ライフサイエンスコーパス: biosynthetic enzyme

1 a gene encoding a crucial catecholaminergic biosynthetic enzyme.

2 ), a major sulfate-modifying heparan sulfate biosynthetic enzyme.

3 ce because NAMPT is the rate-limiting NAD(+) biosynthetic enzyme.

4 o study the biophysical properties of a RiPP biosynthetic enzyme.

5 t constrained by commensurate changes in the biosynthetic enzyme.

6 for DNA synthesis, which include nucleotide-biosynthetic enzymes.

7 in phosphate and metal uptake, and cofactor biosynthetic enzymes.

8 amine levels and expression of catecholamine biosynthetic enzymes.

9 nal molecules that initiate the induction of biosynthetic enzymes.

10 t changes in the concentration of fatty acid biosynthetic enzymes.

11 eric complex that contains most of the CoQ10 biosynthetic enzymes.

12 nd the world reveals unexplored diversity in biosynthetic enzymes.

13 cts upstream of several genes encoding auxin biosynthetic enzymes.

14 d utilizes multiple different classes of TAG biosynthetic enzymes.

15 actor Sre1N that drives expression of sterol biosynthetic enzymes.

16 (miRNA) in the regulation of specific glycan biosynthetic enzymes.

17 N-terminal dehydro amino acid by the cognate biosynthetic enzymes.

18 ndently of leaves, despite low expression of biosynthetic enzymes.

19 may recruit different isoforms of flavonoid biosynthetic enzymes.

20 leader peptide that is required to guide the biosynthetic enzymes.

21 eicosanoids by high expression of eicosanoid biosynthetic enzymes.

22 far by the lethality of null mutants in NAD biosynthetic enzymes.

23 f the precursor peptides and not just by the biosynthetic enzymes.

24 e low-abundance, Golgi membrane-bound pectin biosynthetic enzymes.

25 ation by disrupting the function of farnesyl biosynthetic enzymes.

26 increases in transcripts encoding flavonoid biosynthetic enzymes.

27 the evolution of functional diversity among biosynthetic enzymes.

28 that inhibit key glycan-binding proteins or biosynthetic enzymes.

29 n, xanthine dehydrogenase/oxidase, and lipid biosynthetic enzymes.

30 zed due to the low stability of the purified biosynthetic enzymes.

31 n-protein associations with extracytoplasmic biosynthetic enzymes.

32 a good source for well-behaved lasso peptide biosynthetic enzymes.

33 e, a NAC transcription factor, and two xylan biosynthetic enzymes.

34 f non-natural GPA peptides by these powerful biosynthetic enzymes.

35 , in part, to their metabolism by eicosanoid biosynthetic enzymes.

36 ing the stability of LpxC, a key cytoplasmic biosynthetic enzyme(10-12).

37 4 or RvE1 also induced expression of the SPM biosynthetic enzymes 12-lipoxygenase and 15-lipoxygenase

38 arities to two non-SPASM proteins, butirosin biosynthetic enzyme 2-deoxy-scyllo-inosamine dehydrogena

39 s triggers ubiquitination of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl CoA reduc

40 ciated degradation (ERAD) of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme

41 and subcellular localization of the key SPM biosynthetic enzyme 5-lipoxygenase (LOX) in vascular cel

42 n the cytoplasmic:nuclear ratio of a key SPM biosynthetic enzyme, 5-lipoxygenase.

43 tations in the gene encoding the cholesterol biosynthetic enzyme 7-dehydrocholesterol reductase (DHCR

44 The siderophore biosynthetic enzyme A (SidA) ornithine hydroxylase from

45 Trichothecene biosynthetic enzymes accumulate in organized smooth ER w

46 tin, on the platelet activating factor (PAF) biosynthetic enzymes, acetyl-CoA:lyso-PAF acetyltransfer

47 he large subunit of the rate-limiting starch biosynthetic enzyme, ADP-glucose pyrophosphorylase.

