ライフサイエンスコーパス: bioorthogonal

1 t in any cell, the protein folding sensor is bioorthogonal.

2 Reported here is the endogenous and bioorthogonal activation of a DNAzyme fluorescent sensor

3 lications that illustrate the utility of the bioorthogonal activity.

4 involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the

5 We present a bioorthogonal and modular conjugation method for efficie

6 yclooctene-tetrazine cycloadditions are both bioorthogonal and mutually orthogonal: trans-cyclooctene

7 nd find widespread use for different in vivo bioorthogonal applications, particularly in the biomedic

8 t implications for designing such groups for bioorthogonal applications.

9 Our bioorthogonal approach also enables spatial control.

10 mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged m

11 eptionally mild conditions and constitutes a bioorthogonal approach toward amidines by avoiding the u

12 By combining a tHCA probe and a pretargeted bioorthogonal approach, real-time, non-invasive tumour v

13 Here we present bioorthogonal approaches for making DNA-protein conjugat

14 In an effort to develop a bioorthogonal AS-kinase inhibitor and to extend this tec

15 nt in biological systems, making it a unique bioorthogonal atom for probing molecular interactions in

16 For this purpose, IONPs with bioorthogonal azide and alkyne surfaces masked by polyet

17 Tagged with a bioorthogonal azide group, GalNAzMe serves as an O-glyca

18 recognition motif that allows us to append a bioorthogonal azide or alkyne moiety and use the Cu(I)-c

19 of site-selective bioconjugation followed by bioorthogonal bond cleavage was efficiently employed for

20 f maturing mechanistic understanding and new bioorthogonal bond-cleavage reactions, the broader goal

21 hol-containing molecules and as reagents for bioorthogonal bond-cleavage reactions.

22 The compatibility of bioorthogonal catalysis and physical hydrogels opens up

23 Recent advances in bioorthogonal catalysis are increasing the capacity of r

24 Bioorthogonal catalysis broadens the functional possibil

25 a prominent role in the growing subfield of bioorthogonal catalysis by producing xenobiotics and unc

26 The promising potential of bioorthogonal catalysis in biomedicine is inspiring incr

27 argeting concepts can be translated to rapid bioorthogonal chemical approaches with retained potentia

28 We tailored cell surfaces with bioorthogonal chemical groups on the basis of a liposome

29 In this study, we have demonstrated bioorthogonal chemical imaging of DNA, RNA, protein and

30 tabolic GalNAz labeling of human cells and a bioorthogonal chemical probe to affinity-purify and iden

31 the tubulin-binding maytansinoid DM1 using a bioorthogonal chemical reaction scheme.

32 Fluorogenic probes activated by bioorthogonal chemical reactions can enable biomolecule

33 Bioorthogonal chemical reactions, those that do not inte

34 t thiopeptide variants containing ncAAs with bioorthogonal chemical reactivity can be further postbio

35 Using a bioorthogonal chemical reporter and labeling strategy to

36 complish this goal, we took advantage of the bioorthogonal chemical reporter technique.

37 The bioorthogonal chemical reporters described here should s

38 Here we report bioorthogonal chemical reporters that enable direct in-g

39 provides a versatile general approach to map bioorthogonal-chemically engineered post-translational m

40 Bioorthogonal chemistries enable researchers to interrog

41 The transformational impact of bioorthogonal chemistries has inspired new strategies fo

42 Bioorthogonal chemistries have been widely used to probe

43 Bioorthogonal chemistries have provided tremendous insig

44 openone ligation is also distinct from other bioorthogonal chemistries in that it makes use of readil

45 luorescent probes can make use of selective, bioorthogonal chemistries to report on specific analytes

46 ade towards not only expanding the number of bioorthogonal chemistries, but also fine-tuning existing

47 a non-natural amino acid and two compatible bioorthogonal chemistries, we conjugated mannitol dehydr

48 aheterocycles, offering new opportunities in bioorthogonal chemistry and biological studies.

49 near-infrared probe that can be activated by bioorthogonal chemistry and image tumours in mice by cag

50 Our studies define a novel intersection of bioorthogonal chemistry and metabolite reactivity that m

51 tions of triazines have wide applications in bioorthogonal chemistry and natural product synthesis.

