ライフサイエンスコーパス: biomolecular

1 ively parallel, quantitative measurements of biomolecular activity across sequence space can greatly

2 The vast majority of their biomolecular activity takes place in aqueous environment

3 tuning without necessitating changes to the biomolecular affinities.

4 ments using microstructural, geochemical and biomolecular analyses, including 'palaeoshellomics', the

5 of high-resolution GCIB-SIMS for multiplexed biomolecular analysis at the level of single cells.

6 Biomolecular analysis of the anodic electroactive biofil

7 pies because the fibrous networks facilitate biomolecular and cell transport.

8 s strategy to design and synthesize numerous biomolecular and hybrid materials with diverse architect

9 mination of beverage authenticity, chemical, biomolecular and isotopic approaches could be applied de

10 Biological, biomolecular, and bio-inspired strategies towards improv

11 le atomic multipole optimized energetics for biomolecular applications force field, many-body optimiz

12 radiographic, histological, mechanical, and biomolecular assays and repaired mandibles by radiograph

13 ested this prediction by conducting multiple biomolecular assays on a well-preserved fibula of the di

14 the advantages of using pressure to explore biomolecular assemblies and modulate enzymatic reactions

15 Aggregate-like biomolecular assemblies are emerging as new conformation

16 At the molecular level, the formation of biomolecular assemblies is largely driven by weak, multi

17 Detection of conformational changes in biomolecular assemblies provides critical information in

18 to their conformations, propensities to form biomolecular assemblies, selectivity of interaction part

19 recent discoveries of functionally relevant biomolecular assemblies, which in some cases form throug

20 n an Orbitrap for the analysis of megadalton biomolecular assemblies.

21 ic structural information of complex dynamic biomolecular assemblies.

22 anges with surface chemical modification and biomolecular assembly.

23 This places limits on biomolecular assembly: glycan microheterogeneity becomes

24 llection from 3D to 4D by tracking real-time biomolecular binding events.

25 it is shown that filamentous fd phage, as a biomolecular biocompatible nanofiber, can be engineered

26 century was a golden age of discovery in the biomolecular biosciences, the current century may be rem

27 DNA, as a class of the promising biomolecular capping ligands, has been used to generate

28 e emerged as promising techniques to deliver biomolecular cargo into cells.

29 Unique biomolecular cargos such as RNA and protein are loaded i

30 latform for studying metabolic processes and biomolecular characterization.

31 luded spintronic and nanomagnetic materials, biomolecular chemistry, electronic circuitry, analog and

32 el-free determination of the net charge of a biomolecular coating, which is of interest in material s

33 nable future temperature controlled study of biomolecular complex at the single molecule level.

34 atomic resolution structure of any purified biomolecular complex can, in principle, be determined by

35 Many biomolecular complexes exist in a flexible ensemble of s

36 ass spectrometry involves transferring large biomolecular complexes into the gas phase, enabling the

37 a valuable tool to predict 3D structures of biomolecular complexes.

38 ron lasers (XFEL) to determine structures of biomolecular complexes.

39 es can affect the overall structure of large biomolecular complexes.

40 ome data were generated by a newly developed biomolecular component analysis software, which provides

41 ing-based, cellular studies have defined key biomolecular components that recognize and clear aggrega

42 tion of experimental structural biology with biomolecular computer modelling has yielded mechanistic

43 ical innovation, with applications including biomolecular computing, living therapeutics, microbiome

44 Bacterial RNP-bodies (BR-bodies) are a biomolecular condensate containing the RNA degradosome m

45 ggest that the destruction complex acts as a biomolecular condensate in Wnt pathway regulation.

46 The discovery of a biomolecular condensate involved in DNA replication has

47 dynamic component of the destruction complex biomolecular condensate, while other E3 proteins are not

48 that the nucleolus represents a multilayered biomolecular condensate, whose formation by liquid-liqui

49 uestration of the NF-kappaB subunit p65 to a biomolecular condensate-a mechanism conserved across the

50 indings, we assess if (and how) membraneless biomolecular condensates and IDPs/IDRs are functionally

51 on in concert to provide robust control over biomolecular condensates and suggest new research avenue

52 Biomolecular condensates are emerging as an important or

53 These biomolecular condensates are formed from processes that

54 Biomolecular condensates are found throughout eukaryotic

55 ation of individual residues on molecules in biomolecular condensates can provide specificity that gi

56 ted formation, transport, and interaction of biomolecular condensates containing distinct sets of nuc

57 LPS) as a function of cAMP signaling to form biomolecular condensates enriched in cAMP and PKA activi

58 During T cell activation, biomolecular condensates form at the immunological synap

59 Many biomolecular condensates form via spontaneous phase tran

60 Biomolecular condensates formed by liquid-liquid phase s

61 les of biochemical and cellular functions of biomolecular condensates from the recent literature and

62 forms vary in the formation of RNA-dependent biomolecular condensates in cells and in vitro.