48 enzymatic sulfation with recombinant heparin biosynthetic enzymes afforded perdeuteroheparin comparab

49 We have also identified fusions of polyamine biosynthetic enzymes agmatine deiminase and N-carbamoylp

50 This suggests that the biosynthetic enzyme and the resulting types of hydrocarb

51 tic pathway screens to identify the endpoint biosynthetic enzyme and thus the compound through which

52 molecular evidence of colocalization of eCB biosynthetic enzyme and type I mGluR mRNA in VTA neurons

53 light on the fine substrate specificities of biosynthetic enzymes and confirm the potential sequence

54 e the ER subdomain, we screened phospholipid biosynthetic enzymes and found that the autophagy-initia

55 rehalose concentrations independently of the biosynthetic enzymes and independently of any applied st

56 unctional characterization of genes encoding biosynthetic enzymes and intracellular transporters.

57 thylene production converge on one family of biosynthetic enzymes and overlay several independent rev

58 have yielded insights into large families of biosynthetic enzymes and pheromone receptors, although t

59 epithelial type II cells and MSCs expressed biosynthetic enzymes and receptors for LXA4.

60 up-regulated genes encoding proanthocyanidin biosynthetic enzymes and several novel uncharacterized M

61 t kingdom, arise from specialized fatty acid biosynthetic enzymes and specialized acyltransferases.

62 y unknown concerted interplay between the HS biosynthetic enzymes and suggesting the need to control

63 The identification of these biosynthetic enzymes and the heterologous reconstitution

64 the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de

65 rified, recombinant late stage peptidoglycan biosynthetic enzymes and their respective purified subst

66 a range of genes encoding putative flavonoid biosynthetic enzymes and transcription factors were alte

67 he dopamine (DA) neuron phenotype, including biosynthetic enzymes and transporters.

68 l acyltransferase (AtPDAT1) is the major TAG biosynthetic enzyme), and enhanced TAG biosynthesis by e

69 ACID3-OXIDASE2, encoding a gibberellin (GA) biosynthetic enzyme, and the levels of GA1 and GA4 are h

70 hermore, catecholamine levels, catecholamine biosynthetic enzymes, and sympathetic nerve fibers were

71 uced specialized proresolving mediator (SPM) biosynthetic enzymes arachidonate lipoxygenase (ALOX) 12

72 de transcriptome analysis reveals that lipid biosynthetic enzymes are among the downstream targets of

73 Expression of the alginate machinery and biosynthetic enzymes are controlled by the extracytoplas

74 However, only a few PG biosynthetic enzymes are direct kinase substrates.

75 The fuscanodin biosynthetic enzymes are insensitive to substrate concen

76 We provide evidence that the fusilassin biosynthetic enzymes are not capable of forming branched

77 n pea and maize (Zea mays) indicate that IAA biosynthetic enzymes are not the main enzymes for PAA bi

78 At the enzyme level, active sites of key biosynthetic enzymes are now pinpointed through a curate

79 Such RiPP biosynthetic enzymes are predicted to bind their corresp

80 The genes encoding the identified biosynthetic enzymes are present in clusters of duplicat

81 Because PARPs and the NAD(+) biosynthetic enzymes are subcellularly localized, an eme

82 es (menaquinone, siderophore, and tryptophan biosynthetic enzymes) are structurally homologous and ma

83 CATALASE2 to inhibit auxin and jasmonic acid biosynthetic enzymes as a means to strengthen plant immu

84 ling and cell growth, and suggest HS and its biosynthetic enzymes as potential targets in the treatme

85 als candidate genes encoding uncharacterized biosynthetic enzymes as shown using cytochromes P450 pot

86 ense diversity of animal small molecules and biosynthetic enzymes awaiting discovery.

87 this dehydration is catalyzed by lanthionine biosynthetic enzyme B (LanB) or LanB-like proteins.

88 Here all these sporopollenin biosynthetic enzymes but TKPR2 have been immunolocalized

89 udied extensively by genetic manipulation of biosynthetic enzymes, but chemical tools for probing GAG

90 position involve the overexpression of lipid biosynthetic enzymes, but how these enzymes are assemble

91 ism that stops the expression of phytoalexin biosynthetic enzymes by blocking the antecedent signal t

92 Here, we show that biosynthetic enzymes can display unexpected promiscuity,

93 Loss-of-function mutations in genes for heme biosynthetic enzymes can give rise to congenital porphyr

94 nic plants through down-regulation of lignin biosynthetic enzymes can induce expression of defense re