52 The constraining conditions of bioorthogonal chemistry are beneficial for reaction effi

53 trazines (PMT) are a key enabler for in vivo bioorthogonal chemistry based on the very fast and catal

54 Bioorthogonal chemistry enables a specific moiety in a c

55 Bioorthogonal chemistry has become one of the main drivi

56 oteins and generate iodinated tetrazines for bioorthogonal chemistry has been developed.

57 Metabolic glycan labeling coupled with bioorthogonal chemistry has paved the way for visualizin

58 he alkyl chain and with potential utility in bioorthogonal chemistry have been developed.

59 ecent advances in genetic code expansion and bioorthogonal chemistry have enabled the site-specific l

60 luorescent probes designed for activation by bioorthogonal chemistry have enabled the visualization o

61 Bioorthogonal chemistry is bridging the divide between s

62 mical modification of membrane proteins with bioorthogonal chemistry to explore their structure-funct

63 r strategy has been used in conjunction with bioorthogonal chemistry to image the external glycosylat

64 ting properties of hydroxamic acid groups by bioorthogonal chemistry using Pd-functionalized resins.

65 Combining bioorthogonal chemistry with the use of proteins enginee

66 rating O-propargyl-puromycin (OPP) labeling, bioorthogonal chemistry, and multiplexed proteomics for

67 nt developments in chemoenzymatic reactions, bioorthogonal chemistry, and optogenetics, we tether flu

68 We combine metabolic labeling, bioorthogonal chemistry, and super-resolution localizati

69 These probes, in conjunction with bioorthogonal chemistry, enable selective in situ detect

70 forms the foundation for the development of bioorthogonal chemistry, in which the absence of a pair

71 Cyclopropenones are attractive motifs for bioorthogonal chemistry, owing to their small size and u

72 trazines are important tools to the field of bioorthogonal chemistry, there is a need for new approac

73 a significant advancement on the utility of bioorthogonal chemistry, TUTase, and the CRISPR toolbox,

74 The feasibility of Affibody-based bioorthogonal chemistry-mediated pretargeting was demons

75 e trans-cyclooctene s-TCO are widely used in bioorthogonal chemistry.

76 , yet chemically tractable using copper-free bioorthogonal chemistry.

77 ling of RNA can be profiled and imaged using bioorthogonal chemistry.

78 It holds the crucial characteristics for bioorthogonal chemistry: biocompatibility, selectivity,

79 Here we report the development of a new bioorthogonal cleavage reaction based on trans-cycloocte

80 that uses metabolic labelling combined with bioorthogonal click chemistry (that is, reactions perfor

81 Bioorthogonal click chemistry ensures fast and highly se

82 -Click (sgR-CLK) that harnesses the power of bioorthogonal click chemistry for remodeling guide RNA t

83 We have developed a modification of bioorthogonal click chemistry to assay the palmitoylatio

84 ed metabolic oligosaccharide engineering and bioorthogonal click chemistry to label various commensal

85 jugated dibenzylcyclooctyne (DBCO-Cy5.5) via bioorthogonal click chemistry, resulting in Cy5.5-labele

86 ibodies, complementary oligonucleotides, and bioorthogonal click chemistry.

87 T-cell labeling and tracking strategy using bioorthogonal click chemistry.

88 and Diels-Alder reaction, and other types of bioorthogonal click ligations have had a significant imp

89 he potential of boronic ester formation as a bioorthogonal click reaction between abiotic boronic aci

90 uorescence (NIRF) dye-labeled molecules by a bioorthogonal click reaction in cell cultures and in tum

91 Recently, metabolic glycoengineering with bioorthogonal click reactions has focused on improving t

92 Both components are cross-linked by multiple bioorthogonal click reactions in situ on the surface of

93 ceptor (EGFR) Fab and an anti-CD105 Fab, via bioorthogonal "click" ligation of trans-cyclooctene and

94 Fast, high-yielding, and selective bioorthogonal "click" reactions employing nontoxic reage

95 a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reagents.

96 rotecting group from a protein or drug under bioorthogonal conditions enables accurate spatiotemporal

97 Bioorthogonal conjugation chemistry has enabled the deve

98 face can be selectively functionalized using bioorthogonal conjugation chemistry.

99 ed from the rest of the protein pool through bioorthogonal conjugation of the azide side chain to pro

100 ironment is examined, and its potential as a bioorthogonal conjugation reaction is demonstrated.