63 the beta-catenin destruction complex to form biomolecular condensates in cells, which concentrate key

64 architectures shed light on the formation of biomolecular condensates in cells.

65 protein is capable of forming or regulating biomolecular condensates in vivo by interaction with RNA

66 as direct implications for the regulation of biomolecular condensates in vivo.

67 I argue that the concept of biomolecular condensates is an important advance in cell

68 A major physical underpinning of biomolecular condensates is liquid-liquid phase separati

69 Phase-separated biomolecular condensates of proteins and nucleic acids f

70 Biomolecular condensates play a key role in organizing R

71 own if biophysical or material properties of biomolecular condensates regulate cancer.

72 nd RNA molecules underlies the biogenesis of biomolecular condensates such as membraneless organelles

73 We conclude that RNAP clusters are biomolecular condensates that assemble through LLPS.

74 P bodies are archetypal biomolecular condensates that concentrate proteins and R

75 ontrol of other cell biological processes by biomolecular condensates that form by phase separation t

76 Germ granules are biomolecular condensates that promote germ cell totipote

77 mponents is the formation and dissolution of biomolecular condensates through liquid-liquid phase sep

78 ve to cope with this pressure sensitivity of biomolecular condensates to avoid detrimental impacts to

79 leocapsid proteins of other viruses can form biomolecular condensates to spatiotemporally regulate N

80 tive coarse-grained explicit-chain model for biomolecular condensates underlain by liquid-liquid phas

81 In the presence of tRFs, biomolecular condensates were smaller and in higher numb

82 re phase-separated membraneless organelles ("biomolecular condensates").

83 roduces the role of PARylation in regulating biomolecular condensates, followed by discussion of curr

84 scuss the multifaceted cellular functions of biomolecular condensates, including cell compartmentaliz

85 s also growing recognition that membraneless biomolecular condensates, many of which are organized or

86 Ribonucleoprotein (RNP) granules are biomolecular condensates-liquid-liquid phase-separated d

87 ome cellular components through formation of biomolecular condensates-non-stoichiometric assemblies o

88 the long length and time scales relevant to biomolecular condensates.

89 uctures might also represent phase-separated biomolecular condensates.

90 protein domains and through the assembly of biomolecular condensates.

91 y the stoichiometrically undefined nature of biomolecular condensates.

92 f SARS-CoV-2, together with viral RNA, forms biomolecular condensates.

93 er underly or contribute to the formation of biomolecular condensates.

94 RNA polymerase II and its cofactors, within biomolecular condensates.

95 NAs into processing (P) bodies-membraneless, biomolecular condensates.

96 t lack enveloping membranes, recently termed biomolecular condensates.

97 r speckles (NS) are among the most prominent biomolecular condensates.

98 ein domains promote the formation of various biomolecular condensates.

99 stability and composition of multicomponent biomolecular condensates.

100 transitions that have been observed for many biomolecular condensates.

101 paration of their constituent molecules into biomolecular 'condensates' that have liquid-like propert

102 n this Review, we discuss the role of RNA in biomolecular condensation and highlight considerations f

103 aled that diverse cellular processes rely on biomolecular condensation and that aberrant phase separa

104 Biomolecular condensation is a way of organizing cytosol

105 Biomolecular condensation is emerging as an essential pr

106 Biomolecular condensation partitions cellular contents a

107 gical roles and pathological consequences of biomolecular condensation, as well as for harnessing pha

108 urces via increased transport, autophagy and biomolecular condensation.

109 d domain; these domains are known to promote biomolecular condensation.

110 nfection mechanisms, we set out to determine biomolecular conditions that promote giant virus genome

111 State-of-the-art in situ biomolecular conformation detection techniques rely on f

112 ing approach for ultrasensitive detection of biomolecular conformations through coupling between mole

113 While the full biomolecular corona composition can be investigated by c

114 oughly investigated, the crucial role of the biomolecular corona in drug delivery and the release eff

115 A full consideration of the effects of the biomolecular corona on the controlled release and drug d

116 The formation of the biomolecular corona represents a crucial factor in contr

117 ights not only the crucial importance of the biomolecular corona to the drug release capacity of vari

118 her a reduction or loss of responsiveness to biomolecular cues.

119 metadata, an ELIXIR Deposition Database for Biomolecular Data and the EMBL-EBI sample metadata hub.

