ライフサイエンスコーパス: biophysical

1 We propose a combined psychophysical and biophysical account of two symptomatologically related d

2 x and characterized its core biochemical and biophysical activities.

3 system, a model synapse that allows precise biophysical analyses of synaptic properties.

4 Here, we report structural and biophysical analyses of the C-terminal domain of the bac

5 Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazi

6 Biophysical analyses show that this (GGN)13 repeat forms

7 2 interactions; in combination with reported biophysical analyses they provide chemical insight into

8 that the reported yield, purity, results of biophysical analyses, and stability of PfCSP4/38 warrant

9 In our thorough structural and biophysical analyses, we have found no evidence that the

10 Biophysical analysis indicated that Asp t 36 shows simil

11 ed experimental platform for biochemical and biophysical analysis of isolated mammalian plasma membra

12 MBO Journal (Paoletti et al, 2020), combined biophysical analysis of the RAD51-ssDNA interaction with

13 tic macromolecules are often complemented by biophysical analysis.

14 ted the mechanisms of CYP3A4 allostery using biophysical and advanced spectroscopic techniques, and d

15 We demonstrate the biophysical and biochemical effects of preconditioning h

16 d these differences correlated with distinct biophysical and biochemical features of the germline-tar

17 ptimized hairpin structure and show that its biophysical and biochemical properties are inconsistent

18 sis (Arabidopsis thaliana) and validated the biophysical and biochemical properties of the sensor tha

19 high-fidelity monitoring of a range of vital biophysical and biochemical signals from human bodies, i

20 Here, we present a combined biophysical and biochemical study to explore the structu

21 Hence, our experimental approach combining biophysical and biological tools facilitates the study o

22 A new article combining biophysical and cell-based readouts of 15 mutants of the

23 In this study, using biophysical and computational approaches, we have analyz

24 Biophysical and crystallographic studies demonstrated th

25 nd materials science with notable utility in biophysical and electrochemical measurements.

26 h CI- and SEC-exosomes leads to differential biophysical and functional changes including, adhesion a

27 The convergence of structural, genetic, biophysical and pharmacological approaches is a powerful

28 Here, we provide a biophysical and pharmacological characterization of mefe

29 (HEK293) cells) has hampered studies of its biophysical and pharmacological properties and the devel

30 In this study, we determined the biophysical and pharmacological properties of the TRESK/

31 ns, we detected single-channel activity with biophysical and pharmacological properties similar to th

32 etworks as a model system to demonstrate how biophysical and social features of urban landscapes cont

33 Biophysical and structural achievements were invaluable

34 Using a combination of biophysical and structural approaches, the binding of di

35 nines into stacked tetrads, and considerable biophysical and structural evidence exists for G4 format

36 perform an in silico screening according to biophysical and structural properties extracted from MD

37 l chemistry campaign that exploited virtual, biophysical, and biological investigations led to the id

38 recent convergence of genetic, biochemical, biophysical, and cell biological methods has uncovered s

39 Here, we compared the biochemical, biophysical, and cell biological properties of C. albica

40 Detailed chemical, biophysical, and cellular analyses show that karyopherin

41 Moreover, the data highlight biochemical, biophysical, and functional properties of EF-hand-like m

42 important tool in analytical, bioanalytical, biophysical, and materials measurements, where significa

43 Characterizations by biochemical, biophysical, and reverse genetics approaches provide a b

44 Here, a biophysical approach quantifies environment- species int

45 Using an integrative biophysical approach that includes nuclear magnetic reso

46 tes the importance of robust biochemical and biophysical approaches in the implementation of individu

47 ve used cytotoxicity assays and a variety of biophysical approaches to show that two molecules with t

48 -to-lead flowchart combining biochemical and biophysical approaches, two DENV RdRp nonnucleoside inhi

49 By complementary biophysical approaches, we show that the START domain bi

50 o NETs, we used in vitro adhesion assays and biophysical approaches.

51 Hence, a more comprehensive understanding of biophysical as well as biochemical weathering by S. comm

52 nowledge, novel combination of complementary biophysical assays (circular dichroism, chaperone activi

53 Biophysical assays indicate these compounds did in fact

54 we use ancestral protein reconstruction and biophysical assays to elucidate the origins of vertebrat

55 le the impacts of catastrophic events on the biophysical attributes of communities are sometimes asse

56 entral to improving our understanding of the biophysical basis of amyloid formation in vivo and may o

57 The structural and biophysical basis underlying the function of these recep

58 ency, and robustness can improve multiplexed biophysical bead-tracking applications, especially when

59 es in understanding the primary function and biophysical behavior of these macromolecules.