101 in we report a fast (>10(3) M(-1) s(-1)) and bioorthogonal conjugation reaction that joins semicarbaz

102 oline derivatives were synthesized to permit bioorthogonal conjugation reactions, including azide-alk

103 etrazine moiety, which allowed site-specific bioorthogonal conjugation to an engineered membrane prot

104 Bioorthogonal control of metal-ion sensors for imaging m

105 cals are harnessed to initiate and sustain a bioorthogonal controlled radical polymerization via reve

106 bination of metabolically labeled glycans, a bioorthogonal copper(I)-catalyzed azide-alkyne cycloaddi

107 bsequently be conjugated to fluorophores via bioorthogonal copper-catalyzed click-chemistry.

108 The approach takes advantage of bioorthogonal coupling reactions to generate proteolipos

109 nd relied on copper-free click chemistry for bioorthogonal covalent cross-links throughout the film t

110 functionalized Pt(II)-based agents using the bioorthogonal Cu(I)-catalyzed azide-alkyne cycloaddition

111 Here we employ an optimized first-order bioorthogonal cyclization reaction to control the self-a

112 yl-cyclopropene groups that rapidly react by bioorthogonal cycloaddition in the presence of complemen

113 action can also be used in tandem with other bioorthogonal cycloaddition reactions.

114 d SWCNTs could allow application of targeted bioorthogonal decaging approaches with minimal off-site

115 , IEDDA reactions have recently found use in bioorthogonal decaging to activate proteins or drugs in

116 ogy for pretargeted PET imaging based on the bioorthogonal Diels-Alder click reaction between tetrazi

117 ly efficient extracellular and intracellular bioorthogonal disassembly via omnidirectional tetrazine-

118 ligation of synthetic peptides, followed by bioorthogonal fluorescent labeling.

119 lls can be detected by the newly synthesized bioorthogonal fluorescent probe.

120 est brightness enhancements reported for any bioorthogonal fluorogenic dyes.

121 The isocyano group is a structurally compact bioorthogonal functional group that reacts with tetrazin

122 However, the slow reactivity of the bioorthogonal functional groups that can be encoded gene

123 ercially available amines, including several bioorthogonal functional groups.

124 re analogues of monosaccharides that contain bioorthogonal functionalities and enable the direct visu

125 robenzene (CDNB), and bear a wide variety of bioorthogonal functionalities such as alkynes, aldehydes

126 e of alternative substrates that incorporate bioorthogonal functionality including azides and alkynes

127 Here we report the in vitro bioorthogonal generation of 5-fluorouracil from a biolog

128 lated unnatural monosaccharides containing a bioorthogonal group have been widely used for metabolic

129 inhibitor conjugate contains a complementary bioorthogonal group.

130 The site-specific incorporation of bioorthogonal groups via genetic code expansion provides

131 al motifs, isotopic labels, and a variety of bioorthogonal handles are prepared, along with analogues

132 y trap interactions in vivo and by employing bioorthogonal handles to enrich the protein targets dire

133 Bioorthogonal hydrazide and copper-assisted azide-alkyne

134 The bioorthogonal hyperspectral SRS microscopy imaging revea

135 at Affibody-based pretargeting mediated by a bioorthogonal interaction between trans-cyclooctene (TCO

136 s functionalized tetrazines in vivo, via the bioorthogonal inverse electron demand Diels-Alder (IEDDA

137 ine (Tz)-based radioligand via the rapid and bioorthogonal inverse electron-demand Diels-Alder reacti

138 o predict the second order rate constants of bioorthogonal inverse-electron demand Diels-Alder reacti

139 The bioorthogonal inverse-electron-demand Diels-Alder (IEDDA

140 Simultaneous systemic administration of the bioorthogonal IONPs in tumor-bearing mice demonstrated t

141 rface endogenous RNAs (e.g., microRNAs) with bioorthogonal l-DNA, suggesting applications in bioengin

142 nd developing enzyme-mediated strategies for bioorthogonal labeling in living cells.

143 Metabolic and bioorthogonal labeling methods have previously enabled t

144 Finally, the method is compared to other bioorthogonal labeling methods.

145 strategy, which employs genetic encoding and bioorthogonal labeling of azF in live cells, should be u

146 interaction is utilized for highly efficient bioorthogonal labeling of cellular targets.