120 ortant guidance for the design of successful biomolecular delivery systems via optimizing the physico

121 ssemblies have inspired extensive efforts in biomolecular design(2-5).

122 metalloproteins remains a formidable task in biomolecular design.

123 henomena allow for ultrasensitive electronic biomolecular detection in millimeter scale structures.

124 Here, we construct a versatile biomolecular detection platform based on photo-induced e

125 Therefore, this versatile biomolecular detection platform based on PIERS effect fo

126 and support vector machine (SVM) to quantify biomolecular differences in the tumor microenvironment.

127 tions of this method in: (i) visualizing the biomolecular distribution of whole embryos in three dime

128 ch has provided a basic understanding of the biomolecular driving forces underlying the form and func

129 Biomolecular droplets formed through phase separation ha

130 istic insight into the assembly and aging of biomolecular droplets.

131 DeepFRET's capacity to objectively quantify biomolecular dynamics and the potential to contribute to

132 rged as a powerful method for characterizing biomolecular dynamics in detail, even in cases where exc

133 The technological viability of biomolecular electronics and ionics is also discussed.

134 We have been engaged in the biomolecular engineering and application of FAD dependen

135 We highlight biomolecular engineering methodologies to assemble, regu

136 s longitudinal measurement of two correlated biomolecular events (oxidative stress and cellular apopt

137 xpression signatures representing particular biomolecular events in cancer.

138 Biomolecular fluorescence complementation analysis sugge

139 Biomolecular fluorescence complementation and pull-down/

140 ed mechanistic insights into the dynamics of biomolecular folding and binding, molecular machines, an

141 Biomolecular force fields optimized for globular protein

142 The TIP4P-D water model, combined with three biomolecular force-field parameters for the protein part

143 amework efficiently to quantify and localize biomolecular frustration at atomic resolution by examini

144 ins can potentially enable investigations of biomolecular function beyond the current sequence and st

145 and gene features and helping to understand biomolecular function.

146 e in enzyme engineering and the evolution of biomolecular functions.

147 ting structures are brush polymers wherein a biomolecular graft is positioned at each monomer backbon

148 rystallization, devoting little attention to biomolecular higher-order structures (HOSs) which critic

149 hesis, and long-range self-organization with biomolecular HOSs and opens vast opportunities for multi

150 ic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentration

151 trasound to neurons at the genetic level for biomolecular imaging and sonogenetic control.

152 nt a general and scalable platform entitled 'biomolecular implementation of protocellular communicati

153 Identifying early biomolecular indicators of organ dysfunction may improve

154 However, conventional methods fail to retain biomolecular information associated to the severity of U

155 e visualization and multivariate analysis of biomolecular information extracted from unlabeled zebraf

156 n order to spatially map ultrastructural and biomolecular information simultaneously.

157 ng modalities are unable to access intricate biomolecular information without compromising the integr

158 e co-expression, biochemical regulation, and biomolecular inhibition or activation.

159 cal circuit cascade, which probes a specific biomolecular input, transform the input into a structura

160 uned by the thermodynamics of the underlying biomolecular interaction network.

161 In analysis of biomolecular interaction networks (e.g., protein interac

162 e of applications in real-time monitoring of biomolecular interactions and detection of biological an

163 cule crosslinkers are invaluable for probing biomolecular interactions and for crosslinking mass spec

164 e variations without interfering with native biomolecular interactions are required.

165 meters, has been used for decades to measure biomolecular interactions at nanometer-precision, e.g.,

166 tic and thermodynamic parameters of specific biomolecular interactions detected by AFM for single bon

167 Resolving coordinated biomolecular interactions in living cellular environment

168 ensitive assay capable of directly measuring biomolecular interactions in real time, at low cost, and

169 (PTS) plays a crucial role in extracellular biomolecular interactions that dictate various cellular

170 In this approach, biomolecular interactions trigger changes in particle mo

171 ticular genomic loci and locally promote the biomolecular interactions underlying gene expression.

172 volume of PSA often promotes interference of biomolecular interactions, PSA-binding ligands have impo

173 or for the detection of other affinity-based biomolecular interactions, such as antigen-antibody, nuc

174 Biomolecular interactions-particularly homotypic interac

175 niversal approach for characterizing complex biomolecular interactions.

176 fingerprints that are important for specific biomolecular interactions.

177 bservation, at the single-molecule level, of biomolecular interactions.

178 above 4 k(B)T, which is easily observable in biomolecular interactions.

179 bel-free imaging of nanoscopic particles and biomolecular interactions.

180 or retrieving information on the kinetics of biomolecular interactions.