60 ular and cytoplasmic proximal tagging with a biophysical binding assay increases the precision with w

61 Through atomistic simulations and biophysical, biochemical and cellular assays, we show th

62 Using a series of biophysical, biochemical, and theoretical simulation stu

63 We therefore modeled the biophysical capacity for regional food systems based on

64 The genetic engineering of a biophysical CCM into land plants is being pursued as a s

65 Biophysical CCMs operate by concentrating bicarbonate an

66 Biophysical, cell-based, and murine xenograft experiment

67 roader family of therapeutic peptides, where biophysical challenges may be encountered.

68 that OHCs undergo several morphological and biophysical changes in the ageing cochlea.

69 sed approach for analysis of biochemical and biophysical changes in TS missense mutants within the co

70 The filter-paper biophysical characteristics and the interference of high

71 ther insights into the kinetic and requisite biophysical characteristics of acutely synaptotoxic ex v

72 Yet much remains unknown regarding the biophysical characteristics of different EVs.

73 th its assembly into large clusters, yet the biophysical characteristics of IRE1 clusters remain poor

74 designed to recapitulate the biochemical and biophysical characteristics of the tumour microenvironme

75 dge surrounding tropical peatlands and their biophysical characteristics, distribution and carbon sto

76 ir stability on yeast cell surface, detailed biophysical characterization of 64 designs, and crystal

77 ng and native mass spectrometry (MS) for the biophysical characterization of complex formation of a B

78 oparticles (sub-100 nm) necessitate rigorous biophysical characterization of single EVs.

79 Focusing on the biophysical characterization of the knot region by NMR s

80 , we report the clinical, physiological, and biophysical characterization of three syt1 mutations fro

81 We show through biochemical and biophysical characterization that this cancer-associated

82 nto target macromolecules for structural and biophysical characterization.

83 ived and biologically relevant membranes for biophysical characterization.

84 in fields ranging from materials science to biophysical chemistry.

85 ity of the CO(2)-fixing enzyme Rubisco using biophysical CO(2) concentrating mechanisms (CCMs).

86 tant area of cell biology research where new biophysical concepts are emerging.

87 We found that biophysical connectivity was higher than social connecti

88 architecture have traditionally ignored the biophysical consequences of ATP-fueled active processes

89 We propose that the biophysical consequences of the distribution of transcri

90 is possible that the H1N1 HA is under other biophysical constraints that result in compensatory decr

91 ey remain difficult to study in their native biophysical context.

92 eutralizing epitopes, identifies an in vitro biophysical correlate of SPZ neutralization, and demonst

93 Here, we explore a biophysical cost-benefit principle, namely that the cell

94 dy, we developed an innovative combinatorial biophysical cue sensor array combining a surface modifie

95 Therefore, our innovative combinatorial biophysical cue sensor array to control NSC behavior via

96 re, to better understand how biochemical and biophysical cues interact to regulate keratocyte activat

97 ucociliated epithelium occurs in response to biophysical cues sensed by newly exposed cells on the su

98 can be safely induced in tendon by means of biophysical cues using a woven and electrospun patch.

99 Biophysical cues, such as electrical stimulus, mechanica

100 the intermediate, along with biochemical and biophysical data reveal that -N=C bond formation involve

101 asis, comprise the most comprehensive set of biophysical data yet reported.

102 xplain and integrate previous mutational and biophysical data, particularly the mutational sensitivit

103 l-length ion channels and the structural and biophysical details of Na(V) -accessory protein interact

104 udy were to: identify biological/geochemical/biophysical determinants of and characterize bacterial c

105 Biophysical determinants of recognition specificity are

106 Here, we unravel the biophysical determinants of supralinear Ca(2+) signals a

107 udy, we examined the temporal variations and biophysical drivers of ecosystem-scale F(CH4) in a subtr

108 of flux footprints, and lagged influence of biophysical drivers.

109 her, our theoretical approach identifies key biophysical events in TANGO1-driven procollagen export.

110 Previous biophysical experiments and structural modeling have sug

111 We performed biophysical experiments in combination with mathematical

112 Biophysical experiments on model membranes show common p

113 Biophysical experiments revealed that whereas the isolat

114 For instance, biophysical experiments show that in some systems, DNA r

115 predictive power that is beyond that of the biophysical explanation alone while also uncovering a co

116 ltimeric assemblies appears to be a critical biophysical feature for engendering inherent acute synap

117 ple genetic mechanisms that recruit existing biophysical features into higher-level architectures.

118 These properties can modulate the biophysical features of native condensates, including th

119 rent actin cytoskeletal structures through a biophysical feedback loop.

120 unction, but also a convenient parameter for biophysical folding studies.