95 , suggesting that the nisin and prochlorosin biosynthetic enzymes can produce the correct ring topolo

96 tion by showing that subtle mutations in key biosynthetic enzymes can result in drastic effects on th

97 ng technologies and genome mining tools, new biosynthetic enzymes capable of installing unusual struc

98 Here we show that, starting from a suite of biosynthetic enzymes, catalysts with complementary subst

99 Dopamine beta-hydroxylase (DBH) is the biosynthetic enzyme catalyzing formation of norepinephri

100 essure, including a cascade of catecholamine biosynthetic enzymes, catecholamines themselves and ster

101 encodes an isoform (SlCHI1) of the flavonoid biosynthetic enzyme chalcone isomerase (CHI), which cata

102 ta americana, an antibody raised against the biosynthetic enzyme choline acetyltransferase (ChAT) was

103 Here, we report that the colibactin biosynthetic enzyme ClbL is an amide bond-forming enzyme

104 -function analyses of the P. campanularia RA biosynthetic enzymes clearly indicate that RA biosynthes

105 ed on the coexpression patterns of predicted biosynthetic enzyme-coding genes, and facilitates compar

106 major genomic regions, some of which harbor biosynthetic enzyme-coding genes; can be accurately pred

107 GLYCEROL ACYLTRANSFERASE1 (a triacylglycerol biosynthetic enzyme) combined with suppression of the tr

108 that all subsequently identified downstream biosynthetic enzymes contribute to the synthesis of at l

109 F-C promoted expression of the prostaglandin biosynthetic enzyme COX-2 in lymphatics, a response thou

110 nhanced protein levels of a key phospholipid biosynthetic enzyme (CTP:phosphocholine cytidylyltransfe

111 esorcinol rings using the cylindrocyclophane biosynthetic enzyme CylK.

112 ivery in WT mice or by overexpression of its biosynthetic enzyme CYP46A1, specifically promote mDA ne

113 unoprecipitation (co-IP) approaches with the biosynthetic enzymes CYP71B15 and CYP71A13 as baits and

114 n Arabidopsis-specific paralog of the lignin-biosynthetic enzyme CYP84A1, has neofunctionalized relat

115 atent tRNase that requires activation by the biosynthetic enzyme CysK (O-acetylserine sulfhydrylase A

116 at is only active when bound to the cysteine biosynthetic enzyme CysK.

117 is a prominent EDRF, since mice lacking its biosynthetic enzyme, cystathionine gamma-lyase (CSE), di

118 ordance of CSA levels with expression of its biosynthetic enzyme cysteine dioxygenase 1 (CDO1).

119 cts, measured as >60% inhibition of the heme biosynthetic enzyme delta-aminolevulinic acid dehydratas

120 Therapeutic inhibition of the pyrimidine biosynthetic enzyme DHODH with leflunomide substantially

121 ctional segregation of endocannabinoid (eCB) biosynthetic enzymes diacylglycerol lipase-alpha (DAGLal

122 The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH)

123 The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH)

124 f T16H, to our knowledge, the first alkaloid biosynthetic enzyme displaying two isoforms encoded by d

125 biting protein synthesis of globins and heme biosynthetic enzymes during heme deficiency.

126 tal structure of the anaerobic ergothioneine biosynthetic enzyme EanB from green sulfur bacterium Chl

127 production via a translational fusion of the biosynthetic enzymes, engineer a strong chimeric output

128 ion suggests that these heritable changes in biosynthetic enzyme expression represent primary genetic

129 f rapid progenitor expansion and profiled HS biosynthetic enzyme expression.

130 al levels, respectively, to control ecdysone biosynthetic enzyme expression.