181 axon and myelin is maintained by a number of biomolecular interactions.

182 a biocompatible reaction for site-selective biomolecular labeling and imaging.

183 , polymer conjugation and cross-linking, and biomolecular labeling in the native cellular environment

184 specificity, cellular assays rely heavily on biomolecular labels and tags while label-free cell-based

185 how that negative static charge present in a biomolecular layer on the surface of an SPR sensor resul

186 ed, functional bioelectric interfaces at the biomolecular level to the whole-organ level.

187 erlying molecular interactions that underpin biomolecular LLPS have been of increased interest due to

188 How does a biomolecular machine achieve high speed at high efficien

189 The ribosome is a biomolecular machine that undergoes multiple large-scale

190 he universality, diversity, and evolution of biomolecular machinery.

191 Biomolecular machines are protein complexes that convert

192 s that these mechanisms are commonly used by biomolecular machines.

193 oint-of-care assays for optical detection of biomolecular markers attract growing attention, because

194 ed fragmentation methods have revolutionized biomolecular mass spectrometry, in particular native and

195 cently significant progress has been made on biomolecular materials that can support ion and electron

196 This biomolecular matrix helps manifest the beneficial or det

197 jointly support the hypothesis that similar biomolecular mechanisms may be responsible for this high

198 in severe asthma.Objectives: To identify new biomolecular mechanisms underlying severe asthma by an u

199 ecedented view into an ordered, multilayered biomolecular membrane system induced by the presence of

200 The ability to accurately determine biomolecular mobility both in the condensate interior an

201 The viscous properties and associated biomolecular mobility within these condensed phase dropl

202 a valuable tool for the glycoinformatics and biomolecular modeling communities.

203 We discuss efforts to optimize biomolecular motor performance, construct new motors com

204 he construction of hybrid systems powered by biomolecular motors and try to ascertain if there are th

205 Biological molecular motors (or biomolecular motors for short) are nature's solution to

206 ontrol over the motile structures powered by biomolecular motors has remained a topic of many studies

207 Engineering with biomolecular motors has the potential to yield commercia

208 ent work aiming for the integration of these biomolecular motors into actuators, sensors, and computi

209 ess in the past decade in the integration of biomolecular motors into hybrid nanosystems.

210 cial and biological components, and contrast biomolecular motors with current artificial molecular mo

211 e behavior between motile systems powered by biomolecular motors, and we discuss these advances.

212 ngly, very limited information exists on the biomolecular network of the signaling machineries underl

213 erstood through the elucidation of localized biomolecular networks, or microenvironments.

214 plexity of synthesis and analysis of complex biomolecular networks.

215 ll accelerate the development of low-energy, biomolecular neuromorphic memelements, which, in turn, c

216 heteronuclear direct detection possible for biomolecular NMR applications.

217 xperiments are central to small-molecule and biomolecular NMR spectroscopy, and commonly form the bas

218 tterns assembled by ligands that are akin to biomolecular organization.

219 affinity and specificity of its binding to a biomolecular partner.

220 while providing high binding specificity for biomolecular partners typically observed with proteins.

221 bases of interactions and their roles in the biomolecular pathways that orchestrate key cellular proc

222 The design principles underlying biomolecular phase separation have the potential to driv

223 trides in elucidating the molecular basis of biomolecular phase separation in various disease, stress

224 llular mechanisms that enable the control of biomolecular phase separation: membrane surfaces, post-t

225 als underwent analysis of renal function and biomolecular phenotyping at 24 h, 48 h and 4 weeks after

226 als underwent analysis of renal function and biomolecular phenotyping.

227 Biomolecular piezoelectric materials are considered a st

228 REE profiles as proxies for soft tissue and biomolecular preservation in fossil bones.

229 Herein, we review current cell-based and biomolecular (primarily small-molecule and protein-based

230 xperiments provide meaningful data about the biomolecular process in question; analyzing raw data and

231 s are powerful devices turning "on" or "off" biomolecular processes at the core of critical biologica

232 l groups on the protein surface, which drive biomolecular processes that bury exposed surface.

233 -organized synthetic compartments to control biomolecular processes.

234 ch for elucidating the kinetic mechanisms of biomolecular processes.

235 approach named Patient-Net (P-Net) in which biomolecular profiles of patients are modeled in a graph

236 res at subcellular spatial resolution, (iii) biomolecular profiling and discrimination of wild type a

237 e rapid monitoring of chemical reactions and biomolecular (re)folding are opened.

238 architecture to program localized DNA-based biomolecular reaction networks on cancer cell membranes.