147 zed genetic code expansion and site-specific bioorthogonal labeling of rhodopsin with Alexa488 to ena

148 cient tools for site-specific fluorescent or bioorthogonal labeling of RNA are in high demand.

149 Genetic code expansion and bioorthogonal labeling provide for the first time a way

150 Interest in mutually exclusive pairs of bioorthogonal labeling reagents continues to drive the d

151 This work therefore extends the use of bioorthogonal labeling strategies to problems of clinica

152 2'-AzCyd), a modified nucleoside amenable to bioorthogonal labeling with SPAAC chemistry.

153 hat tolerate SphK mutagenesis and subsequent bioorthogonal labeling.

154 evelopment in the context of chemoselective, bioorthogonal labeling.

155 idely deployed for alkyl-diversification and bioorthogonal labeling.

156 gents, making them the fastest site-specific bioorthogonal labels in eukaryotic systems.

157 Here we introduce genetically directed bioorthogonal ligand tethering (BOLT) and demonstrate se

158 and isonitrile reactants for application in bioorthogonal ligation and release chemistry.

159 Here we report a novel bioorthogonal ligation between cyclopropenones and funct

160 chlorin to a cell penetrating peptide, using bioorthogonal ligation chemistry.

161 Metabolic glycan engineering (MGE) and bioorthogonal ligation have enabled study of biological

162 Bioorthogonal ligation methods with improved reaction ra

163 This bioorthogonal ligation of Tet-v2.0-protein reacts in cel

164 esis, as well as a simple protocol for their bioorthogonal ligation to a model saccharide using a Hui

165 Subsequent bioorthogonal ligation with alkyne-functionalized probes

166 -monophosphate (AMP) allows their subsequent bioorthogonal ligation with azide-fluorescent dyes or af

167 Fluorogenic bioorthogonal ligations offer a promising route towards

168 We have used a bioorthogonal metabolic labeling strategy to detect cell

169 ity, in conjunction with a more reproducible bioorthogonal method of chemical modification and facile

170 Although bioorthogonal methods that use engineered amino acids of

171 is resistant to TFA and thus can serve as a bioorthogonal modification of bioactive peptides.

172 The described bioorthogonal modification of CV with trans-cyclooctene

173 combination of primer extension, bypass, and bioorthogonal modification works also for double and tri

174 The bioorthogonal modifications protect the isolated PG agai

175 The acid-stable ketals 17-19 are bioorthogonal modifications which reconstitute the biolo

176 carbon-centered radical species for targeted bioorthogonal molecular synthesis.

177 ng metabolic labeling and a gadolinium-based bioorthogonal MRI probe.

178 This approach utilizes a bioorthogonal, multifunctional chemical probe that can b

179 , we report the fabrication of protein-sized bioorthogonal nanozymes through the encapsulation of hyd

180 The bioorthogonal nature of perfluorocarbons provides a uniq

181 Here, we apply bioorthogonal non-canonical amino acid tagging (BONCAT)

182 This technique, termed bioorthogonal non-canonical amino acid tagging (BONCAT),

183 Here, we use BONCAT (bioorthogonal non-canonical amino acid tagging) to measu

184 Bioorthogonal noncanonical amino acid tagging (BONCAT) c

185 ling by amino acids in cell culture (pSILAC)/bioorthogonal noncanonical amino acid tagging (BONCAT) m

186 Here, we adapt bioorthogonal noncanonical amino acid tagging (BONCAT) t

187 d a time-selective proteome-labeling method [bioorthogonal noncanonical amino acid tagging (BONCAT)]

188 Modifying the previously developed bioorthogonal noncanonical amino acid tagging method, we

189 sly within the cytosol and mediate efficient bioorthogonal organometallic chemistries (e.g., allylcar

190 , is becoming increasingly important because bioorthogonal organometallic chemistry involves palladiu

191 table masking group for implementing in vivo bioorthogonal organometallic chemistry.

192 A bioorthogonal organometallic reaction is a biocompatible

193 genomic sequences, and can thus form a near bioorthogonal pair with I-SceI for DNAzyme activation wi

194 he development and biological screening of a bioorthogonal palladium-labile prodrug of the nucleoside

195 l and DHHC5-GT (gene-trapped) mice using the bioorthogonal palmitate analog 17-octadecynoic acid.