131 Mutant cells lacking complex sphingolipid biosynthetic enzymes fail to properly maintain residence

132 uring AMS we analyzed the roles of two lipid biosynthetic enzymes (FatM and RAM2) and an ABC transpor

133 e direct phosphorylation of the crucial heme biosynthetic enzyme, ferrochelatase (FECH) by protein ki

134 tion of cystathionine gamma-lyase (CSE), the biosynthetic enzyme for cysteine, in Huntington's diseas

135 P-glucose dehydrogenase (Ugdh), an essential biosynthetic enzyme for GAGs.

136 n increased number of neurons expressing the biosynthetic enzyme for serotonin, tryptophan-hydroxylas

137 ry CB1-expressing inputs and overexpress the biosynthetic enzyme for the endocannabinoid 2-arachidono

138 glycerol lipase-beta (DAGLbeta), a principal biosynthetic enzyme for the endocannabinoid 2-arachidono

139 These include proteinase inhibitors and biosynthetic enzymes for production of volatile terpenes

140 Consequently, the biosynthetic enzymes for these sugars are attractive tar

141 triacylglycerol (TAG) requires not only the biosynthetic enzymes for unusual FAs but also efficient

142 These include IMPDH2, encoding a key purine biosynthetic enzyme, for which robust evidence existed f

143 Evolution of the glucosinolate biosynthetic enzyme from IPMDH results from a single ami

144 omic developments enable the direct study of biosynthetic enzymes from complex microbial communities.

145 eports the characterization of protolimonoid biosynthetic enzymes from different plant species and su

146 action is required for transfer of cell-wall biosynthetic enzymes from the lateral to the mature divi

147 way annotations by distinguishing functional biosynthetic enzymes from those predicted on the basis o

148 show that UBIAD1, a vitamin K2/menaquinone-4 biosynthetic enzyme, functions cell-autonomously to regu

149 s study, we examined the expression of their biosynthetic enzymes, FUT1, FUT2, B3GALT5 and ST3GAL2, i

150 mutation to MUR1, a gene encoding the fucose biosynthetic enzyme GDP-d-mannose-4,6-dehydratase.

151 Prostaglandin levels and prostaglandin biosynthetic enzyme gene expression were measured by liq

152 with differential regulation of a pheromone biosynthetic enzyme gene.

153 y creatine deficiency due to knockout of the biosynthetic enzyme (guanidinoacetate N-methyltransferas

154 ges in NO cofactor tetrahydrobiopterin (BH4) biosynthetic enzymes (guanosine triphosphate cyclohydrol

155 Inhibition of triacylglycerol (TAG) biosynthetic enzymes has been suggested as a promising s

156 ive activation of unreactive hydrocarbons by biosynthetic enzymes has inspired new synthetic methods

157 e targeted modifications of different lignin biosynthetic enzymes have permitted the generation of tr

158 Experimental approaches targeting carotenoid biosynthetic enzymes have successfully increased the see

159 ctivated form of l-Rha and the corresponding biosynthetic enzymes have yet to be explored in algae.

160 enesis phenotype in mice deficient in the HS biosynthetic enzyme, heparan sulfate 2-O sulfotransferas

161 Absence of the biosynthetic enzyme, heparan sulfate 2-O-sulfotransferas

162 ch genic regions and transporters near known biosynthetic enzymes, highlighting how even a draft geno

163 trigger binding of UBIAD1 to the cholesterol biosynthetic enzyme HMG CoA reductase (HMGCR), thereby i

164 imulate binding of UBIAD1 to the cholesterol biosynthetic enzyme HMG CoA reductase, which is subject

165 s sterol-accelerated ERAD of the cholesterol biosynthetic enzyme HMG-CoA reductase.

166 For example, the lysine biosynthetic enzyme homocitrate synthase was recently sh

167 ic compounds and wine extracts inhibited PAF biosynthetic enzymes, however in higher concentrations t

168 sativa) by down-regulation of the monolignol biosynthetic enzyme hydroxycinnamoyl coenzyme A:shikimat

169 Mutations in the gene encoding the purine biosynthetic enzyme hypoxanthine-guanine phosphoribosylt

170 parallel, systematic RNAi knockdown of lipid biosynthetic enzymes identified enzymes required for div

171 Systematic variation of the set of biosynthetic enzymes illustrated how each affects glucan

172 ah2 was AKR1C3, which encodes a key androgen biosynthetic enzyme implicated in castration-resistant p

173 an unexpected nuclear role for a nucleotide biosynthetic enzyme in regulation of a potent tumor supp

174 osyltransferase (NAMPT), an essential NAD(+) biosynthetic enzyme in skeletal muscle, decreased by 14%

175 results also show a decrease in NOS and BH4 biosynthetic enzyme in submandibular glands.