239 Here, we present a biomolecular reaction process that reports the concentra

240 Cooperativity enhances the responsiveness of biomolecular receptors to small changes in the concentra

241 Chirality plays a central role in biomolecular recognition and pharmacological activity of

242 Frustration is thought to underpin biomolecular recognition and the flexibility of protein-

243 Biomolecular recognition between proteins follows comple

244 similar to those observed in the process of biomolecular recognition in proteins.

245 l signal transducers with the specificity of biomolecular recognition strategies.

246 inding and high selectivity are hallmarks of biomolecular recognition.

247 aphonomy, we also draw predictions as to the biomolecular recovery potential of additional REE profil

248 parative metabolomics, which contrasts small biomolecular regulations under different conditions, has

249 ncing) highlight the importance of advancing biomolecular research in artefact studies.

250 The Biobanking BioMolecular Research Infrastructure of the Netherlands

251 user queries in support of hypothesis-driven biomolecular research.

252 ogy and medicine by allowing access to novel biomolecular scaffolds.

253 However, engineering biomolecular self-assembly at solid-liquid interfaces in

254 Biomolecular self-assembly is a key process used by life

255 e proper protein folding in the cell and how biomolecular self-assembly may be optimized evolutionari

256 into the interpretation of IMS-MS data from biomolecular self-assembly studies-an important and time

257 nterface of high-performance electronics and biomolecular self-assembly, such approaches may enable t

258 have become an important label-free optical biomolecular sensing technology and a "gold standard" fo

259 ge is especially important in the context of biomolecular sensing.

260 s to repurpose CRISPR for the development of biomolecular sensors for diagnosing diseases and underst

261 chromatography, DNA sequencing technologies, biomolecular sensors, and surfaces and scaffolds for tar

262 rated landscapes but some strategic parts of biomolecular sequences located at specific sites in the

263 densely functionalized with sequence-defined biomolecular sidechains.

264 The results reveal that, not unlike biomolecular signaling, high density multivalent display

265 Biomolecular simulations are intrinsically high dimensio

266 e-filtering analysis protocols and atomistic biomolecular simulations reveals weak binding events bet

267 mulation algorithms, and computing hardware, biomolecular simulations with advanced force fields at b

268 e directions, of polarizable force fields in biomolecular simulations.

269 aration, concentration and storage of scarce biomolecular species, on-demand chemical reactions and n

270 on interactions in the cell that affect both biomolecular stability and function and modulate them.

271 trates the usefulness of ML in understanding biomolecular states and demystifying complex simulations

272 ssNMR is likely to find many applications to biomolecular structural conversion processes, including

273 lecule technique that may be used to measure biomolecular structure and dynamics.

274 s the predominant geometrical determinant of biomolecular structure and interactions.

275 e previously been demonstrated effective for biomolecular structure similarity search.

276 fficient complexity to encompass fundamental biomolecular structure-function relationships: two-state

277 Data Bank (PDB) currently holds over 140 000 biomolecular structures and continues to release new str

278 methods have been developed to characterise biomolecular structures down to the angstrom level.

279 Structural biology strives to capture biomolecular structures in action, but the samples are o

280 Chemistry is ideally placed to replicate biomolecular structures with tuneable building materials

281 Combined with biochemical and biomolecular studies, these discoveries can help design

282 ther (and how) the electrostatic charge of a biomolecular system influences the SPR biosensor respons

283 ts the structure, dynamics, and stability of biomolecular systems and is a key parameter in the conte

284 e thermodynamics and kinetics of the type of biomolecular systems presented in this work.

285 simulation data sets and to examine how much biomolecular systems resemble both synthetic and experim

286 display on linear platforms is used by many biomolecular systems to effectively interact with their

287 tions, dynamical properties, and activity of biomolecular systems using pressure perturbation.

288 arger molecules containing oxygen, including biomolecular systems.

289 ed to be applicable to a wide range of large biomolecular systems.

290 complexity from simplicity in molecular and biomolecular systems.

291 cavities and average charge distribution in biomolecular systems.

292 between an arbitrary number of ligands and a biomolecular target that is efficient and robust.

293 tep toward establishing hGMPK as a potential biomolecular target, from both an orthosteric (ligand-bi

294 ighly selective attachment onto a variety of biomolecular targets.

295 identification of compounds with affinity to biomolecular targets.

296 ted design space of conventional organic and biomolecular templates restricts the complexity and accu

297 or borrowed from nature using bioassembly or biomolecular templating.

298 mplex yet most predictive aspects of a given biomolecular trajectory.

299 both for treatment options and for the basic biomolecular understanding of how this process intersect

300 ructure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA,