ライフサイエンスコーパス: biophysically

1 e widely different phenotypes clinically and biophysically.

2 pod crustaceans has been studied extensively biophysically.

3 ed the recombinant protein biochemically and biophysically.

4 haracterize its components biochemically and biophysically.

5 peptides have been thoroughly characterized biophysically.

6 conformation changes is not well understood biophysically.

7 trations and characterized biochemically and biophysically.

8 analyzing realistic synaptic integration in biophysically accurate neuronal models, I report a compl

9 aintained more of an rSP-C surfactant in the biophysically active form.

10 ung injury and the amount of large-aggregate biophysically active surfactant in adult lungs.

11 The biophysically altered dermis increased myofibroblast act

12 protein were made and were biochemically and biophysically analyzed.

13 timing in integrate-and-fire units and in a biophysically and anatomically detailed model of a corti

14 Here, using biophysically and anatomically realistic computational m

15 states and regulation within this family, we biophysically and biochemically characterized multiple E

16 r dynamics simulations (MD), we synthesized, biophysically and biochemically characterized, and studi

17 disorder symptomatology, there is a lack of biophysically and biochemically detailed models of these

18 through distinct vascular networks that are biophysically and biochemically entangled, creating comp

19 We compare biophysically and energetically the cellular responses t

20 Libraries are screened biophysically and fragment:protein co-structures are det

21 though mammalian TRPM7 is well characterized biophysically and its pivotal role in cancer, ischemia a

22 mplexes of ERBB receptors have been observed biophysically and offer a theoretical route for ERBB2 ph

23 ition with each other, but how they interact biophysically and pathologically has been challenging to

24 apses formed by striatopallidal neurons were biophysically and pharmacologically heterogeneous.

25 Here, we biophysically and structurally characterize the full-len

26 d this phenomenon at the molecular level, we biophysically and structurally characterized these two m

27 ns to be tested biologically, biochemically, biophysically, and for use in structure-based drug desig

28 uromuscular junctions contain two spatially, biophysically, and pharmacologically distinct subtypes o

29 these proteins has been fully characterized biophysically, and thus the precise effects on molecular

30 s in our laboratory and therefore provides a biophysically based account of the underlying ionic curr

31 recent computational psychiatry advances in biophysically based circuit modeling can be leveraged to

32 we integrate brain-wide transcriptomics with biophysically based circuit modeling to simulate acute n

33 Detailed biophysically based compartmental models can help develo

34 Biophysically based computational modeling of the heart,

35 logical mechanisms underpinning contraction, biophysically based computational models are fitted to s

36 in vivo and in vitro experiments, as well as biophysically based computer models that have been used

37 such flexible behavior, we have developed a biophysically based decision-making network model of spi

38 It provides: (a) biophysically based explanations of putative mechanisms

39 The link between experimental data and biophysically based mathematical models is key to comput

40 We develop a biophysically based model of the neurophonic that accoun

41 fear extinction during REM sleep, we used a biophysically based model that included the infralimbic

42 Using a biophysically based model, we show how top-down signals

43 successful elements of model translation for biophysically based models and the emerging supporting t

44 and discusses insights and predictions from biophysically based models.

45 Biophysically based multicompartmental models of princip

46 le-organ function, we have developed a novel biophysically based multiscale electromechanical model o

47 inical data on BG and PD to begin to build a biophysically based network model of pallidosubthalamic

48 Using a biophysically based network model of spiking neurons, we

49 dulate neuronal communication, we designed a biophysically based recurrent V1 and V4 cortical network

50 Here, we use biophysically based simulations to explore the possible

51 Catch bond engineering is a biophysically based strategy to tune high-sensitivity TC

52 Applying this approach to a biophysically based working memory model, we investigate

53 s may impair perceptual decision-making in a biophysically-based association cortical circuit model.

54 Using biophysically-based excitatory-inhibitory (E-I) neural n

55 Previously, we developed a biophysically-based model of a binaural brainstem nucleu

56 models to investigate the dynamics of how a biophysically-based neuronal network model synchronizes

57 eceptor (LILR)B1 and LILRB2 immune receptors biophysically, biochemically, and by FACS staining.

58 and dynamic antero-posterior asymmetries to biophysically characterize both resiliency to laser pert

59 Here, we structurally and biophysically characterize four antibodies that bind to

60 Here, we biophysically characterize proline-283 NP and serine-283

61 Here, we biophysically characterize the carboxyl-terminal domain

62 Here, we biophysically characterize the strength of the tip-link

63 Finally, we biophysically characterize two topologically interesting

64 Here, we recombinantly produced and biophysically characterized a homolog that comprises one

65 al heavy-light chain mAbs, we identified and biophysically characterized a novel single-domain antibo

66 Here, we structurally and biophysically characterized an HNF-1A protein containing

67 channels remain among the least studied and biophysically characterized channels.

68 0-kDa protein that also binds heme, has been biophysically characterized for its tendency to form hig

69 y expressed recombinant protein fragment and biophysically characterized in comparison to its wild-ty

70 We also biophysically characterized one mutant from each of the

71 Many investigations have biophysically characterized reconstituted cytosolic comp

72 s Hippo kinase and pathway activity, here we biophysically characterized the entire suite of SARAH do

73 previous observations, we biochemically and biophysically characterized the interaction between PC4

74 p104 as a novel tubulin-binding protein, and biophysically characterized the interaction of Cep104 wi

75 To do so, we have structurally and biophysically characterized the interaction of MerB with

76 Here, we biophysically characterized the NFkappaB p50/RelA hetero

77 We biophysically characterized these species with transmiss

78 e mutated proteins have been kinetically and biophysically characterized.

79 VGLUT1 and VGLUT2, were recently cloned and biophysically characterized.

80 expressed in Escherichia coli, purified, and biophysically characterized.

81 bes an optimized workflow for expressing and biophysically characterizing rationally engineered spike

82 with IMPs solvated by a compositionally and biophysically complex lipid matrix.

83 Nuclear mechanosensing encompasses biophysically complex pathways that often converge on th

84 xtracellular ion concentration dynamics in a biophysically consistent way.

85 Here, we construct a simplified, biophysically consistent, reaction-diffusion model of ch

86 interfaces as specialized compartments that biophysically constrain the arrangement and activity of

87 Using a biophysically constrained model of a network of spiking

88 Our study presents a biophysically constrained model of how the interaction o

89 Biophysically constrained models of the complete feedbac

90 enhanced by cellular chaperones that assist biophysically defective clients in navigating complex fo

91 the electrical output of neurochemically and biophysically defined LH cells in mouse brain slices.

92 nic model where anergic B cells respond to a biophysically defined lysozyme epitope displayed on both

93 Most adaptive mutations in viruses are biophysically deleterious, resulting in a viral protein

94 ttle is known about how prior beliefs impact biophysically described processes in the presence of neu

95 els of abstraction-leaky integrate-and-fire, biophysically detailed and abstract binary-we show that

96 Here we developed a novel biophysically detailed and data-constrained large-scale

97 A previously developed biophysically detailed attractor network exhibits sponta

98 Using this biophysically detailed cohort of models we highlight the

99 We have used a biophysically detailed compartmental model to investigat

100 In our biophysically detailed compartmental model, active dendr

101 Here, we use a biophysically detailed computational model of the presyn

102 Using a biophysically detailed computational model, we were not

103 f Physiology in 1952, initiated the field of biophysically detailed computational modelling in neuros

104 Through biophysically detailed computer modelling, this study in

105 ace electrical potentials with a full-scale, biophysically detailed cortical column model.

106 Here we present a biophysically detailed dynamical systems model for a WM

107 en the heart is paced at high rates, using a biophysically detailed electromechanical model of cardia

108 A biophysically detailed heart-torso model was generated f

109 gations were conducted using a population of biophysically detailed human models incorporating variab

110 We used a biophysically detailed human ventricular model to determ

111 precise timing of on- or offset, by using a biophysically detailed large-scale (19,600 model neurons

112 reactions in a consistent, quantitative, and biophysically detailed manner using a diverse set of exp

113 ach facilitates the use of biochemically and biophysically detailed mathematical models to describe a

114 we used data simulated with the large-scale, biophysically detailed model of mouse V1 developed by th

115 Here, we create a biophysically detailed model of the BLA circuit to show

116 In this study, we used a biophysically detailed model of the human atria and tors

117 In this study we present a biophysically detailed model of the normal canine ventri

118 ion perform similarly to the best-performing biophysically detailed models of the auditory periphery,

119 tions at multiple levels of resolution, from biophysically detailed multi-compartmental, to point-neu

120 Utilizing a biophysically detailed multicompartmental model of an SP

121 des the first experimentally constrained and biophysically detailed muscle cell model of C. elegans,

122 Biophysically detailed neural models are a powerful tech

123 Simulations of biophysically detailed neuron models show that frequency

124 Here, using biophysically detailed neuron models, we predict that to

125 d at two levels of granularity, using either biophysically detailed or point neurons.