176 is colocalized with tyrosine hydroxylase, a biosynthetic enzyme in the dopamine pathway.

177 ere, we demonstrate that leader binding by a biosynthetic enzyme in the lasso peptide class of RiPPs

178 residues to govern expression of antibiotic biosynthetic enzymes in a phosphorylation-independent ma

179 egulated by distinct sets of heparan sulfate biosynthetic enzymes in an appropriate growth factor con

180 Conclusively, interference with discrete LM biosynthetic enzymes in different macrophage phenotypes

181 ple erythroid transcription factors and heme biosynthetic enzymes in immature erythroid cells.

182 DLPC treatment induces bile acid biosynthetic enzymes in mouse liver, increases bile acid

183 By expressing 4-OH-ICN biosynthetic enzymes in Saccharomyces cerevisiae and Nic

184 bust and configurable scaffold for arranging biosynthetic enzymes in the cytoplasm of Escherichia col

185 eart, we quantified the expression of NAD(+) biosynthetic enzymes in the human failing heart and in t

186 g those for beta-carotene, encode carotenoid biosynthetic enzymes in their intervals.

187 ogy offers immediate potential to lock these biosynthetic enzymes in their native binding states by p

188 HALCONE SYNTHASE, a gene encoding a flavonol biosynthetic enzyme, in guard cells, but not pavement ce

189 ed expression of SDHA and genes encoding CoQ biosynthetic enzymes, in association with reductions of

190 The signal cascade toward the expression of biosynthetic enzymes includes (1) the activation of phos

191 on of sigma(M) upregulates several cell wall biosynthetic enzymes including one, PBP1, shown here to

192 n of a variety of previously uncharacterized biosynthetic enzymes, including a YcaO domain protein an

193 Proper sulfation is mediated by biosynthetic enzymes, including exostosin-2 (Ext2), N-de

194 enes coding for paucimannosidic proteins and biosynthetic enzymes indicated a novel spatio-temporal b

195 The tryptophan biosynthetic enzyme indole-3-glycerol phosphate synthase

196 A (CoA) carboxylase (ACC), a key fatty acid biosynthetic enzyme, induced caspase-dependent cell deat

197 n level is maintained to mitigate effects of biosynthetic enzyme inhibitors that substantially change

198 The guanine nucleotide biosynthetic enzyme inosine monophosphate dehydrogenase

199 Inositol levels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1)

200 The plant sphingolipid biosynthetic enzyme, inositol phosphorylceramide synthas

201 nsport system for NADP(+) and luminal NAD(+) biosynthetic enzymes integrate signals from a chemokine

202 the utility of DNA scaffolds for assembling biosynthetic enzymes into functional metabolic structure

203 ter represses NLRC4 and the lysophospholipid biosynthetic enzyme iPLA2, causing a decline in intracel

204 es, the only well-characterized endoperoxide biosynthetic enzyme is prostaglandin H synthase, a haem-

205 t in fah1 mutant plants, the activity of HCE biosynthetic enzymes is not limiting for HCE accumulatio

206 rt that spermine synthase (SMS), a polyamine biosynthetic enzyme, is overexpressed in CRC.

207 Thus, much like the lasso peptide biosynthetic enzymes, lasso peptide isopeptidase has bro

208 tide for the lantibiotic lacticin 481 to its biosynthetic enzyme LctM allows the protein to act on co

209 Genetic mutations in the human Moco biosynthetic enzymes lead to a fatal metabolic disorder,

210 high-level, specific expression of key lipid biosynthetic enzymes located in the plastid and the endo

211 econciled by the recent finding that certain biosynthetic enzymes may be spatially organized into two

212 ions, implying that other foci-forming lipid biosynthetic enzymes might retain activity as well.

213 M enzymes, including the molybdenum cofactor biosynthetic enzyme MoaA and the RNA methyltransferase R

214 dehydrogenase anSME, and molybdenum cofactor biosynthetic enzyme MoaA provides support for the establ

215 dehydrogenase (BtrN) and molybdenum cofactor biosynthetic enzyme (MoaA).