121 Here, we assessed the link between biophysical forces and pro-metastatic signaling by testi

122 An updated biophysical foundation is needed to answer such question

123 this image analysis method by presenting its biophysical foundation, practical solutions, biological

124 ative structural approach provides important biophysical foundations for understanding the mechanisms

125 rting from a few first principles, we layout biophysical foundations showing that CCs are not only po

126 ration, providing an extendable, multiscale, biophysical framework for understanding and predicting p

127 Biophysical gradients were evident at all ages examined,

128 Biophysical insight into the binding interaction between

129 owerful tools that complemented and enriched biophysical insights by enabling high-throughput analysi

130 Our study provides novel, to our knowledge, biophysical insights into the understanding of the mecha

131 They are also of considerable biophysical interest; indeed, their physical mechanisms

132 Biophysical interrogation of the mutant variants reveale

133 y in the endothelial plasma membrane, but no biophysical investigation of these parameters has been c

134 Our biophysical investigations show that TNPO1 recognizes an

135 ata with literature values (in this issue of Biophysical Journal).

136 tion (FEP) calculations, chemical synthesis, biophysical mapping and X-ray crystallography to reveal

137 icroscopy imaging of MCTS systems to drive a biophysical mathematical model of MCTS growth and mechan

138 We present the results of utilizing a biophysical mathematical model to predict tumor response

139 ive molecules with anti-cancer effects via a biophysical means.

140 We combined multiple biophysical measurements and computational methodologies

141 ational modelling, genetic manipulations and biophysical measurements, we identify the biophysical un

142 This work describes a simple biophysical mechanism by which cellular proteostasis ada

143 ium influx for lysosome fusion, represents a biophysical mechanism for cell death induction.

144 Together, our results show how a simple biophysical mechanism in single neurons can generate com

145 Thus, our findings reveal a potential biophysical mechanism of glycinergic dis-inhibition and

146 Clarifying the biophysical mechanism of oxygen transport within tissue

147 However, the biophysical mechanisms linking molecular circadian clock

148 ity while advancing our understanding of the biophysical mechanisms of pressure sensing.

149 To probe the diversity of biophysical mechanisms of temperature-sensitivity, we ch

150 advances in understanding the molecular and biophysical mechanisms that connect metabolism and gene

151 Understanding the biophysical mechanisms that stabilize these assemblies i

152 complexity that are directly correlated with biophysical membrane properties such as permeability and

153 ling and excitatory inputs without affecting biophysical membrane properties.

154 Biochemical, toxicological and biophysical methods enable the deconvolution of key step

155 last decade, new single-molecule and in vivo biophysical methods have allowed investigation of the st

156 try and surface plasmon resonance, but these biophysical methods suffer from low to medium throughput

157 contains AD1, as a model, we demonstrate by biophysical methods that the NTD senses osmolytes and hy

158 Using biochemical and biophysical methods we identify multiple components in s

159 structural characterization from a suite of biophysical methods, including TEM, AFM, high-resolution

160 hermore, using a combination of chemical and biophysical methods, we identify phosphatidylserine as a

161 By combining kinetic and biophysical methods, X-ray crystallography, and molecula

162 scopy, X-ray crystallography, NMR, and other biophysical methods.

163 Using circular micropatterns, we measured biophysical metrics associated with cell mechanical stre

164 Here, a biophysical model demonstrates that well-known firing ch

165 In this work, we present a biophysical model for dynamic bundles of actin filaments

166 In this paper, we propose a biophysical model of striatal microcircuits that compreh

167 Simulations using a large-scale biophysical model suggested local elevations of excitati

168 We present a biophysical model that describes how tumor cells regulat

169 We used a biophysical model to simulate different vocal fold oscil

170 ese limitations in a minimal two-compartment biophysical model.

171 Biophysical modeling has been used over the past two dec

172 Here, we combine human connectome data and biophysical modeling to begin filling these gaps.

173 (2020) use optogenetics and biophysical modeling to demonstrate how cells respond to

174 Biophysical modelling of the diffusion MRI signal permit

175 electrical recordings of somatic voltage and biophysical modelling, we demonstrate that four morpholo

176 ing the packaging reaction, but most current biophysical models fail to incorporate this property.

177 In this review, we describe how biophysical models function and how they can be used to

178 cs, there is a pressing need for informative biophysical models.

179 he three conditions using a combination of a biophysical network model of the inferior olive and a no

180 Defects in the biophysical or functional properties of Hensen's cells h

181 It remains unknown if biophysical or material properties of biomolecular conde

182 ar structure contributes to the fluidity and biophysical order.