126 ovides a flexible tool for biochemically and biophysically detailed simulations of different aspects

127 Biophysically detailed simulations of neuronal activity

128 Biophysically detailed simulations revealed that neurons

129 cale model of cardiac tissue incorporating a biophysically detailed three-dimensional model of the ve

130 re is an effort to build an anatomically and biophysically detailed virtual heart, and, although ther

131 nans (CDA) on arrhythmia susceptibility in a biophysically detailed, 3D computer model of the human a

132 Here we used cohorts of biophysically detailed, multicompartmental models of rhe

133 Here, a biophysically detailed, thermodynamically consistent mod

134 of ion channel expression differences into a biophysically-detailed atrial action potential model res

135 Simulations using biophysically-detailed cardiac myocyte models can reveal

136 Biophysically-detailed computational models of human atr

137 Using biophysically-detailed human atria computer models, this

138 Computational modeling of biophysically-detailed human HFpEF SAN was created.

139 imulations using a human torso/biventricular biophysically-detailed model were conducted to quantify

140 lecular, electrophysiological, and in silico biophysically-detailed modeling approaches demonstrated

141 wever, the model neurons associated with the biophysically different phenotypes retained cell type sp

142 Here we systematically structurally and biophysically dissected myoc-OLF to better understand it

143 WaTx stabilizes TRPA1 in a biophysically distinct active state characterized by pro

144 The NMDAR subunits NR2A and NR2B are biophysically distinct and differentially expressed duri

145 nt recordings, mIMCD-3 cells displayed three biophysically distinct Cl(-)-selective currents, which w

146 ow the presence of two pharmacologically and biophysically distinct Cl- currents that could be specif

147 e cells in the cat striate cortex in vivo, a biophysically distinct class of pyramidal neuron termed

148 CaM sample revealed the Na(V)1.5 channel is biophysically distinct from neuronal Na(V)1.2 as Ca(2+)

149 tion of spiny projection neurons composed of biophysically distinct GABAAfast and GABAAslow component

150 Neurons were divided into two biophysically distinct groups based on their frequency-d

151 ctivated PAH tetramer conformation, which is biophysically distinct in solution.

152 Measurements of three biophysically distinct K(+) currents revealed a depolari

153 e present in BMs, creating biochemically and biophysically distinct structures that serve a wide vari

154 te that healthy and IPF airway epithelia are biophysically distinct, identifying pathologic activatio

155 muscarinic receptors selectively modulate a biophysically distinctive subtype of L-type Ca2+ channel

156 We approached this problem by simulating a biophysically diverse population of model neurons based

157 verning the targeting and insertion of these biophysically diverse proteins remain unknown.

158 showed that it is required for insertion of biophysically diverse tail-anchored (TA), signal-anchore

159 tural, functional, and thermal properties of biophysically dynamic samples is needed to address criti

160 HSR condensates are biophysically dynamic spatiotemporal clusters of the seq

161 explore to what extent such compromises are biophysically essential or merely a product of the curre

162 Biophysically, even though neuronal fractional different

163 Using a biophysically explicit, multiscale model of olfactory bu

164 By unifying biophysically grounded circuit models, neuromorphic impl

165 e propose a CMOS circuit implementation of a biophysically grounded neuromorphic (iono-neuromorphic)

166 ly rich and structurally, evolutionarily and biophysically grounded.

167 aperones to promote the folding of otherwise biophysically incompetent viral proteins that enable inn

168 2A fusion proteins form condensates that are biophysically indistinguishable from NPM1c condensates.

169 Here, we augment a biophysically informed mesoscale model of human cortical

170 Using an established, biophysically informed model of a competitive attractor

171 lated a perturbation of neural dynamics in a biophysically informed model of decision-making through

172 Simulations of a biophysically inspired model that accounts for the size

173 h, we therefore study the PS hypothesis in a biophysically inspired recurrent networks of spiking neu

174 tificial electrical circuit-based model as a biophysically inspired simulation demonstrates dynamic i

175 To fill this gap, we investigated a biophysically inspired, metaplastic synaptic model withi

176 d medial and lateral temporal cortices, were biophysically intact compared with those of control subj

177 tractility is a physiologically relevant and biophysically interesting process.

178 lding sequence-to-affinity models based on a biophysically interpretable and extensible model of prot

179 (ii) Pseudo-energies remain biophysically interpretable and hold positional informat

180 ic receptors, thereby providing a universal, biophysically interpretable and predictive framework wit

181 listic machine learning algorithms, enabling biophysically interpretable inference from non-invasive

182 roduce an extensible reimplementation of our biophysically interpretable machine learning framework n

183 The framework offers a unified, biophysically interpretable mathematical structure to ca

184 r learning genotype-phenotype maps-including biophysically interpretable models-from MAVE datasets.