216 rified, recombinant late stage peptidoglycan biosynthetic enzymes (MraY, MurG, FemX, PBP2) and their

217 lizes the activity of a series of nucleotide-biosynthetic enzymes (NBEs) whose expression is represse

218 report that ablation of the heparan sulfate biosynthetic enzyme NDST1 in murine endothelium (Ndst1EC

219 nd on high levels of the iron-sulfur cluster biosynthetic enzyme NFS1.

220 by a new downstream target of Hiw: the NAD+ biosynthetic enzyme nicotinamide mononucleotide adenyltr

221 WRN regulates transcription of a key NAD(+) biosynthetic enzyme nicotinamide nucleotide adenylyltran

222 Targeting the NAD(+) biosynthetic enzyme Nmnat to mitochondria was sufficient

223 gnaling cascade involving loss of the NAD(+) biosynthetic enzyme Nmnat/Nmnat2 in axons, activation of

224 condition caused by mutations in the NAD(+) biosynthetic enzyme NMNAT1.

225 s, the most important of which is the NAD(+) biosynthetic enzyme NMNAT2 that inhibits activation of t

226 nuclease activity when bound to the cysteine biosynthetic enzyme O-acetylserine sulfhydrylase A (CysK

227 GM3 synthase (ST3GAL5) is the first biosynthetic enzyme of a- and b-series gangliosides.

228 using different strategies now show that the biosynthetic enzyme of d-serine, serine racemase (SR), i

229 rol lipase-alpha (DAGL-alpha), the principal biosynthetic enzyme of the endogenous cannabinoid 2-arac

230 They can, however, identify the biosynthetic enzymes of these compounds-findings that ar

231 racterization of an intact animal polyketide biosynthetic enzyme opens the door to understanding the

232 ranscript expression of genes encoding other biosynthetic enzymes or proteoglycan core proteins could

233 Purine biosynthetic enzymes organize into dynamic cellular bodi

234 ls and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC).

235 ne by controlling stability of the polyamine biosynthetic enzyme, ornithine decarboxylase.

236 is thaliana), which is defective in a lignin biosynthetic enzyme p-coumaroyl shikimate 3'-hydroxylase

237 The pyrimidine biosynthetic enzyme Plasmodium falciparum dihydroorotate

238 e show evidence that the remaining essential biosynthetic enzyme PqqB is an iron-dependent hydroxylas

239 egulated (ribosomal, chemotactic and primary biosynthetic enzymes) proteins in the CCR versus batch c

240 w enzymes, such as the mitochondrial proline biosynthetic enzyme PYCR1.

241 y potentiated the evolution of glucosinolate biosynthetic enzymes, regulators, and transporters by na

242 The near-complete identification of biosynthetic enzymes, regulators, and transporters has p

243 ession and protein abundance of other NAD(+) biosynthetic enzymes remained unchanged.

244 nsfer RNA (tRNA) 47 years ago, yet the final biosynthetic enzyme responsible for Q-maturation, epoxyq

245 ns controlling the expression of cholesterol biosynthetic enzymes, resulting in optimal recruitment o

246 In vitro characterizations of pseurotin biosynthetic enzymes revealed that the glutathione S-tra

247 h immunohistochemistry for catecholaminergic biosynthetic enzymes revealed the ventrolateral medulla

248 Previous examination of the initial biosynthetic enzyme (Rv3377c/MtHPS) involved in isoTb bi

249 We have identified gene fusions of polyamine biosynthetic enzymes S-adenosylmethionine decarboxylase

250 activity of a key trypanosomatid spermidine biosynthetic enzyme, S-adenosylmethionine decarboxylase,

251 reticulum-, and mitochondria-localized lipid biosynthetic enzymes sequester into distinct foci.

252 g an increase in transcripts encoding the GA-biosynthetic enzyme SlGA20ox3, as well as a reduction in

253 oteasomal degradation of the key cholesterol biosynthetic enzyme, squalene monooxygenase.

254 that isoforms of all three classes of glucan biosynthetic enzyme (starch/glycogen synthases, branchin

255 replication because inhibition of pyrimidine biosynthetic enzymes substantially decreases the product

256 etabolites are likely formed when tryptophan biosynthetic enzymes substitute synthetic BT for native

257 N also interacts with secreted cell envelope biosynthetic enzymes such as Ag85A via pulldown assays.

258 ion and in increased expression of threonine biosynthetic enzymes suggesting that serine toxicity res

259 s were unaffected by the targeting of purine biosynthetic enzymes, suggesting selective dependence of

260 n transcript abundance for the corresponding biosynthetic enzymes, suggesting that transcriptional re

261 Attempts to harness the catalytic prowess of biosynthetic enzyme systems, for both compound discovery

262 e, we show that mAb CA4 binds to the melanin-biosynthetic enzyme tetrahydroxynaphthalene reductase.