183 neocortical circuit model that accounts for biophysical origins of electrical currents generating ME

184 MDA-MB-231 breast cancer MCTS, we estimated biophysical parameters of cellular diffusion, rate of ce

185 Stochastic modeling using reasonable biophysical parameters recapitulated growth-dependent SB

186 significant differences in these model-based biophysical parameters throughout the treatment time cou

187 ssay, (2) training the algorithm to identify biophysical parameters underlying the formation of diffe

188 stomer (LCE) particles by recapitulating the biophysical patterning mechanism that forms pollen grain

189 ein FUS, is particularly intriguing from the biophysical perspective and is biomedically relevant due

190 Overall, our biophysical perspective on rosette development complemen

191 In this Biophysical Perspective, we look at what makes hERG intr

192 e and locally concentrated molecules akin to biophysical phase separation observable in vitro.

193 providing greater H(2) O supply, alleviating biophysical photosynthetic limitation when soil water is

194 parameters for inputs into a coarse-grained biophysical polymer model that successfully predicts Mre

195 advance our fundamental understanding of key biophysical principles and sequence features important t

196 uniquely tunable module where application of biophysical principles can precisely control assembly an

197 n segments and form liquid droplets, but the biophysical principles underlying heterochromatin compar

198 rder to address this problem, we discuss the biophysical principles underlying the droplet state of p

199 By synthesizing biophysical priors within a modern machine-learning fram

200 Many biophysical problems involve molecular and nanoscale tar

201 f ER residents thus derives in part from the biophysical process of cargo enrichment into a constrain

202 daptation may have implications for multiple biophysical processes in the cell.

203 This discrepancy might be caused by biophysical processes such as extracellular matrix remod

204 living relatives of animals, we quantify the biophysical processes underlying the morphogenesis of ro

205 therapies and consider how the molecular and biophysical properties (e.g. size and charge) of these t

206 equency of <1%) that resulted in compromised biophysical properties (Tm = 61 degrees C and intrinsic

207 e multifunctional proteins that modulate the biophysical properties and cell-surface localization of

208 nce viral fitness, but it is unclear how the biophysical properties and partner specificities of phag

209 esmosomal architecture explains their unique biophysical properties and strength.

210 s highlight that excitation, inhibition, and biophysical properties are differentially sensitive to d

211 ntified alongside precise parametrization of biophysical properties associated with the mitochondrial

212 exhibit elevated membrane excitability, with biophysical properties closely resembling those of fast-

213 ructed as multi-channel voxel grids based on biophysical properties derived from raw atom coordinates

214 rocessing, neurons need to optimize multiple biophysical properties in parallel, but the mechanisms o

215 of excitatory inputs, calcium signaling, and biophysical properties is unknown.

216 ive peptides of the ECM, and their intrinsic biophysical properties make laminin peptide-ELPs promisi

217 address this question by investigating some biophysical properties of a prototypical amyloidogenic s

218 ctions perturbed by mutations, directly from biophysical properties of atoms.

219 igned to: 1) measure mucus concentration and biophysical properties of bronchiectasis mucus; 2) ident

220 In addition to contributing to the biophysical properties of droplets, RNA is a functionall

221 xtend minimal cylinder analysis to study the biophysical properties of hybrid nucleosomes that are kn

222 The improved biophysical properties of intasomes assembled with LEDGF

223 ed in systems that do not fully preserve the biophysical properties of lipid bilayers, and therefore,

224 The structure and biophysical properties of lipid membranes are important

225 New discoveries into the structure and biophysical properties of MAC revealed heterogeneous MAC

226 om the data is crucial for understanding the biophysical properties of molecular processes, but remai

227 smitter receptors and ion channels shape the biophysical properties of neurons, from the sign of the

228 enues for the analysis of the structural and biophysical properties of oligonucleotides and their com

229 We investigated the biochemical and biophysical properties of one of the four alternative ex

230 d patterned substrates that recapitulate the biophysical properties of the early embryo and mediate t

231 difications, as well as changing the overall biophysical properties of the fiber.

232 on membrane function mediated via changes in biophysical properties of the phospholipid bilayer have

233 m cell maintenance through modulation of the biophysical properties of the plasma membrane (PM).

234 a subunits of VGCCs modulate trafficking and biophysical properties of the pore-forming alpha1 subuni

235 xes in which auxiliary proteins modulate the biophysical properties of the pore-forming subunits.

236 is prominence, details of conformational and biophysical properties of these regions have not yet bee

237 , we investigate the structure, dynamics and biophysical properties of two small nanodiscs, MSP1D1Del

238 the effects of lipid mixing on the membrane biophysical properties remain poorly understood.