185 ately define such molecular recognition in a biophysically interpretable way for hundreds of TFs acro

186 sed from brain tumor cells are biochemically/biophysically like other exosomes and have immune-modula

187 t in plants, as in bacteria, crystallization biophysically limits polymerization.

188 ined by previous studies, which consider all biophysically low-quality land to be marginal without co

189 of nonmammalian VSPs have been characterized biophysically, mammalian VSPs are less well understood a

190 Our model capably identifies biophysically meaningful point-mutant peptides that affe

191 Using biophysically measured FAS distributions and swelling si

192 demonstrate how models that are informed by biophysically measured protein dynamics broaden our unde

193 plasma as well as suggesting in general that biophysically mimetic chemistry is exploited in biology

194 To begin to explore this, we designed biophysically mimetic microfluidic reactors with charact

195 ery and measurement of animal electricity by biophysically minded physiologists.

196 ted stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM.

197 of the velocity ODE, which allows solving a biophysically more accurate model in a fully Bayesian fa

198 Our biophysically motivated model provides a more comprehens

199 ng TF-DNA binding and for the development of biophysically motivated neural networks.

200 Using biophysically motivated neuron dynamics and local plasti

201 We develop a pair of biophysically motivated ODE models of viral-host populat

202 yces cerevisiae, we have validated that this biophysically motivated use of evolutionary conservation

203 In this work, we analyze biophysically-motivated subcircuit structures that repre

204 sistent with the activation process observed biophysically on the metabotropic glutamate receptor 2 h

205 Biophysically, our results suggest that the stabilities

206 these channels differ pharmacologically and biophysically, particularly in inactivation kinetics.

207 Imbalanced plasticity is biophysically plausible and leads to more efficient syna

208 el using coupled leaky integrator units with biophysically plausible assumptions about the effect of

209 individual behavioral choices, we propose a biophysically plausible circuit arrangement in which an

210 Thus, we show that a biophysically plausible circuit model can reconstruct co

211 le-cortex E/I ratio by fitting a large-scale biophysically plausible circuit model to resting-state f

212 Our results give a biophysically plausible explanation of how a class of pr

213 wo-variable neural model offers a simple yet biophysically plausible framework for studying perceptua

214 A biophysically plausible implementation of such a first-i

215 parse coding hypothesis, when coupled with a biophysically plausible implementation, can provide a un

216 nal, synaptic and structural properties in a biophysically plausible layer 2/3 microcircuit model, bu

217 Here we adapt a biophysically plausible model of decision-making to pred

218 Using a biophysically plausible model, we link these biases to s

219 new means of linking clinical symptoms with biophysically plausible models of neural circuitry and,

220 We investigated activity in a biophysically plausible network model that transforms in

221 We have reproduced this behavior in a biophysically plausible network model.

222 the spike-based approach can be extended to biophysically plausible networks.

223 resolves the challenging problem of building biophysically plausible spiking neural models that are a

224 g inhibitory interneurons that are much more biophysically plausible.

225 calmodulin dynamics within an idealised, but biophysically-plausible, dendritic spine, we show that S

226 lacuna, we constructed a novel large-scale, biophysically principled model of the subthalamopallidal

227 We developed a biophysically realistic and detailed computational model

228 oding scheme based on network simulations of biophysically realistic compartmental models of VS cells

229 Our biophysically realistic computational model closely repl

230 ly, we created a neuroanatomically detailed, biophysically realistic computational model of hippocamp

231 Next, we use a biophysically realistic computational model to explain t

232 A biophysically realistic computational model using data d

233 simonious hypothesis for this disruption via biophysically realistic computational modeling, namely c

234 d underlying neural dynamics, we developed a biophysically realistic computational SI model that cont

235 s of both sexes, and we stimulated them with biophysically realistic correlated inputs, generated usi

236 hanisms of decision making, I investigated a biophysically realistic cortical network model for a vis

237 gated a simplified two-variable version of a biophysically realistic cortical network model of decisi

238 n by analyzing the dynamics of a large-scale biophysically realistic cortical network model subjected

239 ties of the TBI-induced epileptogenesis in a biophysically realistic cortical network model with dyna