196 Using a bioorthogonal palmitate reporter to quantify palmitoylat

197 shed labeling strategies that originated the bioorthogonal paradigm, we have recently proposed the us

198 use of heterogeneous palladium chemistry and bioorthogonal Pd(0)-labile prodrugs to develop spatially

199 ability that maintain robust reactivity with bioorthogonal phosphines.

200 new ligation of cyclopropeniminium ions with bioorthogonal phosphines.

201 trate a synthetic strategy that exploits two bioorthogonal photochemistries to achieve reversible imm

202 zed as robust polymer fibers via interfacial bioorthogonal polymerization employing the rapid cycload

203 o test novel tetrazines for use with in vivo bioorthogonal pretargeting strategies.

204 e bacterial cell surface by an extracellular bioorthogonal probe, as judged by confocal fluorescence

205 In this work, we developed a specific bioorthogonal probe, itaconate-alkyne (ITalk), for quant

206 e new insights into the development of novel bioorthogonal probes that can be utilized in site-specif

207 these strained alkynes identify them as new bioorthogonal probes that should facilitate the discover

208 This new bioorthogonal process based on miniscule components is t

209 f identifying substrates of individual PMTs, bioorthogonal profiling of protein methylation (BPPM) ha

210 To address such a need, we envisioned a Bioorthogonal Profiling of Protein Methylation (BPPM) te

211 toclick chemistry and afforded rapid (<10 s) bioorthogonal protein labeling.

212 Here, we report that bioorthogonal proteomics of macrophages with an improved

213 Bioorthogonal quenching of excess unreacted SAM-TCOs wit

214 Live-cell Raman imaging based on bioorthogonal Raman probes with distinct signals in the

215 A new bioorthogonal reactant pair, spiro[2.3]hex-1-ene (Sph) a

216 Here we review this bioorthogonal reaction and its promising applications fo

217 usly developed a novel approach based on the bioorthogonal reaction between a radiolabeled tetrazine

218 We focused on the bioorthogonal reaction between a trans-cyclooctene (TCO)

219 The high-fidelity bioorthogonal reaction between the symmetric hydrophilic

220 ze a pretargeting strategy that exploits the bioorthogonal reaction between transcyclooctene (TCO) an

221 this Review, we highlight recent advances in bioorthogonal reaction development, focusing on how phys

222 The ligation exploits the bioorthogonal reaction of aldehydes and alkoxyamines to

223 This bioorthogonal reaction presents broad applicability and

224 udies establish Cu-free click chemistry as a bioorthogonal reaction that can be executed in the physi

225 This ideal bioorthogonal reaction will enable the monitoring of a l

226 Subsequent selective bioorthogonal reaction with a cell-permeable organic dye

227 l sites of chain termination in vivo through bioorthogonal reaction with fluorescent cyclooctyne prob

228 o called "copper-free click chemistry", is a bioorthogonal reaction with widespread applications in b

229 Our strategy exploits a known bioorthogonal reaction, the 1,3-dipolar cycloaddition of

230 Here we explore an alternative bioorthogonal reaction, the 1,3-dipolar cycloaddition of

231 the carbonyl moiety of biomolecules through bioorthogonal reaction, therefore can be utilized for th

232 organic transformation, there is no perfect bioorthogonal reaction.

233 Bioorthogonal reactions are valuable tools for the selec

234 We report the use of bioorthogonal reactions as an original strategy in photo

235 ocyano group is a valuable functionality for bioorthogonal reactions because it rapidly reacts with t

236 ted product can be further functionalized by bioorthogonal reactions between the aldehyde residue and

237 Alder (IEDDA) reaction stands out from other bioorthogonal reactions by virtue of its unmatchable kin

238 Bioorthogonal reactions for labeling biomolecules in liv

239 tages of this approach over state-of-the-art bioorthogonal reactions for protein labelling in vitro a

240 The development of bioorthogonal reactions has classically focused on bond-

241 Although a number of bioorthogonal reactions have been documented in literatu

242 Bioorthogonal reactions have been widely utilized to man

243 der cycloadditions have emerged as important bioorthogonal reactions in chemical biology.

244 system enabled a detailed comparison of the bioorthogonal reactions in live cells and informed the s

245 approaches to introduce terminal alkynes for bioorthogonal reactions into biomolecules still present

246 nse interest in the development of selective bioorthogonal reactions or "click" chemistry that can pr

247 e proline derivatives allowed three parallel bioorthogonal reactions to be conducted in one solution.