263 phate hydrolase LpxH is an essential lipid A biosynthetic enzyme that is conserved in the majority of

264 e interactions of the glycan substrates, the biosynthetic enzymes that act upon them, and the membran

265 tic challenge, we sought to characterize the biosynthetic enzymes that assemble these NPs for applica

266 These include two chlorophyll biosynthetic enzymes that explain the majority of tocoph

267 genes that encode HSPG core proteins and the biosynthetic enzymes that generate and modify HSPG sugar

268 bolism of cholesterol to bile acids, and the biosynthetic enzymes that generate cholestenoic acids ar

269 parasite-specific feature of these collagen biosynthetic enzymes that may be exploited in future par

270 riched in ALA, and this plant has many lipid biosynthetic enzymes that prefer ALA-containing substrat

271 ight recent examples of characterized animal biosynthetic enzymes that reveal an unanticipated breadt

272 Contrary to thylakoid lipid biosynthetic enzymes, the functions of most predicted ch

273 Among glycosaminoglycan (GAG) biosynthetic enzymes, the human beta1,4-galactosyltransf

274 One such substrate is the pyrimidine biosynthetic enzyme thymidylate synthase (EC 2.1.1.45),

275 kahalalidefaciens") uses a diverse array of biosynthetic enzymes to convert simple substrates into a

276 o control the expression level of all of the biosynthetic enzymes to produce heparin in CHO cells.

277 he relocalization of cPLA(2)alpha and 5-HETE biosynthetic enzymes to the cytoplasm and cytoplasmic ve

278 o canonical leader peptides in directing the biosynthetic enzymes to the substrate.

279 GalNAz) is converted by endogenous mammalian biosynthetic enzymes to UDP-GalNAz and then epimerized t

280 that targeted inhibition of heparan sulfate biosynthetic enzymes together with enzyme replacement mi

281 s prolongevity signal requires the serotonin biosynthetic enzyme TPH-1 in neurons and the serotonin r

282 ssential for the production of the serotonin biosynthetic enzyme Tph1.

283 al regulation of the rate-limiting serotonin biosynthetic enzyme tryptophan hydroxylase (TPH) are poo

284 rt crystal structures of the galactofuranose biosynthetic enzyme UDP-galactopyranose mutase (UGM) fro

285 in the context of repression of the key GSL biosynthetic enzyme UDP-glucose ceramide glucosyltransfe

286 point the specific glycans and corresponding biosynthetic enzymes underlying a biological process.

287 We monitored spatial distribution of lipid biosynthetic enzymes upon glucose depletion in Saccharom

288 anscriptional activation of gibberellic acid biosynthetic enzymes via histone demethylation.

289 While expression of glutathione biosynthetic enzymes was unchanged, xCT, a component of

290 protectase in combination with other modular biosynthetic enzymes, we describe the total synthesis of

291 s, whereas candidates more similar to lignan biosynthetic enzymes were catalytically inactive with th

292 identified in the plastoglobule, whereas the biosynthetic enzymes were in the membranes.

293 Proteins corresponding to nine morphine biosynthetic enzymes were represented in the whole stem,

294 olysine that is generated by the pyrrolysine biosynthetic enzymes when the growth media is supplement

295 ecause it allows promiscuous activity of the biosynthetic enzymes with respect to modification of the

296 aused by mutations in genes that encode haem biosynthetic enzymes with resultant buildup of cytotoxic

297 andidate genes encoding cellulose and lignin biosynthetic enzymes, with chemical wood property phenot

298 iles correlate with those of core fatty-acid biosynthetic enzymes, with maximal expression occurring

299 that altered expression/activity of androgen biosynthetic enzymes would regulate tissue availability

300 SUPPRESSION1 (LLS1) gene, encoding the auxin biosynthetic enzyme YUCCA1 in Medicago truncatula.