239 eless assembly of multidomain proteins whose biophysical properties render them incompatible with a s

240 n may underlie the coordinated tuning of the biophysical properties required for rapid firing and sig

241 neurons efficiently coordinate the multiple biophysical properties required to maintain high rates o

242 lated from various immunological niches, the biophysical properties that allow for promiscuity in a p

243 model lipid membranes and alter the membrane biophysical properties, such as membrane molecular order

244 membrane physiology requires maintenance of biophysical properties, which must be buffered from exte

245 of the channel subunits that determine their biophysical properties.

246 ane proteins depends on phospholipid bilayer biophysical properties.

247 in concentration largely failed to alter the biophysical properties.

248 overies on intracellular Ca(2+) dynamics and biophysical properties.

249 nsory evaluation, aroma release analysis and biophysical protein analysis were used to investigate th

250 We discuss the unique biophysical questions raised by the presence of large ex

251 he potential to address some of the critical biophysical questions.

252 Having a suite of predefined biophysical regions at a variety of scales that correspo

253 compare the discrimination in such data that biophysical regions at different scales provide to deter

254 I defined hierarchical biophysical regions based on plant productivity and phen

255 ponses may then be extrapolated based on the biophysical regions.

256 e, yielding a map-like format of distributed biophysical response.

257 n per unit time based on empirically derived biophysical responses to environmental conditions.

258 The combined structural and biophysical results presented here indicate that Tyr-15

259 x that is fully consistent with experimental biophysical results.

260 associated fibroblasts (CAF) play a critical biophysical role in cancer progression, but the precise

261 ular structures visualized historically, the biophysical rules governing its assembly and function ar

262 A-Gd-DTPA and analyzed using a new sub-voxel biophysical signal model.

263 Biophysical simulations for a desert site predict that s

264 an odorant transduction process (OTP) and a biophysical spike generator (BSG).

265 cids conferred remarkable enhancement to the biophysical stability of human insulin while maintaining

266 g such gene regulation arose from pioneering biophysical studies in eubacteria.

267 Structural and biophysical studies indicate some degree of flexibility

268 oldases, but biochemical and single-molecule biophysical studies indicate that ClpXP operates by a pr

269 Biophysical studies involving circular dichroism melting

270 Recent biophysical studies of RNA polymerases and their inhibit

271 While biophysical studies of single WW domain-single PPXY moti

272 ere, Suzanne's incorporation of quantitative biophysical studies of whole tissues, integrated with th

273 d properties, we carried out biochemical and biophysical studies on PHD homologues from the cellular

274 Biophysical studies on single cells have linked cell mec

275 Biophysical studies revealed enhanced discrimination bet

276 Biochemical and biophysical studies show that charge-charge interactions

277 ation of transcription, many biochemical and biophysical studies suggest that activators use nonspeci

278 aper describes the synthesis, solution-phase biophysical studies, and X-ray crystallographic structur

279 Using solution NMR and biophysical studies, we find that each of the two indivi

280 carried out a comprehensive biochemical and biophysical study of their interaction, complemented by

281 nt automated assays by employing an upgraded biophysical system with improved accuracy and precision

282 d synthetic materials with naturally evolved biophysical systems.

283 Biophysical technics have then very recently confirmed t

284 ss spectrometry (HDX-MS) is a widely applied biophysical technique that probes the structure and dyna

285 has been previously investigated by multiple biophysical techniques aimed at identifying hydrophilic

286 Using microscopic and biophysical techniques, we show here that Aap B-repeat c

287 limited due to the current lack of suitable biophysical techniques.

288 -based on-skin electronic devices, including biophysical (temperature, biopotential) sensors, sweat b

289 We also introduce basic biophysical theories of the membrane potential to the mi

290 olecular dynamics (MD) simulation a powerful biophysical tool to investigate a wide range of dynamica

291 g site-directed mutagenesis, biochemical and biophysical tools, LC-MS/MS, and crystallographic analys

292 framework to estimate phenotypic growth and biophysical tumor microenvironment properties.

293 Here, we present a new global mangrove biophysical typology and show that, based on their 2016

294 Overall, our biophysical typology provides a baseline for assessing r

295 , transcriptomics, proteomics, metabolomics, biophysical, ultrastructural and histopathology have bee

296 nd biophysical measurements, we identify the biophysical underpinnings and biological consequences of

297 mage in live cells, as well as in aiding our biophysical understanding of genome integrity in health

298 le, we review progress toward a quantitative biophysical understanding of the mechanisms that drive m

299 ms performed better when using all available biophysical variables compared to using PCA-derived inpu

300 ar polymeric substances was investigated for biophysical weathering.