248 reporters in conjunction with catalyst-free bioorthogonal reactions will greatly streamline protein

249 Ideal bioorthogonal reactions with high reaction rates, high s

250 and can be used directly in cells for rapid bioorthogonal reactions with tetrazines.

251 Subsequent bioorthogonal reactions with the fluorophore-conjugated

252 er, we discuss how one of the most versatile bioorthogonal reactions, "click chemistry", has been exp

253 Bioorthogonal reactions, especially the Cu(I)-catalysed

254 Bioorthogonal reactions, including the strain-promoted a

255 ailable toolkit to tag-free methods based on bioorthogonal reactions, we hope to enable researchers t

256 Herein, we report the use of two bioorthogonal reactions-the condensation reaction of aro

257 his experimental gap through the creation of bioorthogonal reactions.

258 alkenes have become among the most valuable bioorthogonal reactions.

259 heterocycles in synthesis and are popular as bioorthogonal reactions.

260 ogical processes via the cycloaddition-based bioorthogonal reactions.

261 s of times faster than established encodable bioorthogonal reactions.

262 is 3-7 orders of magnitude faster than many bioorthogonal reactions.

263 n exogenous enzyme into cells for performing bioorthogonal reactions.

264 eobases as well as faster and more selective bioorthogonal reactions.

265 t the sites that can be labeled, while many "bioorthogonal" reactions for which a component can be ge

266 on maleimide-toxin conjugates, which include bioorthogonal reactive groups, are also found to block c

267 es were introduced in the VHH to function as bioorthogonal reactive groups.

268 enetically encoded unnatural amino acid with bioorthogonal reactivity and the inhibitor conjugate con

269 Rapid bioorthogonal reactivity can be induced by controllable,

270 The rapid kinetics, bioorthogonal reactivity, and electrochemical control pr

271 ag protein technology for directly comparing bioorthogonal reagent reactivity, specificity, and stabi

272 ring a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex o

273 ically encode the endogenous biosynthesis of bioorthogonal reagents within living organisms.

274 A new class of bioorthogonal reagents, 1,2,4-triazines, is described.

275 Two new bioorthogonal reagents, methylcyclopropene and 3,3,6,6-t

276 ith single-molecule sensitivity, combining a bioorthogonal, selective chemical labeling method of 5-h

277 n mammalian cells, and demonstrate the rapid bioorthogonal site-specific labelling of a protein on th

278 Fluorescent bioorthogonal smart probes across the visible spectrum w

279 rotein inactive until deprotection through a bioorthogonal Staudinger reduction delivers the active w

280 They react via the bioorthogonal strain-promoted azide alkyne cycloaddition

281 jugated to Tyr3-octreotate (Y3-TATE) through bioorthogonal, strain-promoted alkyne azide cycloadditio

282 Herein, we developed bioorthogonal T-cell labeling and tracking strategy usin

283 robed, in principle, by monosaccharides with bioorthogonal tags that would ideally be specific for di

284 aman scattering (SRS), and covers the use of bioorthogonal tags to enhance sample detection, and rece

285 azine ligations have proven to be a powerful bioorthogonal technique for the detection of many labele

286 Bioorthogonal template-driven tetrazine ligations could

287 n this study, we have harnessed the power of bioorthogonal tethering to SNAP and CLIP protein tags to

288 We demonstrate that bioorthogonal tetrazine ligations can be utilized to rap

289 Herein we report a novel bioorthogonal tetrazine uncaging reaction that harnesses

290 The attachment of bioorthogonal tetrazines on complex molecules typically

291 These features fill current voids in the bioorthogonal toolkit.

292 s integrate a coumarin fluorochrome with the bioorthogonal trans-cyclooctene(TCO)-tetrazine chemistry

293 rms of light-induced cargo release, however, bioorthogonal transformation of the modulating tetrazine

294 However, many popular bioorthogonal transformations are incompatible with one

295 eir ability to perform simultaneous multiple bioorthogonal transformations will empower the applicati

296 ous solution and is compatible with existing bioorthogonal transformations.

297 Bioorthogonal uncaging reactions offer versatile tools i

298 Bioorthogonal uncaging strategies have recently emerged

299 A bioorthogonal uncaging strategy is presented, which is t

300 The bioorthogonal utility was demonstrated by the selective