240 To this aim, we constructed a biophysically realistic excitatory-inhibitory network ab

241 We generated biophysically realistic fly photoreceptor models, which

242 Learning is performed via a biophysically realistic learning rule that depends on sy

243 Our data enabled us to formulate a biophysically realistic mathematical model of Kiss1(ARH)

244 A novel, biophysically realistic model for early-stage, acetylcho

245 Simulations of a biophysically realistic model of a cerebellar Purkinje c

246 To quantitatively examine this question, a biophysically realistic model of an idealized central ax

247 Backrubs can therefore provide a biophysically realistic model of local backbone flexibil

248 e, we develop an experimentally constrained, biophysically realistic model of neocortical microcircui

249 We have developed a biophysically realistic model of receptor activation at

250 (A)-mediated excitation, we built a detailed biophysically realistic model of the CA1 pyramidal neuro

251 twork of spiking cortical cell models with a biophysically realistic model of the chemical synapse.

252 n, this information provides the basis for a biophysically realistic model of the circuit that comput

253 Here, we use a large-scale, biophysically realistic model of the epileptic rat denta

254 Here, we present a biophysically realistic model of Treg-mediated self-tole

255 The result is a biophysically realistic model that suggests an improved

256 ther, our experimental data and results from biophysically realistic modeling support the idea that h

257 In this study, using biophysically realistic models of the thalamocortical ne

258 Therefore, we performed biophysically realistic multi-compartmental modelling of

259 g the memristors full potential for building biophysically realistic neural processing systems.

260 esent a systematic method to reduce complex, biophysically realistic neuron models to more tractable,

261 In a network of biophysically realistic neuron models with context-indep

262 By implementing biophysically realistic neuron models, we study how dend

263 , and the hippocampal formation, composed of biophysically realistic neurons and able to generate the

264 ever, traditional models of anatomically and biophysically realistic neurons are computationally dema

265 vity of intrinsic cortical connections among biophysically realistic neurons can account for some of

266 mulating rTMS-induced synaptic plasticity in biophysically realistic neurons exists.

267 as priors in Bayesian inference to estimate biophysically realistic parameter values based on dynami

268 cells, the channel must be tethered for all biophysically realistic parameters of the membrane.

269 nd corresponding stochastic simulations from biophysically realistic photoreceptor models.

270 he LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model.

271 to human data to validate probable models of biophysically realistic SO.

272 Furthermore, our model provides a biophysically realistic solution to the MEG signal and c

273 ions of noisy and spiking neurons coupled by biophysically realistic synapses.

274 study shows that the fitness landscape of a biophysically realistic system is extremely complex, wit

275 Employing a biophysically realistic, computational model of SACs, wh

276 Morphologically and biophysically realistic, computational models of octopus

277 We used a biophysically-realistic model of a TC relay neuron to si

278 Functional forms of biophysically-realistic neuron models are constrained by

279 Here, we present a simple, biophysically relevant model of retinal contrast adaptat

280 In prior work, we considered biophysically relevant neuronal models to account for th

281 f sequence replay depends on a confluence of biophysically relevant parameters including stimulus dur

282 ithms to be designed to predict ensembles of biophysically relevant states.

283 i-anharmonic analysis (QAA), for identifying biophysically-relevant reaction coordinates and substate

284 N4 in these cells, and indicate that I(h) is biophysically similar in morphologically diverse retinal

285 eptors are shown to be pharmacologically and biophysically similar to 'classic' strychnine-sensitive,

286 Ca2+-selective conductance, I(ORCa), that is biophysically similar to TRPM7 currents.

287 of the most-xerophilic halophiles, inhabits biophysically stressful and energetically expensive, sal

288 We developed a biophysically supported computational model for the rewi

289 ed evoked and miniature responses and verify biophysically that these changes correspond to an increa

290 In this study, we characterized biophysically the binding of S100A1, S100A2, S100A4, S10

291 Biophysically, these changes translate into an increase

292 ximately mm scale) and about 10(4)-fold more biophysically tough, while retaining a clonal multicellu

293 27) kHz, and we demonstrate that the ear was biophysically tuned to this signal and to providing hear

294 The Antarctic seafloor is biophysically unique and the site of carbon sequestratio

295 The human mitochondrial outer membrane is biophysically unique as it is the only membrane possessi

296 an mGlu(2) or mGlu(3) NAM rapidly activated biophysically unique PFC pyramidal cell ensembles.

297 STP where we estimate the coupling term as a biophysically unrestrained function of the presynaptic i

298 APK pathway activation, unexpectedly forms a biophysically validated GRB2-MRE11 (GM) complex for effi

299 erase site of D-DT and its homologue MIF are biophysically very different, 4-iodo-6-phenylpyrimidine

300 To test this hypothesis biophysically, we used small-angle X-ray scattering, ele