NiV in the bat reservoir.

237 The extent to which the biology of oncogenesis and ageing are shaped by factors

238 they have provided limited insight into the biology of regulatory elements due to the difficulty of

239 As more knowledge is gained about the biology of relapse through comprehensive genomic profili

240 , we discuss the non-malignant and malignant biology of ROS1, the diagnostic challenges that ROS1 fus

241 present an excellent tool to investigate the biology of TCRV and to explore its potential use as a li

242 me to this Fourth Special Issue of Molecular Biology of the Cell on Forces on and within Cells.

243 r, we focus on the role, function, and basic biology of the ECM in both heart development and in the

244 The biology of the human brain, and in particular the dynami

245 cultures that can provide insights into the biology of the intestinal epithelium and innate immune r

246 ool (ICBM-OCEAN, Institute for Chemistry and Biology of the Marine Environment, Oldenburg-complex mol

247 on is framed around two broad themes: i) the biology of the virus itself; ii) the characteristics of

248 Further insights into the biology of this unique and versatile cell will undoubted

249 ditionally, SpAn infers the emergent network biology of tumor microenvironment spatial domains reveal

250 fully developed and may be used to study the biology of, diagnostic testing for, and treatment of thi

251 hieve selectivity, and applications in basic biology or in the clinic.

252 do not account for current staging, disease biology, or advances in cancer treatments.

253 hB; however, the role of OmpR in V. cholerae biology outside virulence regulation remained unknown.

254 pproaches including genetics, molecular/cell biology, pathogenicity and transcriptomic profiling.

255 as seen staggering progress in strigolactone biology, permitting highly detailed understanding of the

256 wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering.

257 fundamental and underlying role in chemical biology, pharmacology, and medicine to discover safe and

258 for each surgical procedure, based on tumor biology, preoperative treatment sequencing, and response

259 ulation in single live cells to address cell biology questions otherwise intractable and engineer cel

260 function of protein-coding regions of cancer-biology related genes (gHFI) determines which and how ma

261 Structural biology relies on specific file formats to convey inform

262 , and plasticity) and its relevance to human biology remain unclear.

263 However, the role of IL-17RD in tumor biology remains to be studied in vivo.

264 stics, most bioinformatics and computational biology research and funding to date has been concentrat

265 is novel bioassay has usefulness in vascular biology research, patient phenotyping, drug testing, and

266 actions, and blind testing, enabling more of biology's stories to be told in the language of atomisti

267 Chemical biology strategies for directly perturbing protein homeo

268 Biology students had the highest prevalence of GORD symp

269 Chemical biology studies employing photoaffinity probes derived f

270 The performed molecular biology studies revealed no cytotoxicity and no influenc

271 Many functional units in biology, such as enzymes or molecular motors, are compos

272 Here, we investigated the underlying biology supporting this extended duration of pharmacolog

273 The three mainstay structural biology techniques are X-ray crystallography, nuclear ma

274 rsal protocol for extraction based molecular biology techniques such as rt-PCR.

275 to inform a fully integrated and predictive biology that accounts for eco-evolutionary interactions

276 ivated by tubular organelle networks in cell biology that contain molecules searching for reaction pa

277 1C (METTL21C) is a PKMT implicated in muscle biology that has been reported to methylate valosin-cont

278 chnology is making possible studies of human biology that were not previously feasible.

279 e-specific shifts in bioenergetic systems of biology that were paralleled by bioenergetic dysregulati

280 useful in biodesign, sensing, and synthetic biology, the behavior we have demonstrated--functional a

281 Using microscopy, biochemistry and molecular biology, the cellular localization of the ALC, its effec

282 In the second wave of synthetic biology, the simple circuits, combined into complex circ

283 eralis of the pituitary, and triggers summer biology through the eyes absent/thyrotrophin (EYA3/TSH)

284 r engineering(1,2) have positioned synthetic biology to address therapeutic(3,4) and industrial(5) pr

285 Rather than consider stress biology to be relevant only under unusual and threatenin

286 lectrophysiological recordings and molecular biology to confocal microscopy in primary cortical cultu

287 Our aim was to extend our work in IL-13 biology to determine whether airway epithelial cell expr

288 he body of knowledge on Xenopus genomics and biology together with the visualization of biologically

289 as focused on the establishment of molecular biology tools in this fascinating organism, now enabling

290 of DBP in migraine susceptibility and shared biology underlying BP and migraine.

291 train students in computational and systems biology using research-grade technologies.

292 er understanding of ncRNAs in cardiovascular biology we present an outlook on specialized functions s

293 Using genetics, biochemistry, and structural biology, we found that AcrVIA1 interacts with the guide-

294 vances in understanding of innate lymphocyte biology with a focus on skin disease and the roles of co

295 xt of emerging evidence linking sphingolipid biology with cardiovascular pathophysiology, these resul

296 The intersection of HIF biology with diabetes is a complex area in which many fu

297 Here, we combined NMR structural biology with high-throughput iCLIP approaches to identif

298 limited by certain characteristics of phage biology, with structural fragility under the high temper

299 which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling throu

300 hould provide important tools for structural biology, yielding insight into substrate gating and trap